Scientists knew that obesity raises the risk of hypertension. Now Paul Cohen's team has uncovered the mechanism—and the enzyme—that explains how fat can stiffen blood vessels and drive blood pressure upward.
New study shows that beige fat suppresses an enzyme that promotes high blood pressure, revealing a new molecular pathway and a potential target for future precision therapies.
Researchers discovered that a crucial first step in the signaling system operates differently than previously thought, an insight that could lead to the next generation of treatments.
Replicative aging of human cells, the result of telomere shortening, is slower at physiological oxygen than at atmospheric oxygen, a difference now shown to be due to low oxygen impairing the ATM kinase response to withered telomeres.
Researchers have learned that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung.
Kivanç Birsoy is uncovering the hidden metabolic pathways that cancer cells exploit. His work could also optimize strategies for using nutrition to improve human health.
New study demonstrates how high-affinity B cells "bank" their best traits instead of rolling the dice and risking deleterious mutations, with implications for better vaccine design.
A collaboration between Rockefeller, MSK, and Weill Cornell answers a longstanding
mystery about the basic biology of the hepatitis B virus, while also proposing a novel therapy.
