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Leshner A, Pfaff DW
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Quantification of behavior
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011 SEP 13; 108(?):15537-15541
Tamashiro KL, Sakai RR, Shively CA, Karatsoreos IN, Reagan LP
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Chronic stress, metabolism, and metabolic syndrome
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 2011 SEP; 14(5):468-474
The prevalence of obesity has rapidly escalated and now represents a major public health concern. Although genetic associations with obesity and related metabolic disorders such as diabetes and cardiovascular disease have been identified, together they account for a small proportion of the incidence of disease. Environmental influences such as chronic stress, behavioral and metabolic disturbances, dietary deficiency, and infection have now emerged as contributors to the development of metabolic disease. Although epidemiological data suggest strong associations between chronic stress exposure and metabolic disease, the etiological mechanisms responsible remain unclear. Mechanistic studies of the influence of chronic social stress are now being conducted in both rodent and nonhuman primate models, and phenotypic results are consistent with those in humans. The advantage of these models is that potential neural mechanisms may be examined and interventions to treat or prevent disease may be developed and tested. Further, circadian disruption and metabolic conditions such as diabetes mellitus could increase susceptibility to other stressors or serve as a stressor itself. Here, we review data from leading investigators discussing the interrelationship between chronic stress and development of metabolic disorders.
Kreek MJ, Zhou Y, Levran O
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Functions of Arginine Vasopressin and Its Receptors: Importance of Human Molecular Genetics Studies in Bidirectional Translational Research
BIOLOGICAL PSYCHIATRY 2011 SEP 15; 70(6):502-503
Berti C, Bartesaghi L, Ghidinelli M, Zambroni D, Figlia G, Chen ZL, Quattrini A, Wrabetz L, Feltri ML
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Non-redundant function of dystroglycan and beta 1 integrins in radial sorting of axons
DEVELOPMENT 2011 SEP 15; 138(18):4025-4037
Radial sorting allows the segregation of axons by a single Schwann cell (SC) and is a prerequisite for myelination during peripheral nerve development. Radial sorting is impaired in models of human diseases, congenital muscular dystrophy (MDC) 1A, MDC1D and Fukuyama, owing to loss-of-function mutations in the genes coding for laminin alpha 2, Large or fukutin glycosyltransferases, respectively. It is not clear which receptor(s) are activated by laminin 211, or glycosylated by Large and fukutin during sorting. Candidates are alpha beta 1 integrins, because their absence phenocopies laminin and glycosyltransferase deficiency, but the topography of the phenotypes is different and beta 1 integrins are not substrates for Large and fukutin. By contrast, deletion of the Large and fukutin substrate dystroglycan does not result in radial sorting defects. Here, we show that absence of dystroglycan in a specific genetic background causes sorting defects with topography identical to that of laminin 211 mutants, and recapitulating the MDC1A, MDC1D and Fukuyama phenotypes. By epistasis studies in mice lacking one or both receptors in SCs, we show that only absence of beta 1 integrins impairs proliferation and survival, and arrests radial sorting at early stages, that beta 1 integrins and dystroglycan activate different pathways, and that the absence of both molecules is synergistic. Thus, the function of dystroglycan and. 1 integrins is not redundant, but is sequential. These data identify dystroglycan as a functional laminin 211 receptor during axonal sorting and the key substrate relevant to the pathogenesis of glycosyltransferase congenital muscular dystrophies.
Zhou Y, Litvin Y, Piras AP, Pfaff DW, Kreek MJ
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Persistent Increase in Hypothalamic Arginine Vasopressin Gene Expression During Protracted Withdrawal from Chronic Escalating-Dose Cocaine in Rodents
NEUROPSYCHOPHARMACOLOGY 2011 SEP; 36(10):2062-2075
Arginine vasopressin (AVP) from the paraventricular nucleus (PVN) of hypothalamus has important roles in regulation of the hypothalamic-pituitary-adrenal (HPA) axis and stress-related behaviors during chronic stress. It is unknown, however, whether AVP in the PVN is involved in the modulation of HPA activity after chronic cocaine exposure. Here, we examined the gene expression alterations of AVP in the hypothalamus, and V1b receptor and pro-opiomelanocortin (POMC) in the anterior pituitary, as well as HPA hormonal changes, in Fischer rats after chronic cocaine and withdrawal, using two different chronic (14-day) 'binge' pattern administration regimens: steady-dose cocaine (SDC, 45 mg/kg/day) and escalating-dose cocaine (EDC, 45 up to 90 mg/kg/day). There was a significant (7-fold) plasma adrenocorticotropic hormone (ACTH) elevation after chronic EDC (but not SDC), coupled with increased V1b and POMC mRNA levels in the anterior pituitary. From acute (1-day) to protracted (14-day) withdrawal from chronic EDC (but not from SDC), we found persistent elevations of both plasma ACTH and corticosterone levels and AVP mRNA levels in the PVN. Selective V1b antagonist SSR149415 (5 mg/kg) attenuated acute withdrawal-induced HPA activation after EDC. To study potential roles of endogenous opioids in modulating the AVP gene, we administered naloxone (1 mg/kg); we found that opioid receptor antagonism increased AVP mRNA levels in cocaine-naive rats, but not in cocaine-withdrawn rats, suggesting less tonic opioid inhibition of PVN AVP neurons after chronic EDC. To assess the effects of cocaine withdrawal on sub-populations of PVN AVP neurons, we utilized AVP-enhanced green fluorescent protein (EGFP) promoter transgenic mice and found that acute withdrawal following chronic EDC increased the number of AVP-EGFP neurons in the parvocellular PVN (pPVN). These results suggest that during protracted withdrawal, enhanced pPVN AVP gene expression is associated with persistent elevations of basal HPA activity; a hyposensitivity of PVN AVP gene expression to naloxone is indicative of reduced opioidergic tone. Our studies indicate that the AVP and its V1b receptor system may be a potential therapeutic target for treating anxiety and depressive symptoms associated with cocaine addiction. Neuropsychopharmacology (2011) 36, 2062-2075; doi: 10.1038/npp.2011.97; published online 15 June 2011
Chatrchyan S, Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Bergauer T, Dragicevic M, Ero J, Fabjan C, Friedl M, Fruhwirth R, Ghete VM, Hammer J, Hansel S, Hoch M, Hormann N, Hrubec J, Jeitler M, Kiesenhofer W, Krammer M, Liko D, Mikulec I, Pernicka M, Rohringer H, Schofbeck R, Strauss J, Taurok A, Teischinger F, Wagner P, Waltenberger W, Walzel G, Widl E, Wulz CE, Mossolov V, Shumeiko N, Gonzalez JS, Benucci L, De Wolf EA, Janssen X, Maes J, Maes T, Mucibello L, Ochesanu S, Roland B, Rougny R, Selvaggi M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Blekman F, Blyweert S, D'Hondt J, Devroede O, Suarez RG, Kalogeropoulos A, Maes M, Van Doninck W, Van Mulders P, Van Onsem GP, Villella I, Charaf O, Clerbaux B, De Lentdecker G, Dero V, Gay APR, Hammad GH, Hreus T, Marage PE, Thomas L, Vander Velde C, Vanlaer P, Adler V, Cimmino A, Costantini S, Grunewald M, Klein B, Leellouch J, Marinov A, Mccartin J, Ryckbosch D, Thyssen F, Tytgat M, Vanelderen L, Verwilligen P, Walsh S, Zaganidis N, Basegmez S, Bruno G, Caudron J, Ceard L, Gil EC, De Jenerer JD, Delaere C, Favart D, Giammanco A, Gregoire G, Hollar J, Lemaitre V, Liao J, Militaru O, Ovyn S, Pagano D, Pin A, Piotrzkowski K, Schul N, Beliy N, Caebergs T, Daubie E, Alves GA, Damiao DD, Pol ME, Souza MHG, Carvalho W, Da Costa EM, Martins CD, De Souza SF, Mundim L, Nogima H, Oguri V, Da Silva WLP, Santoro A, Do Amaral SMS, Sznajder A, Bernardes CA, Dias FA, Tomei TRFP, Gregores EM, Lagana C, Marinho F, Mercadante PG, Novaes SF, Padula SS, Darmenov N, Dimitrov L, Genchev V, Iaydjiev P, Piperov S, Rodozov M, Stoykova S, Sultanov G, Tcholakov V, Trayanov R, Vankov I, Dimitrov A, Hadjiiska R, Karadzhinova A, Kozhuharov V, Litov L, Mateev M, Pavlov B, Petkov P, Bian JG, Chen GM, Chen HS, Jiang CH, Liang D, Liang S, Meng X, Tao J, Wang J, Wang J, Wang X, Wang Z, Xiao H, Xu M, Zang J, Zhang Z, Ban Y, Guo S, Guo Y, Li W, Mao Y, Qian SJ, Teng H, Zhang L, Zhu B, Zou W, Cabrera A, Moreno BG, Rios AAO, Oliveros AFO, Sanabria JC, Godinovic N, Lelas D, Lelas K, Plestina R, Polic D, Puljak I, Antunovic Z, Dzelalija M, Brigljevic V, Duric S, Kadija K, Morovic S, Attikis A, Galanti M, Mousa J, Nicolaou C, Ptochos F, Razis PA, Finger M, Finger M, Khalil S, Mahmoud MA, Radi A, Hektor A, Kadastik M, Muntel M, Raidal M, Rebane L, Azzolini V, Eerola P, Fedi G, Czellar S, Harkonen J, Heikkinen A, Karimaki V, Kinnunen R, Kortelainen MJ, Lampen T, Lassila-Perini K, Lehti S, Linden T, Luukka P, Maenpaa T, Tuominen E, Tuominiemi J, Tuovinen E, Ungaro D, Wendland L, Banzuzi K, Korpela A, Tuuva T, Sillou D, Besancon M, Choudhury S, Dejardin M, Denegri D, Fabbro B, Faure JL, Ferri F, Ganjour S, Gentit FX, Givernaud A, Gras P, de Monchenault GH, Jarry P, Locci E, Malcles J, Marionneau M, Millischer L, Rander J, Rosowsky A, Shreyber I, Titov M, Verrecchia P, Baffioni S, Beaudette F, Benhabib L, Bianchini L, Bluj M, Broutin C, Busson P, Charlot C, Dahms T, Dobrzynski L, Elgammal S, de Cassagnac RG, Haguenauer M, Mine P, Mironov C, Ochando C, Paganini P, Sabes D, Salerno R, Sirois Y, Thiebaux C, Wyslouch B, Zabi A, Agram JL, Andrea J, Bloch D, Bodin D, Brom JM, Cardaci M, Chabert EC, Collard C, Conte E, Drouhin F, Ferro C, Fontaine JC, Gele D, Goerlach U, Greder S, Juillot P, Karim M, Le Bihan AC, Mikami Y, Van Hove P, Fassi F, Mercier D, Baty C, Beauceron S, Beaupere N, Bedjidian M, Bondu O, Boudoul G, Boumediene D, Brun H, Chasserat J, Chierici R, Contardo D, Depasse P, El Mamouni H, Fay J, Gascon S, Ille B, Kurca T, Le Grand T, Lethuillier M, Mirabito L, Perries S, Sordini V, Tosi S, Tschudi Y, Verdier P, Lomidze D, Anagnostou G, Edelhoff M, Feld L, Heracleous N, Hinidrichs O, Jussen R, Klein K, Merz J, Mohr N, Ostrapchuk A, Perieanu A, Raupach F, Sammet J, Schael S, Sprenger D, Weber H, Weber M, Wittmer B, Ata M, Bender W, Dietz-Laursonn E, Erdmann M, Frangenheim J, Hebbeker T, Hinzmann A, Hoepfner K, Klimkovich T, Klingebiel D, Kreuzer P, Lanske D, Magass C, Merschmeyer M, Meyer A, Papacz P, Pieta H, Reithler H, Schmitz SA, Sonnenschein L, Steggemann J, Teyssier D, Bontenackels M, Davids M, Duda M, Flugge G, Geenen H, Giffels M, Ahmad WH, Heydhausen D, Kress T, Kuessel Y, Linn A, Nowack A, Perchalla L, Pooth O, Rennefeld J, Sauerland P, Stahl A, Thomas M, Tornier D, Zoeller MH, Martin MA, Behrenhoff W, Behrens U, Bergholz M, Bethani A, Borras K, Cakir A, Campbell A, Castro E, Dammann D, Eckerlin G, Eckstein D, Flossdorf A, Flucke G, Geiser A, Hauk J, Jung H, Kasemann M, Katkov I, Katsas P, Kleinwort C, Kluge H, Knutsson A, Kramer M, Krucker D, Kuznetsova E, Lange W, Lohmann W, Mankel R, Marienfeld M, Melzer-Pellmann IA, Meyer AB, Mnich J, Mussgiller A, Olzem J, Pitzl D, Raspereza A, Raval A, Rosin M, Schmidt R, Schoerner-Sadenius T, Sen N, Spiridonov A, Stein M, Tomaszewska J, Walsh R, Wissing C, Autermann C, Blobel V, Bobrovskyi S, Draeger J, Enderle H, Gebbert U, Kaschube K, Kaussen G, Klanner R, Lange J, Mura B, Naumann-Emme S, Nowak F, Pietsch N, Sander C, Schettler H, Schleper P, Schroder M, Schum T, Schwandt J, Stadie H, Steinbruck G, Thomsen J, Barth C, Bauer J, Buege B, Chwalek T, De Boer W, Dierlamm A, Dirkes G, Feindt M, Gruschke J, Hackstein C, Hartmann F, Heinrich M, Held H, Hoffmann KH, Honc S, Komaragiri JR, Kuhr T, Martschei D, Mueller S, Muller T, Niegel M, Oberst O, Oehler A, Ott J, Peiffer T, Quast G, Rabbertz K, Ratnikov F, Ratnikova N, Renz M, Saout C, Scheurer A, Schieferdecker P, Schilling FP, Schmanau M, Schott G, Simonis HJ, Stober FM, Troendle D, Wagner-Kuhr J, Weiler T, Zeise M, Zhukov V, Ziebarth EB, Daskalakis G, Geralis T, Kesisoglou S, Kyriakis A, Loukas D, Manolakos I, Markou A, Markou C, Mavrommatis C, Ntomari E, Petrakou E, Gouskos L, Mertzimekis TJ, Panagiotou A, Stiliaris E, Evangelou I, Foudas C, Kokkas P, Manthos N, Papadopoulos I, Patras V, Triantis FA, Aranyi A, Bencze G, Boldizsar L, Hajdu C, Hidas P, Horvath D, Kapusi A, Krajczar K, Sikler F, Veres GI, Vesztergombi G, Beni N, Molnar J, Palinkas J, Szillasi Z, Veszpremi V, Raics P, Trocsanyi ZL, Ujvari B, Bansal S, Beri SB, Bhatnagar V, Dhingra N, Gupta R, Jindal M, Kaur M, Kohli JM, Mehta MZ, Nishu N, Saini LK, Sharma A, Singh AP, Singh J, Singh SP, Ahuja S, Bhattacharya S, Choudhary BC, Gomber B, Gupta P, Jain S, Jain S, Khurana R, Kumar A, Ranjan K, Shivpuri RK, Choudhury RK, Dutta D, Kailas S, Kumar V, Mehta P, Mohanty AK, Pant LM, Shukla P, Aziz T, Guchait M, Gurtu A, Maity M, Majumder D, Majumder G, Mazumdar K, Mohanty GB, Saha A, Sudhakar K, Wickramage N, Banerjee S, Dugad S, Mondal NK, Arfaei H, Bakhshiansohi H, Etesami SM, Fahim A, Hashemi M, Jafari A, Khakzad M, Mohammadi A, Najafabadi MM, Mehdiabadi SP, Safarzadeh B, Zeinali M, Abbrescia M, Barbone L, Calabria C, Colaleo A, Creanza D, De Filippis N, De Palma M, Fiore L, Iaselli G, Lusito L, Maggi G, Maggi M, Manna N, Marangelli B, My S, Nuzzo S, Pacifico N, Pierro GA, Pompili A, Pugliese G, Romano F, Roselli G, Selvaggi G, Silvestris L, Trentadue R, Tupputi S, Zito G, Abbiendi G, Benvenuti AC, Bonacorsi D, Braibant-Giacomelli S, Brigliadori L, Capiluppi P, Castro A, Cavallo FR, Cuffiani M, Dallavalle GM, Fabbri F, Fanfani A, Fasanella D, Giacomelli P, Giunta M, Grandi C, Marcellini S, Masetti G, Meneghelli M, Montanari A, Navarria FL, Odorici F, Perrotta A, Primavera F, Rossi AM, Rovelli T, Siroli G, Travaglini R, Albergo S, Cappello G, Chiorboli M, Costa S, Tricomi A, Tuve C, Barbagli G, Ciulli V, Civinini C, D'Alessandro R, Focardi E, Frosali S, Gallo E, Gonzi S, Lenzi P, Meschini M, Paoletti S, Sguazzoni G, Tropiano A, Benussi L, Bianco S, Colafranceschi S, Fabbri F, Piccolo D, Fabbricatore P, Musenich R, Benaglia A, De Guio F, Di Matteo L, Gennai S, Ghezzi A, Malvezzi S, Martelli A, Massironi A, Menasce D, Moroni L, Paganoni M, Pedrini D, Ragazzi S, Redaelli N, Sala S, de Fatis TT, Buontempo S, Montoya CAC, Cavallo N, De Cosa A, Fabozzi F, Iorio AOM, Lista L, Merola M, Paolucci P, Azzi P, Bacchetta N, Bellan P, Bisello D, Branca A, Carlin R, Checchia P, De Mattia M, Dorigo T, Dosselli U, Fanzago F, Gasparini F, Gasparini U, Gozzelino A, Lacaprara S, Lazzizzera I, Margoni M, Mazzucato M, Meneguzzo AT, Nespolo M, Perrpzzi L, Pozzobon N, Ronchese P, Simonetto F, Torassa E, Tosi M, Vanini S, Zotto P, Zumerle G, Baesso P, Berzano U, Ratti SP, Riccardi C, Torre P, Vitulo P, Viviani C, Biasini M, Bilei GM, Caponeri B, Fano L, Lariccia P, Lucaroni A, Mantovani G, Menichelli M, Nappi A, Romeo F, Santocchia A, Taroni S, Valdata M, Azzurri P, Bagliesi G, Bernardini J, Boccali T, Broccolo G, Castaldi R, D'Agnolo RT, Dell'Orso R, Fiori F, Foa L, Giassi A, Kraan A, Ligabue F, Lomtadze T, Martini L, Messineo A, Palla F, Segneri G, Serban AT, Spagnolo P, Tenchini R, Tonelli G, Venturi A, Verdini PG, Barone L, Cavallari F, Del Re D, Di Marco E, Diemoz M, Franci D, Grassi M, Longo E, Nourbakhsh S, Organtini G, Pandolfi F, Paramatti R, Rahatlou S, Rovelli C, Amapane N, Arcidiacono R, Argiro S, Arneodo M, Biino C, Botta C, Cartiglia N, Castello R, Costa M, Demaria N, Graziano A, Mariotti C, Marone M, Maselli S, Migliore E, Mila G, Monaco V, Musich M, Obertino MM, Pastrone N, Pelliccioni M, Romero A, Ruspa M, Sacchi R, Sola V, Solano A, Staiano A, Pereira AV, Belforte S, Cossutti F, Della Ricca G, Gobbo B, Montanino D, Penzo A, Heo SG, Nam SK, Chang S, Chang J, Kim DH, Kim GN, Kim JE, Kong DJ, Park H, Ro SR, Son D, Son DC, Son T, Kim Z, Kim JY, Song S, Choi S, Hong B, Jeong MS, Jo M, Kim H, Kim JH, Kim TJ, Lee KS, Moon DH, Park SK, Rhee HB, Seo E, Shin S, Sim KS, Choi M, Kang S, Kim H, Park C, Park IC, Park S, Ryu G, Choi Y, Choi YK, Goh J, Kim MS, Kwon E, Lee J, Lee S, Seo H, Yu I, Bilinskas MJ, Grigelionis I, Janulis M, Martisiute D, Petrov P, Sabonis T, Castilla-Valdez H, De La Cruz-Burelo E, Heredia-de-La Cruz I, Lopez-Fernandez R, Villalba RM, Sanchez-Hernandez A, Villasenor-Cendejas LM, Moreno SC, Valencia FV, Ibarguen HAS, Linares EC, Pineda AM, Reyes-Santo MA, Krofcheck D, Tam J, Yiu CH, Butler PH, Doesburg R, Silverwood H, Ahmad M, Ahmed I, Asghar MI, Hoorani HR, Khan WA, Khurshid T, Qazi S, Brona G, Cwiok M, Dominik W, Doroba K, Kalinowski A, Konecki M, Krolikowski J, Fruboes T, Gokieli R, Gorski M, Kazana M, Nawrocki K, Romanowska-Rybinska K, Szleper M, Wrochna G, Zalewski P, Almeida N, Bargassa P, David A, Faccioli P, Parracho PGF, Gallinaro M, Musella P, Nayak A, Ribeiro PQ, Seixas J, Varela J, Belotelov I, Bunin P, Golutvin I, Kamenev A, Karjavin V, Konoplyanikov V, Kozlov G, Lanev A, Moisenz P, Palichik V, Perelygin V, Shmatov S, Smirnov V, Volodko A, Zarubin A, Golovtsov V, Ivanov Y, Kim B, Levchenko P, Murzin V, Oreshkin V, Smirnov I, Sulimov V, Uvarov L, Vavilov S, Vorobyev A, Vorobyev A, Andreev Y, Dermenev A, Gninenko S, Golubev N, Kirsanov M, Krasnikov N, Matveev V, Pashenkov A, Toropin A, Troitsky S, Epshteyn V, Gavrilov V, Kaftanov V, Kossov M, Krokhotin A, Lychkovskaya N, Popov V, Safronov G, Semenov S, Stolin V, Vlasov E, Zhokin A, Boos E, Dubinin M, Dudko L, Ershov A, Gribushin A, Kodolova O, Lokhtin I, Markina A, Obraztsov S, Perfilov M, Petrushanko S, Sarycheva L, Savrin V, Snigirev A, Andreev V, Azarkin M, Dremin I, Kirakosyan M, Leonidov A, Rusakov SV, Vinogradov A, Azhgirey I, Bitioukov S, Grishin V, Kachanov V, Konstantinov D, Korablev A, Krychkine V, Petrov V, Ryutin R, Slabospitsky S, Sobol A, Tourtchanovitch L, Troshin S, Tyurin N, Uzunian A, Volkov A, Adzic P, Djordjevic M, Krpic D, Milosevic J, Aguilar-Benitez M, Maestre JA, Arce P, Battilana C, Calvo E, Cepeda M, Cerrada M, Llatas MC, Colino N, De La Cruz B, Peris AD, Pardos CD, Vazquez DD, Bedoya CF, Ramo JPF, Ferrando A, Flix J, Fouz MC, Garcia-Abia P, Lopez OG, Lopez SG, Hernandez JM, Josa MI, Merino G, Pelayo JP, Redondo I, Romero L, Santaolalla J, Soares MS, Willmott C, Albajar C, Codispoti G, de Troconiz JF, Cuevas J, Menendez JF, Folgueras S, Caballero IG, Iglesias LL, Garcia JMV, Cifuentes JAB, Cabrillo IJ, Calderon A, Chuang SH, Campderros JD, Felcini M, Fernandez M, Gomez G, Sanchez JG, Jorda C, Pardo PL, Virto AL, Marco J, Marco R, Rivero CM, Matorras F, Sanchez FJM, Gomez JP, Rodrigo T, Rodriguez-Marrero AY, Ruiz-Jimeno A, Scodellaro L, Sanudo MS, Vila I, Cortabitarte RV, Abbaneo D, Auffray E, Auzinger G, Baillon P, Ball AH, Barney D, Bell AJ, Benedetti D, Bernet C, Bialas W, Bloch P, Bocci A, Bolognesi S, Bona M, Breuker H, Bunkowski K, Camporesi T, Cerminara G, Christiansen T, Perez JAC, Cure B, D'Enterria D, De Roeck A, Di Guida S, Dupont-Sagorin N, Elliott-Peosert A, Frisch B, Funk W, Gaddi A, Georgiou G, Gerwig H, Gigi D, Gill K, Giordano D, Glege F, Garrido RGR, Gouzevitch M, Govoni P, Gowdy S, Guiducci L, Hansen M, Hartl C, Harvey J, Hegeman J, Hegner B, Hoffmann HF, Honma A, Innocente V, Jonot P, Kaadze K, Karavakis E, Lecoq P, Lourenco C, Maki T, Malberti M, Malgeri L, Mannelli M, Masetti L, Maurisset A, Meijers F, Mersi S, Meschi E, Moser R, Moser R, Mozer MU, Mulders M, Nesvold E, Nguyen M, Orimoto T, Orsini L, Perez E, Petrilli A, Pfeiffer A, Pierini M, Pimia M, Piparo D, Polese G, Racz A, Antunes JR, Rolandi G, Rommerskirchen T, Rovere M, Sakulin H, Schafer C, Schwick C, Segoni I, Sharma A, Siegrist P, Simon M, Sphicas P, Spiropulu M, Stoye M, Tadel M, Tropea P, Tsirou A, Vichoudis P, Voutilainen M, Zeuner WD, Bertl W, Deiters K, Erdmann W, Gabathuler K, Horisberger R, Ingram Q, Kaestli HC, Konig S, Kotlinski D, Langenegger U, Meier F, Renker D, Rohe T, Sibille J, Starodumov A, Bortignon P, Caminada L, Chanon N, Chen Z, Cittolin S, Dissertori G, Dittmar M, Eugster J, Freudenreich K, Grab C, Herve A, Hintz W, Lecomte P, Lustermann W, Marchica C, del Arbol PMR, Meridiani P, Milenovic P, Moortgat F, Nageli C, Nef P, Nessi-Tedaldi F, Pape L, Pauss F, Punz T, Rizzi A, Ronga FJ, Rossini M, Sala L, Sanchez AK, Sawley MC, Stieger B, Tauscher L, Thea A, Theofilatos K, Treille D, Urscheler C, Wallny R, Weber M, Wehrli L, Weng J, Aguilo E, Amsler C, Chiochia V, De Visscher S, Favaro C, Rikova MI, Mejias BM, Otiougova P, Regenfus C, Robmann P, Schmidt A, Snoek H, Chang YH, Chen KH, Dutta S, Kuo CM, Li SW, Lin W, Liu ZK, Lu YJ, Mekterovic D, Volpe R, Wu JH, Yu SS, Bartalini P, Chang P, Chang YH, Chang YW, Chao Y, Chen KF, Hou WS, Hsiung Y, Kao KY, Lei YJ, Lu RS, Shiu JG, Tzeng YM, Wang M, Adiguzel A, Bakirci MN, Cerci S, Dozen C, Dumanoglu I, Eskut E, Girgis S, Gokbulut G, Hos I, Kangal EE, Topaksu AK, Onengut G, Ozdemir K, Ozturk S, Polatoz A, Sogut K, Cerci DS, Tali B, Topakli H, Uzun D, Vergili LN, Vergili M, Yilmaz S, Akin IV, Aliev T, Bilmis S, Deniz M, Gamsizkan H, Guler AM, Ocalan K, Ozpineci A, Serin M, Sever R, Surat UE, Yildirim E, Zeyrek M, Deliomeroglu M, Demir D, Gulmez E, Isildak B, Kaya M, Kaya O, Ozkorucuklu S, Sonmez N, Levchuk L, Bostock F, Brooke JJ, Cheng TL, Clement E, Cussans D, Frazier R, Goldstein J, Grimes M, Hansen M, Hartley D, Heath GP, Heath HF, Kreczko L, Metson S, Newbold DM, Nirunpong K, Poll A, Senkin S, Smith VJ, Ward S, Basso L, Bell KW, Belyaev A, Brew C, Brown RM, Camanzi B, Cockerill DJA, Coughlan JA, Harder K, Harper S, Jackson J, Kennedy BW, Olaiya E, Petyt D, Radburn-Smith BC, Shepherd-Themistocleous CH, Tomalin IR, Womersley WJ, Worm SD, Bainbridge R, Ball G, Ballin J, Beuselinck R, Buchmuller O, Colling D, Cripps N, Cutajar M, Davies G, Della Negra M, Ferguson W, Fulcher J, Futyan D, Gilbert A, Bryer AG, Hall G, Hatherell Z, Hays J, Iles G, Jarvis M, Karapostoli G, Lyons L, MacEvoy BC, Magnan AM, Marrouche J, Mathias B, Nandi R, Nash J, Nikitenko A, Papageorgiou A, Pesaresi M, Petridis K, Pioppi M, Raymond DM, Rogerson S, Rompotis N, Rose A, Ryan MJ, Seez C, Sharp P, Sparrow A, Tapper A, Tourneur S, Acosta MV, Virdee T, Wakefield S, Wardle N, Wardrope D, Whyntie T, Barrett M, Chadwick M, Cole JE, Hobson PR, Khan A, Kyberd P, Leslie D, Martin W, Reid ID, Teodorescu L, Hatakeyama K, Liu H, Bose T, Jarrin EC, Fantasia C, Heister A, St John J, Lawson P, Lazic D, Rohlf J, Sperka D, Sulak L, Avetisyan A, Bhattacharya S, Chou JP, Cutts D, Ferapontov A, Heintz U, Jabeen S, Kukartsev G, Landsberg G, Luk M, Narain M, Nguyen D, Segala M, Sinthuprasith T, Speer T, Tsang KV, Breedon R, Sanchez MCD, Chauhan S, Chertok M, Conway J, Cox PT, Dolen J, Erbacher R, Friis E, Ko W, Kopecky A, Lander R, Liu H, Maruyama S, Miceli T, Nikolic M, Pellett D, Robles J, Salur S, Schwarz T, Searle M, Smith J, Squires M, Tripathi M, Sierra RV, Veelken C, Andreev V, Arisaka K, Cline D, Cousins R, Deisher A, Duris J, Erhan S, Farrell C, Hauser J, Ignatenko M, Jarvis C, Plager C, Rakness G, Schlein P, Tucker J, Valuev V, Babb J, Chandra A, Clare R, Ellison J, Gary JW, Giordano F, Hanson G, Jeng GY, Kao SC, Liu F, Liu H, Long OR, Luthra A, Nguyen H, Shen BC, Stringer R, Sturdy J, Sumowidagdo S, Wilken R, Wimpenny S, Andrews W, Branson JG, Cerati GB, Evans D, Golf F, Holzner A, Kelly R, Lebourgeois M, Letts J, Mangano B, Padhi S, Palmer C, Petrucciani G, Pi H, Pieri M, Ranieri R, Sani M, Sharma V, Simon S, Sudano E, Tu Y, Vartak A, Wasserbaech S, Wurthwein F, Yagil A, Yoo J, Barge D, Bellan R, Campagnari C, D'Alfonson M, Danielson T, Flowers K, Geffert P, Incandela J, Justus C, Kalavase P, Koay SA, Kovalskyi D, Krutelyov V, Lowette S, Mccoll N, Pavlunin V, Rebassoo F, Ribnik J, Richman J, Rossin R, Stuart D, To W, Vlimant JR, Apresyan A, Bornheim A, Bunn J, Chen Y, Gataullin M, Ma Y, Mott A, Newman HB, Rogan C, Shin K, Timciuc V, Traczyk P, Veverka J, Wilkinson R, Yang Y, Zhu RY, Akgun B, Carroll R, Ferguson T, Iiyama Y, Jang DW, Jun SY, Liu YF, Paulini M, Russ J, Vogel H, Vorobiev I, Cumalat JP, Dinardo ME, Drell BR, Edelmaier CJ, Ford WT, Gaz A, Heyburn B, Lopez EL, Nauenberg U, Smith JG, Stenson K, Ulmer KA, Wagner SR, Zang SL, Agostino L, Alexander J, Cassel D, Chatterjee A, Das S, Eggert N, Gibbons LK, Heltsley B, Hopkins W, Khukhunaishvili A, Kreis B, Kaufman GN, Patterson JR, Puigh D, Ryd A, Salvati E, Shi X, Sun W, Teo WD, Thom J, Thompson J, Vaughan J, Weng Y, Winstrom L, Wittich P, Biselli A, Cirino G, Winn D, Abdullin S, Albrow M, Anderson J, Apollinari G, Atac M, Bakken JA, Banerjee S, Bauerdick LAT, Beretvas A, Berryhill J, Bhat PC, Bloch I, Borcherding F, Burkett K, Butler JN, Chetluru V, Cheung HWK, Chlebana F, Cihangir S, Cooper W, Eartly DP, Elvira VD, Esen S, Fisk I, Freeman J, Gao Y, Gottschalk E, Green D, Gunthoti K, Gutsche O, Hanlon J, Harris RM, Hirschauer J, Hooberman B, Jensen H, Johnson M, Joshi U, Khatiwada R, Klima B, Kousouris K, Kunori S, Kwan S, Leonidopoulos C, Limon P, Lincoln D, Lipton R, Lykken J, Maeshima K, Marraffino JM, Mason D, McBride P, Miao T, Mishra K, Mrenna S, Musienko Y, Newman-Holmes C, O'Dell V, Pordes R, Prodofyev O, Saoulidou N, Sexton-Kennedy E, Sharma S, Spalding WJ, Spiegel L, Tan P, Taylor L, Tkaczyk S, Uplegger L, Vaandering EW, Vidal R, Whitmore J, Wu W, Yang F, Yumiceva F, Yun JC, Acosta D, Avery P, Bourilkov D, Chen M, De Gruttola M, Di Giovanni GP, Dobur D, Drozdetskiy A, Field RD, Fisher M, Fu Y, Furic IK, Gartner J, Kim B, Konigsberg J, Korytov A, Kropivnitskaya A, Kypreos T, Matchev K, Mitselmakher G, Muniz L, Prescott C, Remington R, Schmitt M, Scurlock B, Sellers P, Skhirtladze N, Snowball M, Wang D, Yelton J, Zakaria M, Ceron C, Gaultney V, Kramer L, Lebolo LM, Linn S, Markowitz P, Martinez G, Mesa D, Rodriguez JL, Adams T, Askew A, Bochenek J, Chen J, Diamond B, Gleyzer SV, Hass J, Hagopian S, Hagopian V, Jenkins M, Johnson KF, Prosper H, Quertenmont L, Sekmen S, Veeraraghavan V, Baarmand MM, Dorney B, Guragain S, Hohlmann M, Kalakhety H, Ralich R, Vodopiyanov I, Adams MR, Anghel IM, Apanasevich L, Bai Y, Bazterra VE, Betts RR, Callner J, Cavanaugh R, Dragoiu C, Gauthier L, Gerber CE, Hamdan S, Hofman DJ, Khalatyan S, Kunde GJ, Lacroix F, Malek M, O'Brien C, Silvestre C, Smoron A, Strom D, Varelas N, Akgun U, Albayrak EA, Bilki B, Clarida W, Duru F, Lae CK, McCliment E, Merlo JP, Mermerkaya H, Mestvirishvili A, Moeller A, Nachtman J, Newsom CR, Norbeck E, Olson J, Onel Y, Ozok F, Sen S, Wetzel J, Yetkin T, Yi K, Barnett BA, Blumenfeld B, Bonato A, Eskew C, Fehling D, Giurgiu G, Gritsan AV, Guo ZJ, Hu G, Maksimovic P, Rappoccio S, Swartz M, Tran NV, Whitbeck A, Baringer P, Bean A, Benelli G, Grachov O, Kenny RP, Murray M, Noonan D, Sanders S, Wood JS, Zhukova V, Barfuss AF, Bolton T, Chakaberia I, Ivanov A, Khalil S, Makouski M, Maravin Y, Shrestha S, Svintradez I, Wan Z, Gronberg J, Lange D, Wright D, Baden A, Boutemeur M, Eno SC, Ferencek D, Gomez JA, Hadley NJ, Kellogg RG, Kirn M, Lu Y, Mignerey AC, Rossato K, Rumerio P, Santanastasio F, Skuja A, Temple J, Tonjes MB, Tonwar SC, Twedt E, Alver B, Bauer G, Bendavid J, Busza W, Butz E, Cali IA, Chan M, Dutta V, Everaerts P, Ceballos GG, Goncharov M, Hahn KA, Harris P, Kim Y, Klute M, Lee YJ, Li W, Loizides C, Luckey PD, Ma T, Nahn S, Paus C, Ralph D, Roland C, Roland G, Rudolph M, Stephans GSF, Stockli F, Sumorok K, Sung K, Wenger EA, Wolf R, Xie S, Yang M, Yilmaz Y, Yoon AS, Zanetti M, Cooper SI, Cushman P, Dahmes B, De Benedetti A, Dudero PR, Franzoni G, Haupt J, Klapoetke K, Kubota Y, Mans J, Rekovic V, Rusack R, Sasseville M, Singovsky A, Cremaldi LM, Godang R, Kroeger R, Perera L, Rahmat R, Sanders DA, Summers D, Bloom K, Bose S, Butt J, Claes DR, Dominguez A, Eads M, Keller J, Kelly T, Kravchenko I, Lazo-Flores J, Malbouisson H, Malik S, Snow GR, Baur U, Godshalk A, Iashvili I, Jain S, Kharchilava A, Kumar A, Shipkowski SP, Smith K, Alverson G, Barberis E, Baumgartel D, Boeriu O, Chasco M, Reucroft S, Swain J, Trocino D, Wood D, Zhang J, Anastassov A, Kubik A, Odell N, Ofierzynski RA, Pollack B, Pozdnyakov A, Schmitt M, Stoynev S, Velasco M, Won S, Antonelli L, Berry D, Hildreth M, Jessop C, Karmgard DJ, Kolb J, Kolberg T, Lannon K, Luo W, Lynch S, Marinelli N, Morse DM, Pearson T, Ruchti R, Slaunwhite J, Valls N, Wayne M, Ziegler J, Bylsma B, Durkin LS, Gu J, Hill C, Killewald P, Kotov K, Ling TY, Rodenburg M, Williams G, Adam N, Berry E, Elmer P, Gerbaudo D, Halyo V, Hebda P, Hunt A, Jones J, Laird E, Pegna DL, Marlow D, Medvedeva T, Mooney M, Olsen J, Piroue P, Quan X, Saka H, Stickland D, Tully C, Werner JS, Zuranski A, Acosta JG, Hunag XT, Lopez A, Mendez H, Oliveros S, Vargas JER, Zatserklyaniy A, Alagoz E, Barnes VE, Bolla G, Borrello L, Bortoletto D, Everett A, Garfinkel AF, Gutay L, Hu Z, Jones M, Koybasi O, Kress M, Laasanen AT, Leonardo N, Liu C, Maroussov V, Merkel P, Miller DH, Neumeister N, Shipsey I, Silvers D, Svyatkovskiy A, Yoo HD, Zablocki J, Zheng Y, Jindal P, Parashar N, Boulahouache C, Cuplov V, Ecklund KM, Geurts FJM, Padley BP, Redjimi R, Roberts J, Zabel J, Betchart B, Bodek A, Chung YS, Covarelli R, de Barbaro P, Demina R, Eshaq Y, Flacher H, Garcia-Bellido A, Goldenzweig P, Gotra Y, Han J, Harel A, Miner DC, Orbaker D, Petrillo G, Vishnevskiy D, Zielinski M, Bhatti A, Ciesielski R, Demortier L, Goulianos K, Lungu G, Malik S, Mesropian C, Yan M, Atramentov O, Barker A, Duggan D, Gershtein Y, Gray R, Halkiadakis E, Hidas D, Hits D, Lath A, Panwalkar S, Patel R, Richards A, Rose K, Schnetzer S, Somalwar S, Stone R, Thomas S, Cerizza G, Hollingsworth M, Spanier S, Yang ZC, York A, Eusebi R, Gilmore J, Gurrola A, Kamon T, Khotilovich V, Montalvo R, Osipenkov I, Pakhotin Y, Pivarski J, Safonov A, Sengupta S, Tatarinov A, Toback D, Weinberger M, Akchurin N, Bardak C, Damgov J, Jeong C, Kovitanggoon K, Lee SW, Mane P, Roh Y, Sill A, Volobouev I, Wigmans R, Yazgan E, Appelt E, Brownson E, Engh D, Florez C, Gabella W, Issah M, Johns W, Kurt P, Maguire C, Melo A, Sheldon P, Snook B, Tuo S, Velkovska J, Arenton MW, Balazs M, Boutle S, Cox B, Francis B, Hirosky R, Ledovskoy A, Lin C, Neu C, Yohay R, Gollapinni S, Harr R, Karchin PE, Lamichhane P, Mattson M, Milstene C, Sakharov A, Anderson M, Bachtis M, Bellinger JN, Carlsmith D, Dasu S, Efron J, Flood K, Gray L, Grogg KS, Grothe M, Hall-Wilton R, Herndon M, Klabbers P, Klukas J, Lanaro A, Lazaridis C, Leonard J, Loveless R, Mohapatra A, Palmonari F, Reeder D, Ross I, Savin A, Smith WH, Swanson J, Weinberg M
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Missing transverse energy performance of the CMS detector
JOURNAL OF INSTRUMENTATION 2011 SEP; 6(?):? Article P09001
During 2010 the LHC delivered pp collisions with a centre-of-mass energy of 7 TeV. paper, the results of comprehensive studies of missing transverse energy as measured by the CMS detector are presented. The results cover the measurements of the scale and resolution for missing transverse energy, and the effects of multiple pp interactions within the same bunch crossings on the scale and resolution. Anomalous measurements of missing transverse energy are studied, and algorithms for their identification are described. The performance of several reconstruction algorithms for calculating missing transverse energy are compared. An algorithm, called missing-transverse-energy significance, which estimates the compatibility of the reconstructed missing transverse energy with zero, is described, and its performance is demonstrated.
Boisson B, Lacroix C, Bischoff E, Gueirard P, Bargieri DY, Franke-Fayard B, Janse CJ, Menard R, Baldacci P
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The novel putative transporter NPT1 plays a critical role in early stages of Plasmodium berghei sexual development
MOLECULAR MICROBIOLOGY 2011 SEP; 81(5):1343-1357
Transmission of Plasmodium species from a mammalian host to the mosquito vector requires the uptake, during an infected blood meal, of gametocytes, the precursor cells of the gametes. Relatively little is known about the molecular mechanisms involved in the developmental switch from asexual development to sexual differentiation or the maturation and survival of gametocytes. Here, we show that a gene coding for a novel putative transporter, NPT1, plays a crucial role in the development of Plasmodium berghei gametocytes. Parasites lacking NPT1 are severely compromised in the production of gametocytes and the rare gametocytes produced are unable to differentiate into fertile gametes. This is the earliest block in gametocytogenesis obtained by reverse genetics and the first to demonstrate the role of a protein with a putative transport function in sexual development. These results and the high degree of conservation of NPT1 in Plasmodium species suggest that this protein could be an attractive target for the development of novel drugs to block the spread of malaria.
Biswas D, Milne TA, Basrur V, Kim J, Elenitoba-Johnson KSJ, Allis CD, Roeder RG
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Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2011 SEP 20; 108(38):15751-15756
A number of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a variety of fusion partners that have been reported to reside in one or more poorly defined complexes linked to transcription elongation through interactions with the histone H3-K79 methyltransferase DOT1 and positive transcription elongation factor b (P-TEFb). Here we first identify natural complexes (purified through fusion partners AF9, AF4, and ELL) with overlapping components, different elongation activities, and different cofactor associations that suggest dynamic interactions. Then, through reconstitution of defined, functionally active minimal complexes, we identify stable subcomplexes that, through newly defined protein-protein interactions, form distinct higher order complexes. These definitive analyses show, for example, that (i) through direct interactions with AF9 and cyclinT1, family members AF4 and AFF4 independently mediate association of P-TEFb with AF9, (ii) P-TEFb, through direct interactions, provides the link for association of ELL and ELL-associated factors 1 and 2 (EAF1 and EAF2) with AF4, and (iii) in the absence of other factors, DOT1 forms a stable complex with AF9 and does not interact with AF9.AF4.P-TEFb complexes. Finally, we show the importance of defined higher order complex formation in MLL-AF9-mediated transcriptional up-regulation and cell immortalization potential in vivo. Thus, our study provides direct mechanistic insight into the role of fusion partners in MLL fusion-mediated leukemogenesis.
Aaltonen T, Gonzalez BA, Amerio S, Amidei D, Anastassov A, Annovi A, Antos J, Apollinari G, Appel JA, Apresyan A, Arisawa T, Artikov A, Asaadi J, Ashmanskas W, Auerbach B, Aurisano A, Azfar F, Badgett W, Barbaro-Galtieri A, Barnes VE, Barnett BA, Barria P, Bartos P, Bauce M, Bauer G, Bedeschi F, Beecher D, Behari S, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Bhatti A, Binkley M, Bisello D, Bizjak I, Bland KR, Blumenfeld B, Bocci A, Bodek A, Bortoletto D, Boudreau J, Boveia A, Brau B, Brigliadori L, Brisuda A, Bromberg C, Brucken E, Bucciantonio M, Budagov J, Budd HS, Budd S, Burkett K, Busetto G, Bussey P, Buzatu A, Calancha C, Camarda S, Campanelli M, Campbell M, Canelli F, Canepa A, Carls B, Carlsmith D, Carosi R, Carrillo S, Carron S, Casal B, Casarsa M, Castro A, Catastini P, Cauz D, Cavaliere V, Cavalli-Sforza M, Cerri A, Cerrito L, Chen YC, Chertok M, Chiarelli G, Chlachidze G, Chlebana F, Cho K, Chokheli D, Chou JP, Chung WH, Chung YS, Ciobanu CI, Ciocci MA, Clark A, Compostella G, Convery ME, Conway J, Corbo M, Cordelli M, Cox CA, Cox DJ, Crescioli F, Almenar CC, Cuevas J, Culbertson R, Dagenhart D, d'Ascenzo N, Datta M, de Barbaro P, De Cecco S, De Lorenzo G, Dell'Orso M, Deluca C, Demortier L, Deng J, Deninno M, Devoto F, d'Errico M, Di Canto A, Di Ruzza B, Dittmann JR, D'Onofrio M, Donati S, Dong P, Dorigo M, Dorigo T, Ebina K, Elagin A, Eppig A, Erbacher R, Errede D, Errede S, Ershaidat N, Eusebi R, Fang HC, Farrington S, Feindt M, Fernandez JP, Ferrazza C, Field R, Flanagan G, Forrest R, Frank MJ, Franklin M, Freeman JC, Funakoshi Y, Furic I, Gallinaro M, Galyardt J, Garcia JE, Garfinkel AF, Garosi P, Gerberich H, Gerchtein E, Giagu S, Giakoumopoulou V, Giannetti P, Gibson K, Ginsburg CM, Giokaris N, Giromini P, Giunta M, Giurgiu G, Glagolev V, Glenzinski D, Gold M, Goldin D, Goldschmidt N, Golossanov A, Gomez G, Gomez-Ceballos G, Goncharov M, Gonzalez O, Gorelov I, Goshaw AT, Goulianos K, Gresele A, Grinstein S, Grosso-Pilcher C, Group RC, da Costa JG, Gunay-Unalan Z, Haber C, Hahn SR, Halkiadakis E, Hamaguchi A, Han JY, Happacher F, Hara K, Hare D, Hare M, Harr RF, Hatakeyama K, Hays C, Heck M, Heinrich J, Herndon M, Hewamanage S, Hidas D, Hocker A, Hopkins W, Horn D, Hou S, Hughes RE, Hurwitz M, Husemann U, Hussain N, Hussein M, Huston J, Introzzi G, Iori M, Ivanov A, James E, Jang D, Jayatilaka B, Jeon EJ, Jha MK, Jindariani S, Johnson W, Jones M, Joo KK, Jun SY, Junk TR, Kamon T, Karchin PE, Kato Y, Ketchum W, Keung J, Khotilovich V, Kilminster B, Kim DH, Kim HS, Kim HW, Kim JE, Kim MJ, Kim SB, Kim SH, Kim YK, Kimura N, Kirby M, Klimenko S, Kondo K, Kong DJ, Konigsberg J, Kotwal AV, Kreps M, Kroll J, Krop D, Krumnack N, Kruse M, Krutelyov V, Kuhr T, Kurata M, Kwang S, Laasanen AT, Lami S, Lammel S, Lancaster M, Lander RL, Lannon K, Lath A, Latino G, Lazzizzera I, LeCompte T, Lee E, Lee HS, Lee JS, Lee SW, Leo S, Leone S, Lewis JD, Lin CJ, Linacre J, Lindgren M, Lipeles E, Lister A, Litvintsev DO, Liu C, Liu Q, Liu T, Lockwitz S, Lockyer NS, Loginov A, Lucchesi D, Lueck J, Lujan P, Lukens P, Lungu G, Lys J, Lysak R, Madrak R, Maeshima K, Makhoul K, Maksimovic P, Malik S, Manca G, Manousakis-Katsikakis A, Margaroli F, Marino C, Martinez M, Martinez-Ballarin R, Mastrandrea P, Mathis M, Mattson ME, Mazzanti P, McFarland KS, McIntyre P, McNulty R, Mehta A, Mehtala P, Menzione A, Mesropian C, Miao T, Mietlicki D, Mitra A, Miyake H, Moed S, Moggi N, Mondragon MN, Moon CS, Moore R, Morello MJ, Morlock J, Fernandez PM, Mukherjee A, Muller T, Murat P, Mussini M, Nachtman J, Nagai Y, Naganoma J, Nakano I, Napier A, Nett J, Neu C, Neubauer MS, Nielsen J, Nodulman L, Norniella O, Nurse E, Oakes L, Oh SH, Oh YD, Oksuzian I, Okusawa T, Orava R, Ortolan L, Griso SP, Pagliarone C, Palencia E, Papadimitriou V, Paramonov AA, Patrick J, Pauletta G, Paulini M, Paus C, Pellett DE, Penzo A, Phillips TJ, Piacentino G, Pianori E, Pilot J, Pitts K, Plager C, Pondrom L, Potamianos K, Poukhov O, Pranko A, Prokoshin F, Ptohos F, Pueschel E, Punzi G, Pursley J, Rahaman A, Ramakrishnan V, Ranjan N, Redondo I, Renton P, Rescigno M, Rimondi F, Ristori L, Robson A, Rodrigo T, Rodriguez T, Rogers E, Rolli S, Roser R, Rossi M, Rubbo F, Ruffini F, Ruiz A, Russ J, Rusu V, Safonov A, Sakumoto WK, Sakurai Y, Santi L, Sartori L, Sato K, Saveliev V, Savoy-Navarro A, Schlabach P, Schmidt A, Schmidt EE, Schmidt MP, Schmitt M, Schwarz T, Scodellaro L, Scribano A, Scuri F, Sedov A, Seidel S, Seiya Y, Semenov A, Sforza F, Sfyrla A, Sgalaberna D, Shalhout SZ, Shears T, Shepard PF, Shimojima M, Shiraishi S, Shochet M, Shreyber I, Simonenko A, Sinervo P, Sissakian A, Sliwa K, Smith JR, Snider FD, Soha A, Somalwar S, Sorin V, Squillacioti P, Stancari M, Stanitzki M, Denis RS, Stelzer B, Stelzer-Chilton O, Stentz D, Strologas J, Strycker GL, Sudo Y, Sukhanov A, Suslov I, Takemasa K, Takeuchi Y, Tang J, Tecchio M, Teng PK, Thom J, Thome J, Thompson GA, Thomson E, Ttito-Guzman P, Tkaczyk S, Toback D, Tokar S, Tollefson K, Tomura T, Tonelli D, Torre S, Torretta D, Totaro P, Trovato M, Tu Y, Ukegawa F, Uozumi S, Varganov A, Vazquez F, Velev G, Vellidis C, Vidal M, Vila I, Vilar R, Vizan J, Vogel M, Volpi G, Wagner P, Wagner RL, Wakisaka T, Wallny R, Wang SM, Warburton A, Waters D, Weinberger M, Wester WC, Whitehouse B, Whiteson D, Wicklund AB, Wicklund E, Wilbur S, Wick F, Williams HH, Wilson JS, Wilson P, Winer BL, Wittich P, Wolbers S, Wolfe H, Wright T, Wu X, Wu Z, Yamamoto K, Yamaoka J, Yang T, Yang UK, Yang YC, Yao WM, Yeh GP, Yi K, Yoh J, Yorita K, Yoshida T, Yu GB, Yu I, Yu SS, Yun JC, Zanetti A, Zeng Y, Zucchelli S
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Measurement of the Cross Section for Prompt Isolated Diphoton Production in p (p)over-bar Collisions at root s=1.96 TeV
PHYSICAL REVIEW LETTERS 2011 SEP 2; 107(10):? Article 102003
This Letter reports a measurement of the cross section of prompt isolated photon pair production in p (p) over bar collisions at a total energy root s = 1.96 TeV using data of 5.36 fb(-1) integrated luminosity collected with the CDF II detector at the Fermilab Tevatron. The measured cross section, differential in basic kinematic variables, is compared with three perturbative QCD predictions, a leading order parton shower calculation and two next- to- leading order calculations. The next-to-leading order calculations reproduce most aspects of the data. By including photon radiation from quarks before and after hard scattering, the parton shower prediction becomes competitive with the next-to-leading order predictions.
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Measurement of branching ratio and B-s(0) lifetime in the decay B-s(0) -> J/psi f(0)(980) at CDF
PHYSICAL REVIEW D 2011 SEP 30; 84(5):? Article 052012
We present a study of B-s(0) decays to the CP-odd final state J/psi f(0)(980) with J/psi -> mu(+)mu(-) and f(0)(980) -> pi(+)pi(-). Using p(p) over bar $ collision data with an integrated luminosity of 3.8 fb(-1) collected by the CDF II detector at the Tevatron we measure a B-s(0) lifetime of tau(B-s(0) -> J/psi f(0)(980)) = 1.70(-0.11)(+0.12)(stat) +/- 0.03(syst)ps. This is the first measurement of the B-s(0) lifetime in a decay to a CP eigenstate and corresponds in the standard model to the lifetime of the heavy B-s(0) eigenstate. We also measure the product of branching fractions of B-s(0) -> J/psi f(0)(980) and f(0)(980) -> pi(+)pi(-) relative to the product of branching fractions of B-s(0) -> J/psi phi and phi -> K+K- to be R-f0/phi = 0.257 +/- 0: 020(stat) +/- 0.014(syst), which is the most precise determination of this quantity to date.