A diverse immune response hinges on naive B cells mingling with high affinity ones in the late-stage germinal center. Whether that helps or hinders, however, depends on the virus.
Patients with Fanconi anemia have an elevated risk for squamous cell carcinoma, a highly aggressive head-and-neck cancer. New findings pinpoint the mechanisms linking the two conditions, and also shed new light on how smoking or drinking may elevate anyone’s cancer risk.