Publications search
Found 37769 matches. Displaying 4561-4570
Lechien JR, Hsieh JW, Saussez S
Show All Authors
Unusual case of chronic maxillary rhinosinusitis
ENT-EAR NOSE & THROAT JOURNAL 2017 MAR; 96(3):100-104
Maciejowski J, de Lange T
Show All Authors
Telomeres in cancer: tumour suppression and genome instability
NATURE REVIEWS MOLECULAR CELL BIOLOGY 2017 MAR; 18(3):175-186
The shortening of human telomeres has two opposing effects during cancer development. On the one hand, telomere shortening can exert a tumour-suppressive effect through the proliferation arrest induced by activating the kinases ATM and ATR at unprotected chromosome ends. On the other hand, loss of telomere protection can lead to telomere crisis, which is a state of extensive genome instability that can promote cancer progression. Recent data, reviewed here, provide new evidence for the telomere tumour suppressor pathway and has revealed that telomere crisis can induce numerous cancer-relevant changes, including chromothripsis, kataegis and tetraploidization.
Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Asilar E, Bergauer T, Brandstetter J, Brondolin E, Dragicevic M, Ero J, Flechl M, Friedl M, Fruhwirth R, Ghete VM, Hartl C, Hormann N, Hrubec J, Jeitler M, Konig A, Kratschmer I, Liko D, Matsushita T, Mikulec I, Rabady D, Rad N, Rahbaran B, Rohringer H, Schieck J, Strauss J, Treberer-Treberspurg W, Waltenberger W, Wulz CE, Mossolov V, Shumeiko N, Gonzalez JS, Alderweireldt S, De Wolf EA, Janssen X, Lauwers J, Van de Klundert M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Van Spilbeeck A, Abu Zeid S, Blekman F, D'Hondt J, Daci N, De Bruyn I, Deroover K, Heracleous N, Lowette S, Moortgat S, Moreels L, Olbrechts A, Python Q, Tavernier S, Van Doninck W, Van Mulders P, Van Parijs I, Brun H, Caillol C, Clerbaux B, De Lentdecker G, Delannoy H, Fasanella G, Favart L, Goldouzian R, Grebenyuk A, Karapostoli G, Lenzi T, Leonard A, Luetic J, Maer-Schalk T, Marinov A, Randle-Conde A, Seva T, Vander Velde C, Vanlaer P, Yonamine R, Zenoni F, Zhang F, Cimmino A, Cornelis T, Dobur D, Fagot A, Garcia G, Gul M, Poyraz D, Salva S, Schofbeck R, Tytgat M, Van Driessche W, Yazgan E, Zaganidis N, Beluffi C, Bondu O, Brochet S, Bruno G, Caudron A, Ceard L, De Visscher S, Delaere C, Delcourt M, Forthomme L, Francois B, Giammanco A, Jafari A, Jez P, Komm M, Lemaitre V, Magitteri A, Mertens A, Musich M, Nuttens C, Piotrzkowski K, Quertenmont L, Selvaggi M, Marono MV, Wertz S, Beliy N, Alda WL, Alves FL, Alves GA, Brito L, Hensel C, Moraes A, Pol ME, Teles PR, Das Chagas EBB, Carvalho W, Chinellato J, Custodio A, Da Costa EM, Da Silveira GG, Damiao DD, Martins CD, De Souza SF, Guativa LMH, Malbouisson H, Figueiredo DM, Herrera CM, Mundim L, Nogima H, Da Silva WLP, Santoro A, Sznajder A, Manganote EJT, Pereira AV, Ahuja S, Bernardes CA, Dogra S, Tomei TRFP, Gregores EM, Mercadante PG, Moon CS, Novaes SF, Padula SS, Abad DR, Vargas JCR, Aleksandrov A, Hadjiiska R, Iaydjiev P, Rodozov M, Stoykova S, Sultanov G, Vu-Tova M, Dimitrov A, Glushkov I, Litov L, Pavlov B, Petkov P, Fang W, Ahmad M, Bian JG, Chen GM, Chen HS, Chen M, Chen Y, Cheng T, Jiang CH, Leggat D, Liu Z, Romeo F, Shaheen SM, Spiezia A, Tao J, Wang C, Wang Z, Zhang H, Zhao J, Asawatangtrakuldee C, Ban Y, Li Q, Liu S, Mao Y, Qian SJ, Wang D, Xu Z, Avila C, Cabrera A, Sierra LFC, Florez C, Gomez JP, Hernandez CFG, Alvarez JDR, Sanabria JC, Godinovic N, Lelas D, Puljak I, Cipriano PMR, Antunovic Z, Kovac M, Brigljevic V, Ferencek D, Kadija K, Micanovic S, Sudic L, Attikis A, Mavromanolakis G, Mousa J, Nicolaou C, Ptochos F, Razis PA, Rykaczewski H, Finger M, Finger M, Jarrin EC, Assran Y, Elkafrawy T, Kamel AE, Mahrous A, Calpas B, Kadastik M, Murumaa M, Perrini L, Raidal M, Tiko A, Veelken C, Eerola P, Pekkanen J, Voutilainen M, Harkonen J, Karimaki V, Kinnunen R, Lampen T, Lassila-Perini K, Lehti S, Linden T, Luukka P, Peltola T, Tuominiemi J, Tuovinen E, Wendland L, Talvitie J, Tuuva T, Besancon M, Couderc F, Dejardin M, Denegri D, Fabbro B, Faure JL, Favaro C, Ferri F, Ganjour S, Ghosh S, Givernaud A, Gras P, De Monchenault GH, Jarry P, Kucher I, Locci E, Machet M, Malcles J, Rander J, Rosowsky A, Titov M, Zghiche A, Abdulsalam A, Antropov I, Baffioni S, Beaudette F, Busson P, Cadamuro L, Chapon E, Charlot C, Davignon O, De Cassagnac RG, Jo M, Lisniak S, Mine P, Naranjo IN, Nguyen M, Ochando C, Ortona G, Paganini P, Pigard P, Regnard S, Salerno R, Sirois Y, Strebler T, Yilmaz Y, Zabi A, Agram JL, Andrea J, Aubin A, Bloch D, Brom JM, Buttignol M, Chabert EC, Chanon N, Collard C, Conte E, Coubez X, Fontaine JC, Gele D, Goerlach U, Le Bihan AC, Merlin JA, Skovpen K, Van Hove P, Gadrat S, Beauceron S, Bernet C, Boudoul G, Bouvier E, Montoya CAC, Chierici R, Contardo D, Courbon B, Depasse P, El Mamouni H, Fan J, Fay J, Gascon S, Gouzevitch M, Grenier G, Ille B, Lagarde F, Laktineh IB, Lethuillier M, Mirabito L, Pequegnot AL, Perries S, Popov A, Sabes D, Sordini V, Vander Donckt M, Verdier P, Viret S, Khvedelidze A, Lomidze D, Autermann C, Beranek S, Feld L, Heister A, Kiesel MK, Klein K, Lipinski M, Ostapchuk A, Preuten M, Raupach F, Schael S, Schomakers C, Schulte JF, Schulz J, Verlage T, Weber H, Zhukov V, Brodski M, Dietz-Laursonn E, Duchardt D, Endres M, Erdmann M, Erdweg S, Esch T, Fischer R, Guth A, Hebbeker T, Heidemann C, Hoepfner K, Knutzen S, Merschmeyer M, Meyer A, Millet P, Mukherjee S, Olschewski M, Padeken K, Papacz P, Pook T, Radziej M, Reithler H, Rieger M, Scheuch F, Sonnenschein L, Teyssier D, Thuer S, Cherepanov V, Erdogan Y, Flugge G, Hoehle F, Kargoll B, Kress T, Kuunsken A, Lingemann J, Nehrkorn A, Nowack A, Nugent IM, Pistone C, Pooth O, Stahl A, Martin MA, Asin I, Beernaert K, Behnke O, Behrens U, Bin Anuar AA, Borras K, Campbell A, Connor P, Contreras-Campana C, Costanza F, Pardos CD, Dolinska G, Eckerlin G, Eckstein D, Eren E, Gallo E, Garcia JG, Geiser A, Gizhko A, Luyando JMG, Gunnellini P, Harb A, Hauk J, Hempel M, Jung H, Kalogeropoulos A, Karacheban O, Kasemann M, Keaveney J, Kieseler J, Kleinwort C, Korol I, Kuprash O, Lange W, Lelek A, Leonard J, Lipka K, Lobanov A, Lohmann W, Mankel R, Melzer-Pellmann IA, Meyer AB, Mittag G, Mnich J, Mussgiller A, Ntomari E, Pitzl D, Placakyte R, Raspereza A, Roland B, Sahin MO, Saxena P, Schoerner-Sadenius T, Seitz C, Spannagel S, Stefaniuk N, Trippkewitz KD, Van Onsem GP, Walsh R, Wissing C, Blobel V, Vignali MC, Draeger AR, Dreyer T, Garutti E, Goebel K, Gonzalez D, Haller J, Hoffmann M, Junkes A, Klanner R, Kogler R, Kovalchuk N, Lapsien T, Lenz T, Marchesini I, Marconi D, Meyer M, Niedziela M, Nowatschin D, Ott J, Pantaleo F, Peiffer T, Perieanu A, Poehlsen J, Sander C, Scharf C, Schleper P, Schmidt A, Schumann S, Schwandt J, Stadie H, Steinbruck G, Stober FM, Stover M, Tholen H, Troendle D, Usai E, Vanelderen L, Vanhoefer A, Vormwald B, Barth C, Baus C, Berger J, Butz E, Chwalek T, Colombo F, De Boer W, Dierlamm A, Fink S, Friese R, Giffels M, Gilbert A, Haitz D, Hartmann F, Heindl SM, Husemann U, Katkov I, Kornmayer A, Pardo PL, Maier B, Mildner H, Mozer MU, Muller T, Muller T, Plagge M, Quast G, Rabbertz K, Rocker S, Roscher F, Schroder M, Sieber G, Simonis HJ, Ulrich R, Wagner-Kuhr J, Wayand S, Weber M, Weiler T, Williamson S, Wohrmann C, Wolf R, Anagnostou G, Daskalakis G, Geralis T, Giakoumopoulou VA, Kyriakis A, Loukas D, Topsis-Giotis I, Agapitos A, Kesisoglou S, Panagiotou A, Saoulidou N, Tziaferi E, Evangelou I, Flouris G, Foudas C, Kokkas P, Loukas N, Manthos N, Papadopoulos I, Paradas E, Filipovic N, Bencze G, Hajdu C, Hidas P, Horvath D, Sikler F, Veszpremi V, Vesztergombi G, Zsigmond AJ, Beni N, Czellar S, Karancsi J, Molnar J, Szillasi Z, Bartok M, Makovec A, Raics P, Trocsanyi ZL, Ujvari B, Bahinipati S, Choudhury S, Mal P, Mandal K, Nayak A, Sahoo DK, Sahoo N, Swain SK, Bansal S, Beri SB, Bhatnagar V, Chawla R, Gupta R, Bhawandeep U, Kalsi AK, Kaur A, Kaur M, Kumar R, Mehta A, Mittal M, Singh JB, Walia G, Kumar A, Bhardwaj A, Choudhary BC, Garg RB, Keshri S, Kumar A, Mal-Hotra S, Naimuddin M, Nishu N, Ranjan K, Sharma R, Sharma V, Bhattacharya R, Bhattacharya S, Chatterjee K, Dey S, Dutt S, Dutta S, Ghosh S, Majumdar N, Modak A, Mondal K, Mukhopadhyay S, Nandan S, Purohit A, Roy A, Roy D, Chowdhury SR, Sarkar S, Sharan M, Thakur S, Behera PK, Chudasama R, Dutta D, Jha V, Kumar V, Mohanty AK, Netrakanti PK, Pant LM, Shukla P, Topkar A, Aziz T, Dugad S, Kole G, Mahakud B, Mitra S, Mohanty GB, Sur N, Sutar B, Banerjee S, Bhowmik S, Dewanjee RK, Ganguly S, Guchait M, Jain S, Kumar S, Maity M, Majumder G, Mazumdar K, Parida B, Sarkar T, Wickramage N, Chauhan S, Dube S, Kapoor A, Kothekar K, Rane A, Sharma S, Bakhshiansohi H, Behnamian H, Chenarani S, Tadavani EE, Etesami SM, Fahim A, Khakzad M, Najafabadi MM, Naseri M, Mehdiabadi SP, Hosseinabadi FR, Safarzadeh B, Zeinali M, Felcini M, Grunewald M, Abbrescia M, Calabria C, Caputo C, Colaleo A, Creanza D, Cristella L, De Filippis N, De Palma M, Fiore L, Iaselli G, Maggi G, Maggi M, Miniello G, My S, Nuzzo S, Pompili A, Pugliese G, Radogna R, Ranieri A, Selvaggi G, Silvestris L, Venditti R, Verwilligen P, Abbiendi G, Battilana C, Bonacorsi D, Braibant-Giacomelli S, Brigliadori L, Campanini R, Capiluppi P, Castro A, Cavallo FR, Chhibra SS, Codispoti G, Cuffiani M, Dallavalle GM, Fabbri F, Fanfani A, Fasanella D, Giacomelli P, Grandi C, Guiducci L, Marcellini S, Masetti G, Montanari A, Navarria FL, Perrotta A, Rossi AM, Rovelli T, Siroli GP, Tosi N, Albergo S, Chiorboli M, Costa S, Di Mattia A, Giordano F, Potenza R, Tricomi A, Tuve C, Barbagli G, Ciulli V, Civinini C, D'Alessandro R, Focardi E, Gori V, Lenzi P, Meschini M, Paoletti S, Sguazzoni G, Viliani L, Benussi L, Bianco S, Fabbri F, Piccolo D, Primavera F, Calvelli V, Ferro F, Lo Vetere M, Monge MR, Robutti E, Tosi S, Brianza L, Dinardo ME, Fiorendi S, Gennai S, Ghezzi A, Govoni P, Malvezzi S, Manzoni RA, Marzocchi B, Menasce D, Moroni L, Paganoni M, Pedrini D, Pigazzini S, Ragazzi S, de Fatis TT, Buontempo S, Cavallo N, De Nardo G, Di Guida S, Esposito M, Fabozzi F, Iorio AOM, Lanza G, Lista L, Meola S, Merola M, Paolucci P, Sciacca C, Thyssen F, Azzi P, Bacchetta N, Benato L, Biasotto M, Boletti A, De Oliveira ACA, Dall'Osso M, Manzano PD, Dorigo T, Dosselli U, Fantinel S, Fanzago F, Gasparini F, Gasparini U, Gulmini M, Lacaprara S, Margoni M, Meneguzzo AT, Pazzini J, Pozzobon N, Ronchese P, Torassa E, Ventura S, Zanetti M, Zotto P, Zucchetta A, Zumerle G, Braghieri A, Magnani A, Montagna P, Ratti SP, Re V, Riccardi C, Salvini P, Vai I, Vitulo P, Solestizi LA, Bilei GM, Ciangottini D, Fano L, Lariccia P, Leonardi R, Mantovani G, Menichelli M, Saha A, Santocchia A, Androsov K, Azzurri P, Bagliesi G, Bernardini J, Boccali T, Castaldi R, Ciocci MA, Dell'Orso R, Donato S, Fedi G, Giassi A, Grippo MT, Ligabue F, Lomtadze T, Martini L, Messineo A, Palla F, Rizzi A, Savoy-Navarro A, Spagnolo P, Tenchini R, Tonelli G, Venturi A, Verdini PG, Barone L, Cavallari F, Cipriani M, D'imperio G, Del Re D, Diemoz M, Gelli S, Jorda C, Longo E, Margaroli F, Meridiani P, Organtini G, Paramatti R, Preiato F, Rahatlou S, Rovelli C, Santanastasio F, Amapane N, Arcidiacono R, Argiro S, Arneodo M, Bartosik N, Bellan R, Biino C, Cartiglia N, Cenna F, Costa M, Covarelli R, Degano A, Demaria N, Finco L, Kiani B, Mariotti C, Maselli S, Migliore E, Monaco V, Monteil E, Obertino MM, Pacher L, Pastrone N, Pelliccioni M, Angioni GLP, Ravera F, Romero A, Ruspa M, Sacchi R, Shchelina K, Sola V, Solano A, Staiano A, Traczyk P, Belforte S, Casarsa M, Cossutti F, Della Ricca G, La Licata C, Schizzi A, Zanetti A, Kim DH, Kim GN, Kim MS, Lee S, Lee SW, Oh YD, Sekmen S, Son DC, Yang YC, Kim H, Lee A, Cifuentes JAB, Kim TJ, Cho S, Choi S, Go Y, Gyun D, Ha S, Hong B, Jo Y, Kim Y, Lee B, Lee K, Lee KS, Lee S, Lim J, Park SK, Roh Y, Almond J, Kim J, Oh SB, Seo SH, Yang UK, Yoo HD, Yu GB, Choi M, Kim H, Kim H, Kim JH, Lee JSH, Park IC, Ryu G, Ryu MS, Choi Y, Goh J, Hwang C, Kim D, Lee J, Yu I, Dudenas V, Juodagalvis A, Vaitkus J, Ahmed I, Ibrahim ZA, Komaragiri JR, Ali MABM, Idris FM, Abdullah WATW, Yusli MN, Zolkapli Z, Castilla-Valdez H, De la Cruz-Burelo E, Heredia-De la Cruz I, Hernandez-Almada A, Lopez-Fernandez R, Guisao JM, Sanchez-Hernandez A, Moreno SC, Barrera CO, Valencia F, Carpinteyro S, Pedraza I, Ibarguen HAS, Estrada CU, Pineda AM, Krofcheck D, Butler PH, Ahmad A, Ahmad M, Hassan Q, Hoorani HR, Khan WA, Shah MA, Shoaib M, Waqas M, Bialkowska H, Bluj M, Boimska B, Frueboes T, Gorski M, Kazana M, Nawrocki K, Romanowska-Rybinska K, Szleper M, Zalewski P, Bunkowski K, Byszuk A, Doroba K, Kalinowski A, Konecki M, Krolikowski J, Misiura M, Olszewski M, Walczak M, Bargassa P, Silva CBDE, Di Francesco A, Faccioli P, Parracho PGF, Gallinaro M, Hollar J, Leonardo N, Iglesias LL, Nemallapudi MV, Antunes JR, Seixas J, Toldaiev O, Vadruccio D, Varela J, Vischia P, Afanasiev S, Bunin P, Golutvin I, Karjavin V, Korenkov V, Lanev A, Malakhov A, Matveev V, Mitsyn VV, Moisenz P, Palichik V, Perelygin V, Shmatov S, Shulha S, Skatchkov N, Smirnov V, Tikhonenko E, Voytishin N, Zarubin A, Chtchipounov L, Golovtsov V, Ivanov Y, Kim V, Kuznetsova E, Murzin V, Oreshkin V, Sulimov V, Vorobyev A, Andreev Y, Dermenev A, Gninenko S, Golubev N, Karneyeu A, Kirsanov M, Krasnikov N, Pashenkov A, Tlisov D, Toropin A, Epshteyn V, Gavrilov V, Lychkovskaya N, Popov V, Pozdnyakov I, Safronov G, Spiridonov A, Toms M, Vlasov E, Zhokin A, Chistov R, Rusinov V, Tarkovskii E, Andreev V, Azarkin M, Dremin I, Kirakosyan M, Leonidov A, Rusakov SV, Terkulov A, Baskakov A, Belyaev A, Boos E, Dubinin M, Dudko L, Ershov A, Gribushin A, Klyukhin V, Kodolova O, Lokhtin I, Miagkov I, Obraztsov S, Petrushanko S, Savrin V, Snigirev A, Azhgirey I, Bayshev I, Bitioukov S, Elumakhov D, Kachanov V, Kalinin A, Kon-Stantinov D, Krychkine V, Petrov V, Ryutin R, Sobol A, Troshin S, Tyurin N, Uzunian A, Volkov A, Adzic P, Cirkovic P, Devetak D, Milosevic J, Rekovic V, Maestre JA, Calvo E, Cerrada M, Llatas MC, Colino N, De la Cruz B, Peris AD, Del Valle AE, Bedoya CF, Ramos JPF, Flix J, Fouz MC, Garcia-Abia P, Lopez OG, Lopez SG, Hernandez JM, Josa MI, De Martino EN, Yzquierdo APC, Pelayo JP, Olmeda AQ, Redondo I, Romero L, Soares MS, de Troconiz JF, Missiroli M, Moran D, Cuevas J, Menendez JF, Caballero IG, Fernandez JRG, Cortezon EP, Cruz SS, Garcia JMV, Cabrillo IJ, Calderon A, De Saa JRC, Curras E, Fernandez M, Garcia-Ferrero J, Gomez G, Virto AL, Marco J, Rivero CM, Matorras F, Gomez JP, Rodrigo T, Ruiz-Jimeno A, Scodellaro L, Trevisani N, Vila I, Cortabitarte RV, Abbaneo D, Auffray E, Auzinger G, Bachtis M, Baillon P, Ball AH, Barney D, Bloch P, Bocci A, Bonato A, Botta C, Camporesi T, Castello R, Cepeda M, Cerminara G, D'Alfonso M, d'Enterria D, Dabrowski A, Daponte V, David A, De Gruttola M, De Guio F, De Roeck A, Di Marco E, Dobson M, Dordevic M, Dorney B, Du Pree T, Duggan D, Duenser M, Dupont N, Elliott-Peisert A, Fartoukh S, Franzoni G, Fulcher J, Funk W, Gigi D, Gill K, Girone M, Glege F, Gulhan D, Gundacker S, Guthoff M, Hammer J, Harris P, Hegeman J, Innocente V, Janot P, Kirschenmann H, Knunz V, Kortelainen MJ, Kousouris K, Krammer M, Lecoq P, Lourenco C, Lucchini MT, Malgeri L, Mannelli M, Martelli A, Meijers F, Mersi S, Meschi E, Moortgat F, Morovic S, Mulders M, Neugebauer H, Orfanelli S, Orsini L, Pape L, Perez E, Peruzzi M, Petrilli A, Petrucciani G, Pfeiffer A, Pierini M, Racz A, Reis T, Rolandi G, Rovere M, Ruan M, Sakulin H, Sauvan JB, Schafer C, Schwick C, Seidel M, Sharma A, Silva P, Simon M, Sphicas P, Steggemann J, Stoye M, Takahashi Y, Tosi M, Treille D, Triossi A, Tsirou A, Veckalns V, Veres GI, Wardle N, Wohri HK, Zagozdzinska A, Zeuner WD, Bertl W, Deiters K, Erdmann W, Horisberger R, Ingram Q, Kaestli HC, Kotlinski D, Langenegger U, Rohe T, Bachmair F, Bani L, Bianchini L, Casal B, Dissertori G, Dittmar M, Donega M, Eller P, Grab C, Heidegger C, Hits D, Hoss J, Kasieczka G, Lecomte P, Lustermann W, Mangano B, Marionneau M, del Arbol PMR, Masciovecchio M, Meinhard MT, Meister D, Micheli F, Musella P, Nessi-Tedaldi F, Pandolfi F, Pata J, Pauss F, Perrin G, Perrozzi L, Quittnat M, Rossini M, Schonenberger M, Starodumov A, Takahashi M, Tavolaro VR, Theofilatos K, Wallny R, Aarrestad TK, Amsler C, Caminada L, Canelli MF, Chiochia V, De Cosa A, Galloni C, Hinzmann A, Hreus T, Kilminster B, Lange C, Ngadiuba J, Pinna D, Rauco G, Robmann P, Salerno D, Yang Y, Candelise V, Doan TH, Jain S, Khurana R, Konyushikhin M, Kuo CM, Lin W, Lu YJ, Pozdnyakov A, Yu SS, Kumar A, Chang P, Chang YH, Chang YW, Chao Y, Chen KF, Chen PH, Dietz C, Fiori F, Hou WS, Hsiung Y, Liu YF, Lu RS, Moya MM, Paganis E, Psallidas A, Tsai JF, Tzeng YM, Asavapibhop B, Singh G, Srimanobhas N, Suwonjandee N, Adiguzel A, Cerci S, Damarseckin S, Demiroglu ZS, Dozen C, Dumanoglu I, Girgis S, Gokbulut G, Guler Y, Gurpinar E, Hos I, Kangal EE, Kara O, Topaksu AK, Kiminsu U, Oglakci M, Onengut G, Ozdemir K, Cerci DS, Topakli H, Turkcapar S, Zorbakir IS, Zorbilmez C, Bilin B, Bilmis S, Isildak B, Karapinar G, Yalvac M, Zeyrek M, Gulmez E, Kaya M, Kaya O, Yetkin EA, Yetkin T, Cakir A, Cankocak K, Sen S, Grynyov B, Levchuk L, Sorokin P, Aggleton R, Ball F, Beck L, Brooke JJ, Burns D, Clement E, Cussans D, Flacher H, Goldstein J, Grimes M, Heath GP, Heath HF, Jacob J, Kreczko L, Lucas C, Newbold DM, Paramesvaran S, Poll A, Sakuma T, El Nasr-Storey SS, Smith D, Smith VJ, Bell KW, Belyaev A, Brew C, Brown RM, Calligaris L, Cieri D, Cockerill DJA, Coughlan JA, Harder K, Harper S, Olaiya E, Petyt D, Shepherd-Themistocleous CH, Thea A, Tomalin IR, Williams T, Baber M, Bainbridge R, Buchmuller O, Bundock A, Burton D, Casasso S, Citron M, Colling D, Corpe L, Dauncey P, Davies G, De Wit A, Della Negra M, Dunne P, Elwood A, Futyan D, Haddad Y, Hall G, Iles G, Lane R, Laner C, Lucas R, Lyons L, Magnan AM, Malik S, Mastrolorenzo L, Nash J, Nikitenko A, Pela J, Penning B, Pesaresi M, Raymond DM, Richards A, Rose A, Seez C, Tapper A, Uchida K, Acosta MV, Virdee T, Zenz SC, Cole JE, Hobson PR, Khan A, Kyberd P, Leslie D, Reid ID, Symonds P, Teodorescu L, Turner M, Borzou A, Call K, Dittmann J, Hatakeyama K, Liu H, Pastika N, Charaf O, Cooper SI, Henderson C, Rumerio P, Arcaro D, Avetisyan A, Bose T, Gastler D, Rankin D, Richardson C, Rohlf J, Sulak L, Zou D, Benelli G, Berry E, Cutts D, Garabedian A, Hakala J, Heintz U, Jesus O, Laird E, Landsberg G, Mao Z, Narain M, Piperov S, Sagir S, Spencer E, Syarif R, Breedon R, Breto G, Burns D, Sanchez MCD, Chauhan S, Chertok M, Conway J, Conway R, Cox PT, Erbacher R, Flores C, Funk G, Gardner M, Ko W, Lander R, Mclean C, Mulhearn M, Pellett D, Pilot J, Ricci-Tam F, Shalhout S, Smith J, Squires M, Stolp D, Tripathi M, Wilbur S, Yohay R, Cousins R, Everaerts P, Florent A, Hauser J, Ignatenko M, Saltzberg D, Takasugi E, Valuev V, Weber M, Burt K, Clare R, Ellison J, Gary JW, Hanson G, Heilman J, Jandir P, Kennedy E, Lacroix F, Long OR, Malberti M, Negrete MO, Paneva MI, Shrinivas A, Wei H, Wimpenny S, Yates BR, Branson JG, Cerati GB, Cittolin S, Derdzinski M, Gerosa R, Holzner A, Klein D, Letts J, Macneill I, Olivito D, Padhi S, Pieri M, Sani M, Sharma V, Simon S, Tadel M, Vartak A, Wasserbaech S, Welke C, Wood J, Wurthwein F, Yagil A, Della Porta GZ, Bhandari R, Bradmiller-Feld J, Campagnari C, Dishaw A, Dutta V, Flowers K, Sevilla MF, Geffert P, George C, Golf F, Gouskos L, Gran J, Heller R, Incandela J, Mccoll N, Mullin SD, Ovcharova A, Richman J, Stuart D, Suarez I, West C, Yoo J, Anderson D, Apresyan A, Bendavid J, Bornheim A, Bunn J, Chen Y, Duarte J, Mott A, Newman HB, Pena C, Spiropulu M, Vlimant JR, Xie S, Zhu RY, Andrews MB, Azzolini V, Carlson B, Ferguson T, Paulini M, Russ J, Sun M, Vogel H, Vorobiev I, Cumalat JP, Ford WT, Jensen F, Johnson A, Krohn M, Mulholland T, Stenson K, Wagner SR, Alexander J, Chaves J, Chu J, Dittmer S, Mirman N, Kaufman GN, Patterson JR, Rinkevicius A, Ryd A, Skinnari L, Tan SM, Tao Z, Thom J, Tucker J, Wittich P, Winn D, Abdullin S, Albrow M, Apollinari G, Banerjee S, Bauerdick LAT, Beretvas A, Berryhill J, Bhat PC, Bolla G, Burkett K, Butler JN, Cheung HWK, Chlebana F, Cihangir S, Cremonesi M, Elvira VD, Fisk I, Freeman J, Gottschalk E, Gray L, Green D, Grunendahl S, Gutsche O, Hare D, Harris RM, Hasegawa S, Hirschauer J, Hu Z, Jayatilaka B, Jindariani S, Johnson M, Joshi U, Klima B, Kreis B, Lammel S, Linacre J, Lincoln D, Lipton R, Liu T, De Sa RL, Lykken J, Maeshima K, Magini N, Marraffino JM, Maruyama S, Mason D, McBride P, Merkel P, Mrenna S, Nahn S, Newman-Holmes C, O'Dell V, Pedro K, Prokofyev O, Rakness G, Ristori L, Sexton-Kennedy E, Soha A, Spalding WJ, Spiegel L, Stoynev S, Strobbe N, Taylor L, Tkaczyk S, Tran NV, Uplegger L, Vaandering EW, Vernieri C, Verzocchi M, Vidal R, Wang M, Weber HA, Whitbeck A, Acosta D, Avery P, Bortignon P, Bourilkov D, Brinkerhoff A, Carnes A, Carver M, Curry D, Das S, Field RD, Furic IK, Konigsberg J, Korytov A, Ma P, Matchev K, Mei H, Milenovic P, Mitselmakher G, Rank D, Shchutska L, Sperka D, Thomas L, Wang J, Wang S, Yelton J, Linn S, Markowitz P, Martinez G, Rodriguez JL, Ackert A, Adams JR, Adams T, Askew A, Bein S, Diamond B, Hagopian S, Hagopian V, Johnson KF, Khatiwada A, Prosper H, Santra A, Weinberg M, Baarmand MM, Bhopatkar V, Colafranceschi S, Hohlmann M, Noonan D, Roy T, Yumiceva F, Adams MR, Apanasevich L, Berry D, Betts RR, Bucinskaite I, Cavanaugh R, Evdokimov O, Gauthier L, Gerber CE, Hofman DJ, Kurt P, O'Brien C, Gonzalez IDS, Turner P, Varelas N, Wu Z, Zakaria M, Zhang J, Bilki B, Clarida W, Dilsiz K, Durgut S, Gandrajula RP, Haytmyradov M, Khristenko V, Merlo JP, Mermerkaya H, Mestvirishvili A, Moeller A, Nachtman J, Ogul H, Onel Y, Ozok F, Penzo A, Snyder C, Tiras E, Wetzel J, Yi K, Anderson I, Blumenfeld B, Cocoros A, Eminizer N, Fehling D, Feng L, Gritsan AV, Maksimovic P, Osherson M, Roskes J, Sarica U, Swartz M, Xiao M, Xin Y, You C, Al-Bataineh A, Baringer P, Bean A, Bowen J, Bruner C, Castle J, Kenny RP, Kropivnitskaya A, Majumder D, Mcbrayer W, Murray M, Sanders S, Stringer R, Takaki JDT, Wang Q, Ivanov A, Kaadze K, Khalil S, Makouski M, Maravin Y, Mohammadi A, Saini LK, Skhirtladze N, Toda S, Lange D, Rebassoo F, Wright D, Anelli C, Baden A, Baron O, Belloni A, Calvert B, Eno SC, Ferraioli C, Gomez JA, Hadley NJ, Jabeen S, Kellogg RG, Kolberg T, Kunkle J, Lu Y, Mignerey AC, Shin YH, Skuja A, Tonjes MB, Tonwar SC, Apyan A, Barbieri R, Baty A, Bi R, Bierwagen K, Brandt S, Busza W, Cali IA, Demiragli Z, Di Matteo L, Ceballos GG, Goncharov M, Hsu D, Iiyama Y, Innocenti GM, Klute M, Kovalskyi D, Krajczar K, Lai YS, Lee YJ, Levin A, Luckey PD, Marini AC, Mcginn C, Mironov C, Narayanan S, Niu X, Paus C, Roland C, Roland G, Salfeld-Nebgen J, Stephans GSF, Sumorok K, Tatar K, Varma M, Velicanu D, Veverka J, Wang J, Wang TW, Wyslouch B, Yang M, Zhukova V, Benvenuti AC, Chatterjee RM, Evans A, Finkel A, Gude A, Hansen P, Kalafut S, Kao SC, Kubota Y, Lesko Z, Mans J, Nourbakhsh S, Ruckstuhl N, Rusack R, Tambe N, Turkewitz J, Acosta JG, Oliveros S, Avdeeva E, Bartek R, Bloom K, Bose S, Claes DR, Dominguez A, Fangmeier C, Suarez RG, Kamalieddin R, Knowlton D, Kravchenko I, Rodrigues AM, Meier F, Monroy J, Siado JE, Snow GR, Stieger B, Alyari M, Dolen J, George J, Godshalk A, Harrington C, Iashvili I, Kaisen J, Kharchilava A, Kumar A, Parker A, Rappoccio S, Roozbahani B, Alverson G, Barberis E, Baumgartel D, Chasco M, Hortiangtham A, Massironi A, Morse DM, Nash D, Orimoto T, De Lima RT, Trocino D, Wang RJ, Wood D, Bhattacharya S, Hahn KA, Kubik A, Low JF, Mucia N, Odell N, Pollack B, Schmitt MH, Sung K, Trovato M, Velasco M, Dev N, Hildreth M, Anampa KH, Jessop C, Karmgard DJ, Kellams N, Lannon K, Marinelli N, Meng F, Mueller C, Musienko Y, Planer M, Reinsvold A, Ruchti R, Smith G, Taroni S, Valls N, Wayne M, Wolf M, Woodard A, Alimena J, Antonelli L, Brinson J, Bylsma B, Durkin LS, Flowers S, Francis B, Hart A, Hill C, Hughes R, Ji W, Liu B, Luo W, Puigh D, Winer BL, Wulsin HW, Cooperstein S, Driga O, Elmer P, Hardenbrook J, Hebda P, Luo J, Marlow D, Medvedeva T, Mooney M, Olsen J, Palmer C, Piroue P, Stickland D, Tully C, Zuranski A, Malik S, Barker A, Barnes VE, Benedetti D, Folgueras S, Gutay L, Jha MK, Jones M, Jung AW, Jung K, Miller DH, Neumeister N, Radburn-Smith BC, Shi X, Sun J, Svyatkovskiy A, Wang F, Xie W, Xu L, Parashar N, Stupak J, Adair A, Akgun B, Chen Z, Ecklund KM, Geurts FJM, Guilbaud M, Li W, Michlin B, Northup M, Padley BP, Redjimi R, Roberts J, Rorie J, Tu Z, Zabel J, Betchart B, Bodek A, De Barbaro P, Demina R, Duh YT, Ferbel T, Galanti M, Garcia-Bellido A, Han J, Hindrichs O, Khukhunaishvili A, Lo KH, Tan P, Verzetti M, Mesropian C, Chou JP, Contreras-Campana E, Gershtein Y, Espinosa TAG, Halkiadakis E, Heindl M, Hidas D, Hughes E, Kaplan S, Elayavalli RK, Kyriacou S, Lath A, Nash K, Saka H, Salur S, Schnetzer S, Sheffield D, Somalwar S, Stone R, Thomas S, Thomassen P, Walker M, Foerster M, Heideman J, Riley G, Rose K, Spanier S, Thapa K, Bouhali O, Celik A, Dalchenko M, De Mattia M, Delgado A, Dildick S, Eusebi R, Gilmore J, Huang T, Juska E, Kamon T, Krutelyov V, Mueller R, Pakhotin Y, Patel R, Perloff A, Pernie L, Rathjens D, Rose A, Safonov A, Tatarinov A, Ulmer KA, Akchurin N, Cowden C, Damgov J, Dragoiu C, Dudero PR, Faulkner J, Kunori S, Lamichhane K, Lee SW, Libeiro T, Undleeb S, Volobouev I, Wang Z, Delannoy AG, Greene S, Gurrola A, Janjam R, Johns W, Maguire C, Melo A, Ni H, Sheldon P, Tuo S, Velkovska J, Xu Q, Arenton MW, Barria P, Cox B, Goodell J, Hirosky R, Ledovskoy A, Li H, Neu C, Sinthuprasith T, Sun X, Wang Y, Wolfe E, Xia F, Clarke C, Harr R, Karchin PE, Lamichhane P, Sturdy J, Belknap DA, Dasu S, Dodd L, Duric S, Gomber B, Grothe M, Herndon M, Herve A, Klabbers P, Lanaro A, Levine A, Long K, Loveless R, Ojalvo I, Perry T, Pierro GA, Polese G, Ruggles T, Savin A, Sharma A, Smith N, Smith WH, Taylor D, Woods N
Show All Authors
Measurement and QCD analysis of double-differential inclusive jet cross sections in pp collisions at root s=8 TeV and cross section ratios to 2.76 and 7 TeV
JOURNAL OF HIGH ENERGY PHYSICS 2017 MAR 29; ?(3):? Article 156
A measurement of the double-differential inclusive jet cross section as a function of the jet transverse momentum p(T) and the absolute jet rapidity |y| is presented. Data from LHC proton-proton collisions at root s = 8 TeV, corresponding to an integrated luminosity of 19.7 fb(-1), have been collected with the CMS detector. Jets are reconstructed using the anti-k(T) clustering algorithm with a size parameter of 0.7 in a phase space region covering jet p(T) from 74 GeV up to 2.5 TeV and jet absolute rapidity up to |y| = 3.0. The low-p(T) jet range between 21 and 74 GeV is also studied up to |y| = 4.7, using a dedicated data sample corresponding to an integrated luminosity of 5.6 pb(-1). The measured jet cross section is corrected for detector effects and compared with the predictions from perturbative QCD at next-to-leading order (NLO) using various sets of parton distribution functions (PDF). Cross section ratios to the corresponding measurements performed at 2.76 and 7 TeV are presented. From the measured double-differential jet cross section, the value of the strong coupling constant evaluated at the Z mass is alpha(S)(M-Z) = 0.1164(-0.0043)(+0.0060) , where the errors include the PDF, scale, nonperturbative effects and experimental uncertainties, using the CT10 NLO PDFs. Improved constraints on PDFs based on the inclusive jet cross section measurement are presented.
Campbell EA, Kamath S, Rajashankar KR, Wu MY, Darst SA
Show All Authors
Crystal structure of Aquifex aeolicus sigma(N) bound to promoter DNA and the structure of sigma(N)-holoenzyme
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2017 MAR 7; 114(10):E1805-E1814
The bacterial sigma factors confer promoter specificity to the RNA polymerase (RNAP). One alternative sigma factor, sigma(N), is unique in its structure and functional mechanism, forming transcriptionally inactive promoter complexes that require activation by specialized AAA(+) ATPases. We report a 3.4- angstrom resolution X-ray crystal structure of a sigma(N) fragment in complex with its cognate promoter DNA, revealing the molecular details of promoter recognition by sigma(N). The structure allowed us to build and refine an improved sigma(N)-holoenzyme model based on previously published 3.8-angstrom resolution X-ray data. The improved sigma(N)-holoenzyme model reveals a conserved interdomain interface within sigma(N) that, when disrupted by mutations, leads to transcription activity without activator intervention (so-called bypass mutants). Thus, the structure and stability of this interdomain interface are crucial for the role of sigma(N) in blocking transcription activity and in maintaining the activator sensitivity of sigma(N).
Rout MP, Obado SO, Schenkman S, Field MC
Show All Authors
Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity
PLOS PATHOGENS 2017 MAR; 13(3):? Article e1006170
Langston L, O'Donnell M
Show All Authors
Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase
ELIFE 2017 MAR 27; 6(?):? Article e23449
Replicative helicases are ring-shaped hexamers that encircle DNA for duplex unwinding. The currently accepted view of hexameric helicase function is by steric exclusion, where the helicase encircles one DNA strand and excludes the other, acting as a wedge with an external DNA unwinding point during translocation. Accordingly, strand-specific blocks only affect these helicases when placed on the tracking strand, not the excluded strand. We examined the effect of blocks on the eukaryotic CMG and, contrary to expectations, blocks on either strand inhibit CMG unwinding. A recent cryoEM structure of yeast CMG shows that duplex DNA enters the helicase and unwinding occurs in the central channel. The results of this report inform important aspects of the structure, and we propose that CMG functions by a modified steric exclusion process in which both strands enter the helicase and the duplex unwinding point is internal, followed by exclusion of the non-tracking strand.
Yuste R, Bargmann C
Show All Authors
Toward a Global BRAIN Initiative
CELL 2017 MAR 9; 168(6):956-959
Neuroscience is entering a collaborative era in which powerful new technologies, generated by large scientific projects in many countries, will have a dramatic impact on science, medicine, and society. Coordinating these international initiatives and ensuring broad distribution of novel technologies and open accessibility of the generated data will multiply their value, while tapping creativity and expertise from every source.
Czarnowicki T, Santamaria-Babi LF, Guttman-Yassky E
Show All Authors
Circulating CLA(+) T cells in atopic dermatitis and their possible role as peripheral biomarkers
ALLERGY 2017 MAR; 72(3):366-372
Cutaneous lymphocyte-associated antigen (CLA(+)) T cells are specialized for skin homing and represent the main T-cell population in atopic dermatitis (AD) lesions. CLA(+) is expressed on the surface of circulating CD45RO(+) memory T cells and most skin-infiltrating T cells. Mechanistic studies and thus treatment advancements are limited by the need of large number of skin biopsies. Circulating CLA(+) T cells may be a reliable surrogate marker of the inflammatory events occurring in the skin, and thus, the evaluation of CLA(+) T cells in the blood may eliminate the need for skin biopsies. Preliminary work in AD has established that disease-associated T-cell abnormalities can be approached by either a study of skin lesions or activated CLA(+) T-cell subsets in peripheral blood. Future studies in adults and children, across different skin disorders, correlating blood and skin phenotypes and determining skin-homing T-cell functional properties are needed to establish whether CLA(+) memory subsets can be used as biomarkers and a substitute for skin biopsies. This review summarizes the latest advancements reached on circulating CLA(+) in AD and the great potential they harbor in understanding AD mechanisms.
Bournazos S, Ravetch JV
Show All Authors
Attenuated Vaccines for Augmented Immunity
CELL HOST & MICROBE 2017 MAR 8; 21(3):314-315
Live attenuated vaccines are more immunogenic and have the capacity to elicit long-lasting immune responses. In two recent studies, Wang et al. (2017) and Si et al. (2016) describe strategies for the generation of live attenuated influenza viruses, which elicited robust humoral, mucosal, and cellular immunity against diverse virus strains.
Lim AI, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella LA, Rogge L, Norel X, Sallenave JM, Allez M, Graf T, Hendriks RW, Casanova JL, Amit I, Yssel H, Di Santo JP
Show All Authors
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation
CELL 2017 MAR 9; 168(6):1086-1100.e10
Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCPs). How ILCPs give rise to mature tissue-resident ILCs remains unclear. Here, we identify circulating and tissue ILCPs in humans that fail to express the transcription factors and cytokine outputs of mature ILCs but have these signature loci in an epigenetically poised configuration. Human ILCPs robustly generate all ILC subsets in vitro and in vivo. While human ILCPs express low levels of retinoic acid receptor (RAR)-related orphan receptor C (RORC) transcripts, these cells are found in RORC-deficient patients and retain potential forEOMES(+) natural killer (NK) cells, interferon gamma-positive (IFN-gamma(+)) ILC1s, interleukin (IL)-13(+) ILC2s, and for IL-22(+), but not for IL-17A(+) ILC3s. Our results support a model of tissue ILC differentiation ("ILC-poiesis''), whereby diverse ILC subsets are generated in situ from systemically distributed ILCPs in response to local environmental signals.