Most people infected with the coronavirus are able to fight it off because their immune system produces effective antibodies. Rockefeller scientists are working to turn such antibodies into a drug.
Using atomic-resolution technology, scientists have constructed the most detailed view yet of the molecular complex that decides where microtubules form.
Over 130 scientists in 18 labs are conducting research to advance the development of new, urgently needed approaches for the prevention and treatment of COVID-19.
Scientists have identified the mechanism that allows skin cells to sense changes in their environment, and very quickly respond to reinforce the skin's outermost layer. The findings provide insight into how errors in this process might lead to skin conditions like psoriasis.
The novel compounds are based on so-called broadly neutralizing antibodies, molecules that make rare people's immune systems capable of fighting HIV. They could potentially yield new treatment and prevention approaches benefitting people around the world, including in developing countries.
Scientists have identified a particular type of skin cell that looks and behaves similar to a nerve cell, prompting new questions about the body's biggest organ.
For reasons that have long been unclear, cells stop dividing when the pH rises inside tiny cellular compartments called lysosomes. Now scientists have found an explanation for this phenomenon, with potential implications for drug development.
For some unlucky people, a bout of intestinal distress like traveler’s diarrhea leads to irritable bowel syndrome. Recent discoveries have given scientists a better idea of how this happens, and potential leads for new treatments.
Scientists find a new brain area in control of our attention skills, raising new questions in what has long been considered a settled scientific field.
To scientists' surprise, the immune system develops its response to each virus variant mostly from scratch, instead of building on what it has already learned.
Researchers have identified a set of biological factors in mice that seem to determine one's ability to bounce back from a traumatic event, and provide preliminary evidence that a naturally-occurring substance may help boost resiliency in the face of stressful situations.
Protein clumps are routinely found in the brains of patients with neurodegenerative diseases. Now researchers find a link between this buildup and the intracellular movement of proteasomes, molecular machines tasked with degrading protein waste inside cells.
Research that began with the analysis of two developmental syndromes ultimately helped scientists understand how diverse epigenetic mechanisms can combine to drive tissue overgrowth in cancer.
A new study finds that neurons affected in Parkinson’s disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wreaks havoc in the brain, as well as ideas for new treatments.
To grow new hair, stem cells throughout the skin must work in sync. Researchers have discovered the molecular communication tool, part of the lymphatic system, that the cells use to synchronize their activities.
The human papilloma virus is usually kept in check by the immune system, but scientists identified a genetic variant that makes some infected children prone to developing warts in the throat.
In studying cell division, scientists happened upon a new way of understanding how a chemotherapy compound works. The findings could make it possible to predict which patients are most likely to benefit from the drug.
Scientists have found that many receptors with high potential for drug discovery take a different configuration inside the body than in the test tube. The findings could explain why some promising drugs fail in clinical trials, and potentially open doors to new drug-development approaches.
Using a new technique to study brain development, scientists were able to trace the causes of Huntington's back to early developmental stages when the brain has only just begun to form.
A common birthplace of new genes, the male testes are a hotspot for biological innovation. Within these organs, scientists have found a trove of virgin genetic sequences—and a better understanding of how evolution moves forward.
Researchers have shown that antibodies against Zika might be involved in causing birth defects in babies born to infected women. The findings might provide important caveats for the development of a vaccine.
Cell division is critical to creating and sustaining life. It’s also incredibly difficult to study. Now, advanced technology is enabling researchers to take their understanding of this process to the next level.
For the brain to function smoothly, its cells must carefully regulate which proteins are produced and when. By studying gene regulation, researchers are now shedding light on complex brain conditions like autism and stroke.
Navigating fruit flies do not have the luxury of GPS, but they do have a kind of neural compass. In a new study, researchers found that the animals decide which way to turn by comparing this internal compass needle to a fixed goal.
