The rockefeller university

Event Details

Type

Other Tri-Institutional Events

Speaker(s)

1:00 p.m.: Anna Marie Pyle, Ph.D., Sterling Professor of Molecular, Cellular, and Developmental Biology, Yale University, HHMI, Structure and Mechanism of RNA Self-splicing Machines: Implications for Evolution, Regulated Gene Expression, and the Targeting of RNA with Small Molecule Drugs

2:00 p.m.: Saurja DasGupta, Ph.D., Massachusetts General Hospital, Harvard Medical School, Primordial RNA Assembly: Chemistry, Catalysis, and Compartmentalization

2:15 p.m.: Yang Luo, Ph.D., Sloan Kettering Institute, mRNA Interactions with Disordered Regions Control Protein Activity

3:45 p.m.: Rohit Roy, Duke University School of Medicine, Columbia University, Kinetic Resolution of the Atomic 3D Structures Formed by Ground and Excited Conformational States in an RNA Dynamic Ensemble

4:00 p.m.: Mildred Unti, Weill Cornell Medicine, Highly Efficient Cellular Expression of Circular mRNA Enables Prolonged Protein Expression from Virus-like Particles

4:15 p.m.: Ariel Pourmorady, Columbia University, Olfactory Receptor mRNAs Act as “Selfish” Non-coding RNAs That Enforce Transcriptional Singularity

4:30 p.m.: Shira Weingarten-Gabbay, Ph.D., Broad Institute of MIT and Harvard, The Rockefeller University, Systematic Discovery of Thousands of ORFs in ~700 Human Viruses Using Massively Parallel Ribosome Profiling

4:45 p.m.: Madeline Sherlock, Ph.D., New York Structural Biology Center, University of Colorado Anschutz Medical Campus, Widespread Viral RNA Structures Induce Downstream Reinitiation through Dynamic Ribosome Interactions

Speaker bio(s)

Anna Marie Pyle is a Yale Sterling Professor, serving as a faculty member in the Department of Molecular, Cellular and Developmental Biology and in the Department of Chemistry. Dr. Pyle has been a Howard Hughes Medical Institute Investigator since 1997. She is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. After graduating from Princeton University, she received a Ph.D. in Chemistry from Columbia University in 1990, with Professor Jacqueline Barton and then worked as a postdoctoral fellow with Thomas Cech at the University of Colorado. Dr. Pyle formed her own research group in 1992 in the Department of Biochemistry and Molecular Biophysics at Columbia University Medical Center. In 2002, she moved to Yale University, where her group studies the structure and function of large RNA molecules and associated protein enzymes. Her projects focus on RNA molecular recognition by small molecules and proteins, with a special emphasis on systems relevant to molecular virology, innate immunity and retroelement function. Dr. Pyle is Past-President of the RNA Society, she is Vice-Chair of the Science and Technology Steering Committee for Brookhaven National Laboratory, and she serves on the Scientific Advisory Board of the Max Planck Institute for Multidisciplinary Sciences. She is the founder of RIGImmune Therapeutics. Pyle is the author of over 200 publications and has mentored more than 50 graduate students and postdocs.

Open to

Public

Contact

Seungtaek Oh

Phone

(201) 364-7920

Sponsor

Sebastian Klinge
(212) 327-7136
klinge@rockefeller.edu