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Found 37769 matches. Displaying 8841-8850
Grant AV, Boisson-Dupuis S, Herquelot E, de Beaucoudrey L, Filipe-Santos O, Nolan DK, Feinberg J, Boland A, Al-Muhsen S, Sanal O, Camcioglu Y, Palanduz A, Kilic SS, Bustamante J, Casanova JL, Abel L
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Accounting for genetic heterogeneity in homozygosity mapping: application to Mendelian susceptibility to mycobacterial disease
JOURNAL OF MEDICAL GENETICS 2011 AUG; 48(8):567-571
Introduction Genome-wide homozygosity mapping is a powerful method for locating rare recessive Mendelian mutations. However, statistical power decreases dramatically in the presence of genetic heterogeneity. Methods The authors applied an empirical approach to test for linkage accounting for genetic heterogeneity by calculating the sum of positive per-family multipoint LOD scores (S) across all positions, and obtaining corresponding empirical p values (EmpP) through permutations. Results The statistical power of the approach was found to be consistently higher than the classical heterogeneity LOD by simulations. Among 21 first-cousin matings with a single affected child, for five families linked to a locus of interest and 16 families to other loci, S/EmpP achieved a power of 40% versus 28% for heterogeneity LOD at an alpha level of 0.001. The mean size of peak linkage regions was markedly higher for true loci than false positive regions. The S/EmpP approach was applied to a sample of 17 consanguineous families with Mendelian susceptibility to mycobacterial disease, leading to the identification of two mutations in IL12RB1 and TYK2 from the largest of six linkage regions at p<10(-3). Conclusions The S/EmpP approach is a flexible and powerful approach that can be applied to linkage analysis of families with suspected Mendelian disorders.
Zhou CC, Pridgen B, King N, Xu JX, Breslow JL
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Hyperglycemic Ins2(Akita)Ldlr(-/-) mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease
JOURNAL OF LIPID RESEARCH 2011 AUG; 52(8):1483-1493
Accelerated atherosclerosis is the leading cause of death in type 1 diabetes, but the mechanism of type 1 diabetes-accelerated atherosclerosis is not well understood, in part due to the lack of a good animal model for the long-term studies required. In an attempt to create a model for studying diabetic macrovascular disease, we have generated type 1 diabetic Akita mice lacking the low density lipoprotein receptor (Ins2(Akita)Ldlr(-/-)). Ins2(Akita)Ldlr(-/-) mice were severely hyperglycemic with impaired glucose tolerance. Compared with Ldlr(-/-) mice, 20-week-old Ins2(Akita)Ldlr(-/-) mice fed a 0.02% cholesterol AIN76a diet showed increased plasma triglyceride and cholesterol levels, and increased aortic root cross-sectional atherosclerotic lesion area [224% (P < 0.001) in males and 30% (P < 0.05) in females]. Microarray and quantitative PCR analyses of livers from Ins2(Akita)Ldlr(-/-) mice revealed altered expression of lipid homeostatic genes, including sterol-regulatory element binding protein (Srebp) 1, liver X receptor (Lxr)alpha, Abca1, Cyp7b1, Cyp27a1, and Lp1, along with increased expression of pro-inflammatory cytokine genes, including interleukin (Il) 1 alpha, Il1 beta, Il2, tumor necrosis factor (Tnf)alpha, and Mcp1. Immunofluorescence staining showed that the expression levels of Mcp1, Tnf alpha, and Il1 beta were also increased in the atherosclerotic lesions and artery walls of Ins2(Akita)Ldlr(-/-) mice. Thus, the Ins2(Akita)Ldlr(-/-) mouse appears to be a promising model for mechanistic studies of type 1 diabetes-accelerated atherosclerosis.-Zhou, C., B. Pridgen, N. King, J. Xu, and J. L. Breslow. Hyperglycemic Ins2(Akita)Ldlr(-/-) mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. J. Lipid Res. 2011. 52: 1483-1493.
Pasolli HA
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The Hair Follicle Bulge: A Niche for Adult Stem Cells
MICROSCOPY AND MICROANALYSIS 2011 AUG; 17(4):513-519
Adult stem cells (SCs) are essential for tissue homeostasis and wound repair. They have the ability to both self-renew and differentiate into multiple cell types. They often reside in specialized microenvironments or niches that preserve their proliferative and tissue regenerative capacity. The murine hair follicle (HF) has a specialized and permanent compartment-the bulge, which safely lodges SCs and provides the necessary molecular cues to regulate their function. The HF undergoes cyclic periods of destruction, regeneration, and rest, making it an excellent system to study SC biology.
Aaltonen T, AlvarezGonzalez B, Amerio S, Anastassov A, Annovi A, Antos J, Apollinari G, Apresyan A, Arisawa T, Artikov A, Asaadi J, Ashmanskas W, Auerbach B, Aurisano A, Azfar F, Badgett W, Barbaro-Galtieri A, Barnes VE, Barnett BA, Barria P, Bartos P, Bauce M, Bedeschi F, Beecher D, Behari S, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Bhatti A, Binkley M, Bisello D, Bizjak I, Bland KR, Blumenfeld B, Bocci A, Bodek A, Bortoletto D, Boudreau J, Boveia A, Brau B, Brigliadori L, Brisuda A, Bromberg C, Brucken E, Bucciantonio M, Budagov J, Budd HS, Budd S, Burkett K, Busetto G, Bussey P, Buzatu A, Calancha C, Camarda S, Campanelli M, Campbell M, Canelli F, Carls B, Carlsmith D, Carosi R, Carrillo S, Carron S, Casal B, Casarsa M, Castro A, Catastini P, Cauz D, Cavaliere V, Cavalli-Sforza M, Cerri A, Cerrito L, Chen YC, Chiarelli G, Chlachidze G, Chlebana F, Cho K, Chokheli D, Chou JP, Chung WH, Chung YS, Ciobanu CI, Ciocci MA, Clark A, Clarke C, Compostella G, Convery ME, Corbo M, Cordelli M, Cox CA, Cox DJ, Crescioli F, Almenar CC, Cuevas J, Dagenhart D, d'Ascenzo N, Datta M, de Barbaro P, De Cecco S, De Lorenzo G, Dell'Orso M, Deluca C, Demortier L, Deng J, Deninno M, Devoto F, d'Errico M, Di Canto A, Di Ruzza B, Dittmann JR, D'Onofrio M, Donati S, Dong P, Dorigo M, Dorigo T, Ebina K, Elagin A, Eppig A, Erbacher R, Errede D, Errede S, Ershaidat N, Eusebi R, Fang HC, Fernandez JP, Ferrazza C, Field R, Flanagan G, Forrest R, Frank MJ, Franklin M, Freeman JC, Funakoshi Y, Furic I, Gallinaro M, Galyardt J, Garcia JE, Garfinkel AF, Garosi P, Gerberich H, Gerchtein E, Giagu S, Giakoumopoulou V, Giannetti P, Gibson K, Ginsburg CM, Giokaris N, Giromini P, Giunta M, Giurgiu G, Glagolev V, Glenzinski D, Gold M, Goldin D, Goldschmidt N, Golossanov A, Gomez G, Gomez-Ceballos G, Goncharov M, Gonzalez O, Gorelov I, Goshaw AT, Goulianos K, Grinstein S, Grosso-Pilcher C, Group RC, da Costa JG, Gunay-Unalan Z, Haber C, Hahn SR, Halkiadakis E, Hamaguchi A, Han JY, Happacher F, Hara K, Hare D, Hare M, Harr RF, Hatakeyama K, Herndon M, Hewamanage S, Hidas D, Hocker A, Hopkins W, Hou S, Hughes RE, Hurwitz M, Husemann U, Hussain N, Hussein M, Huston J, Introzzi G, Iori M, Ivanov A, Jang D, Jayatilaka B, Jeon EJ, Jha MK, Jindariani S, Johnson W, Jones M, Joo KK, Jun SY, Junk TR, Kamon T, Kasmi A, Kato Y, Ketchum W, Khotilovich V, Kilminster B, Kim DH, Kim HS, Kim HW, Kim JE, Kim MJ, Kim SB, Kim SH, Kim YK, Kimura N, Kirby M, Klimenko S, Kondo K, Kong DJ, Konigsberg J, Krop D, Krumnack N, Kruse M, Krutelyov V, Kurata M, Kwang S, Laasanen AT, Lami S, Lammel S, Lancaster M, Lander RL, Lannon K, Lath A, Latino G, Lee E, Lee HS, Lee JS, Lee SW, Leo S, Leone S, Lewis JD, Limosani A, Lin CJ, Linacre J, Lindgren M, Lister A, Litvintsev DO, Liu C, Liu Q, Liu T, Lockwitz S, Loginov A, Lucchesi D, Lujan P, Lukens P, Lungu G, Lys J, Lysak R, Madrak R, Maeshima K, Makhoul K, Malik S, Manca G, Manousakis-Katsikakis A, Margaroli F, Martinez M, Martinez-Ballarin R, Mastrandrea P, Mattson ME, Mazzanti P, McFarland KS, McIntyre P, McNulty R, Mehta A, Mehtala P, Menzione A, Mesropian C, Miao T, Mietlicki D, Mitra A, Miyake H, Moed S, Moggi N, Mondragon MN, Moon CS, Moore R, Morello MJ, Fernandez PM, Mukherjee A, Mussini M, Nachtman J, Nagai Y, Naganoma J, Nakano I, Napier A, Nett J, Neu C, Neubauer MS, Nielsen J, Norniella O, Nurse E, Oakes L, Oh SH, Oh YD, Oksuzian I, Okusawa T, Orava R, Ortolan L, Griso SP, Pagliarone C, Palencia E, Papadimitriou V, Patrick J, Pauletta G, Paus C, Pellett DE, Penzo A, Phillips TJ, Piacentino G, Pilot J, Pitts K, Plager C, Pondrom L, Potamianos K, Poukhov O, Prokoshin F, Pronko A, Ptohos F, Pueschel E, Punzi G, Pursley J, Rahaman A, Ramakrishnan V, Ranjan N, Redondo I, Rescigno M, Riddick T, Rimondi F, Ristori L, Robson A, Rodrigo T, Rogers E, Rolli S, Roser R, Rossi M, Rubbo F, Ruffini F, Ruiz A, Russ J, Rusu V, Safonov A, Sakumoto WK, Sakurai Y, Santi L, Sartori L, Sato K, Saveliev V, Savoy-Navarro A, Schlabach P, Schmidt EE, Schmidt MP, Schmitt M, Schwarz T, Scodellaro L, Scribano A, Scuri F, Sedov A, Seidel S, Seiya Y, Semenov A, Sforza F, Sfyrla A, Shalhout SZ, Shears T, Shepard PF, Shimojima M, Shiraishi S, Shochet M, Shreyber I, Simonenko A, Sinervo P, Sissakian A, Sliwa K, Smith JR, Snider FD, Soha A, Somalwar S, Sorin V, Squillacioti P, Stancari M, Stanitzki M, Denis RS, Stelzer B, Stelzer-Chilton O, Stentz D, Strologas J, Strycker GL, Sudo Y, Sukhanov A, Suslov I, Takemasa K, Takeuchi Y, Tang J, Tecchio M, Teng PK, Thom J, Thome J, Thompson GA, Ttito-Guzman P, Tkaczyk S, Toback D, Tokar S, Tollefson K, Tomura T, Torre S, Torretta D, Totaro P, Trovato M, Ukegawa F, Uozumi S, Varganov A, Vazquez F, Velev G, Vellidis C, Vidal M, Vila I, Vilar R, Vizan J, Vogel M, Volpi G, Wagner RL, Wakisaka T, Wallny R, Wang SM, Warburton A, Waters D, Weinberger M, Whitehouse B, Wicklund AB, Wicklund E, Wilbur S, Wilson JS, Wilson P, Winer BL, Wittich P, Wolbers S, Wolfe H, Wright T, Wu X, Wu Z, Yamamoto K, Yamaoka J, Yang T, Yang UK, Yang YC, Yao WM, Yeh GP, Yi K, Yoh J, Yorita K, Yoshida T, Yu GB, Yu I, Yu SS, Yun JC, Zanetti A, Zeng Y, Zucchelli S
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Improved determination of the sample composition of dimuon events produced in p(p)over-bar collisions at root s=1.96 TeV
EUROPEAN PHYSICAL JOURNAL C 2011 AUG; 71(8):? Article 1720
We use a new method to estimate with 5% accuracy the contribution of pion and kaon in-flight-decays to the dimuon data set acquired with the CDF detector. Based on this improved estimate, we show that the total number and the properties of the collected dimuon events are not yet accounted for by ordinary sources of dimuons which also include the contributions, as measured in the data, of heavy flavor, gamma, and Drell-Yan production in addition to muons mimicked by hadronic punchthrough. The number of unaccounted events corresponds to (12.8 +/- 3.2)% of the b (b) over bar production. We find that (23 +/- 6)% of the unaccounted events contain additional muon candidates. For comparison, this fraction is (6.9 +/- 0.4)% for events due to b (b) over bar production.
Chatrchyan S, Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Bergauer T, Dragicevic M, Ero J, Fabjan C, Friedl M, Fruhwirth R, Ghete VM, Hammer J, Hansel S, Hoch M, Hormann N, Hrubec J, Jeitler M, Kiesenhofer W, Krammer M, Liko D, Mikulec I, Pernicka M, Rahbaran B, Rohringer H, Schofbeck R, Strauss J, Taurok A, Teischinger F, Wagner P, Waltenberger W, Walzel G, Widl E, Wulz CE, Mossolov V, Shumeiko N, Gonzalez JS, Bansal S, Benucci L, De Wolf EA, Janssen X, Maes T, Mucibello L, Ochesanu S, Roland B, Rougny R, Selvaggi M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Blekman F, Blyweert S, D'Hondt J, Devroede O, Suarez RG, Kalogeropoulos A, Maes M, Van Doninck W, Van Mulders P, Van Onsem GP, Villella I, Charaf O, Clerbaux B, De Lentdecker G, Dero V, Gay APR, Hammad GH, Hreus T, Marage PE, Raval A, Thomas L, Vander Velde C, Vanlaer P, Adler V, Cimmino A, Costantini S, Grunewald M, Klein B, Lellouch J, Marinov A, Mccartin J, Ryckbosch D, Thyssen F, Tytgat M, Vanelderen L, Verwilligen P, Walsh S, Zaganidis N, Basegmez S, Bruno G, Caudron J, Ceard L, Gil EC, De Jeneret JDF, Delaere C, Favart D, Giammanco A, Gregoire G, Hollar J, Lemaitre V, Liao J, Militaru O, Nuttens C, Ovyn S, Pagano D, Pin A, Piotrzkowski K, Schul N, Beliy N, Caebergs T, Daubie E, Alves GA, Brito L, Damiao DD, Pol ME, Souza MHG, Alda WL, Carvalho W, Da Costa EM, Martins CD, De Souza SF, Mundim L, Nogima H, Oguri V, Da Silva WLP, Santoro A, Do Amaral SMS, Sznajder A, Bernardes CA, Dias FA, Tomei TRFP, Gregores EM, Lagana C, Marinho F, Mercadante PG, Novaes SF, Padula SS, Darmenov N, Genchev V, Iaydjiev P, Piperov S, Rodozov M, Stoykova S, Sultanov G, Tcholakov V, Trayanov R, Dimitrov A, Hadjiiska R, Karadzhinova A, Kozhuharov V, Litov L, Mateev M, Pavlov B, Petkov P, Bian JG, Chen GM, Chen HS, Jiang CH, Liang D, Liang S, Meng X, Tao J, Wang J, Wang J, Wang X, Wang Z, Xiao H, Xu M, Zang J, Zhang Z, Ban Y, Guo S, Guo Y, Li W, Mao Y, Qian SJ, Teng H, Zhu B, Zou W, Cabrera A, Moreno BG, Rios AAO, Oliveros AFO, Sanabria JC, Godinovic N, Lelas D, Lelas K, Plestina R, Polic D, Puljak I, Antunovic Z, Dzelalija M, Brigljevic V, Duric S, Kadija K, Morovic S, Attikis A, Galanti M, Mousa J, Nicolaou C, Ptochos F, Razis PA, Finger M, Finger M, Assran Y, Kamel AE, Khalil S, Mahmoud MA, Hektor A, Kadastik M, Muntel M, Raidal M, Rebane L, Tiko A, Azzolini V, Eerola P, Fedi G, Czellar S, Harkonen J, Heikkinen A, Karimaki V, Kinnunen R, Kortelainen MJ, Lampen T, Lassila-Perini K, Lehti S, Linden T, Luukka P, Maenpaa T, Tuominen E, Tuominiemi J, Tuovinen E, Ungaro D, Wendland L, Banzuzi K, Karjalainen A, Korpela A, Tuuva T, Sillou D, Besancon M, Choudhury S, Dejardin M, Denegri D, Fabbro B, Faure JL, Ferri F, Ganjour S, Gentit FX, Givernaud A, Gras P, De Monchenault GH, Jarry P, Locci E, Malcles J, Marionneau M, Millischer L, Rander J, Rosowsky A, Shreyber I, Titov M, Verrecchia P, BaffiOni S, Beaudette F, Benhabib L, Bianchini L, Bluj M, Broutin C, Busson P, Charlot C, Dahms T, Dobrzynski L, Elgammal S, de Cassagnac RG, Haguenauer M, Mine P, Mironov C, Ochando C, Paganini P, Sabes D, Salerno R, Sirois Y, Thiebaux C, Wyslouch B, Zabi A, Agram JL, Andrea J, Bloch D, Bodin D, Brom JM, Cardaci M, Chabert EC, Collard C, Conte E, Drouhin F, Ferro C, Fontaine JC, Gele D, Goerlach U, Greder S, Juillot P, Karim M, Le Bihan AC, Mikami Y, Van Hove P, Fassi F, Mercier D, Baty C, Beauceron S, Beaupere N, Bedjidian M, Bondu O, Boudoul G, Boumediene D, Brun H, Chasserat J, Chierici R, Contardo D, Depasse P, El Mamouni H, Fay J, Gascon S, Ille B, Kurca T, Le Grand T, Lethuillier M, Mirabito L, Perries S, Sordini V, Tosi S, Tschudi Y, Verdier P, Lomidze D, Anagnostou G, Beranek S, Edelhoff M, Feld L, Heracleous N, Hindrichs O, Jussen R, Klein K, Merz J, Mohr N, Ostapchuk A, Perieanu A, Raupach F, Sammet J, Schael S, Sprenger D, Weber H, Weber M, Wittmer B, Ata M, Dietz-Laursonn E, Erdmann M, Hebbeker T, Heidemann C, Hinzmann A, Hoepfner K, Klimkovich T, Klingebiel D, Kreuzer P, Lanske D, Lingemann J, Magass C, Merschmeyer M, Meyer A, Papacz P, Pieta H, Reithler H, Schmitz SA, Sonnenschein L, Steggemann J, Teyssier D, Bontenackels M, Davids M, Duda M, Flugge G, Geenen H, Giffels M, Ahmad WH, Heydhausen D, Hoehle F, Kargoll B, Kress T, Kuessel Y, Linn A, Nowack A, Perchalla L, Pooth O, Rennefeld J, Sauerland P, Stahl A, Thomas M, Tornier D, Zoeller MH, Martin MA, Behrenhoff W, Behrens U, Bergholz M, Bethani A, Borras K, Cakir A, Campbell A, Castro E, Dammann D, Eckerlin G, Eckstein D, Flossdorf A, Flucke G, Geiser A, Hauk J, Jung H, Kasemann M, Katkov I, Katsas P, Kleinwort C, Kluge H, Knutsson A, Kramer M, Krucker D, Kuznetsova E, Lange W, Lohmann W, Mankel R, Marienfeld M, Melzer-Pellmann IA, Meyer AB, Mnich J, Mussgiller A, Olzem J, Petrukhin A, Pitzl D, Raspereza A, Rosin M, Schmidt R, Schoerner-Sadenius T, Sen N, Spiridonov A, Stein M, Tomaszewska J, Walsh R, Wissing C, Autermann C, Blobel V, Bobrovskyi S, Draeger J, Enderle H, Gebbert U, Gorner M, Hermanns T, Kaschube K, Kaussen G, Kirschenmann H, Klanner R, Lange J, Mura B, Naumann-Emme S, Nowak F, Pietsch N, Sander C, Schettler H, Schleper P, Schlieckau E, Schroder M, Schum T, Stadie H, Steinbruck G, Thomsen J, Barth C, Bauer J, Berger J, Buege V, Chwalek T, De Boer W, Dierlamm A, Dirkes G, Feindt M, Gruschke J, Hackstein C, Hartmann F, Heinrich M, Held H, Hoffmann KH, Honc S, Komaragiri JR, Kuhr T, Martschei D, Mueller S, Muller T, Niegel M, Oberst O, Oehler A, Ott J, Er TPF, Quast G, Rabbertz K, Ratnikov F, Ratnikova N, Renz M, Saout C, Scheurer A, Schieferdecker P, Schilling FP, Schott G, Simonis HJ, Stober FM, Troendle D, Wagner-Kuhr J, Weiler T, Zeise M, Zhukov V, Ziebarth EB, Daskalakis G, Geralis T, Kesisoglou S, Kyriakis A, Loukas D, Manolakos I, Markou A, Markou C, Mavrommatis C, Ntomari E, Petrakou E, Gouskos L, Mertzimekis TJ, Panagiotou A, Saoulidou N, Stiliaris E, Evangelou I, Foudas C, Kokkas P, Manthos N, Papadopoulos I, Patras V, Triantis FA, Aranyi A, Bencze G, Boldizsar L, Hajdu C, Hidas P, Horvath D, Kapusi A, Krajczar K, Sikler F, Veres GI, Vesztergombi G, Beni N, Molnar J, Palinkas J, Szillasi Z, Veszpremi V, Raics P, Trocsanyi ZL, Ujvari B, Beri SB, Bhatnagar V, Dhingra N, Gupta R, Jindal M, Kaur M, Kohli JM, Mehta MZ, Nishu N, Saini LK, Sharma A, Singh AP, Singh J, Singh SP, Ahuja S, Choudhary BC, Gupta P, Jain S, Kumar A, Kumar A, Naimuddin M, Ranjan K, Shivpuri RK, Banerjee S, Bhattacharya S, Dutta S, Gomber B, Jain S, Khurana R, Sarkar S, Choudhury RK, Dutta D, Kailas S, Kumar V, Mehta P, Mohanty AK, Pant LM, Shukla P, Aziz T, Guchait M, Gurtu A, Maity M, Majumder D, Majumder G, Mazumdar K, Mohanty GB, Saha A, Sudhakar K, Wickramage N, Banerjee S, Dugad S, Mondal NK, Arfaei H, Bakhshiansohi H, Etesami SM, Fahim A, Hashemi M, Hesari H, Jafari A, Khakzad M, Mohammadi A, Najafabadi MM, Mehdiabadi SP, Safarzadeh B, Zeinali M, Abbrescia M, Barbone L, Calabria C, Colaleo A, Creanza D, De Filippis N, De Palma M, Fiore L, Iaselli G, Lusito L, Maggi G, Maggi M, Manna N, Marangelli B, My S, Nuzzo S, Pacifico N, Pierro GA, Pompili A, Pugliese G, Romano F, Roselli G, Selvaggi G, Silvestris L, Trentadue R, Tupputi S, Zito G, Abbiendi G, Benvenuti AC, Bonacorsi D, Braibant-Giacomelli S, Brigliadori L, Capiluppi P, Castro A, Cavallo FR, Cuffiani M, Dallavalle GM, Fabbri F, Fanfani A, Fasanella D, Giacomelli P, Giunta M, Grandi C, Marcellini S, Masetti G, Meneghelli M, Montanari A, Navarria FL, Odorici F, Perrotta A, Primavera F, Rossi AM, Rovelli T, Siroli G, Travaglini R, Albergo S, Cappello G, Chiorboli M, Costa S, Potenza R, Tricomi A, Tuve C, Barbagli G, Ciulli V, Civinini C, D'Alessandro R, Focardi E, Frosali S, Gallo E, Gonzi S, Lenzi P, Meschini M, Paoletti S, Sguazzoni G, Tropiano A, Benussi L, Bianco S, Colafranceschi S, Fabbri F, Piccolo D, Fabbricatore P, Musenich R, Benaglia A, De Guio F, Di Matteo L, Gennai S, Ghezzi A, Malvezzi S, Martelli A, Massironi A, Menasce D, Moroni L, Paganoni M, Pedrini D, Ragazzi S, Redaelli N, Sala 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Search for same-sign top-quark pair production at root s=7 TeV and limits on flavour changing neutral currents in the top sector
JOURNAL OF HIGH ENERGY PHYSICS 2011 AUG; ?(8):? Article 005
An inclusive search for same-sign top-quark pair production in pp collisions at root s = 7 TeV is performed using a data sample recorded with the CMS detector in 2010, corresponding to an integrated luminosity of 35 pb(-1). This analysis is motivated by recent studies of p (p) over bar -> t (t) over bar reporting mass-dependent forward-backward asymmetries larger than expected from the standard model. These asymmetries could be due to Flavor Changing Neutral Currents (FCNC) in the top sector induced by t -channel exchange of a massive neutral vector boson (Z'). Models with such a Z' also predict enhancement of same-sign top-pair production in pp or pp collisions. Limits are set as a function of the Z' mass and its couplings to u and t quarks. These limits disfavour the FCNC interpretation of the Tevatron results.
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Gunay-Unalan Z, Haber C, Hahn SR, Halkiadakis E, Hamaguchi A, Han JY, Happacher F, Hara K, Hare D, Hare M, Harr RF, Hatakeyama K, Hays C, Heck M, Heinrich J, Herndon M, Hewamanage S, Hidas D, Hocker A, Hopkins W, Horn D, Hou S, Hughes RE, Hurwitz M, Husemann U, Hussain N, Hussein M, Huston J, Introzzi G, Iori M, Ivanov A, James E, Jang D, Jayatilaka B, Jeon EJ, Jha MK, Jindariani S, Johnson W, Jones M, Joo KK, Jun SY, Junk TR, Kamon T, Karchin PE, Kasmi A, Kato Y, Ketchum W, Keung J, Khotilovich V, Kilminster B, Kim DH, Kim HS, Kim HW, Kim JE, Kim MJ, Kim SB, Kim SH, Kim YK, Kimura N, Kirby M, Klimenko S, Kondo K, Kong DJ, Konigsberg J, Kotwal AV, Kreps M, Kroll J, Krop D, Krumnack N, Kruse M, Krutelyov V, Kuhr T, Kurata M, Kwang S, Laasanen AT, Lami S, Lammel S, Lancaster M, Lander RL, Lannon K, Lath A, Latino G, LeCompte T, Lee E, Lee HS, Lee JS, Lee SW, Leo S, Leone S, Lewis JD, Limosani A, Lin CJ, Linacre J, Lindgren M, Lipeles E, Lister A, Litvintsev DO, Liu C, Liu Q, Liu T, 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Totaro P, Trovato M, Tu Y, Ukegawa F, Uozumi S, Varganov A, Vazquez F, Velev G, Vellidis C, Vidal M, Vila I, Vilar R, Vizan J, Vogel M, Volpi G, Wagner P, Wagner RL, Wakisaka T, Wallny R, Wang SM, Warburton A, Waters D, Weinberger M, Wester WC, Whitehouse B, Whiteson D, Wicklund AB, Wicklund E, Wilbur S, Wick F, Williams HH, Wilson JS, Wilson P, Winer BL, Wittich P, Wolbers S, Wolfe H, Wright T, Wu X, Wu Z, Yamamoto K, Yamaoka J, Yang T, Yang UK, Yang YC, Yao WM, Yeh GP, Yi K, Yoh J, Yorita K, Yoshida T, Yu GB, Yu I, Yu SS, Yun JC, Zanetti A, Zeng Y, Zucchelli S
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Observation of the Xi(0)(b) Baryon
PHYSICAL REVIEW LETTERS 2011 AUG 31; 107(10):? Article 102001
The observation of the bottom, strange baryon Xi(0)(b) through the decay chain Xi(0)(b) -> Xi(+)(c)pi(-), where Xi(+)(c) -> Xi(-) pi(+) pi(+), Xi(-) -> Lambda pi(-), and Lambda -> p pi(-), is reported by using data corresponding to an integrated luminosity of 4.2 fb(-1) from p (p) over bar collisions at root s = 1.96 TeV recorded with the Collider Detector at Fermilab. A signal of 25.3(-5.4)(+5.6) candidates is observed whose probability of arising from a background fluctuation is 3.6 x 10(-12), corresponding to 6.8 Gaussian standard deviations. The Xi(0)(b) mass is measured to be 5787.8 +/- 5.0(stat) +/- 1.3(syst) MeV/c(2). In addition, the Xi(-)(b) baryon is observed through the process Xi(-)(b) -> Xi(0)(c)pi(-), where Xi(0)(c) -> Xi(-) pi(+), Xi(-) -> Lambda pi(-), and Lambda -> p pi(-).
Lopez CB, Hermesh T
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Systemic responses during local viral infections: type I IFNs sound the alarm
CURRENT OPINION IN IMMUNOLOGY 2011 AUG; 23(4):495-499
Type I IFNs are well known for their role in controlling virus replication and spread. Type I IFNs produced by the infected tissue also signal beyond the boundaries of the infection to regulate different elements of the anti-viral immune response. Recent reports show that type I IFNs directly condition naive monocytes residing in the distal bone marrow (BM) and induce the expression of effector molecules in memory T cells, before their recruitment to the infected site. In addition, hematopoietic stem cells (HSCs) were shown to enter the cell cycle in response to systemically distributed type I IFNs. These discoveries expand our understanding of the pleiotropic effects of type I IFNs during infection and highlight the critical role of systemic signals in the development of an effective response to a localized viral infection.
Liao CF, Wang SF, Lin YT, Ho DD, Chen YMA
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Identification of the DC-SIGN-Interactive Domains on the Envelope Glycoprotein of HIV-1 CRF07_BC
AIDS RESEARCH AND HUMAN RETROVIRUSES 2011 AUG; 27(8):831-839
DC-SIGN, a C-type lection expressed on dendritic cells, enhances HIV-1 infection in cis and in trans. HIV-1 circulating recombinant form (CRF) 07_BC viruses have been the predominant strain found among injection drug users in southern China and Taiwan. The goal of this study was to map the DC-SIGN-interactive domain on the gp120 of CRF07_BC. Pseudotyped viruses containing single (N233Q, N275Q, N330Q, N351Q, N355Q, N381Q, and N387Q), double (N233Q + N275Q, N233Q + N351Q, N275Q + N351Q), or triple (N233Q + N275Q + N351Q) N-glycan mutant gp120 were generated. Capture assays showed that the DC-SIGN-binding capacity of pseudoviruses with N275Q or N351Q decreased significantly. Rabbit antisera against synthetic peptides covering the N275 (R72 antiserum) or N351 (R77 antiserum) region blocked the interaction between wild-type gp120 and DC-SIGN in the capture assay. Furthermore, pseudotype viruses containing gp120 from five different CRF07_BC isolates were generated and R72 and R77 antisera blocked their interactions with DC-SIGN (80% for R72 and 40% for R77, respectively) in the capture assays. In conclusion, the N275 and N351 glycan sites on the CRF07_BC gp120 play an important role in mediating the interaction between gp120 and DC-SIGN. This information is valuable for developing both therapeutic and preventive agents for HIV-1 infection.
Nguyen DP, Elliott T, Holt M, Muir TW, Chin JW
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Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011 AUG 3; 133(30):11418-11421
We report evolved orthogonal pyrrolysyl-tRNA synthetase/tRNA(CUA) pairs that direct the efficient, site-specific incorporation of N(epsilon)-L-thiaprolyl-L-lysine, N(epsilon)-D-cysteinyl-L-lysine, and N(epsilon)-L-cysteinyl-L-lysine into recombinant proteins in Escherichia coli. We demonstrate that the unique 1,2-aminothiol introduced by our approach can be efficiently, rapidly, and specifically labeled via a cyanobenzothiazole condensation to quantitatively introduce biophysical probes into proteins. Moreover, we show that, in combination with cysteine labeling, this approach allows the dual labeling of proteins with distinct probes at two distinct, genetically defined sites.