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Scientists engineer human-germ hybrid molecules to attack drug-resistant bacteria

The centromere region of chromosomes retains the same DNA from one generation to the next. Scientists have gained new insights into how it avoids being scrambled in normal cells, and how it becomes unstable in cancer.

Shooting the messenger: how one protein allows germ cells to develop

Researchers have identified a molecule that guides the formation of eggs and sperm by preventing a host of factors related to cell death and inflammation from killing the precursors to these cells. Their findings reveal new knowledge about how a mutation in this molecule leads to male sterility.

Viral fossils reveal how our ancestors eliminated an ancient infection

Some viruses can insert their genetic material into the genome of their host, creating a genetic fossil record. Researchers have uncovered how our ancestors may have wiped out one such virus around 11 million years ago.

A new way to reset gene expression in cancer cells shows promise for leukemia treatment

New findings from Rockefeller University researchers could guide the development of potent combination therapies that deliver more effective and durable treatment of leukemia. In recent work published in Nature, they show it’s possible to deactivate cellular programs involved in tumor growth by d...

Paul Greengard Professorship established with $5 million gift from the Fisher Center Foundation

Late last year, guests at the President’s House raised a glass in celebration of one of Rockefeller’s most beloved colleagues. In his nearly 35 years at Rockefeller, Paul Greengard has led pioneering studies that have transformed our understanding of how the nervous system works, and have paved ...

New research explains why a common bacterium can produce severe illness

As much as we try to avoid it, ­we are constantly sharing germs with those around us. But even when two people have the same infection, the resulting illnesses can be dramatically different—mild for one person, severe or even life-threatening for the other. Now, new research from The Rockefell...

Talking Science lecture introduces students to the genetic aspects of infectious diseases

As he opened this year’s Talking Science lecture, geneticist Jean-Laurent Casanova made a stark observation to his teenage audience: “If we had been here 150 years ago, about half of you would already have died.” The primary reason, he told the 350 high school students and 60 teachers present,...

Mouse studies offer new insights about cocaine’s effect on the brain

 Cocaine is one of the most addictive substances known to man, and for good reason: By acting on levels of the “feel-good” chemical dopamine, it produces a tremendous sensation of euphoria. Now the laboratory of Rockefeller University Professor and Nobel Laureate Paul Greengard has shown...

Researchers develop automated melanoma detector for skin cancer screening

Even experts can be fooled by melanoma. People with this type of skin cancer often have mole-looking growths on their skin that tend to be irregular in shape and color, and can be hard to tell apart from benign ones, making the disease difficult to diagnose. Now, researchers at The Rockefeller Un...

Human embryo discovery wins People’s Choice of Science Breakthrough of the Year

A revolutionary method developed by Rockefeller University scientists that allows researchers to study human embryo development in the lab has been voted Breakthrough of the Year by Science magazine readers. The technique, pioneered by Ali Brivanlou, Robert and Harriet Heilbrunn Professor of the ...