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Event Detail (Archived)

A Model for the Development of Orientation Preference Maps in the Visual Cortex of Mice

  • This event already took place in January 2020
  • A Level Physics Seminar Room, Room A30, Smith Hall Annex (CRC)

Event Details

Type
Center for Studies in Physics and Biology Seminars
Speaker(s)
Jennifer Crodelle, Ph.D., NSF Postdoctoral Research Fellow, New York University
Speaker bio(s)

The mammalian primary visual cortex (V1) contains neurons that respond preferentially to oriented visual stimuli (e.g., horizontal bars). In the mouse, these orientation-preferring neurons are scattered throughout V1 in what's called a ''salt and pepper'' orientation-preference (OP) map. Despite the seemingly random distribution of OPs in the visual cortex of mice, it has been shown that radially-distributed clonally-related cells show similar stimulus feature selectivity, as well as preferential synaptic connectivity with fellow sister cells. Importantly, each of these characteristics relies on gap-junction coupling between sister cells during the first postnatal week. Crodelle constructs an idealized model of the mouse visual cortex during the first two postnatal weeks of development and analyzes the effect of gap-junction coupling on the formation of synaptic connections both into and within V1. In particular, she uses this model to propose a role for gap-junction coupling between sister cells in facilitating the formation of the salt-and-pepper OP that is typical of the adult mouse visual cortex.

Open to
Public
Contact
Melanie Lee
Phone
(212) 327-8636
Sponsor
Melanie Lee
(212) 327-8636
leem@rockefeller.edu


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