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Found 35038 matches. Displaying 181-190
Frank I
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A Tat/Rev Induced Limiting Dilution Assay to Measure Viral Reservoirs in

SCIENTIFIC REPORTS 2019 AUG 19; 9(?):? Article 12078
The establishment of latent infection and poorly characterized viral
Zhang SY, Jouanguy E, Zhang Q, Abel L, Puel A, Casanova JL
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Human inborn errors of immunity to infection affecting cells other than leukocytes: from the immune system to the whole organism

Studies of vertebrate immunity have traditionally focused on professional cells, including circulating and tissue-resident leukocytes. Evidence that non-professional cells are also intrinsically essential (i.e. not via their effect on leukocytes) for protective immunity in natural conditions of infection has emerged from three lines of research in human genetics. First, studies of Mendelian resistance to infection have revealed an essential role of DARC-expressing erythrocytes in protection against Plasmodium vivax infection, and an essential role of FUT2-expressing intestinal epithelial cells for protection against norovirus and rotavirus infections. Second, studies of inborn errors of non-hematopoietic cell-extrinsic immunity have shown that APOL1 and complement cascade components secreted by hepatocytes are essential for protective immunity to trypanosome and pyogenic bacteria, respectively. Third, studies of inborn errors of non-hematopoietic cell-intrinsic immunity have suggested that keratinocytes, pulmonary epithelial cells, and cortical neurons are essential for tissue-specific protective immunity to human papillomaviruses, influenza virus, and herpes simplex virus, respectively. Various other types of genetic resistance or predisposition to infection in human populations are not readily explained by inborn variants of genes operating in leukocytes and may, therefore, involve defects in other cells. The probing of this unchartered territory by human genetics is reshaping immunology, by scaling immunity to infection up from the immune system to the whole organism.
Galea S, Vaughan R
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On Choosing the Right Starting Question: A Public Health of Consequence, August 2019

Munoz E
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Canal shaping with a reciprocating system is easy to learn

Aim To assess progressive learning of root canal shaping in order to
Witt E
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Testis single-cell RNA-seq reveals the dynamics of de novo gene

ELIFE 2019 AUG 16; 8(?):? Article e47138
The testis is a peculiar tissue in many respects. It shows patterns of
Wang XY
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C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation,

RNA 2019 AUG; 25(8):935-947
Some neurological disorders, including amyotrophic lateral sclerosis
Etchegaray JP
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The Histone Deacetylase SIRT6 Restrains Transcription Elongation via

MOLECULAR CELL 2019 AUG 22; 75(4):683-699.e7
Transcriptional regulation in eukaryotes occurs at promoter-proximal
Hawkes JE
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Impact of Online Prescription Management Systems on Biologic Treatment

ADVANCES IN THERAPY 2019 AUG; 36(8):2021-2033
IntroductionPharmaceutical firms have begun offering online prescription
Frank MO
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Sequencing and curation strategies for identifying candidate

BMC MEDICAL GENOMICS 2019 AUG 2; 12(1):? Article 114
Colosimo DA
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Mapping Interactions of Microbial Metabolites with Human

CELL HOST & MICROBE 2019 AUG 14; 26(2):273-282.e7
Despite evidence linking the human microbiome to health and disease, how