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Displaying 91 of 2813 articles.

An immune flaw may cause West Nile virus’s deadliest symptoms

...What is it that makes these select few so vulnerable? An international team of researchers led by Rockefeller University’s Jean-Laurent Casanova and Alessandro Borghesi of the San Matteo Research Hospital in Pavia, Italy, recently pinpointed the cause: an autoimmune defect...

Homing in on the genetics of severe COVID in children

...The patients are sick not because of the virus,” says Rockefeller geneticist Jean-Laurent Casanova. “They're sick because they excessively respond to the virus.” Inborn errors An enduring mystery of COVID has been its wildly varied impact on individuals, with one person ge...

Eight Rockefeller scientists designated most influential researchers

...The 2022 list includes: Paul Bieniasz Marina Caskey Luciano Marraffini Jean-Laurent Casanova James G. Krueger Michel C. Nussenzweig Jeffrey V. Ravetch Charles M. Rice Clarivate selects influential scientists for its prestigious list by first compiling the most highly cited...

A new institute devoted to research on global infectious disease is funded by a $75 million grant

...The institute will also support COVID research launched by geneticist Jean-Laurent Casanova at the outset of the pandemic. His effort to identify genetic differences that predispose some people to developing severe COVID-19 quickly evolved into a collaboration of extraordi...

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Missing immune molecule may explain why some HPV patients sprout giant horn-like growths

...How could one virus provoke such a severe reaction in a select few, but leave most people symptom-free? In a new study published in Cell, Rockefeller’s Jean-Laurent Casanova answers this question by examining the genetics of an otherwise healthy patient who contracted a se...

Jean-Laurent Casanova receives the 2016 Inserm Grand Prix

Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has won the 2016 Inserm Grand Prix for his work on the genetic basis of infectious diseases. The prestigious award, given annually by Inserm—the French National Ins...

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The common thread in severe COVID-19 

...Two papers from the laboratory of Jean-Laurent Casanova previously demonstrated that at least 10 percent of severe cases can be chalked up to either a genetic condition that cripples IFN production, or misguided antibodies that attack those crucial proteins. Now, two new s...

The genetic underpinnings of severe staph infections

...Rockefeller immunologist Jean-Laurent Casanova examined the protein-coding genomes of more than 100 patients who had suffered from unexplained severe staph infections. The common genetic thread linking some of th...

Jean-Laurent Casanova honored with the Korsmeyer Award

Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, is the recipient of the 2016 Stanley J. Korsmeyer Award for his work investigating the genetic basis of pediatric infectious diseases. The award, given by the Ameri...

Jean-Laurent Casanova elected to the National Academy of Medicine

Jean-Laurent Casanova, who investigates genetic vulnerability to infectious diseases among children, has been elected to the U.S. National Academy of Medicine, the health and medicine arm of the National Academy of Sciences. Casanova is professor and head of the St. Gi...
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