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Missing immune molecule may explain why some HPV patients sprout giant horn-like growths

...How could one virus provoke such a severe reaction in a select few, but leave most people symptom-free? In a new study published in Cell, Rockefeller’s Jean-Laurent Casanova answers this question by examining the genetics of an otherwise healthy patient who contracted a severe case of tree-man syn...

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The common thread in severe COVID-19 

...Two papers from the laboratory of Jean-Laurent Casanova previously demonstrated that at least 10 percent of severe cases can be chalked up to either a genetic condition that cripples IFN production, or misguided antibodies that attack those crucial proteins. Now, two new studies in Science...

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How one patient’s rare mutation helped solve a mycobacterial mystery

...The lab of Jean-Laurent Casanova, which has spent 25 years studying the interplay between human genes and mycobacterial disease, continues to uncover the genetic defects that separate those who develop serious infections from those who remain symptomless after being exposed to mycobacteria. Their la...

Jean-Laurent Casanova receives the 2016 Inserm Grand Prix

Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, has won the 2016 Inserm Grand Prix for his work on the genetic basis of infectious diseases. The prestigious award, given annually by Inserm—the French National Institute of Health and M...

Llamas immune to coronavirus, what zebrafish are thinking, and other memorable science stories of 2020 

...Shortly thereafter, Jean-Laurent Casanova and colleagues made headlines with two reports revealing that people with the most severe cases of the disease frequently lack interferon I, a cluster of proteins that repel viruses, providing the first molecular explanation for why some young, otherwi...

Scientists trace severe COVID-19 to faulty genes and autoimmune condition

...These findings provide compelling evidence that the disruption of type I interferon is often the cause of life-threatening COVID-19,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University and a Howard Hughes Medical I...

Jean-Laurent Casanova honored with the Korsmeyer Award

Jean-Laurent Casanova, professor and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, is the recipient of the 2016 Stanley J. Korsmeyer Award for his work investigating the genetic basis of pediatric infectious diseases. The award, given by the American Society for Clinical...

Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19

...We may find a genetic clue that could help explain what is driving this severe complication in these children, which can in turn inform their clinical care,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University. A...

Jean-Laurent Casanova elected to the National Academy of Medicine

Jean-Laurent Casanova, who investigates genetic vulnerability to infectious diseases among children, has been elected to the U.S. National Academy of Medicine, the health and medicine arm of the National Academy of Sciences. Casanova is professor and head of the St. Giles Laboratory of Human Gen...

The gene hunt to explain why some young, healthy people die from COVID-19

...Infectious diseases are always an interplay between a pathogen and the host’s immunity,” says Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University. “At least some of these patients may suffer from a genetic variation ...

Recent Awards and Honors

Katya Vinogradova

Ekaterina V. Vinogradova receives Damon Runyon-Rachleff Innovation Award

January 11, 2022

Vinogradova receives the award for her work exploring how lung tumors suppress immune responses.

Charles M. Rice

Charles M. Rice is elected to the National Academy of Inventors

December 7, 2021

Rice receives the honor for pioneering novel methods for growing and studying hepatitis C virus.

More awards and honors

Rockefeller in the News

STAT News

For his part, Paul Bieniasz is feeling more optimistic than he was earlier in the Omicron wave, but he’s not looking for a respite. He wants something more sustained. “I’m not so interested in breathers. These waves, I want to diminish the amplitude rather than the frequency,” he said.  

The New York Times

“People that are vaccinated really are doing very well in terms of hospitalization,” said Michel Nussenzweig, an immunologist at Rockefeller University in New York.

The New York Times

“What molnupiravir does is it disguises itself,” Elizabeth Campbell, an expert in structural biology at the Rockefeller University who studies coronavirus antivirals, said in an interview. “It can propagate errors that are going to be sprinkled all over the genome.”

Seek magazine

Rockefeller’s flagship publication is interested not just in scientific results, but in the people, ideas, and conversations that ignite discovery. The latest issue takes a look at how the brain’s internal states drive its remarkable ability to reach different conclusion based on the same information. Also: The latest from Rockefeller’s COVID labs, and much more.


From this issue

 


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