Activity-based Proteomics: Applications for Enzyme and Inhibitor Discovery
William H. Stein Memorial Lecture
Event Details
- Type
- Friday Lecture Series
- Speaker(s)
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Benjamin F. Cravatt, Ph.D., chairman, department of chemical physiology, The Scripps Research Institute
- Speaker bio(s)
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Genome sequencing projects have revealed that eukaryotic and prokaryotic organisms universally possess a large number of uncharacterized enzymes. The functional annotation of enzymatic pathways thus represents a grand challenge for researchers in the genome era. To address this problem, Dr. Cravatt and colleagues have introduced chemical proteomic and metabolomic technologies that globally profile enzyme activities in complex biological systems. These methods include activity-based protein profiling (ABPP), which utilizes active site-directed chemical probes to determine the functional state of large numbers of enzymes in native proteomes. Dr. Cravatt will describe the integrated application of ABPP and complementary metabolomic methods to discover and functionally annotate enzyme activities in mammalian systems, including cancer and the nervous system. He will also present competitive ABPP platforms for developing selective inhibitors for poorly characterized enzymes and discuss ongoing challenges faced by researchers interested in assigning protein function using chemoproteomic methods.
Dr. Cravatt received a B.A. in history and a B.S. in biological sciences from Stanford University. In 1996 he earned his Ph.D. from the Scripps Research Institute in macromolecular and cellular structure and chemistry and was subsequently named assistant professor at Scripps' Skaggs Institute for Chemical Biology and the department of cell biology. He was named professor in 2004 and has been chair of the department of chemical physiology since 2007. Among Dr. Cravatt's honors are the Eli Lilly Award in Biological Chemistry from the American Chemical Society, the Cope Scholar Award from the American Chemical Society and the MERIT Award from National Cancer Institute. A member of the American Chemical Society since 1997, Dr. Cravatt has also served on the scientific advisory boards of a number of pharmaceutical companies and research foundations and is a cofounder of Activx Biosciences and Abide Therapeutics.
- Open to
- Public
- Host
- Tarun Kapoor
- Reception
- Refreshments, 3:15 p.m. - 3:45 p.m., Abby Lounge
- Contact
- Gloria Phipps
- Phone
- (212) 327-8967
- Sponsor
-
Gloria Phipps
(212) 327-8967
phippsg@rockefeller.edu