Insights into Metabolic and Endocrine Phenotypes from Humans Carrying Rare Genetic Variants
- This event already took place in November 2025
- Carson Family Auditorium (CRC)
Event Details
- Type
- Other Seminars
- Speaker(s)
-
Stephen O’Rahilly, M.D., FMedSci, professor of clinical biochemistry and medicine, Institute of Metabolic Science; director, Medical Research Council Metabolic Diseases Unit; scientific director, Cambridge NIHR Biomedical Research Centre
- Speaker bio(s)
-
In this talk, Dr. O’Rahilly will describe how the study of humans with rare, functionally impactful genetic variants has provided novel insights into a range of human endocrine and metabolic phenotypes. In particular, he will discuss: i) The control of energy balance and its disturbances in obesity, and how those investigations have led to new insights into the link between nutritional state and sexual maturation; ii) The control of insulin sensitivity and its disturbances in states of insulin resistance, including a novel class of adipose tissue dysfunction that appears to be a prevalent contributor to metabolic ill-health; iii) How human genetics has contributed to a deeper understanding of the nausea and vomiting of pregnancy, leading to trials of novel therapeutic and preventive strategies.
- Open to
- Tri-Institutional