Event Detail (Archived)
Mind the Gap: Size-based Organization at Cell-Cell Contacts
- This event already took place in March 2020
- A Level Physics Seminar Room, Room A30, Smith Hall Annex (CRC)
Event Details
- Type
- Center for Studies in Physics and Biology Seminars
- Speaker(s)
-
Daniel Fletcher, Ph.D., professor, University of California, Berkeley
- Speaker bio(s)
-
Membrane interfaces formed at junctions between cells are often associated with characteristic patterns of protein organization, such as in epithelial tissues and between cells of the immune system. Size is emerging as a critical feature of cell surface proteins that can directly affect cell-cell interface formation and contribute to spatial arrangement of proteins at junctions, as well as their downstream signaling. This talk will present a new method for characterizing cell surface protein size that enables nanometer-scale height measurements, and will describe the implications of protein height on macrophage phagocytosis, cell-cell fusion, and viral entry. Results from these studies support a model in which the topography of cell surfaces plays a key role in mediating cell-cell interaction and communication.
- Open to
- Public
- Contact
- Melanie Lee
- Phone
- (212) 327-8636
- Sponsor
-
Melanie Lee
(212) 327-8636
leem@rockefeller.edu