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Found 35038 matches. Displaying 151-160
Laurin M
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An RNAi screen unravels the complexities of Rho GTPase networks in skin

ELIFE 2019 SEP 25; 8(?):? Article e50226
During mammalian embryogenesis, extensive cellular remodeling is needed
McEwen BS
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The good side of "stress"

Stress has both a good and bad side which are discussed in terms of the
Duvall LB
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Mosquito Host-Seeking Regulation: Targets for Behavioral Control

TRENDS IN PARASITOLOGY 2019 SEP; 35(9):704-714
Female Aedes aegypti mosquitoes require protein from blood to develop
Weinberg DN, Papillon-Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan KN, Horth C, McGuire JT, Xu X, Nikbakht H, Lemiesz AE, Marchione DM, Marunde MR, Meiners MJ, Cheek MA, Keogh MC, Bareke E, Djedid A, Harutyunyan AS, Jabado N, Garcia BA, Li H, Allis CD, Majewski J, Lu C
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The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

NATURE 2019 SEP 12; 573(7773):281-286
Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue development and homeostasis1-4. They are also implicated in human developmental disorders and cancers5-8, supporting the critical role of DNA methylation in the specification and maintenance of cell fate. Previous studies have suggested that post-translational modifications of histones are involved in specifying patterns of DNA methyltransferase localization and DNA methylation at promoters and actively transcribed gene bodies9-11. However, the mechanisms that control the establishment and maintenance of intergenic DNA methylation remain poorly understood. Tatton-Brown-Rahman syndrome (TBRS) is a childhood overgrowth disorder that is defined by germline mutations in DNMT3A. TBRS shares clinical features with Sotos syndrome (which is caused by haploinsufficiency of NSD1, a histone methyltransferase that catalyses the dimethylation of histone H3 at K36 (H3K36me2)8,12,13), which suggests that there is a mechanistic link between these two diseases. Here we report that NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at intergenic regions. Genome-wide analysis shows that the binding and activity of DNMT3A colocalize with H3K36me2 at non-coding regions of euchromatin. Genetic ablation of Nsd1 and its paralogue Nsd2 in mouse cells results in a redistribution of DNMT3A to H3K36me3-modified gene bodies and a reduction in the methylation of intergenic DNA. Blood samples from patients with Sotos syndrome and NSD1-mutant tumours also exhibit hypomethylation of intergenic DNA. The PWWP domain of DNMT3A shows dual recognition of H3K36me2 and H3K36me3 in vitro, with a higher binding affinity towards H3K36me2 that is abrogated by TBRS-derived missense mutations. Together, our study reveals a trans-chromatin regulatory pathway that connects aberrant intergenic CpG methylation to human neoplastic and developmental overgrowth.
Huang CM
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Hemoglobin Levels and Serum C-Reactive Protein in Patients With Moderate

Introduction: Anemia of chronic inflammation is associated with many
Ferreira L
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Investigation of foreign materials in gingival lesions: a

Objectives. This study aimed to evaluate the clinical and
Marat A
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Early Career Advisory Board: Q&A on career and publishing

JOURNAL OF CELL BIOLOGY 2019 SEP; 218(9):2815-2818
We interviewed our Early Career Advisory Board to learn about their
Letts JA
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Structures of Respiratory Supercomplex I+III2 Reveal Functional and

MOLECULAR CELL 2019 SEP 19; 75(6):1131-1146.e6
The mitochondrial electron transport chain complexes are organized into
Islam MS
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Application of a Phage Cocktail for Control of Salmonella in Foods and

VIRUSES-BASEL 2019 SEP; 11(9):? Article 841
Salmonella contamination in foods and their formation of biofilms in
Kochhar S
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Defining the interval for monitoring potential adverse events following

VACCINE 2019 SEP 10; 37(38):5796-5802
Live viral vectors that express heterologous antigens of the target