Upcoming Event

Modeling Human Embryogenesis Ex Utero

Event Details

Type
Center for Studies in Physics and Biology Seminars
Speaker(s)
Mo R. Ebrahimkhani, Ph.D., Associate Professor, University of Pittsburgh
Speaker bio(s)

I will present recent work from my team describing a self-organizing human embryo model, termed the heX-embryoid, and its applications in regenerative medicine. Implantation represents a profound transition marked by symmetry breaking, cavity formation, body axis establishment, and germ layer specification, while multilineage extra-embryonic yolk sac morphogenesis drives temporally ordered waves of blood emergence. In humans, these post-implantation stages remain largely inaccessible and poorly understood. I show how heX-embryoids enable ex utero reconstruction of early programs of human embryogenesis, allowing development to be studied as an emergent, multiscale collective process. I will discuss new strategies to build in programmability and enable exploration of developmental morphospace in heX-embryoids, and present examples showing how access to youthful tissue states can be leveraged for regenerative and rejuvenative applications.

Open to
Public
Reception
Refreshments, 3:30 p.m. - 4:00 p.m., Lower Level Greenberg Building (CRC)
Phone
(212) 327-8636
Sponsor
Melanie Lee
(212) 327-8636
leem@rockefeller.edu

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