The rockefeller university

Event Details

Type

Friday Lecture Series

Speaker(s)

Carolyn Bertozzi, Ph.D., Anne T. and Robert M. Bass Professor of Chemistry and professor of chemical and systems biology and radiology (by courtesy), Stanford University; investigator, Howard Hughes Medical Institute

Speaker bio(s)

Cell surface sialosides constitute a central axis of immune modulation that is exploited by tumors to evade both innate and adaptive immune destruction. Therapeutic strategies that target tumor-associated sialosides may therefore potentiate anti-tumor immunity. Dr. Bertozzi’s presentation will focus on her laboratory’s recent work toward defining the roles of sialylated glycans in tumor evolution, and on the development of antibody-sialidase conjugates that enhance tumor cell susceptibility to immune destruction by selective desialylation of the tumor cell glycocalyx. Central to her laboratory’s effort is the use of synthetic glycopolymers that remodel the cell surface glycocalyx, as well as bioorthogonal chemistries for assembly of antibody-enzyme conjugates.

 

Dr. Bertozzi's research interests span the disciplines of chemistry and biology, with an emphasis on studies of cell surface glycosylation pertinent to disease states. Her laboratory focuses on profiling changes in cell surface glycosylation associated with cancer, inflammation, and bacterial infection, and exploiting this information for development of diagnostic and therapeutic approaches, most recently in the area of immuno-oncology.  

 

Dr. Bertozzi received her A.B. in chemistry from Harvard University in 1988 and her Ph.D. in chemistry from the University of California, Berkeley, in 1993. After completing her postdoctoral work at the University of California, San Francisco, in the field of cellular immunology, she joined the UC Berkeley faculty in 1996. In June 2015, she joined the faculty at Stanford University coincident with the launch of Stanford's ChEM-H institute. Dr. Bertozzi is a member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences. She has received many honors for her research accomplishments, including a MacArthur Foundation Fellowship in 1999, the Lemelson-MIT Prize in 2010, and the Heinrich Wieland Prize in 2012.

Open to

Public

Host

Graduate Fellows

Reception

Refreshments, 3:15 p.m. - 3:45 p.m., Abby Lounge

Contact

Linda Hanssler

Phone

(212) 327-7714

Sponsor

Linda Hanssler
(212) 327-7714
lhanssler@rockefeller.edu

Readings

http://librarynews.rockefeller.edu/?p=4103