News & HighlightsNews
Rogue enzymes cause numerous diseases. A new method could help design drugs to treat them.
...The paper, published in the Journal of the American Chemical Society, describes how researchers used this innovative new platform to design molecules that take aim at helicases involved in COVID and certain cancers. "High-resolution structural and biochemical data alone are not sufficie...
Waddling water bears, grandmother neurons, and other memorable science stories of 2021
...Basic biomedical research went on, unabated, through the second year of New York City's touch-and-go battle with COVID. Investigations into the nature of the novel coronavirus and its intractable variants intensified, demanding the attention of more than 25 Rockefeller laboratories, all...
Study of “breakthrough” cases suggests COVID testing may be here to stay
In rare cases, people who have been fully vaccinated against COVID and are immune to the virus can nevertheless develop the disease. New findings from The Rockefeller University now suggest that these so-called breakthrough cases may be driven by rapid evolution of the virus, and that ongo...
This technique for studying cell receptors could have sweeping implications for drug development
...While this work is the culmination of a team effort over a long period of time, Kotliar made herculean efforts to drag it across the finish line—shuttling samples and scarce reagents back and forth from Sweden in rare travel windows during COVID. It paid off. The results provide a handf...
Rockefeller begins testing of new COVID-19 antibody drug in people
With green light from the FDA, Rockefeller scientists started human trials this week for a new monoclonal antibody drug as a potential treatment for COVID-19. Monoclonal antibodies are mass-produced replicas of natural antibodies made by the immune system to fight viruses. Designed to prev...
Llama antibodies could help fight SARS-CoV-2 variants
Amid the growing threat of a new and potentially more dangerous SARS-CoV-2 variant, scientists are ramping up the quest for COVID treatments. A recent study demonstrates the therapeutic potential of an unusual class of immune proteins: miniature antibodies called nanobodies, derived from l...
Lonely flies, like many humans, eat more and sleep less
COVID-19 lockdowns scrambled sleep schedules and stretched waistlines. One culprit may be social isolation itself. Scientists have found that lone fruit flies quarantined in test tubes sleep too little and eat too much after only about one week of social isolation, according to a new study...
A third vaccine dose may increase protection from Omicron
The mRNA vaccines used against COVID were never designed to battle the Omicron variant, a now dominant strain of the coronavirus that recently claimed 18,000 lives in a single week. Yet individuals who receive their third dose appear to be protected from the worst of Omicron, and a new stu...
What bats can teach us about COVID-19
...But at the outset of the COVID-19 pandemic, he diverted his expertise and applied the same methods to instead to see if they could crack the mystery of bats’ exceptional immunity to coronavirus. His group began by sequencing the genome of the horseshoe bat, thought to be the initial hos...
Rockefeller scientists investigate life-threatening inflammation affecting children with COVID-19
...As part of an international study of genetic causes behind severe COVID-19 in young people, Casanova and collaborators have been enrolling these unusual cases since early March, when they were first reported by European doctors. Collaborating with the New York Genome Center and the stat...
View
View