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Found 35038 matches. Displaying 161-170
Rock J
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Tuberculosis drug discovery in the CRISPR era

PLOS PATHOGENS 2019 SEP; 15(9):? Article e1007975
Stewart Cole and colleagues determined the complete genome sequence of
Li MMH
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Characterization of Novel Splice Variants of Zinc Finger Antiviral

JOURNAL OF VIROLOGY 2019 SEP; 93(18):? Article e00715-19
Given the unprecedented scale of the recent Ebola and Zika viral
Spiegelman NA
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SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell

ACS CHEMICAL BIOLOGY 2019 SEP; 14(9):2014-2023
Protein lysine fatty acylation is increasingly recognized as a prevalent
Whinn KS
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Nuclease dead Cas9 is a programmable roadblock for DNA replication

SCIENTIFIC REPORTS 2019 SEP 16; 9(?):? Article 13292
Limited experimental tools are available to study the consequences of
Roeder RG
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50+years of eukaryotic transcription: an expanding universe of factors

NATURE STRUCTURAL & MOLECULAR BIOLOGY 2019 SEP; 26(9):783-791
The landmark 1969 discovery of nuclear RNA polymerases I, II and III in
Puel A
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The nature of human IL-6

JOURNAL OF EXPERIMENTAL MEDICINE 2019 SEP; 216(9):1969-1971
Nasca C
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Multidimensional Predictors of Susceptibility and Resilience to Social

BIOLOGICAL PSYCHIATRY 2019 SEP 15; 86(6):483-491
BACKGROUND: Previous studies identified several separate risk factors
Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S
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Force-induced conformational changes in PIEZO1

NATURE 2019 SEP 12; 573(7773):230-234
PIEZO1 is a mechanosensitive channel that converts applied force into electrical signals. Partial molecular structures show that PIEZO1 is a bowl-shaped trimer with extended arms. Here we use cryo-electron microscopy to show that PIEZO1 adopts different degrees of curvature in lipid vesicles of different sizes. We also use high-speed atomic force microscopy to analyse the deformability of PIEZO1 under force in membranes on a mica surface, and show that PIEZO1 can be flattened reversibly into the membrane plane. By approximating the absolute force applied, we estimate a range of values for the mechanical spring constant of PIEZO1. Both methods of microscopy demonstrate that PIEZO1 can deform its shape towards a planar structure. This deformation could explain how lateral membrane tension can be converted into a conformation-dependent change in free energy to gate the PIEZO1 channel in response to mechanical perturbations
Krueger JG
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IL-17A inhibition by secukinumab induces early clinical,

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2019 SEP; 144(3):750-763
Background: Hyperactivity of the IL-23/IL-17 axis is central to plaque
Alushin G
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Early Career Advisory Board

JOURNAL OF CELL BIOLOGY 2019 SEP; 218(9):2813-2814