Event Detail (Archived)
mRNP Granules in Health and Disease
Event Details
- Type
- Friday Lecture Series
- Speaker(s)
-
Roy Parker, Ph.D., Cech-Leinwand Endowed Chair of Chemistry and Biochemistry, department of chemistry and biochemistry, University of Colorado at Boulder; investigator, Howard Hughes Medical Institute
- Speaker bio(s)
-
The regulation of translation and mRNA degradation is an important aspect of the control of gene expression in eukaryotic cells. In addition to the translating pool of mRNA associated with polysomes, recent experiments have defined specific cytoplasmic compartments, such as stress granules and P-bodies, wherein untranslated mRNAs accumulate in conjunction with factors regulating translation and/or the mRNA decay machinery. Stress granules and P-bodies are biochemically related to mRNP granules found in neurons and embryos revealing they serve a conserved and biologically important role in the post-transcriptional regulation of gene expression. Moreover, perturbation of stress granule dynamics contributes to the etiology of some neurodegenerative diseases. Dr. Parker's laboratory is defining the mechanisms by which P-bodies and stress granules assemble, how cells regulate the movement of mRNAs between these different biochemical and cell biological compartments, and how those transitions modulate the translation and degradation of specific mRNAs.Dr. Parker received his Ph.D. from the University of California, San Francisco, and completed postdoctoral work at the University of Massachusetts, Worcester. His research focuses on the biogenesis, translation, and degradation of eukaryotic RNA and how cells regulate different steps in this process to modulate gene expression. He is an elected Fellow of the American Academy of Arts and Sciences and Member of the National Academy of Sciences, among other honors.
- Open to
- Public
- Host
- Sohail Tavazoie, M.D., Ph.D.
- Reception
- Refreshments, 3:15 p.m. - 3:45 p.m., Abby Lounge
- Contact
- Linda Hanssler
- Phone
- (212) 327-7714
- Sponsor
-
Linda Hanssler
(212) 327-7714
lhanssler@rockefeller.edu - Readings
-
http://librarynews.rockefeller.edu/?p=3955