Mechanical Feedback During Embryonic Self-Organization.
Event Details
- Type
- Center for Studies in Physics and Biology Seminars
- Speaker(s)
-
Jerome Gros, Ph.D., Head of Structure, Pasteur Institute
- Speaker bio(s)
-
Morphogenesis is fundamentally a mechanical process, in which forces generated by cells are integrated over space and time to shape tissues. While the genetic and molecular regulation of morphogenesis has been extensively characterized, how the mechanical properties of embryonic tissues emerge, and how active forces are generated, remain poorly understood. This is largely due to the difficulty of making direct, quantitative measurements in living embryos over morphogenetic timescales, which in amniotes are typically long, spanning tens of hours. In this talk, I will discuss our recent advances toward a quantitative, physical description of early embryonic morphogenesis using the quail embryo as a model for amniote development. I will show how live imaging and quantitative image analysis can be combined with minimally invasive mechanical probing assays to measure tissue material properties and active force generation in developing embryos. Finally, I will discuss how mechanics feeds back on cell behavior, signaling, and fate to drive the self-organization of early embryonic development.
- Open to
- Public
- Reception
- Refreshments, 3:30 p.m. - 4:00 p.m., Lower Level Greenberg Building (CRC)
- Phone
- (212) 327-8636
- Sponsor
-
Melanie Lee
(212) 327-8636
leem@rockefeller.edu