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Found 37769 matches. Displaying 8811-8820
Oikonomou G, Perens EA, Lu Y, Watanabe S, Jorgensen EM, Shaham S
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Opposing Activities of LIT-1/NLK and DAF-6/Patched-Related Direct Sensory Compartment Morphogenesis in C. elegans
PLOS BIOLOGY 2011 AUG; 9(8):? Article e1001121
Glial cells surround neuronal endings to create enclosed compartments required for neuronal function. This architecture is seen at excitatory synapses and at sensory neuron receptive endings. Despite the prevalence and importance of these compartments, how they form is not known. We used the main sensory organ of C. elegans, the amphid, to investigate this issue. daf-6/Patched-related is a glia-expressed gene previously implicated in amphid sensory compartment morphogenesis. By comparing time series of electron-microscopy (EM) reconstructions of wild-type and daf-6 mutant embryos, we show that daf-6 acts to restrict compartment size. From a genetic screen, we found that mutations in the gene lit-1/Nemo-like kinase (NLK) suppress daf-6. EM and genetic studies demonstrate that lit-1 acts within glia, in counterbalance to daf-6, to promote sensory compartment expansion. Although LIT-1 has been shown to regulate Wnt signaling, our genetic studies demonstrate a novel, Wnt-independent role for LIT-1 in sensory compartment size control. The LIT-1 activator MOM-4/TAK1 is also important for compartment morphogenesis and both proteins line the glial sensory compartment. LIT-1 compartment localization is important for its function and requires neuronal signals. Furthermore, the conserved LIT-1 C-terminus is necessary and sufficient for this localization. Two-hybrid and co-immunoprecipitation studies demonstrate that the LIT-1 C-terminus binds both actin and the Wiskott-Aldrich syndrome protein (WASP), an actin regulator. We use fluorescence light microscopy and fluorescence EM methodology to show that actin is highly enriched around the amphid sensory compartment. Finally, our genetic studies demonstrate that WASP is important for compartment expansion and functions in the same pathway as LIT-1. The studies presented here uncover a novel, Wnt-independent role for the conserved Nemo-like kinase LIT-1 in controlling cell morphogenesis in conjunction with the actin cytoskeleton. Our results suggest that the opposing daf-6 and lit-1 glial pathways act together to control sensory compartment size.
Wacker SA, Kashyap S, Li X, Kapoor TM
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Examining the Mechanism of Action of a Kinesin Inhibitor Using Stable Isotope Labeled Inhibitors for Cross-Linking (SILIC)
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2011 AUG 17; 133(32):12386-12389
It is difficult to determine a chemical inhibitor's binding site in multiprotein mixtures, particularly when high-resolution structural studies are not straightforward. Building upon previous research involving photo-cross-linking and the use of mixtures of stable isotopes, we report a method, Stable Isotope Labeled Inhibitors for Cross-linking (SILIC), for mapping a small molecule inhibitor's binding site in its target protein. In SILIC, structure-activity relationship data is used to design inhibitor analogues that incorporate a photo-cross-linking group along with either natural or 'heavy' stable isotopes. An equimolar mixture of these inhibitor analogues is cross-linked to the target protein to yield a robust signature for identifying inhibitor-modified peptide fragments in complex mass spectrometry data. As a proof of concept, we applied this approach to an ATP-competitive inhibitor of kinesin-5, a widely conserved motor protein required for cell division and an anticancer drug target. This analysis, along with mutagenesis studies, suggests that the inhibitor binds at an allosteric site in the motor protein.
Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang CY, Wang LG, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE
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A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms
SCIENCE TRANSLATIONAL MEDICINE 2011 AUG 31; 3(98):? Article 98ra83
A long-sought, and thus far elusive, goal has been to develop drugs to manage diseases of excitability. One such disease that affects millions each year is cardiac arrhythmia, which occurs when electrical impulses in the heart become disordered, sometimes causing sudden death. Pharmacological management of cardiac arrhythmia has failed because it is not possible to predict how drugs that target cardiac ion channels, and have intrinsically complex dynamic interactions with ion channels, will alter the emergent electrical behavior generated in the heart. Here, we applied a computational model, which was informed and validated by experimental data, that defined key measurable parameters necessary to simulate the interaction kinetics of the anti-arrhythmic drugs flecainide and lidocaine with cardiac sodium channels. We then used the model to predict the effects of these drugs on normal human ventricular cellular and tissue electrical activity in the setting of a common arrhythmia trigger, spontaneous ventricular ectopy. The model forecasts the clinically relevant concentrations at which flecainide and lidocaine exacerbate, rather than ameliorate, arrhythmia. Experiments in rabbit hearts and simulations in human ventricles based on magnetic resonance images validated the model predictions. This computational framework initiates the first steps toward development of a virtual drug-screening system that models drug-channel interactions and predicts the effects of drugs on emergent electrical activity in the heart.
Chatrchyan S, Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Bergauer T, Dragicevic M, Ero J, Fabjan C, Friedl M, Fruhwirth R, Ghete VM, Hammer J, Hansel S, Hoch M, Hormann N, Hrubec J, Jeitler M, Kiesenhofer W, Krammer M, Liko D, Mikulec I, Pernicka M, Rahbaran B, Rohringer H, Schofbeck R, Strauss J, Taurok A, Teischinger F, Wagner P, Waltenberger W, Walzel G, Widl E, Wulz CE, Mossolov V, Shumeiko N, Gonzalez JS, Bansal S, Benucci L, De Wolf EA, Janssen X, Maes T, Mucibello L, Ochesanu S, Roland B, Rougny R, Selvaggi M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Blekman F, Blyweert S, D'Hondt J, Devroede O, Suarez RG, Kalogeropoulos A, Maes M, Van Doninck W, Van Mulders P, Van Onsem GP, Villella I, Charaf O, Clerbaux B, De Lentdecker G, Dero V, Gay APR, Hammad GH, Hreus T, Marage PE, Raval A, Thomas L, Vander Velde C, Vanlaer P, Adler V, Cimmino A, Costantini S, Grunewald M, Klein B, Lellouch J, Marinov A, Mccartin J, Ryckbosch D, Thyssen F, Tytgat M, Vanelderen L, Verwilligen P, Walsh S, Zaganidis N, Basegmez S, Bruno G, Caudron J, Ceard L, Gil EC, De Jeneret JD, Delaere C, Favart D, Giammanco A, Gregoire G, Hollar J, Lemaitre V, Liao J, Militaru O, Nuttens C, Ovyn S, Pagano D, Pin A, Piotrzkowski K, Schul N, Beliy N, Caebergs T, Daubie E, Alves GA, Brito L, Damiao DD, Pol ME, Souza MHG, Alda WL, Carvalho W, Da Costa EM, Martins CD, De Souza SF, Mundim L, Nogima H, Oguri V, Da Silva WLP, Santoro A, Do Amaral SMS, Sznajder A, Bernardes CA, Dias FA, Costa TD, Tomei TRFP, Gregores EM, Lagana C, Marinho F, Mercadante PG, Novaes SF, Padula SS, Darmenov N, Genchev V, Iaydjiev P, Piperov S, Rodozov M, Stoykova S, Sultanov G, Tcholakov V, Trayanov R, Dimitrov A, Hadjiiska R, Karadzhinova A, Kozhuharov V, Litov L, Mateev M, Pavlov B, Petkov P, Bian JG, Chen GM, Chen HS, Jiang CH, Liang D, Liang S, Meng X, Tao J, Wang J, Wang J, Wang X, Wang Z, Xiao H, Xu M, Zang J, Zhang Z, Ban Y, Guo S, Guo Y, Li W, Mao Y, Qian SJ, Teng H, Zhu B, Zou W, Cabrera A, Moreno BG, Rios AAO, Oliveros AFO, Sanabria JC, Godinovic N, Lelas D, Lelas K, Plestina R, Polic D, Puljak I, Antunovic Z, Dzelalija M, Brigljevic V, Duric S, Kadija K, Morovic S, Attikis A, Galanti M, Mousa J, Nicolaou C, Ptochos F, Razis PA, Finger M, Finger M, Assran Y, Kamel AE, Khalil S, Mahmoud MA, Hektor A, Kadastik M, Muntel M, Raidal M, Rebane L, Tiko A, Azzolini V, Eerola P, Fedi G, Czellar S, Harkonen J, Heikkinen A, Karimaki V, Kinnunen R, Kortelainen MJ, Lampen T, Lassila-Perini K, Lehti S, Linden T, Luukka P, Maenpaa T, Tuominen E, Tuominiemi J, Tuovinen E, Ungaro D, Wendland L, Banzuzi K, Karjalainen A, Korpela A, Tuuva T, Sillou D, Besancon M, Choudhury S, Dejardin M, Denegri D, Fabbro B, Faure JL, Ferri F, Ganjour S, Gentit FX, Givernaud A, Gras P, de Monchenault GH, Jarry P, Locci E, Malcles J, Marionneau M, Millischer L, Rander J, Rosowsky A, Shreyber I, Titov M, Verrecchia P, Baffioni S, Beaudette F, Benhabib L, Bianchini L, Bluj M, Broutin C, Busson P, Charlot C, Dahms T, Dobrzynski L, Elgammal S, de Cassagnac RG, Haguenauer M, Mine P, Mironov C, Ochando C, Paganini P, Sabes D, Salerno R, Sirois Y, Thiebaux C, Wyslouch B, Zabi A, Agram JL, Andrea J, Bloch D, Bodin D, Brom JM, Cardaci M, Chabert EC, Collard C, Conte E, Drouhin F, Ferro C, Fontaine JC, Gele D, Goerlach U, Greder S, Juillot P, Karim M, Le Bihan AC, Mikami Y, Van Hove P, Fassi F, Mercier D, Baty C, Beauceron S, Beaupere N, Bedjidian M, Bondu O, Boudoul G, Boumediene D, Brun H, Chasserat J, Chierici R, Contardo D, Depasse P, El Mamouni H, Fay J, Gascon S, Ille B, Kurca T, Le Grand T, Lethuillier M, Mirabito L, Perries S, Sordini V, Tosi S, Tschudi Y, Verdier P, Lomidze D, Anagnostou G, Beranek S, Edelhoff M, Feld L, Heracleous N, Hindrichs O, Jussen R, Klein K, Merz J, Mohr N, Ostapchuk A, Perieanu A, Raupach F, Sammet J, Schael S, Sprenger D, Weber H, Weber M, Wittmer B, Ata M, Dietz-Laursonn E, Erdmann M, Hebbeker T, Heidemann C, Hinzmann A, Hoepfner K, Klimkovich T, Klingebiel D, Kreuzer P, Lanske D, Lingemann J, Magass C, Merschmeyer M, Meyer A, Papacz P, Pieta H, Reithler H, Schmitz SA, Sonnenschein L, Steggemann J, Teyssier D, Bontenackels M, Davids M, Duda M, Flugge G, Geenen H, Giffels M, Ahmad WH, Heydhausen D, Hoehle F, Kargoll B, Kress T, Kuessel Y, Linn A, Nowack A, Perchalla L, Pooth O, Rennefeld J, Sauerland P, Stahl A, Tornier D, Zoeller MH, Martin MA, Behrenhoff W, Behrens U, Bergholz M, Bethani A, Borras K, Cakir A, Campbell A, Castro E, Dammann D, Eckerlin G, Eckstein D, Flossdorf A, Flucke G, Geiser A, Hauk J, Jung H, Kasemann M, Katkov I, Katsas P, Kleinwort C, Kluge H, Knutsson A, Kramer M, Krucker D, Kuznetsova E, Lange W, Lohmann W, Mankel R, Marienfeld M, Melzer-Pellmann IA, Meyer AB, Mnich J, Mussgiller A, Olzem J, Petrukhin A, Pitzl D, Raspereza A, Rosin M, Schmidt R, Schoerner-Sadenius T, Sen N, Spiridonov A, Stein M, Tomaszewska J, Walsh R, Wissing C, Autermann C, Blobel V, Bobrovskyi S, Draeger J, Enderle H, Gebbert U, Gorner M, Hermanns T, Kaschube K, Kaussen G, Kirschenmann H, Klanner R, Lange J, Mura B, Naumann-Emme S, Nowak F, Pietsch N, Sander C, Schettler H, Schleper P, Schlieckau E, Schroder M, Schum T, Stadie H, Steinbruck G, Thomsen J, Barth C, Bauer J, Berger J, Buege V, Chwalek T, De Boer W, Dierlamm A, Dirkes G, Feindt M, Gruschke J, Hackstein C, Hartmann F, Heinrich M, Held H, Hoffmann KH, Honc S, Komaragiri JR, Kuhr T, Martschei D, Mueller S, Muller T, Niegel M, Oberst O, Oehler A, Ott J, Peiffer T, Quast G, Rabbertz K, Ratnikov F, Ratnikova N, Renz M, Saout C, Scheurer A, Schieferdecker P, Schilling FP, Schott G, Simonis HJ, Stober FM, Troendle D, Wagner-Kuhr J, Weiler T, Zeise M, Zhukov V, Ziebarth EB, Daskalakis G, Geralis T, Kesisoglou S, Kyriakis A, Loukas D, Manolakos I, Markou A, Markou C, Mavrommatis C, Ntomari E, Petrakou E, Gouskos L, Mertzimekis TJ, Panagiotou A, Saoulidou N, Stiliaris E, Evangelou I, Foudas C, Kokkas P, Manthos N, Papadopoulos I, Patras V, Triantis FA, Aranyi A, Bencze G, Boldizsar L, Hajdu C, Hidas P, Horvath D, Kapusi A, Krajczar K, Sikler F, Veres GI, Vesztergombi G, Beni N, Molnar J, Palinkas J, Szillasi Z, Veszpremi V, Raics P, Trocsanyi ZL, Ujvari B, Beri SB, Bhatnagar V, Dhingra N, Gupta R, Jindal M, Kaur M, Kohli JM, Mehta MZ, Nishu N, Saini LK, Sharma A, Singh AP, Singh J, Singh SP, Ahuja S, Choudhary BC, Gupta P, Jain S, Kumar A, Naimuddin M, Ranjan K, Shivpuri RK, Banerjee S, Bhattacharya S, Dutta S, Gomber B, Jain S, Khurana R, Sarkar S, Choudhury RK, Dutta D, Kailas S, Kumar V, Mehta P, Mohanty AK, Pant LM, Shukla P, Aziz T, Guchait M, Gurtu A, Maity M, Majumder D, Majumder G, Mazumdar K, Mohanty GB, Saha A, Sudhakar K, Wickramage N, Banerjee S, Dugad S, Mondal NK, Arfaei H, Bakhshiansohi H, Etesami M, Fahim A, Hashemi M, Hesari H, Jafari A, Khakzad M, Mohammadi A, Najafabadi MM, Mehdiabadi SP, Safarzadeh B, Zeinali M, Abbrescia M, Barbone L, Calabria C, Colaleo A, Creanza D, De Filippis N, De Palma M, Fiore L, Iaselli G, Lusito L, Maggi G, Maggi M, Manna N, Marangelli B, My S, Nuzzo S, Pacifico N, Pierro GA, Pompili A, Pugliese G, Romano F, Roselli G, Selvaggi G, Silvestris L, Trentadue R, Tupputi S, Zito G, Abbiendi G, Benvenuti AC, Bonacorsi D, Braibant-Giacomelli S, Brigliadori L, Capiluppi P, Castro A, Cavallo FR, Cuffiani M, Dallavalle GM, Fabbri F, Fanfani A, Fasanella D, Giacomelli P, Giunta M, Grandi C, Marcellini S, Masetti G, Meneghelli M, Montanari A, Navarria FL, Odorici F, Perrotta A, Primavera F, Rossi AM, Rovelli T, Siroli G, Travaglini R, Albergo S, Cappello G, Chiorboli M, Costa S, Potenza R, Tricomi A, Tuve C, Barbagli G, Ciulli V, Civinini C, D'Alessandro R, Focardi E, Frosali S, Gallo E, Gonzi S, Lenzi P, Meschini M, Paoletti S, Sguazzoni G, Tropiano A, Benussi L, Bianco S, Colafranceschi S, Fabbri F, Piccolo D, Fabbricatore P, Musenich R, Benaglia A, De Guio F, Di Matteo L, Gennai S, Ghezzi A, Malvezzi S, Martelli A, Massironi A, Menasce D, Moroni L, Paganoni M, Pedrini D, Ragazzi S, Redaelli N, Sala S, de Fatis TT, Buontempo S, Montoya CAC, Cavallo N, De Cosa A, Fabozzi F, Iorio AOM, Lista L, Merola M, Paolucci P, Azzi P, Bacchetta N, Bellan P, Bisello D, Branca A, Carlin R, Checchia P, Dorigo T, Dosselli U, Fanzago F, Gasparini F, Gasparini U, Gozzelino A, Lacaprara S, Lazzizzera I, Margoni M, Mazzucato M, Meneguzzo AT, Nespolo M, Perrozzi L, Pozzobon N, Ronchese P, Simonetto F, Torassa E, Tosi M, Vanini S, Zotto P, Zumerle G, Baesso P, Berzano U, Ratti SP, Riccardi C, Torre P, Vitulo P, Viviani C, Biasini M, Bilei GM, Caponeri B, Fano L, Lariccia P, Lucaroni A, Mantovani G, Menichelli M, Nappi A, Romeo F, Santocchia A, Taroni S, Valdata M, Azzurri P, Bagliesi G, Bernardini J, Boccali T, Broccolo G, Castaldi R, D'Agnolo RT, Dell'Orso R, Fiori F, Foa L, Giassi A, Kraan A, Ligabue F, Lomtadze T, Martini L, Messineo A, Palla F, Palmonari F, Segneri G, Serban AT, Spagnolo P, Tenchini R, Tonelli G, Venturi A, Verdini PG, Barone L, Cavallari F, Del Re D, Di Marco E, Diemoz M, Franci D, Grassi M, Longo E, Meridiani P, Nourbakhsh S, Organtini G, Pandolfi F, Paramatti R, Rahatlou S, Rovelli C, Amapane N, Arcidiacono R, Argiro S, Arneodo M, Biino C, Botta C, Cartiglia N, Castello R, Costa M, Demaria N, Graziano A, Mariotti C, Marone M, Maselli S, Migliore E, Mila G, Monaco V, Musich M, Obertino MM, Pastrone N, Pelliccioni M, Potenza A, Romero A, Ruspa M, Sacchi R, Sola V, Solano A, Staiano A, Pereira AV, Belforte S, Cossutti F, Della Ricca G, Gobbo B, Montanino D, Penzo A, Heo SG, Nam SK, Chang S, Chung J, Kim DH, Kim GN, Kim JE, Kong DJ, Park H, Ro SR, Son DC, Son T, Kim Z, Kim JY, Song S, Choi S, Hong B, Jo M, Kim H, Kim JH, Kim TJ, Lee KS, Moon DH, Park SK, Sim KS, Choi M, Kang S, Kim H, Park C, Park IC, Park S, Ryu G, Choi Y, Choi YK, Goh J, Kim MS, Lee B, Lee J, Lee S, Seo H, Yu I, Bilinskas MJ, Grigelionis I, Janulis M, Martisiute D, Petrov P, Polujanskas M, Sabonis T, Castilla-Valdez H, De La Cruz-Burelo E, Heredia-De La Cruz I, Lopez-Fernandez R, Villalba RM, Sanchez-Hernandez A, Villasenor-Cendejas LM, Carrillo Moreno S, Valencia FV, Ibarguen HAS, Linares EC, Pineda AM, Reyes-Santos MA, Krofcheck D, Tam J, Butler PH, Doesburg R, Silverwood H, Ahmad M, Ahmed I, Asghar MI, Hoorani HR, Doroba K, Kalinowski A, Konecki M, Krolikowski J, Frueboes T, Gokieli R, Gorski M, Kazana M, Nawrocki K, Romanowska-Rybinska K, Szleper M, Wrochna G, Zalewski P, Almeida N, Bargassa P, David A, Faccioli P, Parracho PGF, Gallinaro M, Musella P, Nayak A, Pela J, Ribeiro PQ, Seixas J, Varela J, Afanasiev S, Bunin P, Golutvin I, Karjavin V, Konoplyanikov V, Kozlov G, Lanev A, Moisenz P, Palichik V, Perelygin V, Savina M, Shmatov S, Smirnov V, Volodko A, Zarubin A, Golovtsov V, Ivanov Y, Kim V, Levchenko P, Murzin V, Oreshkin V, Smirnov I, Sulimov V, Uvarov L, Vavilov S, Vorobyev A, Vorobyev A, Andreev Y, Dermenev A, Gninenko S, Golubev N, Kirsanov M, Krasnikov N, Matveev V, Pashenkov A, Toropin A, Troitsky S, Epshteyn V, Gavrilov V, Kaftanov V, Kossov M, Krokhotin A, Lychkovskaya N, Popov V, Safronov G, Semenov S, Stolin V, Vlasov E, Zhokin A, Belyaev A, Boos E, Dubinin M, Dudko L, Ershov A, Gribushin A, Kodolova O, Lokhtin I, Markina A, Obraztsov S, Perfilov M, Petrushanko S, Sarycheva L, Savrin V, Snigirev A, Andreev V, Azarkin M, Dremin I, Kirakosyan M, Leonidov A, Rusakov SV, Vinogradov A, Azhgirey I, Bayshev I, Bitioukov S, Grishin V, Kachanov V, Konstantinov D, Korablev A, Krychkine V, Petrov V, Ryutin R, Sobol A, Tourtchanovitch L, Troshin S, Tyurin N, Uzunian A, Volkov A, Adzic P, Djordjevic M, Krpic D, Milosevic J, Aguilar-Benitez M, Maestre JA, Arce P, Battilana C, Calvo E, Cepeda M, Cerrada M, Llatas MC, Colino N, De La Cruz B, Peris AD, Pardos CD, Vazquez DD, Bedoya CF, Ramos JPF, Ferrando A, Flix J, Fouz MC, Garcia-Abia P, Lopez OG, Lopez SG, Hernandez JM, Josa MI, Merino G, Pelayo JP, Redondo I, Romero L, Santaolalla J, Soares MS, Willmott C, Albajar C, Codispoti G, de Troconiz JF, Cuevas J, Menendez JF, Folgueras S, Caballero IG, Iglesias LL, Garcia JMV, Cifuentes JAB, Cabrillo IJ, Calderon A, Chuang SH, Campderros JD, Felcini M, Fernandez M, Gomez G, Sanchez JG, Jorda C, Pardo PL, Virto AL, Marco J, Marco R, Rivero CM, Matorras F, Sanchez FJM, Gomez JP, Rodrigo T, Rodriguez-Marrero AY, Ruiz-Jimeno A, Scodellaro L, Sanudo MS, Vila I, Cortabitarte RV, Abbaneo D, Auffray E, Auzinger G, Baillon P, Ball AH, Barney D, Bell AJ, Benedetti D, Bernet C, Bialas W, Bloch P, Bocci A, Bolognesi S, Bona M, Breuker H, Bunkowski K, Camporesi T, Cerminara G, Christiansen T, Perez JAC, Cure B, D'Enterria D, De Roeck A, Di Guida S, Dupont-Sagorin N, Elliott-Peisert A, Frisch B, Funk W, Gaddi A, Georgiou G, Gerwig H, Gigi D, Gill K, Giordano D, Glege F, Garrido RGR, Gouzevitch M, Govoni P, Gowdy S, Guiducci L, Hansen M, Hartl C, Harvey J, Hegeman J, Hegner B, Hoffmann HF, Honma A, Innocente V, Janot P, Kaadze K, Karavakis E, Lecoq P, Lourenco C, Maki T, Malberti M, Malgeri L, Mannelli M, Masetti L, Maurisset A, Meijers F, Mersi S, Meschi E, Moser R, Mozer MU, Mulders M, Nesvold E, Nguyen M, Orimoto T, Orsini L, Cortezon EP, Perez E, Petrilli A, Pfeiffer A, Pierini M, Pimia M, Piparo D, Polese G, Racz A, Reece W, Antunes JR, Rolandi G, Rommerskirchen T, Rovere M, Sakulin H, Schafer C, Schwick C, Segoni I, Sharma A, Siegrist P, Silva P, Simon M, Sphicas P, Spiropulu M, Stoye M, Tropea P, Tsirou A, Vichoudis P, Voutilainen M, Zeuner WD, Bertl W, Deiters K, Erdmann W, Gabathuler K, Horisberger R, Ingram Q, Kaestli HC, Konig S, Kotlinski D, Langenegger U, Meier F, Renker D, Rohe T, Sibille J, Starodumov A, Bani L, Bortignon P, Caminada L, Casal B, Chanon N, Chen Z, Cittolin S, Dissertori G, Dittmar M, Eugster J, Freudenreich K, Grab C, Hintz W, Lecomte P, Lustermann W, Marchica C, del Arbol PMR, Milenovic P, Moortgat F, Nageli C, Nef P, Nessi-Tedaldi F, Pape L, Pauss F, Punz T, Rizzi A, Ronga FJ, Rossini M, Sala L, Sanchez AK, Sawley MC, Stieger B, Tauscher L, Thea A, Theofilatos K, Treille D, Urscheler C, Wallny R, Weber M, Wehrli L, Weng J, Aguilo E, Amsler C, Chiochia V, De Visscher S, Favaro C, Rikova MI, Mejias BM, Otiougova P, Robmann P, Schmidt A, Snoek H, Chang YH, Chen KH, Kuo CM, Li SW, Lin W, Liu ZK, Lu YJ, Mekterovic D, Volpe R, Wu JH, Yu SS, Bartalini P, Chang P, Chang YH, Chang YW, Chao Y, Chen KF, Hou WS, Hsiung Y, Kao KY, Lei YJ, Lu RS, Shiu JG, Tzeng YM, Wan X, Wang M, Adiguzel A, Bakirci MN, Cerci S, Dozen C, Dumanoglu I, Eskut E, Girgis S, Gokbulut G, Hos I, Kangal EE, Topaksu AK, Onengut G, Ozdemir K, Ozturk S, Polatoz A, Sogut K, Cerci DS, Tali B, Topakli H, Uzun D, Vergili LN, Vergili M, Akin IV, Aliev T, Bilin B, Bilmis S, Deniz M, Gamsizkan H, Guler AM, Ocalan K, Ozpineci A, Serin M, Sever R, Surat UE, Yalvac M, Yildirim E, Zeyrek M, Deliomeroglu M, Demir D, Gulmez E, Isildak B, Kaya M, Kaya O, Ozbek M, Ozkorucuklu S, Sonmez N, Levchuk L, Bostock F, Brooke JJ, Cheng TL, Clement E, Cussans D, Frazier R, Goldstein J, Grimes M, Hartley D, Heath GP, Heath HF, Kreczko L, Metson S, Newbold DM, Nirunpong K, Poll A, Senkin S, Smith VJ, Basso L, Bell KW, Belyaev A, Brew C, Brown RM, Camanzi B, Cockerill DJA, Coughlan JA, Harder K, Harper S, Jackson J, Kennedy BW, Olaiya E, Petyt D, Radburn-Smith BC, Shepherd-Themistocleous CH, Tomalin IR, Womersley WJ, Worm SD, Bainbridge R, Ball G, Ballin J, Beuselinck R, Buchmuller O, Colling D, Cripps N, Cutajar M, Davies G, Della Negra M, Ferguson W, Fulcher J, Futyan D, Gilbert A, Bryer AG, Hall G, Hatherell Z, Hays J, Iles G, Jarvis M, Karapostoli G, Lyons L, MacEvoy BC, Magnan AM, Marrouche J, Mathias B, Nandi R, Nash J, Nikitenko A, Papageorgiou A, Pesaresi M, Petridis K, Pioppi M, Raymond DM, Rogerson S, Rompotis N, Rose A, Ryan MJ, Seez C, Sharp P, Sparrow A, Tapper A, Tourneur S, Acosta MV, Virdee T, Wakefield S, Wardle N, Wardrope D, Whyntie T, Barrett M, Chadwick M, Cole JE, Hobson PR, Khan A, Kyberd P, Leslie D, Martin W, Reid ID, Teodorescu L, Hatakeyama K, Liu H, Henderson C, Bose T, Jarrin EC, Fantasia C, Heister A, St John J, Lawson P, Lazic D, Rohlf J, Sperka D, Sulak L, Avetisyan A, Bhattacharya S, Chou JP, Cutts D, Ferapontov A, Heintz U, Jabeen S, Kukartsev G, Landsberg G, Luk M, Narain M, Nguyen D, Segala M, Sinthuprasith T, Speer T, Tsang KV, Breedon R, Breto G, Sanchez MCD, Chauhan S, Chertok M, Conway J, Cox PT, Dolen J, Erbacher R, Friis E, Ko W, Kopecky A, Lander R, Liu H, Maruyama S, Miceli T, Nikolic M, Pellett D, Robles J, Rutherford B, Salur S, Schwarz T, Searle M, Smith J, Squires M, Tripathi M, Sierra RV, Veelken C, Andreev V, Arisaka K, Cline D, Cousins R, Deisher A, Duris J, Erhan S, Farrell C, Hauser J, Ignatenko M, Jarvis C, Plager C, Rakness G, Schlein P, Tucker J, Valuev V, Babb J, Chandra A, Clare R, Ellison J, Gary JW, Giordano F, Hanson G, Jeng GY, Kao SC, Liu F, Liu H, Long OR, Luthra A, Nguyen H, Paramesvaran S, Shen BC, Stringer R, Sturdy J, Sumowidagdo S, Wilken R, Wimpenny S, Andrews W, Branson JG, Cerati GB, Evans D, Golf F, Holzner A, Kelley R, Lebourgeois M, Letts J, Mangano B, Padhi S, Palmer C, Petrucciani G, Pi H, Pieri M, Ranieri R, Sani M, Sharma V, Simon S, Sudano E, Tadel M, Tu Y, Vartak A, Wasserbaech S, Wurthwein F, Yagil A, Yoo J, Barge D, Bellan R, Campagnari C, D'Alfonso M, Danielson T, Flowers K, Geffert P, Incandela J, Justus C, Kalavase P, Koay SA, Kovalskyi D, Krutelyov V, Lowette S, Mccoll N, Pavlunin V, Rebassoo F, Ribnik J, Richman J, Rossin R, Stuart D, To W, Vlimant JR, Apresyan A, Bornheim A, Bunn J, Chen Y, Gataullin M, Ma Y, Mott A, Newman HB, Rogan C, Shin K, Timciuc V, Traczyk P, Veverka J, Wilkinson R, Yang Y, Zhu RY, Akgun B, Carroll R, Ferguson T, Iiyama Y, Jang DW, Jun SY, Liu YF, Paulini M, Russ J, Vogel H, Vorobiev I, Cumalat JP, Dinardo ME, Drell BR, Edelmaier CJ, Ford WT, Gaz A, Heyburn B, Lopez EL, Nauenberg U, Smith JG, Stenson K, Ulmer KA, Wagner SR, Zang SL, Agostino L, Alexander J, Chatterjee A, Eggert N, Gibbons LK, Heltsley B, Henriksson K, Hopkins W, Khukhunaishvili A, Kreis B, Liu Y, Kaufman GN, Patterson JR, Puigh D, Ryd A, Saelim M, Salvati E, Shi X, Sun W, Teo WD, Thom J, Thompson J, Vaughan J, Weng Y, Winstrom L, Wittich P, Biselli A, Cirino G, Winn D, Abdullin S, Albrow M, Anderson J, Apollinari G, Atac M, Bakken JA, Bauerdick LAT, Beretvas A, Berryhill J, Bhat PC, Bloch I, Borcherding F, Burkett K, Butler JN, Chetluru V, Cheung HWK, Chlebana F, Cihangir S, Cooper W, Eartly DP, Elvira VD, Esen S, Fisk I, Freeman J, Gao Y, Gottschalk E, Green D, Gunthoti K, Gutsche O, Hanlon J, Harris RM, Hirschauer J, Hooberman B, Jensen H, Johnson M, Joshi U, Khatiwada R, Klima B, Kousouris K, Kunori S, Kwan S, Leonidopoulos C, Limon P, Lincoln D, Lipton R, Lykken J, Maeshima K, Marraffino JM, Mason D, McBride P, Miao T, Mishra K, Mrenna S, Musienko Y, Newman-Holmes C, O'Dell V, Pivarski J, Pordes R, Prokofyev O, Sexton-Kennedy E, Sharma S, Spalding WJ, Spiegel L, Tan P, Taylor L, Tkaczyk S, Uplegger L, Vaandering EW, Vidal R, Whitmore J, Wu W, Yang F, Yumiceva F, Yun JC, Acosta D, Avery P, Bourilkov D, Chen M, Das S, De Gruttola M, Di Giovanni GP, Dobur D, Drozdetskiy A, Field RD, Fisher M, Fu Y, Furic IK, Gartner J, Hugon J, Kim B, Konigsberg J, Korytov A, Kropivnitskaya A, Kyprcos T, Low JF, Matchev K, Mitselmakher G, Muniz L, Prescott C, Remington R, Rinkevicius A, Schmitt M, Scurlock B, Sellers P, Skhirtladze N, Snowball M, Wang D, Yelton J, Zakaria M, Gaultney V, Lebolo LM, Linn S, Markowitz P, Martinez G, Rodriguez JL, Adams T, Askew A, Bochenek J, Chen J, Diamond B, Gleyzer SV, Haas J, Hagopian S, Hagopian V, Jenkins M, Johnson KF, Prosper H, Quertenmont L, Sekmen S, Veeraraghavan V, Baarmand MM, Dorney B, Guragain S, Hohlmann M, Kalakhety H, Vodopiyanov I, Adams MR, Anghel IM, Apanasevich L, Bai Y, Bazterra VE, Betts RR, Callner J, Cavanaugh R, Dragoiu C, Gauthier L, Gerber CE, Hofman DJ, Khalatyan S, Kunde GJ, Lacroix F, Malek M, O'Brien C, Silkworth C, Silvestre C, Smoron A, Strom D, Varelas N, Akgun U, Albayrak EA, Bilki B, Clarida W, Duru F, Lae CK, McCliment E, Merlo JP, Mermerkaya H, Mestvirishvili A, Moeller A, Nachtman J, Newsom CR, Norbeck E, Olson J, Onel Y, Ozok F, Sen S, Wetzel J, Yetkin T, Yi K, Barnett BA, Blumenfeld B, Bonato A, Eskew C, Fehling D, Giurgiu G, Gritsan AV, Guo ZJ, Hu G, Maksimovic P, Rappoccio S, Swartz M, Tran NV, Whitbeck A, Baringer P, Bean A, Benelli G, Grachov O, Iii RPK, Murray M, Noonan D, Sanders S, Wood JS, Zhukova V, Barfuss AF, Bolton T, Chakaberia I, Ivanov A, Khalil S, Makouski M, Maravin Y, Shrestha S, Svintradze I, Wan Z, Gronberg J, Lange D, Wright D, Baden A, Boutemeur M, Eno SC, Ferencek D, Gomez JA, Hadley NJ, Kellogg RG, Kirn M, Lu Y, Mignerey AC, Rossato K, Rumerio P, Santanastasio F, Skuja A, Temple J, Tonjes MB, Tonwar SC, Twedt E, Alver B, Bauer G, Bendavid J, Busza W, Butz E, Cali IA, Chan M, Dutta V, Everaerts P, Ceballos GG, Goncharov M, Hahn KA, Harris P, Kim Y, Klute M, Lee YJ, Li W, Loizides C, Luckey PD, Ma T, Nahn S, Paus C, Ralph D, Roland C, Roland G, Rudolph M, Stephans GSF, Stockli F, Sumorok K, Sung K, Velicanu D, Wenger EA, Wolf R, Xie S, Yang M, Yilmaz Y, Yoon AS, Zanetti M, Cooper SI, Cushman P, Dahmes B, De Benedetti A, Dudero PR, Franzoni G, Gude A, Haupt J, Klapoetke K, Kubota Y, Mans J, Pastika N, Rekovic V, Rusack R, Sasseville M, Singovsky A, Tambe N, Cremaldi LM, Godang R, Kroeger R, Perera L, Rahmat R, Sanders DA, Summers D, Bloom K, Bose S, Butt J, Claes DR, Dominguez A, Eads M, Jindal P, Keller J, Kelly T, Kravchenko I, Lazo-Flores J, Malbouisson H, Malik S, Snow GR, Baur U, Godshalk A, Iashvili I, Jain S, Kharchilava A, Kumar A, Shipkowski SP, Smith K, Alverson G, Barberis E, Baumgartel D, Boeriu O, Chasco M, Reucroft S, Swain J, Trocino D, Wood D, Zhang J, Anastassov A, Kubik A, Odell N, Ofierzynski RA, Pollack B, Pozdnyakov A, Schmitt M, Stoynev S, Velasco M, Won S, Antonelli L, Berry D, Brinkerhoff A, Hildreth M, Jessop C, Karmgard DJ, Kolb J, Kolberg T, Lannon K, Luo W, Lynch S, Marinelli N, Morse DM, Pearson T, Ruchti R, Slaunwhite J, Valls N, Wayne M, Ziegler J, Bylsma B, Durkin LS, Gu J, Hill C, Killewald P, Kotov K, Ling TY, Rodenburg M, Vuosalo C, Williams G, Adam N, Berry E, Elmer P, Gerbaudo D, Halyo V, Hebda P, Hunt A, Laird E, Pegna DL, Marlow D, Medvedeva T, Mooney M, Olsen J, Piroue P, Quan X, Safdi B, Saka H, Stickland D, Tully C, Werner JS, Zuranski A, Acosta JG, Huang XT, Lopez A, Mendez H, Oliveros S, Vargas JER, Zatserklyaniy A, Alagoz E, Barnes VE, Bolla G, Borrello L, Bortoletto D, De Mattia M, Everett A, Garfinkel AF, Gutay L, Hu Z, Jones M, Koybasi O, Kress M, Laasanen AT, Leonardo N, Liu C, Maroussov V, Merkel P, Miller DH, Neumeister N, Shipsey I, Silvers D, Svyatkovskiy A, Yoo HD, Zablocki J, Zheng Y, Parashar N, Adair A, Boulahouache C, Ecklund KM, Geurts FJM, Padley BP, Redjimi R, Roberts J, Zabel J, Betchart B, Bodek A, Chung YS, Covarelli R, de Barbaro P, Demina R, Eshaq Y, Flacher H, Garcia-Bellido A, Goldenzweig P, Gotra Y, Han J, Harel A, Miner DC, Orbaker D, Petrillo G, Sakumoto W, Vishnevskiy D, Zielinski M, Bhatti A, Ciesielski R, Demortier L, Goulianos K, Lungu G, Malik S, Mesropian C, Atramentov O, Barker A, Duggan D, Gershtein Y, Gray R, Halkiadakis E, Hidas D, Hits D, Lath A, Panwalkar S, Patel R, Richards A, Rose K, Schnetzer S, Somalwar S, Stone R, Thomas S, Cerizza G, Hollingsworth M, Spanier S, Yang ZC, York A, Eusebi R, Flanagan W, Gilmore J, Gurrola A, Kamon T, Khotilovich V, Montalvo R, Osipenkov I, Pakhotin Y, Safonov A, Sengupta S, Suarez I, Tatarinov A, Toback D, Weinberger M, Akchurin N, Bardak C, Damgov J, Jeong C, Kovitanggoon K, Lee SW, Libeiro T, Mane P, Roh Y, Sill A, Volobouev I, Wigmans R, Yazgan E, Appelt E, Brownson E, Engh D, Florez C, Gabella W, Issah M, Johns W, Kurt P, Maguire C, Melo A, Sheldon P, Snook B, Tuo S, Velkovska J, Arenton MW, Balazs M, Boutle S, Cox B, Francis B, Goodell J, Hirosky R, Ledovskoy A, Lin C, Neu C, Yohay R, Gollapinni S, Harr R, Karchin PE, Don CKK, Lamichhane P, Mattson M, Milstene C, Sakharov A, Anderson M, Bachtis M, Belknap D, Bellinger JN, Carlsmith D, Dasu S, Efron J, Gray L, Grogg KS, Grothe M, Hall-Wilton R, Herndon M, Herve A, Klabbers P, Klukas J, Lanaro A, Lazaridis C, Leonard J, Loveless R, Mohapatra A, Ojalvo I, Reeder D, Ross I, Savin A, Smith WH, Swanson J, Weinberg M
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Search for Three-Jet Resonances in pp Collisions at root s=7 TeV
PHYSICAL REVIEW LETTERS 2011 AUG 29; 107(10):? Article 101801
A search for three-jet hadronic resonance production in pp collisions at a center-of-mass energy of 7 TeV has been conducted by the CMS Collaboration at the LHC, using a data sample corresponding to an integrated luminosity of 35 pb(-1). Events with high jet multiplicity and a large scalar sum of jet transverse momenta are analyzed using a signature-based approach. The number of expected standard model background events is found to be in good agreement with the observed events. Limits on the cross section times branching ratio are set in a model of gluino pair production with an R-parity-violating decay to three quarks, and the data rule out such particles within the mass range of 200 to 280 GeV/c(2).
Amrani YM, Gill J, Matevossian A, Alonzo ES, Yang CW, Shieh JH, Moore MA, Park CY, Sant'Angelo DB, Denzin LK
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The Paf oncogene is essential for hematopoietic stem cell function and development
JOURNAL OF EXPERIMENTAL MEDICINE 2011 AUG 29; 208(9):1757-1765
Hematopoietic stem cells (HSCs) self-renew to maintain the lifelong production of all blood populations. Here, we show that the proliferating cell nuclear antigen-associated factor (Paf) is highly expressed in cycling bone marrow HSCs and plays a critical role in hematopoiesis. Mice lacking Paf exhibited reduced bone marrow cellularity; reduced numbers of HSCs and committed progenitors; and leukopenia. These phenotypes are caused by a cell-intrinsic blockage in the development of long-term (LT)-HSCs into multipotent progenitors and preferential loss of lymphoid progenitors caused by markedly increased p53-mediated apoptosis. In addition, LT-HSCs from Paf(-/-) mice had increased levels of reactive oxygen species (ROS), failed to maintain quiescence, and were unable to support LT hematopoiesis. The loss of lymphoid progenitors was likely due the increased levels of ROS in LT-HSCs caused by treatment of Paf(-/-) mice with the anti-oxidant N-acetylcysteine restored lymphoid progenitor numbers to that of Paf(+/+) mice. Collectively, our studies identify Paf as a novel and essential regulator of early hematopoiesis.
Tang AC, Jiang H, Yang Z, Zhang Y, Romeo RD, McEwen BS
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Converging influence of neonatal novelty experience and maternal self-stress regulation on the plasticity of offspring acoustic startle response latency
BEHAVIOURAL BRAIN RESEARCH 2011 AUG 1; 221(1):253-260
Behavioral and brain development is influenced by both maternal and non-maternal aspects of the postnatal environment and the precise nature of their interaction is the topic of an ongoing debate. Here, we consider the joint influence of neonatal environmental novelty and maternal self-stress regulation on the development of acoustic startle reflex (ASR), an extensively investigated model system for learning and neural plasticity. We test the hypothesis in the rat that brief repeated neonatal exposures to novelty can affect ASR in late adulthood and that this influence is sensitive to postnatal context of maternal self-stress regulation. We carried out the neonatal and early adulthood novelty exposure (PND 1-21 and PND 54-63 respectively), obtained measures of maternal self-stress regulation after weaning (PND 25-26), and evaluated in the male rats, ASR and ASR plasticity at adulthood (ASR1 and ASR2, one week apart, at 13.5 months of age). During ASR1, offspring, whose mothers had poor self-stress regulation as indexed by a high circulating basal corticosterone (CORT) concentration, showed a novelty-induced decrease of ASR latency. Offspring whose mothers had good self regulation as indexed by a low CORT, showed a novelty-induced increase in ASR latency. From ASR1 to ASR2, offspring whose mothers had poor self-stress regulation, showed a novelty-induced ASR latency habituation (increase in latency) while offspring whose mothers had good self regulation showed no novelty effect. These findings support a novel framework in which maternal and non-maternal postnatal environments exert interacting influences on the neonates, with maternal individual differences in self-stress regulation providing a critical context to enable bidirectional novelty-induced influence across different rat families. (C) 2011 Elsevier B.V. All rights reserved.
Aaltonen T, AlvarezGonzalez B, Amerio S, Anastassov A, Annovi A, Antos J, Apollinari G, Apresyan A, Arisawa T, Artikov A, Asaadi J, Ashmanskas W, Auerbach B, Aurisano A, Azfar F, Badgett W, Barbaro-Galtieri A, Barnes VE, Barnett BA, Barria P, Bartos P, Bauce M, Bedeschi F, Beecher D, Behari S, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Bhatti A, Binkley M, Bisello D, Bizjak I, Bland KR, Blumenfeld B, Bocci A, Bodek A, Bortoletto D, Boudreau J, Boveia A, Brau B, Brigliadori L, Brisuda A, Bromberg C, Brucken E, Bucciantonio M, Budagov J, Budd HS, Budd S, Burkett K, Busetto G, Bussey P, Buzatu A, Calancha C, Camarda S, Campanelli M, Campbell M, Canelli F, Carls B, Carlsmith D, Carosi R, Carrillo S, Carron S, Casal B, Casarsa M, Castro A, Catastini P, Cauz D, Cavaliere V, Cavalli-Sforza M, Cerri A, Cerrito L, Chen YC, Chiarelli G, Chlachidze G, Chlebana F, Cho K, Chokheli D, Chou JP, Chung WH, Chung YS, Ciobanu CI, Ciocci MA, Clark A, Clarke C, Compostella G, Convery ME, Corbo M, Cordelli M, Cox CA, Cox DJ, Crescioli F, Almenar CC, Cuevas J, Dagenhart D, d'Ascenzo N, Datta M, de Barbaro P, De Cecco S, De Lorenzo G, Dell'Orso M, Deluca C, Demortier L, Deng J, Deninno M, Devoto F, d'Errico M, Di Canto A, Di Ruzza B, Dittmann JR, D'Onofrio M, Donati S, Dong P, Dorigo M, Dorigo T, Ebina K, Elagin A, Eppig A, Erbacher R, Errede D, Errede S, Ershaidat N, Eusebi R, Fang HC, Fernandez JP, Ferrazza C, Field R, Flanagan G, Forrest R, Frank MJ, Franklin M, Freeman JC, Funakoshi Y, Furic I, Gallinaro M, Galyardt J, Garcia JE, Garfinkel AF, Garosi P, Gerberich H, Gerchtein E, Giagu S, Giakoumopoulou V, Giannetti P, Gibson K, Ginsburg CM, Giokaris N, Giromini P, Giunta M, Giurgiu G, Glagolev V, Glenzinski D, Gold M, Goldin D, Goldschmidt N, Golossanov A, Gomez G, Gomez-Ceballos G, Goncharov M, Gonzalez O, Gorelov I, Goshaw AT, Goulianos K, Grinstein S, Grosso-Pilcher C, Group RC, da Costa JG, Gunay-Unalan Z, Haber C, Hahn SR, Halkiadakis E, Hamaguchi A, Han JY, Happacher F, Hara K, Hare D, Hare M, Harr RF, Hatakeyama K, Herndon M, Hewamanage S, Hidas D, Hocker A, Hopkins W, Hou S, Hughes RE, Hurwitz M, Husemann U, Hussain N, Hussein M, Huston J, Introzzi G, Iori M, Ivanov A, Jang D, Jayatilaka B, Jeon EJ, Jha MK, Jindariani S, Johnson W, Jones M, Joo KK, Jun SY, Junk TR, Kamon T, Kasmi A, Kato Y, Ketchum W, Khotilovich V, Kilminster B, Kim DH, Kim HS, Kim HW, Kim JE, Kim MJ, Kim SB, Kim SH, Kim YK, Kimura N, Kirby M, Klimenko S, Kondo K, Kong DJ, Konigsberg J, Krop D, Krumnack N, Kruse M, Krutelyov V, Kurata M, Kwang S, Laasanen AT, Lami S, Lammel S, Lancaster M, Lander RL, Lannon K, Lath A, Latino G, Lee E, Lee HS, Lee JS, Lee SW, Leo S, Leone S, Lewis JD, Limosani A, Lin CJ, Linacre J, Lindgren M, Lister A, Litvintsev DO, Liu C, Liu Q, Liu T, Lockwitz S, Loginov A, Lucchesi D, Lujan P, Lukens P, Lungu G, Lys J, Lysak R, Madrak R, Maeshima K, Makhoul K, Malik S, Manca G, Manousakis-Katsikakis A, Margaroli F, Martinez M, Martinez-Ballarin R, Mastrandrea P, Mattson ME, Mazzanti P, McFarland KS, McIntyre P, McNulty R, Mehta A, Mehtala P, Menzione A, Mesropian C, Miao T, Mietlicki D, Mitra A, Miyake H, Moed S, Moggi N, Mondragon MN, Moon CS, Moore R, Morello MJ, Fernandez PM, Mukherjee A, Mussini M, Nachtman J, Nagai Y, Naganoma J, Nakano I, Napier A, Nett J, Neu C, Neubauer MS, Nielsen J, Norniella O, Nurse E, Oakes L, Oh SH, Oh YD, Oksuzian I, Okusawa T, Orava R, Ortolan L, Griso SP, Pagliarone C, Palencia E, Papadimitriou V, Patrick J, Pauletta G, Paus C, Pellett DE, Penzo A, Phillips TJ, Piacentino G, Pilot J, Pitts K, Plager C, Pondrom L, Potamianos K, Poukhov O, Prokoshin F, Pronko A, Ptohos F, Pueschel E, Punzi G, Pursley J, Rahaman A, Ramakrishnan V, Ranjan N, Redondo I, Rescigno M, Riddick T, Rimondi F, Ristori L, Robson A, Rodrigo T, Rogers E, Rolli S, Roser R, Rossi M, Rubbo F, Ruffini F, Ruiz A, Russ J, Rusu V, Safonov A, Sakumoto WK, Sakurai Y, Santi L, Sartori L, Sato K, Saveliev V, Savoy-Navarro A, Schlabach P, Schmidt EE, Schmidt MP, Schmitt M, Schwarz T, Scodellaro L, Scribano A, Scuri F, Sedov A, Seidel S, Seiya Y, Semenov A, Sforza F, Sfyrla A, Shalhout SZ, Shears T, Shepard PF, Shimojima M, Shiraishi S, Shochet M, Shreyber I, Simonenko A, Sinervo P, Sissakian A, Sliwa K, Smith JR, Snider FD, Soha A, Somalwar S, Sorin V, Squillacioti P, Stancari M, Stanitzki M, Denis RS, Stelzer B, Stelzer-Chilton O, Stentz D, Strologas J, Strycker GL, Sudo Y, Sukhanov A, Suslov I, Takemasa K, Takeuchi Y, Tang J, Tecchio M, Teng PK, Thom J, Thome J, Thompson GA, Ttito-Guzman P, Tkaczyk S, Toback D, Tokar S, Tollefson K, Tomura T, Torre S, Torretta D, Totaro P, Trovato M, Ukegawa F, Uozumi S, Varganov A, Vazquez F, Velev G, Vellidis C, Vidal M, Vila I, Vilar R, Vizan J, Vogel M, Volpi G, Wagner RL, Wakisaka T, Wallny R, Wang SM, Warburton A, Waters D, Weinberger M, Whitehouse B, Wicklund AB, Wicklund E, Wilbur S, Wilson JS, Wilson P, Winer BL, Wittich P, Wolbers S, Wolfe H, Wright T, Wu X, Wu Z, Yamamoto K, Yamaoka J, Yang T, Yang UK, Yang YC, Yao WM, Yeh GP, Yi K, Yoh J, Yorita K, Yoshida T, Yu GB, Yu I, Yu SS, Yun JC, Zanetti A, Zeng Y, Zucchelli S
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Improved determination of the sample composition of dimuon events produced in p(p)over-bar collisions at root s=1.96 TeV
EUROPEAN PHYSICAL JOURNAL C 2011 AUG; 71(8):? Article 1720
We use a new method to estimate with 5% accuracy the contribution of pion and kaon in-flight-decays to the dimuon data set acquired with the CDF detector. Based on this improved estimate, we show that the total number and the properties of the collected dimuon events are not yet accounted for by ordinary sources of dimuons which also include the contributions, as measured in the data, of heavy flavor, gamma, and Drell-Yan production in addition to muons mimicked by hadronic punchthrough. The number of unaccounted events corresponds to (12.8 +/- 3.2)% of the b (b) over bar production. We find that (23 +/- 6)% of the unaccounted events contain additional muon candidates. For comparison, this fraction is (6.9 +/- 0.4)% for events due to b (b) over bar production.
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Johns W, Kurt P, Maguire C, Melo A, Sheldon P, Tuo S, Velkovska J, Arenton MW, Balazs M, Boutle S, Buehler M, Conetti S, Cox B, Francis B, Hirosky R, Ledovskoy A, Lin C, Neu C, Yohay R, Gollapinni S, Harr R, Karchin PE, Lamichhane P, Mattson M, Milstene C, Sakharov A, Anderson M, Bachtis M, Bellinger JN, Carlsmith D, Dasu S, Efron J, Flood K, Gray L, Grogg KS, Grothe M, Hall-Wilton R, Herndon M, Klabbers P, Klukas J, Lanaro A, Lazaridis C, Leonard J, Loveless R, Mohapatra A, Reeder D, Ross I, Savin A, Smith WH, Swanson J, Weinberg M
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Observation and studies of jet quenching in PbPb collisions at root s(NN)=2.76 TeV
PHYSICAL REVIEW C 2011 AUG 12; 84(2):? Article 024906
Jet production in PbPb collisions at a nucleon-nucleon center-of-mass energy of 2.76 TeV was studied with the Compact Muon Solenoid (CMS) detector at the LHC, using a data sample corresponding to an integrated luminosity of 6.7 mu b(-1). Jets are reconstructed using the energy deposited in the CMS calorimeters and studied as a function of collision centrality. With increasing collision centrality, a striking imbalance in dijet transverse momentum is observed, consistent with jet quenching. The observed effect extends from the lower cutoff used in this study (jet p(T) = 120 GeV/c) up to the statistical limit of the available data sample (jet p(T) approximate to 210 GeV/c). Correlations of charged particle tracks with jets indicate that the momentum imbalance is accompanied by a softening of the fragmentation pattern of the second most energetic, away-side jet. The dijet momentum balance is recovered when integrating low transverse momentum particles distributed over a wide angular range relative to the direction of the away-side jet.
Feng ZY, Kallifidas D, Brady SF
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Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011 AUG 2; 108(31):12629-12634
A single gram of soil is predicted to contain thousands of unique bacterial species. The majority of these species remain recalcitrant to standard culture methods, prohibiting their use as sources of unique bioactive small molecules. The cloning and analysis of DNA extracted directly from environmental samples (environmental DNA, eDNA) provides a means of exploring the biosynthetic capacity of natural bacterial populations. Environmental DNA libraries contain large reservoirs of bacterial genetic diversity from which new secondary metabolite gene clusters can be systematically recovered and studied. The identification and heterologous expression of type II polyketide synthase-containing eDNA clones is reported here. Functional analysis of three soil DNA-derived polyketide synthase systems in Streptomyces albus revealed diverse metabolites belonging to well-known, rare, and previously uncharacterized structural families. The first of these systems is predicted to encode the production of the known antibiotic landomycin E. The second was found to encode the production of a metabolite with a previously uncharacterized pentacyclic ring system. The third was found to encode the production of unique KB-3346-5 derivatives, which show activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. These results, together with those of other small-molecule-directed metagenomic studies, suggest that culture-independent approaches are capable of accessing biosynthetic diversity that has not yet been extensively explored using culture-based methods. The large-scale functional screening of eDNA clones should be a productive strategy for generating structurally previously uncharacterized chemical entities for use in future drug development efforts.
Pasolli HA
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The Hair Follicle Bulge: A Niche for Adult Stem Cells
MICROSCOPY AND MICROANALYSIS 2011 AUG; 17(4):513-519
Adult stem cells (SCs) are essential for tissue homeostasis and wound repair. They have the ability to both self-renew and differentiate into multiple cell types. They often reside in specialized microenvironments or niches that preserve their proliferative and tissue regenerative capacity. The murine hair follicle (HF) has a specialized and permanent compartment-the bulge, which safely lodges SCs and provides the necessary molecular cues to regulate their function. The HF undergoes cyclic periods of destruction, regeneration, and rest, making it an excellent system to study SC biology.