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Keratinocyte skin cells
Science News

Researchers uncover molecular mechanisms of rare skin disease

...Led by Rockefeller scientist Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases, a group of researchers recently elucidated the molecular mechanisms that make people with EV vulnerable to ß-HPVs. In a new study, published in th...
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In Brief

Genetic mutation identified as culprit in rare infectious disease

...In an article published in eLife, Jean-Laurent Casanova has uncovered the human genetics factors that make these outliers susceptible to infection. His team suspected that Whipple’s is the latest in a growing number of genetic defects that increases people’s vulnerability ...
Campus News

Awards, arrivals, and promotions

Congratulations to our latest award winners: Jean-Laurent Casanova has been recognized with the Stanley J. Korsmeyer Award for his work investigating the genetic basis of pediatric infectious diseases. The award is given by the American Society for Clinical Investigation, an ...
Mycobacterium tuberculosis
Science News

Study identifies genetic mutation responsible for tuberculosis vulnerability

...Hoping to better understand why only some people are prone to TB, Jean-Laurent Casanova worked with clinicians across the world to collect DNA samples from patients with active forms of the disease. By analyzing these samples, the researchers discovered that the risk of de...
Campus News

Rockefeller hosts the first New York City symposium on human genetics

...Spearheaded by Rockefeller professor Jean-Laurent Casanova, who is working closely with physician-scientist Bruce Gelb at Icahn School of Medicine at Mount Sinai and geneticist David Goldstein at Columbia University, the group plans to organize two meetings annually. “The ...
Science News

Researchers develop gene-filtering tool to identify disease-causing mutations

...A new tool, developed by scientists in Jean-Laurent Casanova’s St. Giles Laboratory of Human Genetics of Infectious Diseases at Rockefeller University aims to predict whether a given human gene is likely to harbor disease-causing mutations. The hope is that their tool, des...
Science News

New research explains why a common bacterium can produce severe illness

...Jean-Laurent Casanova, head of St. Giles Laboratory of Human Genetics of Infectious Diseases and Howard Hughes Medical Institute Investigator, led a team of researchers to uncover how two different conditions—a genetic immunodeficiency and delayed acquired immunity—can com...
Nussenzweig portrait
Awards and Honors

Michel C. Nussenzweig wins 2017 Sanofi-Institut Pasteur Award

...Ravetch in 2012 and Jean-Laurent Casanova in 2014.
Campus News

Awards, arrivals, and promotions

...Jean-Laurent Casanova has been elected to the National Academy of Medicine, the health and medicine arm of the National Academy of Sciences. In what is considered one of the highest honors in medicine, new members are elected to the academy based on their outstanding profe...
Campus News

Talking Science lecture introduces students to the genetic aspects of infectious diseases

As he opened this year’s Talking Science lecture, geneticist Jean-Laurent Casanova made a stark observation to his teenage audience: “If we had been here 150 years ago, about half of you would already have died.” The primary reason, he told the 350 high school students and 60...
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