New findings describe how the enzyme CST is recruited to the end of the telomere, where it maintains telomere length with the help of subtle chemical changes made to the protein POT1.
The end replication problem dictates that telomeres shrink unless telomerase intervenes. But the problem is actually twice as complicated, with telomerase providing only part of the solution.
Birsoy is honored for groundbreaking research uncovering metabolic weaknesses of diseased cells, such as cancer, while shedding light on debilitating mitochondrial diseases and rare genetic disorders.
Researchers have long disagreed over whether 𝛄𝛅T cells in the gut promote or discourage tumor growth, but new evidence suggests they have the capacity to do both.
Unlike conventional antiretroviral drugs, treatment with broadly neutralizing antibodies does not rely on vigilant daily dosing and could potentially reduce the body’s reservoir of latent viruses.
Birsoy's groundbreaking research has highlighted key nutrients that cancer cells need to survive, while shedding light on debilitating mitochondrial diseases and rare genetic disorders.
Cohen, a physician-scientist exploring obesity and metabolic disease, has conducted groundbreaking research on the complex inner workings of fat tissue.
Researchers have found the first evidence that telomere shortening is not just a sign of aging, but a key component of the body's cancer prevention system.
Rice will receive the 2020 Nobel Prize in Physiology or Medicine for research that led to a cure for hepatitis C, a viral disease affecting 170 million people worldwide. His lab worked on the virus for three decades and became the first to produce a version of it that could be grown and studied i...
New research suggests that breast and lung tumors metastasize by hijacking a neural signaling pathway, potentially opening the door to better diagnostics and treatments.
Researchers studying two forms of skin cancer identified a long-overlooked factor determining why some tumors are more likely to metastasize than others: the physical properties of the tissue in which the cancer originates. The findings might set the stage for new ways to monitor and treat the di...
Scientists have long struggled to understand what drives a tumor to seed itself elsewhere in the body. New research implicates our own pre-existing genetics.
The novel compounds are based on so-called broadly neutralizing antibodies, molecules that make rare people's immune systems capable of fighting HIV. They could potentially yield new treatment and prevention approaches benefitting people around the world, including in developing countries.
For reasons that have long been unclear, cells stop dividing when the pH rises inside tiny cellular compartments called lysosomes. Now scientists have found an explanation for this phenomenon, with potential implications for drug development.
Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
Allis, whose pioneering research established that enzymes that modify histone proteins, which package DNA in the nucleus, regulate gene expression, has been elected to the National Academy of Medicine.
In studying cell division, scientists happened upon a new way of understanding how a chemotherapy compound works. The findings could make it possible to predict which patients are most likely to benefit from the drug.
Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.
In many cancer patients who have been treated with immunotherapy, the tumor comes back. New research identifies the cells responsible for thwarting the treatment and offers new insights into how they do it.
Researchers successfully modified immune cells to produce antibodies that fight HIV. This strategy could eventually be used to develop a vaccine against the virus, among other conditions.
