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Proceedings of the National Academy of Sciences USA online: March 18, 2013

Proceedings of the National Academy of Sciences USA online: March 18, 2013 RecA acts as a switch to regulate polymerase occupancy in a moving replication fork Chiara Indiani, Meghna Patel, Myron F. Goodman and Mike E. O’Donnell

Proceedings of the National Academy of Sciences USA online: March 11, 2013

Proceedings of the National Academy of Sciences USA online: March 11, 2013 Ring cycle for dilating and constricting the nuclear pore Sozanne R. Solmaz, Günter Blobel and Ivo Melcák  
Campus News

Rockefeller University hosts workshop on Next Generation Science Standards

A series of workshops, to be held this weekend at The Rockefeller University, is designed to help scientists and educators prepare for the adoption of new standards for teaching science in elementary and high schools. The event, titled "Improving Dialogue between Scientists & Educators: Implicati...

In the News

Legendary drug industry executives warn U.S. science cuts endanger the future   "In short, even prior to the 5 percent budget cut brought about last week by sequestration, our basic research enterprise has been in crisis. This erosion in our basic science investment has occurred at the very time ...
Awards and Honors

Teresa Davoli wins 2013 Weintraub Graduate Student Award

Rockefeller University graduate student Teresa Davoli, who will receive her degree this June, has been given a Harold M. Weintraub Graduate Student Award, one of the country’s most prestigious graduate student prizes. Davoli has been a member of Titia de Lange’s Laboratory of Cell Biology and Ge...

Nature Biotechnology 3-13

Nature Biotechnology 31: 233-239 RNA-guided editing of bacterial genomes using CRISPR-Cas systems Wenyan Jiang, David Bikard, David Cox, Feng Zhang and Luciano A Marraffini

Cell 152: 1021-1036 2-28-13

Cell 152: 1021-1036 H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation Shannon M. Lauberth, Takahiro Nakayama, Xiaolin Wu, Andrea L. Ferris, Zhanyun Tang, Stephen H. Hughes and Robert G. Roeder

Proceedings of the National Academy of Sciences USA online: February 25, 2013

Proceedings of the National Academy of Sciences USA online: February 25, 2013 Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations Zev Williams, Iddo Z. Ben-Dov, Rony Elias, Aleksandra Mihailovic, Miguel Brown, Zev ...

In the News

Scientists win millions for breakthrough research   "Dr. Cori Bargmann of Rockefeller University received an unexpected phone call...she was told that she had been chosen to receive a $3 million cash prize for her research in brain development, which will hopefully provide breakthroughs in disord...
Awards and Honors

Vanessa Ruta awarded Sloan Research Fellowship

Vanessa Ruta, assistant professor and head of the Laboratory of Neurophysiology and Behavior at The Rockefeller University, has been awarded a 2012 Sloan Research Fellowship. Ruta will receive $50,000 to further her research on how neural circuits are modified by experience. The two-year fellowsh...

Genes and Development online: February 21, 2013

Genes and Development online: February 21, 2013 Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation Jasbir Dalal, Jee Hoon Roh, Susan E. Maloney, Afua Akuffo, Samir  Shah, Han Yuan, Brie Wamsley, Wendell B. Jones, Cristina de Guzman Strong, Paul A. Gr...

In the News

How stress gets under the skin: Q&A with neuroscientist Bruce McEwen   "Be physically active, get a good diet, [get] adequate sleep, [create] social support, have a good hobby, meditate. All of these things really are common sense and now we know they do have the benefits of improving our brain a...
Awards and Honors

Cori Bargmann, Titia de Lange win inaugural Breakthrough Prizes worth $3 million

Two Rockefeller University scientists are among 11 winners of the first annual Breakthrough Prize in Life Sciences, an award established by six tech entrepreneurs dedicated to advancing breakthrough research. At $3 million each, the prizes are worth more than twice the amount of the Nobel. Cori B...

Proceedings of the National Academy of Sciences USA online: February 19, 2013

Proceedings of the National Academy of Sciences USA online: February 19, 2013 Phenotypic model for early T-cell activation displaying sensitivity, specificity and antagonism Paul François, Guillaume Voisinne, Eric D. Siggia, Grégoire Altan-Bonnet and Massimo Vergassola

Proceedings of the National Academy of Sciences USA online: February 19, 2013

Proceedings of the National Academy of Sciences USA online: February 19, 2013 Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W. Maurer, Stella M. Ranuncolo, Hong Zhao, Weihong...

Proceedings of the National Academy of Sciences USA online: February 19, 2013

Proceedings of the National Academy of Sciences USA online: February 19, 2013 Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma Michael Chiorazzi, Lixin Rui, Yandan Yang, Michele Ceribelli, Nima Tishbi, Carine W. Maurer, Stella M. Ranuncolo, Hong Zhao, Weihong...
Campus News

New book explores history of cell biology at Rockefeller

The story of how a Rockefeller University laboratory contributed to the founding of the new science of modern cell biology has been published by The Rockefeller University Press. Entering an Unseen World: A Founding Laboratory and Origins of Modern Cell Biology 1910–1974, by Carol L. Moberg, is a...

Current Biology 23: 328-332 (2-18-13)

Current Biology 23: 328-332 Enforcement of reproductive synchrony via policing in a clonal ant Serafino Teseo, Daniel J.C. Kronauer, Pierre Jaisson and Nicolas Châline

Nature Chemical Biology online: February 17, 2013

Nature Chemical Biology online: February 17, 2013 Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells Scott Barbuto, Juliana Idoyaga, Miquel Vila-Perelló, Maria P. Longhi, Gaëlle Breton, Ralph M. Steinman and Tom W. Muir

Cell 152:831-843 (2-14-13)

Cell 152:831-843 SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action Yong-Seok Oh, Pu Gao, Ko-Woon Lee, Ilaria Ceglia, Ji-Seon Seo, Xiaozhu Zhang, Jung-Hyuck Ahn, Brian T. Chait, Dinshaw J. Patel, Yong Kim and Paul Greengard

Proceedings of the National Academy of Sciences USA online: February 14, 2013

Proceedings of the National Academy of Sciences USA online: February 14, 2013 Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia Eric Wang, Shinpei Kawaoka, Ming Yu, Junwei Shi, Ting Ni, Wenjing Yang, Jun  Zhu, Robert G. Roeder and Christopher R. Vakoc
Science News

In sync: stem cells work together to make hair grow, give it color

Your hair may seem unwilling to cooperate some mornings, but at the root of each strand is a tiny partnership of stem cells that work very well together to make hair happen. New research from The Rockefeller University has elucidated how these adult stem cells communicate with each other to make ...

Nature online: February 6, 2013

Nature online: February 6, 2013 NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche Chiung-Ying Chang, H. Amalia Pasolli, Eugenia G. Giannopoulou, Géraldine Guasch, Richard M. Gronostajski, Olivier Elemento and Elaine Fuchs

Proceedings of the National Academy of Sciences USA online: February 4, 2013

Proceedings of the National Academy of Sciences USA online: February 4, 2013 Innate immunity receptor CD36 promotes cerebral amyloid angiopathy Laibaik Park, Joan Zhou, Ping Zhou, Rose Pistick, Sleiman El Jamal, Linda Younkin, Joseph Pierce, Andrea Arreguin, Josef Anrather, Steven G. Younkin, Geo...
Awards and Honors

David Allis awarded $1 million grant from Starr Cancer Consortium

C. David Allis, Joy and Jack Fishman Professor and head of the Laboratory of Chromatin Biology and Epigenetics at Rockefeller, has been awarded a $1 million grant from the Starr Cancer Consortium. Allis leads one of five cancer research teams from the New York City based members of the consortium...

Cell 152: 431-441 (1-31-13)

Cell 152: 431-441 Structural basis of transcriptional pausing in bacteria Albert Weixlbaumer, Katherine Leon, Robert Landick and Seth A. Darst
Awards and Honors

Jeff Friedman to receive King Faisal and BBVA prizes

Jeffrey M. Friedman, the Marilyn M. Simpson Professor and head of the Laboratory of Molecular Genetics, will be the recipient of two international scientific awards announced this week. The King Faisal International Prize in Medicine, from the Saudi Arabian King Faisal Foundation, and the BBVA Fr...
Awards and Honors

Wiley Prize in Biomedical Sciences awarded to Mike Young and colleagues

Michael W. Young, Richard and Jeanne Fisher Professor and head of the Laboratory of Genetics, has been awarded the twelfth annual Wiley Prize in Biomedical Sciences along with his colleagues, Jeffrey Hall and Michael Rosbash of Brandeis University. The researchers are being honored for their disc...
Science News

Ant executions serve a higher purpose, research shows

Natural selection can be an agonizingly long process. Some organisms have a way of taking matters into their own hands, or — in the case of the ant species Cerapachys biroi — mandibles. Researchers at The Rockefeller University and University of Paris 13 have found that when a C. biroi ant step...

In the News

Scarred for life? The biology of childhood hardship "Elsewhere, research by one of us, Bruce McEwen, has closed in on how pre- and postnatal stress affects a complex set of interactions between the hypothalamus, the pituitary gland and the adrenal glands (the HPA axis). These are all part of the ...

In the News

Food Fraud? Watchdog Group Raises Concerns   "High school students supervised by New York's Rockefeller University found alarming results in testing done over the last three years. Sixteen percent of the grocery store food they DNA tested, from expensive sheep's milk cheese that had only cow DNA ...

Proceedings of the National Academy of Sciences USA online: January 22, 2013

Proceedings of the National Academy of Sciences USA online: January 22, 2013 Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel Stephen G. Brohawn, Ernest B. Campbell and Roderick MacKinnon

Proceedings of the National Academy of Sciences USA online: January 22, 2013

Proceedings of the National Academy of Sciences USA online: January 22, 2013 Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel Stephen G. Brohawn, Ernest B. Campbell and Roderick MacKinnon

In the News

Epigenetics: How Our Experiences Affect Our Offspring   "We were all brought up to think the genome was it," said Rockefeller University molecular biologist C. David Allis. "It's really been a watershed in understanding that there is something beyond the genome."

Nature Immunology online: January 20, 2013

Nature Immunology online: January 20, 2013 Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes Daniel Mucida, Mohammad Mushtaq Husain, Sawako Muroi, Femke van Wijk, Ryo Shinnakasu, Yoshinori Naoe, Bernardo Sgarbi Reis, Y...

Nature Immunology online: January 20, 2013

Nature Immunology online: January 20, 2013 Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes Daniel Mucida, Mohammad Mushtaq Husain, Sawako Muroi, Femke van Wijk, Ryo Shinnakasu, Yoshinori Naoe, Bernardo Sgarbi Reis, Y...

Developmental Cell 24: 52-63 (1-14-13)

Developmental Cell 24: 52-63 Roundabout receptors are critical for foregut separation from the body wall Eric Thomas Domyan, Kelsey Branchfield, Daniel A. Gibson, L.A. Naiche, Mark Lewandoski, Marc Tessier-Lavigne, Le Ma and Xin Sun

Nature Methods online: January 13, 2013

Nature Methods online: January 13, 2013 An optimized fluorescent probe for visualizing glutamate neurotransmission Jonathan S. Marvin, Bart G. Borghuis, Lin Tian, Joseph Cichon, Mark T. Harnett, Jasper Akerboom, Andrew Gordus, Sabine L. Renninger, Tsai-Wen Chen, Cornelia I. Bargmann, Michael B. O...

Science online: January 10, 2013

Science online: January 10, 2013 53BP1 regulates DSB repair using Rif1 to control 5' end resection Michal Zimmermann, Francisca Lottersberger, Sara B. Buonomo, Agnel Sfeir and Titia de Lange

Science online: January 10, 2013

Science online: January 10, 2013 53BP1 regulates DSB repair using Rif1 to control 5' end resection Michal Zimmermann, Francisca Lottersberger, Sara B. Buonomo, Agnel Sfeir and Titia de Lange

Proceedings of the National Academy of Sciences USA online: January 9, 2013

Proceedings of the National Academy of Sciences USA online: January 9, 2013 Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening Fang-Yuan Chang and Sean F. Brady

The Journal of Clinical Investigation online: January 9, 2013

The Journal of Clinical Investigation online: January 9, 2013 Specialized role of migratory dendritic cells in peripheral tolerance induction Juliana Idoyaga, Christopher Fiorese, Lori Zbytnuik, Ashira Lubkin, Jennifer Miller, Bernard Malissen, Daniel Mucida, Miriam Merad and Ralph M. Steinman

Science online: January 4, 2013

Science online: January 4, 2013 Dynamic persistence of antibiotic-stressed mycobacteria Yuichi Wakamoto, Neeraj Dhar, Remy Chait, Katrin Schneider, François Signorino-Gelo, Stanislas Leibler and John D. McKinney

Science online: January 3, 2012

Science online: January 3, 2012 Multiplex genome engineering using CRISPR/Cas systems Le Cong, F. Ann Ran, David Cox, Shuailiang Lin, Robert Barretto, Naomi Habib, Patrick D. Hsu, Xuebing Wu, Wenyan Jiang, Luciano A. Marraffini and Feng Zhang

In the News

New Method Enables Multiplex Genome Engineering "A consortium of scientists [including The Rockefeller University] announced that they had devised a way to enable simultaneous editing of several sites within the mammalian genome. The technology, based on a bacterial defense system against viruses...

Molecular Cell online: January 1, 2013

Molecular Cell online: January 1, 2013 53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma Mila Jankovic, Niklas Feldhahn, Thiago Y. Oliveira, Israel T.  Silva, Kyong-Rim Kieffer-Kwon, Arito Yamane, Wolfgang Resch, Isaac Klein, Davide F. Robbiani, Rafael Ca...

Proceedings of the National Academy of Sciences USA online: December 31, 2012

Proceedings of the National Academy of Sciences USA online: December 31, 2012 Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase Rebecca K. Delker, Yanjiao Zhou, Alexandros Strikoudis, C. Erec Stebbins and F. Nina Papavasiliou

Molecular Cell online: December 22, 2012

Molecular Cell online: December 22, 2012 An H3K36 methylation-engaging tudor motif of polycomb-like proteins mediates PRC2 complex targeting Ling Cai, Scott B. Rothbart, Rui Lu, Bowen Xu, Wei-Yi Chen, Ashutosh Tripathy, Shira Rockowitz, Deyou Zheng, Dinshaw J. Patel, C. David Allis, Brian D. Stra...

Molecular Cell online: December 27, 2012

Molecular Cell online: December 27, 2012 Activation of DSB processing requires phosphorylation of CtIP by ATR Shaun E. Peterson, Yinyin Li, Foon Wu-Baer, Brian T. Chait, Richard Baer, Hong Yan, Max E. Gottesman and Jean Gautier

Proceedings of the National Academy of Sciences USA 109: 21319-21324 (12-26-12)

Proceedings of the National Academy of Sciences USA 109: 21319-21324 Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes Shaun D. McCullough, Xiaojiang Xu, Sharon Y. R. Dent, Stefan  Bekiranov, Robert G. Roederc and Patrick A. Grant
Science News

Changes in population growth, consumption and farming begin to return former farmlands to nature

With the global population racing past seven billion, demographers and world leaders have been concerned with depletion of resources to support everyone. The future, though, may be less bleak than some have feared. Changes in population growth and how farmers use land have brought the world to “p...

Cell 151: 1417-1430 (12-21-12)

Cell 151: 1417-1430 MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system Marian Mellén, Pinar Ayata, Scott Dewell, Skirmantas Kriaucionis and Nathaniel Heintz

In the News

Is the Cure for Cancer Inside You?   "In the long struggle that was to come, [Ralph] Steinman would try anything and everything that might extend his life, but he placed his greatest hope in a field he helped create, one based on discoveries for which he would earn his Nobel Prize. He hoped to re...

In the News

Farmland Peaks, Crop Space to Revert Back to Nature, Report Finds   "Humanity has reached what Rockefeller University scientists, in a new report, call 'peak farmland.' In the next half-century, a geographical area more than twice the size of France — or equivalent to 10 Iowas — will return to...

In the News

Worried about Underwater Creatures, Scientists Want to Hush the Noisy Oceans   "[O]ceans have actually become very loud due to man-made noise from oil rigs, sonar and ship propellers. And scientists are worried that all that added noise is hurting marine life. So they’re planning a massive exper...

Nature 492: 382–386 (12-20-12)

Nature 492: 382–386 FMRP targets distinct mRNA sequence elements to regulate protein expression Manuel Ascano, Neelanjan Mukherjee, Pradeep Bandaru, Jason B. Miller, Jeffrey D. Nusbaum, David L. Corcoran, Christine Langlois, Mathias  Munschauer, Scott Dewell, Markus Hafner, Zev Williams, Uwe Ohle...

Proceedings of the National Academy of Sciences USA 109: 21076-21080 (12-18-12)

Proceedings of the National Academy of Sciences USA 109: 21076-21080 Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea Fumiaki Nin, Tobias Reichenbach, Jonathan A. N. Fisher and A. J. Hudspeth

Journal of Experimental Medicine: December 17, 2012

Journal of Experimental Medicine: December 17, 2012 Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching Anne Bothmer, Philipp C. Rommel, Anna Gazumyan, Federica  Polato, Colleen R. Reczek, Matthias F. Muellenbeck, Sonja Schaetzlein, Winfried Edelman...
Campus News

Announcements

Annual holiday party is December 20. Celebrate the season with friends and colleagues: this year’s holiday party will showcase the diversity of New York City with food, drinks, music, dancing and entertainment, in Abby Lounge and Dining Room and throughout the CRC, from 3:30 to 5:30 p.m. For more...
Campus News

No scientific losses from Hurricane Sandy

by ZACH VEILLEUX When water from the East River first spilled over its banks and began washing onto the FDR Drive late in the evening of October 29, the several dozen or so administrators and essential personnel monitoring the storm knew it was not likely to stop at the curb. The lowest levels of...
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