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Academic Opportunities

The Rockefeller University is an Equal Opportunity Employer with a policy that forbids discrimination in employment for protected characteristics. The Administration has an Affirmative Action Program to increase outreach to women, minorities, individuals with disabilities, and protected veterans.

 

(Senior) Research Associate | Research Assistant / Associate Professor; Advanced Neuro-Imaging & Technologies; VAZIRI LABORATORY OF NEUROTECHNOLOGY AND BIOPHYSICS

The emergence of new optical technologies combined with molecular sensors and advanced computational tools have led to major advances of our understanding of how the circuitry and dynamics of neuronal population give rise to brain functions and behavior. The Vaziri Lab of Neurotechnology and Biophysics (LNB) has a major focus on the development and application of advanced optical imaging technologies with applications for systems neuroscience. Over the last few years the lab has developed a portfolio of optical techniques that allow near-simultaneous stimulation [1, 2]and functional imaging of neuronal activity on the whole-brain level at single-cell level in small model organisms [3,4] and more recently in the more scattering rodent brain [5-8].

Position

To further push the boundaries of neurotechnology development and brain-imaging, we are seeking to fill a leadership role in the LNB who can develop an independent and highly synergistic research program aligned with the ongoing efforts in the laboratory. The successful candidate will be imbedded in LNB benefiting from the existing laboratory infrastructure and scientific environment while leading a team supported by independently as well as jointly acquired external funding. Possible areas of the focus of the research program of the applicants may include but are not limited to:

  • Development of new optical or non-optical methods for interrogating neuroactivity
  • Imaging through scattering media
  • Computational imaging technologies, machine learning and advanced statistics
  • Development of early stage technologies for bioimaging and biology based on conceptually new approaches from quantum optics/quantum sensing, ultrafast optics, nano-photonics or other areas
  • Development of new molecular sensors and use of biochemical or synthetic biological approaches

Key Responsibilities

  • Support multiple research projects at senior level, independently lead projects while training and mentoring junior scientists
  • Support Head of Laboratory with execution of the laboratory research program and acquisition of external funding
  • Author, publish, and present research findings
  • As needed, serve as a liaison to industry and support the dissemination of developed technologies

Qualifications

  • Highly motivated, ambitious and goal-driven
  • PhD in physics, optics, optical / electrical engineering or related fields
  • Demonstrated scientific excellence and substantial contributions in research in candidate’s field
  • Ability to manage multiple tasks and projects and work as a key part of an interdisciplinary team, excellent organizational and communication skills and willingness to work outside their core expertise
  • Prior experimental work experience in academia or industry on one and more of these areas is highly desired: designing and building optical systems, ultra-fast optics, fiber optics, computational modeling, systems neuroscience
  • Track record of acquisition of research funding is required for appointments at Research Assistant / Associate Professor level

Depending on candidates’ qualifications and scientific achievements, the initial appointment can be made as a (Senior) Research Associate or Research Assistant / Associate Professor. Appointment as a Research Assistant / Associate Professor will be subject to successful review by a university committee.

How to Apply

Interested candidates should send their CV including a list of publications, a statement of research interests as well as the contact information of at least three references to vaziri@rockefeller.edu. For more information please visit our website www.vaziria.com.

References

1. Andrasfalvy, B., et al., Two-photon Single Cell Optogenetic Control of Neuronal Activity by Sculpted Light. PNAS, (2010). 107.
2.Losonczy, A., et al., Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons. Nature Neuroscience, (2010). 13(8): p. 967-72.
3.Schrodel, T., et al., Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light. Nature Methods, (2013). 10(10): p. 1013-1020.
4.Prevedel, R., et al., Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy. Nature Methods, (2014). 11(7): p. 727-730
5.Robert, R. et al., Fast volumetric calcium imaging across multiple cortical layers using sculpted light. Nature Methods, (2016)13, 1021-1028
6. Skocek,O., et al.,High-speed volumetric imaging of neuronal activity in freely moving rodents. Nature Methods,(2018). 15, 429–432.
7. Nöbauer, T., et al., Video rate volumetric Ca2+imaging across cortex using seeded iterative demixing (SID) microscopy. Nature Methods, (2017).14, 811-81.
8. Weisenburger, S. et al., Volumetric Ca2+ Imaging in the Mouse Brain using Hybrid Multiplexed Sculpted Light (HyMS) Microscopy. Cell (2019), 177, 1–17

 

Postdoctoral Fellowships

The Center for Studies in Physics and Biology expects to have a small number of postdoctoral fellowships available for appointments in September 2021. We are seeking theoretical physicists, mathematicians and computer scientists with a demonstrable interest in the interface between their discipline and biology. The Fellows are to be at that stage of career as to function as independent members of the Center, free to work alone or in collaboration with any members of The Rockefeller University faculty. The appointment is nominally for two years, with a third year implicit, but based on mutual satisfaction.

Applicants should submit curriculum vitae, including a list of publications, a research statement and three letters of recommendation by November 30, 2020. The contents of all letters should be addressed to: Director, Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Avenue, Box 75, New York, NY  10065-6399. Applications should be e-mailed in PDF format to: leem@rockefeller.edu.

Consideration will be given to late received applications.

Synthetic Chemistry Postdoctoral Researcher

We seek a Synthetic Chemistry Postdoctoral researcher to join the Laboratory of Chemical Immunology and Proteomics. This is an exciting opportunity for a candidate who is interested in working in an interdisciplinary environment, contributing with their synthetic skillset, while gaining expertise in proteomics methods and chemical biology and immunology.

The laboratory of Chemical Immunology and Proteomics applies synthetic chemistry, chemical biology, and proteomics methods toward the goals of discovering and characterizing (a) novel selective chemical probes that perturb the functions of key proteins regulating immunological and neuroimmunological processes; (b) new mechanisms for small molecule-induced protein degradation; and, more broadly, (c) the pharmacological landscape and signal transduction pathways in immune and neuroimmunological disorders. By developing and applying innovative chemical proteomic profiling technologies, we aim to enrich our understanding of the molecular differences between pathologic and physiologic states in immune cells and cells of the nervous system and to leverage them from a pharmacological perspective for the development of new therapies that not only target specific immune cell subtypes, but also the defined activation states of these cells. Please see www.vinogradovalab.com for more information.

Job Requirements/Qualifications

  • 3+ years of research experience in organic chemistry, including multi-step organic synthesis on milligram to gram reaction scales, in either an academic or industry setting;
  • Thorough working knowledge of organic chemistry, experience with modern chromatographic and analytical techniques, including flash chromatography, HPLC, LCMS, NMR, and elemental analysis for compound characterization;
  • Must be able to work independently as well as part of a multi-disciplinary team in a fast-paced, highly collaborative environment;
  • Consistent track record of academic accomplishments (e.g., peer-reviewed publications and/or patents);
  • Initial understanding of biological and pharmaceutical principles and a working knowledge of the use of structure-based or other computer-aided drug design tools;
  • Effective written and oral communication skills;
  • PhD degree in Organic chemistry, Medicinal Chemistry, Pharmacology, Chemical Biology, or related field required.

Please e-mail your CV and a cover letter to Prof. Ekaterina (Katya) Vinogradova (vinograd@rockefeller.edu) and arrange for 3 reference letters to be sent directly to Prof. Vinogradova.

Postdoctoral Researcher

We seek a Postdoctoral researcher with strong cell and molecular biology background to join the Laboratory of Chemical Immunology and Proteomics. This is an exciting opportunity for a candidate who is interested in working in an interdisciplinary environment, contributing with their molecular biology skillset, while gaining expertise in proteomics methods, chemical biology, and immunology.

The laboratory of Chemical Immunology and Proteomics applies synthetic chemistry, chemical biology, and proteomics methods toward the goals of discovering and characterizing (a) novel selective chemical probes that perturb the functions of key proteins regulating immunological and neuroimmunological processes; (b) new mechanisms for small molecule-induced protein degradation; and, more broadly, (c) the pharmacological landscape and signal transduction pathways in immune and neuroimmunological disorders. By developing and applying innovative chemical proteomic profiling technologies, we aim to enrich our understanding of the molecular differences between pathologic and physiologic states in immune cells and cells of the nervous system and to leverage them from a pharmacological perspective for the development of new therapies that not only target specific immune cell subtypes, but also the defined activation states of these cells. Please see www.vinogradovalab.com for more information.

Job Requirements/Qualifications

  • Strong working knowledge of cell biology is essential, expertise in immunology and/or chemical biology highly desirable.
  • Extensive experience with some of the following cell and molecular biology techniques is required: mammalian cell culture, PCR, RT-PCR, cloning, viral transduction, CRISPR-Cas9 gene editing, protein expression, immunoprecipitation, SDS-PAGE, and Western-blot, as well as biochemical assay development;
  • The candidate should be scientifically motivated, detail-oriented, capable of independently conceiving, conducting and critically analyzing their own research;
  • Consistent track record of academic accomplishments (e.g., peer-reviewed publications and/or patents);
  • Effective written and oral communication skills;
  • PhD degree in Cell biology, Chemical Biology, Molecular biology, Biochemistry, Immunology, Pharmacology or a related field of biology is required.

Please e-mail your CV and a cover letter to Prof. Ekaterina (Katya) Vinogradova (vinograd@rockefeller.edu) and arrange for 3 reference letters to be sent directly to Prof. Vinogradova.

Senior Research Associate in the Laboratory of Immune Cell Epigenetics and Signaling

The position of Senior Research Associate is available in the Laboratory of Immune Cell Epigenetics and Signaling at The Rockefeller University. We are looking for a highly qualified immunologist to study the epigenetic mechanisms of the immune cell dormancy. The candidate must have excellent skills in mouse immunology, genetics and molecular biology and be interested in building an independent research group within the lab. The successful candidate will be given all necessary resources and ample allocation within the new laboratory space and provide an opportunity to advance her/his research by applying for career development awards at the NIH.

Interested candidates must send a letter of intent, a current CV and two letters of references to Marianne Labriola (labriom@mail.rockefeller.edu).

Postdoctoral Researcher

Speech and language are quintessential human traits underpinned by vocal learning. Yet remarkably, humans share many behavioral, neuroanatomical, and genetic similarities with other distantly related vocal learning species, like songbirds and cetaceans. In the Laboratory of Neurogenetics of Language, we are investigating the evolutionary, developmental, and functional origins of these similarities at the level of neural circuits using a variety of model organisms and experimental approaches.

The Laboratory of the Neurogenetics of Language is currently inviting applications for two postdoctoral research positions. We are seeking highly qualified and motivated candidates with electrophysiological expertise and/or molecular biology and viral vector expertise to investigate the formation of vocal learning-like neural circuits in genetically manipulated mice. The overall goal of this project is to better understand how the function of specific genes influence the formation of vocal motor circuits that are found across widely highly divergent vocal learning species. The candidate will work with a multidisciplinary team of scientists.

https://www.rockefeller.edu/our-scientists/heads-of-laboratories/1159-erich-d-jarvis/

Education and/or Experience

The ideal candidate will have a Ph.D. in a relevant scientific discipline (e.g. neuroscience, genetics, molecular biology, physiology, etc.) and previous research experience in electrophysiology, animal behavior, virology, and/or gene editing. Interested applicants are strongly encouraged to submit the following documents to Drs. Erich Jarvis (ejarvis@rockefeller.edu) and Samara Brown (sbrown02@rockefeller.edu).

  •           Curriculum vitae including publications
  •           Names and complete contact information for three references
  •           Research statement summarizing relevant experience and interest in our group

Postdoctoral Researcher

A postdoctoral position is available at the Laboratory of Epigenetics and Immune Cell Signaling at The Rockefeller University to study the epigenetic control of the immune cell dormancy. Candidates must have expertise in immunology and mouse genetics and be familiar with basic principles of gene regulation.  The position is available starting September 1. 2020. Candidates must submit their CV and names of two to three referees to Alexander Tarakhovsky at tarakho@rockefeller.edu

Postdoctoral Researcher

The Funabiki lab at the Rockefeller University has an opening for a postdoctoral researcher. The lab pursues a wide range of questions, related to mitosis, genome integrity, and diseases connected to chromosome structure defects. We combine a variety of approaches, including Cryo-EM, state-of-art microscopy, and biochemistry.

Ongoing lab projects are:

  1. The mechanisms by which nucleosomes and their regulators control mitotic chromosome structure and function
  2. The mechanisms that maintain integrity of centromere-associated repetitive elements
  3. The function of a novel nucleosome remodeling complex that we previously identified, related to DNA methylation and the congenital disease syndrome Immunodeficiency, Centromere instability and Facial anomalies (ICF)
  4. The mechanism by which cGAS, the major cytoplasmic DNA sensor for innate immunity, is regulated by nucleosomes and throughout the cell cycle
  5. The mechanisms by which mitotic defects determine cell fates

For more information of the Funabiki lab projects and publications, please visit https://www.rockefeller.edu/research/2371-funabiki-laboratory/

Qualifications

  • A passion for mitosis and chromosome biology research
  • D. with research experience in biochemistry, biophysics, cell biology, chemical biology, structural biology, systems biology, genetics, genomics, cancer biology or immunology
  • A strong track record of research productivity
  • The ability to have constructive discussions and to contribute to a healthy creative lab environment
  • Having a strong work ethic

Applications should be sent via email to Prof. Hironori Funabiki at funabih@rockefeller.edu with a CV, brief description of past research experience and potential future research directions, and contact information of at least two references.

Features of the Funabiki lab are:

  1. Funded by NIH R35 GM132111
  2. A collegial atmosphere that encourages open discussions
  3. Ample of training opportunities (new techniques, writing, presentation, etc.)
  4. A readily available PI who takes active interest in mentoring
  5. A transparent and fair working environment
  6. Institutional, domestic and international collaboration opportunities
  7. Interaction opportunities with campus labs through joint lab meetings
  8. Lab and institutional retreats
  9. Great track record in obtaining postdoctoral fellowships – all current and past postdocs received one or more
  10. All past trainees have gone on to highly successful careers. Our alumni are now PIs, or have highly competitive positions at companies and in the public sector

Selected publications

  1. Zierhut, C. et al. The cytoplasmic DNA sensor cGAS promotes mitotic cell death. 178, 302–315 (2019).
  2. Jenness, C. et al. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.  Natl. Acad. Sci. U.S.A.115, E876–E885 (2018).
  3. Giunta, S. and Funabiki, H. Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T.  Natl. Acad. Sci. U.S.A.114, 1928–1933 (2017).
  4. Zierhut, C. et al. Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion.  Struct. Mol. Biol.21, 617–625 (2014).
  5. Kelly, A.E. et al. Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science330, 235–239 (2010).

 

Postdoctoral Clinical Research Engineer in the Laboratory of Investigative Dermatology

Start Date: August 1, 2020

Groundbreaking clinical and translational research at The Rockefeller University is transforming medicine, advancing science for the benefit of humanity, and fueling the biomedical breakthroughs for which we are known. In our lab we have introduced imaging biomarkers that combine combines data science and medical imaging as a visual translation of machine learning in order to make it interpretable.

The Engineer will be a “jack-of-THREE-trades” engineer, working closely with clinicians, instrumentation engineers and scientists to develop and support custom software and hardware systems for hyperspectral imaging biomarker analysis.

  • Clinical Study Engineering (25%FTE): Working independently and closely with the study coordinator, principal investigator and medical doctors, the Engineer will be expected to complete project milestones at the end of year 1 and year 2, reviewing and augmenting the study analytics design, device fabrication, analysis and endpoint metrics. The Engineer will interface with a Site Principal Investigator at each academic medical center study site to maintain IRB approval and driving weekly enrollment. Duties include maintaining and developing a flexible, real-time software platform for expanding the clinical study data set (extending a database of hyperspectral images of skin).
  • Instrumentation Engineering (25% FTE): The Engineer will be expected to physically maintain a set of hyperspectral cameras (see Figure 2, ncbi.nlm.nih.gov/pubmed/30653684) and interface with clinical teams using these cameras in a clinical study taking place at clinical sites located in various US cities. The Engineer/Coordinator will need to have a basic understanding of and be comfortable using optics, mechanical and electronic-circuit design and fabrication methods (milling, lathing, 3D printing, etc.).
  • Data Science (50%FTE): Duties include building a medical imaging diagnostic, which will require data acquisition and development of a machine learning algorithm in Matlab and Python. Duties will also include developing a diagnostic sensory cue integration algorithm that displays imaging biomarkers as interpretable machine learning.

You Have

  • A Ph.D. in engineering with an emphasis on complex data set management.
  • Experience in multi-center clinical research studies
  • The organizational skills needed under FDA regulatory oversight
  • An interest in working closely with clinicians on optimizing device functionality in the clinical workflow
  • A willingness and ability to rapidly assimilate new fields of knowledge, from machine learning/vision algorithms to electronic circuit design, for the purpose of building functional electro-optical instrumentation.
  • The ability to clearly communicate engineering principles, design and coding with the Principal Investigator and the study team, including biologists and clinicians
  • The capacity to work collaboratively to optimize diagnostic accuracy as experimental needs require.

You Are

  • A good communicator with the ability to track with respect to data acquisition and analysis
  • Experienced writing code in multiple languages including Python, C++, and Matlab and comfortable designing and building experimental prototypes as well as experimental analyses methods.
  • Excited by the opportunity to rapidly assimilate new information for the purpose of solving varied computational and design challenges.
  • Detail-oriented, accurate, and precise
  • Capable of working both independently and within a small team
  • Creative and enjoy the iterative process of design development

How to Apply
We offer a competitive salary, comprehensive benefits, starting August 1st, 2020 with 2 years of salary support (pending year 1-end progress review) in a collaborative, intellectually stimulating work environment. Please contact dgareau@rockefeller.edu with questions about this position.

Postdoctoral Position in Single-cell Genomics

The Laboratory of single-cell genomics and population dynamics at the Rockefeller University is currently inviting applications for a postdoctoral research fellow position. We are seeking highly qualified and motivated candidates with genomics expertise. The postdoctoral associate will work on developing genomic techniques to profile and perturb cell dynamics at single-cell resolution and dissecting its connection with the internal transcriptome state.

Research in the Laboratory of single-cell genomics and population dynamics aims to investigate how a cell population maintains homeostasis and how it is disrupted in cancer and aging-related disorders. To this end, we focus on three major areas of research: 1) Profiling cell population dynamics at single-cell resolution and dissecting its connection with internal transcriptome/epigenome state. 2) Profiling single-cell microenvironments at scale and investigating environmental signals regulating cell state dynamics. 3) Developing tools for targeted in vivo cell perturbation. For more information, please see: http://caojunyuelab.org/research/

Our lab integrates both computational and experimental approaches to understand fundamental questions in single-cell genomics. Key approaches include high-throughput genomic techniques and state-of-the-art machine learning methods.

The ideal candidate should have a Ph.D. in a relevant scientific discipline (e.g., genetics, cell biology, developmental biology, computational biology, etc.) and previous research experience in genomics. Interested applicants should email Dr. Junyue Cao at jcao@rockefeller.edu and include a CV and contact information for three references. Applications will be accepted until positions are filled.

Postdoctoral Position in the Laboratory of Behavioral Neurobiology

The laboratory of Dr. Sarah Leibowitz at The Rockefeller University in New York is seeking a highly motivated and outstanding candidate to fill a postdoctoral fellowship position available immediately. This position is for a behavioral neurobiologist with a Ph.D., interest in alcohol or drug research, and experience with different techniques used to analyze neurochemical/neuroimmune mechanisms in the rodent or zebrafish brain. This position is available for two years, with a third year possible based on mutual satisfaction. Salary will be at or above guidelines set by the National Institutes of Health.

Interested applicants should send a cover letter, curriculum vitae (with a research statement and list of publications), and the names and contact information of three (3) references. This should be emailed to: Dr. Sarah Leibowitz, The Rockefeller University, 1230 York Avenue, New York, NY 10065, at leibow@rockefeller.edu.

Post-doctoral Positions in Host-Microbial Interactions

The Laboratory of Genetically Encoded Small Molecules at The Rockefeller University is seeking highly motivated and outstanding candidates to work on projects related to the human microbiome, bacterial small molecules and host-microbial interactions. The post-doctoral associate will work on the planning, data collection and data analysis for multi-faceted translational studies. Our research is focused on identifying bacterial genes, pathways and molecules that influence host-cellular functions and developing these host-microbial interactions into novel treatments for human disease. To this end we focus on three major areas of research: 1) high throughput screening of bacterial metabolites and genes to identify effector functions, 2) mouse models of inflammatory and metabolic diseases and 3) in vivo validation of bacterial metabolites and genes in human cohorts. Experience with cell cultures and mouse immunology are highly desirable.

Interested applicants should send a cover letter, CV, and names and contact information of three (3) references to Dr. Sean Brady at sbrady@rockefeller.edu. Please include “post-doctoral position in host-microbial interactions” in the subject heading of your e-mail.

Applications will be accepted until positions are filled.

Postdoctoral Associate — Molecular Basis of Nuclear Transport

As part of a long term collaboration between the Rout Lab and Cowburn Lab, we seek to appoint immediately a biochemistry/biophysics postdoctoral associate to characterize the mechanisms, interactions, and modelling associated with transport in the nuclear pore complex (NPC). Previous publications from this collaboration are listed below.

The project is focused on analysis and characterization of complexes of nucleoporins and transport factors, from simple binary complexes to the complete nuclear pore complex. The project will focus particularly on domains in certain nucleoporins with multiple intrinsically disordered Phe-Gly (FG) repeat motifs, and how these FG motifs mediate selective nucleocytoplasmic transport across the NPC through specific interactions with nuclear transport factors, which carry their cognate macromolecular cargoes. Resources include the protein expression and cell fractionation methodologies associated with the National Center for Dynamic Interactome Research , NMR resources at Rockefeller, Einstein, and NYSBC, and collaboration with the integrative modelling approaches of the Sali lab. The position will be in the Laboratory of Cellular and Structural Biology, which has an internationally recognized focus on the application of a variety of approaches towards an integrated understanding of the structure and function of the NPC.

Michael P. Rout, and David Cowburn

Interested applicants should send a cover letter, CV, and names and contact information of three (3) references to hattonb@mail.rockefeller.edu.

________________________________________

1. Sparks, S.; Temel, D. B.; Rout, M. P.; Cowburn, D., Deciphering the “Fuzzy” Interaction of FG Nucleoporins and Transport Factors Using Small-Angle Neutron Scattering. Structure 2018, 26 (3), 477-484 e4.
2. Hayama, R.; Sparks, S.; Hecht, L. M.; Dutta, K.; Karp, J. M.; Cabana, C. M.; Rout, M. P.; Cowburn, D., Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex. J Biol Chem 2018, 293 (12), 4555-4563.
3. Upla, P.; Kim, S. J.; Sampathkumar, P.; Dutta, K.; Cahill, S. M.; Chemmama, I. E.; Williams, R.; Bonanno, J. B.; Rice, W. J.; Stokes, D. L.; Cowburn, D.; Almo, S. C.; Sali, A.; Rout, M. P.; Fernandez-Martinez, J., Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex. Structure 2017, 25 (3), 434-445.
4. Raveh, B.; Karp, J. M.; Sparks, S.; Dutta, K.; Rout, M. P.; Sali, A.; Cowburn, D., Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex. Proc Natl Acad Sci U S A 2016, 113 (18), E2489-97.
5. Hough, L. E.; Dutta, K.; Sparks, S.; Temel, D. B.; Kamal, A.; Tetenbaum-Novatt, J.; Rout, M. P.; Cowburn, D., The molecular mechanism of nuclear transport revealed by atomic-scale measurements. Elife 2015, 4.

Postdoctoral Position in Bioinformatics

The Laboratory of Genetically Encoded Small Molecules at The Rockefeller University is seeking a highly motivated and outstanding candidate for a postdoctoral position in Bioinformatics. The ideal candidate will have a Ph.D. in Bioinformatics. Candidates must also demonstrate a strong track record of research productivity, scientific rigor, excellent communication skills, and an ability to work both independently and as part of a team.

The post-doctoral associate will work on identifying biosynthetic gene clusters in the soil microbiome and study small molecule biosynthesis in the human microbiome.

Interested applicants should send a cover letter, CV, and names and contact information of three (3) references to Dr. Sean Brady at sbrady@rockefeller.edu.

Natural products or more generally, genetically encoded small molecules play a wide variety of roles in biology and have proved useful in the development of small molecule therapeutic agents. The Brady Lab’s research centers on the discovery, biosynthesis and characterization of new, genetically encoded small molecules from microbial sources, with a special focus on those produced by uncultured soil bacteria and pathogenic bacteria.

Postdoctoral Positions in Peptide Chemistry

The Laboratory of Genetically Encoded Small Molecules at The Rockefeller University is seeking highly motivated and outstanding candidates for postdoctoral positions in peptide chemistry. The ideal candidate will have a Ph.D. in chemistry or a related field and have prior research experience in the field. Candidates must also demonstrate a strong track record of research productivity, scientific rigor, excellent communication skills, and an ability to work both independently and as part of a team.

Interested applicants should send a cover letter, CV, and names and contact information of three (3) references to Dr. Sean Brady at sbrady@rockefeller.edu.

Applications will be accepted until positions are filled.

Natural products or more generally, genetically encoded small molecules play a wide variety of roles in biology and have proved useful in the development of small molecule therapeutic agents. The Brady Lab’s research centers on the discovery, biosynthesis and characterization of new, genetically encoded small molecules from microbial sources, with a special focus on those produced by uncultured soil bacteria and pathogenic bacteria.

Postdoctoral Position: Chromatin Structure, Laboratory of Genome Architecture and Dynamics

Lab Description

The Laboratory of Genome Architecture and Dynamics studies how the three-dimensional architecture of the genome reflects and regulates DNA-based processes, with a focus on short-range contacts and biophysical mechanisms of transcriptional silencing. By developing integrative models of the molecular interactions that regulate access to the genome, we hope to understand and rationally manipulate changes in chromatin architecture and gene expression during differentiation and cell reprogramming, in transitions between growth, quiescence and senescence, and in the dysregulated cellular states found in cancer. We use mammalian cell lines as model systems. Our approaches include sequencing-based genomic assays such as RICC-seq and ATAC-seq, biochemistry, microscopy and modeling. We are also actively developing new methods for probing chromatin architecture in intact cells. We will be housed in the new River Campus of Rockefeller University and be part of a vibrant research community with excellent research support including more than 12 core facilities. The Rockefeller University provides excellent housing options for postdocs in Manhattan. Please see www.riscalab.org for more information.

Job Description

Multiple postdoctoral scholar positions are available in areas including development of next-generation methods for in situ chromatin structure mapping, extending RICC-seq to new model systems such as yeasts or plants, modeling chromatin fiber conformations at the oligo-nucleosome scale, exploring the biophysical mechanisms involved in transcriptional repression in mammalian cells, and studying the relationship between chromatin structure and exit from the cell cycle.

With mentorship from the Head of Lab, postdocs are expected to develop their own line of research that is based on their interests and is compatible with the broad scientific scope of the lab. They will also help build a lab at the intersection of cutting-edge epigenomics and biophysics and help to train and supervise junior lab members including graduate students and research assistants. As founding members, they will have a major impact on the culture of the lab and will have extensive interactions with the Head of Lab.

Job Requirements

The candidate must be a self-driven and rigorous scientist who is passionate about chromatin biology, is proficient in quantitative data analysis, and can work in an interdisciplinary, collaborative environment. A successful Ph.D. in a relevant area (including molecular or cell biology, biophysics, biochemistry, chemistry, physics, applied mathematics, bioengineering) and a first-author or co-first-author publication in a peer-reviewed journal are required. Previous experience with genomics, protein biochemistry, biophysical modeling, genome editing or quantitative microscopy is desirable.

How to apply

Please submit a CV that includes a publication list, PDFs of any unpublished manuscripts that are not otherwise available, and contact information for at least three references, by email to vrisca@rockefeller.edu. Please use “Postdoc application” as the subject line. See www.riscalab.org for more details.

Postdoctoral Position in Neurodegeneration

The Laboratory of Molecular Biology at The Rockefeller University is seeking a highly motivated and outstanding candidate for a postdoctoral position to study the selective vulnerability and degeneration of upper motor neurons in amyotrophic lateral sclerosis (ALS). ALS presents a paradox in that most known disease-causing mutations are ubiquitously expressed, yet only discrete populations of cells degenerate. We therefore use a multidisciplinary approach, centered on advanced molecular profiling methods to elucidate cell type-specific phenotypes during disease progression in preclinical mouse models and postmortem human tissue. By contrasting vulnerable and resilient neuronal populations as well as non-neuronal cells, we hope to identify novel disease mechanisms and putative entry points for therapeutic intervention These studies are also integrated with modern anatomical and circuit-tracing methods and behavior to map the identity, connectivity, and function of neuronal cell types in cortical and motor circuits.

The ideal candidate will have a Ph.D. in neuroscience or a related field and have prior research experience in molecular or cellular biology. Preference will also be given to those with familiarity with at least one of the following: next generation sequencing, quantitative analysis of sequencing data, animal models of CNS disorders, neuroanatomy and immunohistological methods, and/or functional circuit-mapping. Candidates must also demonstrate a strong track record of research productivity, scientific rigor, excellent communication skills, and an ability to work both independently and as part of a team.

Interested applicants should send a cover letter, CV, and names and contact information of three (3) references to Dr. Eric Schmidt (eschmidt@rockefeller.edu). Applications will be accepted until the position is filled.

Rockefeller University NIH CTSA KL2 Clinical Scholars Program
Post Fellowship Patient-Oriented Research Training for Physician-Scientists

The CTSA-supported KL2 Clinical Scholars Program is a three-year Master’s degree program with fully protected time designed to provide an optimal environment for physician-scientists starting a career in patient-oriented research. It combines focused research on a project involving human subjects under the direction of a senior Rockefeller University mentor with a comprehensive tutorial-based curriculum in patient-oriented research led by Dr. Barry Coller, Physician-in-Chief. See http://www.rockefeller.edu/ccts/training/KL2program for details. Salary and benefits are competitive.

Please apply on-line at http://scholarapplication.rockefeller.edu/.
For additional information contact:

Dr. Barry Coller
Laboratory of Blood and Vascular Biology
The Rockefeller University
1230 York Avenue
New York, NY 10065.


Disability Accommodations
The University provides reasonable accommodations to qualified individuals with disabilities who can perform the essential functions for the position. If you require a reasonable accommodation for any part of the application and/or hiring process, please notify Human Resources by calling 212-327-8300 or emailing hris@rockefeller.edu.

The Rockefeller University is an Equal Opportunity Employer with a policy that forbids discrimination in employment for protected characteristics. The Administration has an Affirmative Action Program to increase outreach to women, minorities, individuals with disabilities, and protected veterans.