The rockefeller university

Event Details

Type

Friday Lecture Series

Speaker(s)

George Q. Daley, M.D., Ph.D., Samuel E. Lux, IV Professor of Hematology and director, Stem Cell Transplantation Program, Boston Children's Hospital; investigator, Howard Hughes Medical Institute

Speaker bio(s)

A major goal of stem cell research is the creation of personalized, patient-specific stem cells for use in disease modeling and as a foundation for gene repair in the context of autologous cell therapy. The ability to restore pluripotency to somatic cells through the ectopic co-expression of reprogramming factors has created powerful new opportunities for modeling human diseases. Dr. Daley's lab has derived induced pluripotent stem cells (iPSC) from patients with a variety of genetic bone marrow failure disorders, including Dyskeratosis congenita, Fanconi's anemia, Shwachman-Diamond syndrome and Diamond Blackfan anemia. Hematopoietic differentiation of these lines in vitro recapitulates certain aspects of these diseases and enables novel insights into disease mechanisms, thereby confirming their utility in disease modeling for studies of pathogenesis. Some skepticism remains, however, whether subtle differences between iPS cells and ES cells might impact research applications and therapeutic potential. Aspects of these studies highlighting advantages and limitations of iPS-based disease modeling will be presented.

Dr. Daley earned his Ph.D. in biology from the Massachusetts Institute of Technology in 1989 and his M.D. from Harvard Medical School in 1991. He has served as past-President of the International Society for Stem Cell Research (ISSCR), led the special task forces that produced the ISSCR Guidelines for Stem Cell Research and Clinical Translation, and is currently the ISSCR clerk. Dr. Daley has been elected to the Institute of Medicine of the National Academies, American Society for Clinical Investigation, American Association of Physicians, American Pediatric Societies, American Academy of Arts and Sciences and American Association for the Advancement of Science, and has received the NIH Director’s Pioneer Award, the Judson Daland Prize from the American Philosophical Society, the E. Mead Johnson Award from the American Pediatric Society and the E. Donnall Thomas Prize from the American Society for Hematology.

Open to

Public

Reception

Refreshments, 3:15 p.m. - 3:45 p.m., Abby Lounge

Contact

Alena Powell

Phone

(212) 327-7745

Sponsor

Alena Powell
(212) 327-7745
apowell@rockefeller.edu

Readings

http://librarynews.rockefeller.edu/?p=3177