Regulation of Systemic Metabolism Through Adipose Bioenergetics and Thermogenesis
Event Details
- Type
- Friday Lecture Series
- Speaker(s)
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Bruce Spiegelman, Ph.D., professor of cell biology, Harvard Medical School; Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Dana-Farber Cancer Institute
- Speaker bio(s)
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Regulation of metabolic rates and energy expenditure is critical to understanding obesity and diabetes in mammalian systems. Recent years have shown that adipose cells run futile cycles beyond UCP1. Our work on a futile creatine cycle (FCC) demonstrated that the classic creatine shuttle is modified in certain adipose cells whereby phosphocreatine is hydrolyzed in a regulated fashion in order to release free energy in the form of heat. While UCP1 expression is prominent in the classical brown fat, rodent beige fat runs an FCC in response to cold and certain hormonal signals. Human adipose tissues express high levels of components of the FCC, while UCP1 expression is more limited. Our group and others have presented a more unified view of energy expenditure at a systemic level.
Bruce Spiegelman is the Stanley Korsmeyer Professor at Harvard Medical School/Dana-Farber Cancer Institute. Spiegelman received a B.S. from the College of William and Mary, Ph.D from Princeton University, and completed postdoctoral work at MIT. His research focuses on fat cell biology, diabetes and muscular diseases. Major honors include Bristol-Myers Squibb Award for Distinguished Achievement in Metabolic Research; Rolf Luft Award in Endocrinology; Banting Medal for Scientific Achievement; Manpei Suzuki International Prize for Diabetes Research, InBev-Baillet Latour Health Prize. Spiegelman has been elected to the American Academy of Arts and Sciences, the National Academy of Sciences and the Institute of Medicine.
- Open to
- Tri-Institutional