Nuclear cGAS: From Detection of Viruses to Cancer Immunotherapy

Event Details

Type

SNF Institute

Speaker(s)

Nicolas Manel, Ph.D., group leader, research director, INSERM U932 Unit, Curie Institute

Speaker bio(s)

My research activity has focused on the central question of self/non-self discrimination in biology, at the interface between virology and immunology. During my PhD, we identified that the glucose receptor GLUT1 is the receptor for the Human T-cell Leukemia/Lymphoma Virus (Manel et al. Cell 2003). During my postdoc in Dan Littman’s lab at NYU, we discovered that human dendritic cells could sense intracellular HIV (Manel et al. Nature 2010). As an independent PI since 2010 at Institut Curie, the initial interest of the lab in HIV sensing expanded to general mechanisms of nucleic acid immunity, and their relevance to viral infections, cancer, aging and their applications.

Open to

Tri-Institutional