The rockefeller university

Event Details

Type

Special Seminar Series

Speaker(s)

Joshua D. Milner, M.D., clinical investigator and head, allergic inflammation unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Speaker bio(s)

Human monogenic diseases associated with atopy are few and far between, yet their identification and mechanistic elucidation has the potential to reveal specific pathways involved in the pathogenesis of allergic disease and other disorders of the immune system. By identifying and examining novel and known syndromes associated with atopy, Dr. Milner's lab has been able to discern the contributions of several pathways to allergic disease, and in the process reveal previously unappreciated roles for these pathways in both cell biology and clinical medicine. PLAID, a newly identified dominant disorder of cold urticaria and immune dysregulation due to mutations in PLCG2, has led to insights into cold-sensitive mast cell and B-cell signaling. Study of the autosomal dominant hyper-IgE syndrome due to STAT3 mutations has led to the identification of roles for STAT3 in mast cell degranulation and anaphylaxis, central memory T-cell generation and control of chronic viruses. Finally IL-21 receptor deficiency, am immune deficiency associated with elevated IgE, has, in concert with study of STAT3 mutant patients, yielded insight into inter-STAT regulation and host defense.

Dr. Milner earned his M.D. with special distinction in immunology from Albert Einstein College of Medicine in 2000 and completed his residency in pediatrics at Children's National Medical Center from 2000 to 2003. He then joined the National Institute of Allergy and Infectious Diseases as clinical fellow in allergy and immunology, followed by a clinical research transition program, and entered his current role as clinical tenure track investigator and chief of the Allergic Inflammation Unit in 2009. He was awarded an NIH Director’s Award in 2012 and 2008, a National Institute of Allergy and Infectious Diseases Merit Award in 2011, an NIH Fellows Award for Research Excellence in 2007 and a Howard Hughes Medical Institute Medical Student Training Fellowship in 1997, among other honors. He serves on the editorial boards of the Journal of Allergy and Clinical Immunology and Clinical and Experimental Immunology. Dr. Milner is board-certified in allergy and immunology and pediatrics.

Open to

Public

Host

Jean-Laurent Casanova

Reception

Refreshments, 3:45 p.m. - 4:00 p.m., Abby Lounge

Contact

Jill Benz

Phone

(212) 327-7244

Sponsor

Jill Benz
(212) 327-7244
benzj@rockefeller.edu