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Danese A, McEwen BS
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Adverse childhood experiences, allostasis, allostatic load, and age-related disease
PHYSIOLOGY & BEHAVIOR 2012 APR 12; 106(1):29-39
How do adverse childhood experiences get 'under the skin' and influence health outcomes through the life-course? Research reviewed here suggests that adverse childhood experiences are associated with changes in biological systems responsible for maintaining physiological stability through environmental changes, or allostasis. Children exposed to maltreatment showed smaller volume of the prefrontal cortex, greater activation of the HPA axis, and elevation in inflammation levels compared to non-maltreated children. Adults with a history of childhood maltreatment showed smaller volume of the prefrontal cortex and hippocampus, greater activation of the HPA axis, and elevation in inflammation levels compared to non-maltreated individuals. Despite the clear limitations in making longitudinal claims from cross-sectional studies, work so far suggests that adverse childhood experiences are associated with enduring changes in the nervous, endocrine, and immune systems. These changes are already observable in childhood years and remain apparent in adult life. Adverse childhood experiences induce significant biological changes in children (biological embedding), modifying the maturation and the operating balance of allostatic systems. Their chronic activation can lead to progressive wear and tear, or allostatic load and overload, and, thus, can exert long-term effects on biological aging and health. (C) 2011 Elsevier Inc. All rights reserved.
Islam K, Bothwell I, Chen YL, Sengelaub C, Wang R, Deng HT, Luo MK
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Bioorthogonal Profiling of Protein Methylation Using Azido Derivative of S-Adenosyl-L-methionine
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2012 APR 4; 134(13):5909-5915
Protein methyltransferases (PMTs) play critical roles in multiple biological processes. Because PMTs often function in vivo through forming multimeric protein complexes, dissecting their activities in the native contexts is challenging but relevant. To address such a need, we envisioned a Bioorthogonal Profiling of Protein Methylation (BPPM) technology, in which a SAM analogue cofactor can be utilized by multiple rationally engineered PMTs to label substrates of the corresponding native PMTs. Here, 4-azidobut-2-enyl derivative of S-adenosyl-L-methionine (Ab-SAM) was reported as a suitable BPPM cofactor. The resultant cofactor enzyme pairs were implemented to label specifically the substrates of closely related PMTs (e.g., EuHMT1 and EuHMT2) in a complex cellular mixture. The BPPM approach, coupled with mass spectrometric analysis, enables the identification of the nonhistone targets of EuHMT1/2. Comparison of EuHMT1/2's methylomes indicates that the two human PMTs, although similar in terms of their primary sequences, can act on the distinct sets of nonhistone targets. Given the conserved active sites of PMTs, Ab-SAM and its use in BPPM are expected to be transferable to other PMTs for target identification.
Rolo J, Miragaia M, Turlej-Rogacka A, Empel J, Bouchami O, Faria NA, Tavares A, Hryniewicz W, Fluit AC, de Lencastre H
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High Genetic Diversity among Community-Associated Staphylococcus aureus in Europe: Results from a Multicenter Study
PLOS ONE 2012 APR 27; 7(4):? Article e34768
Background: Several studies have addressed the epidemiology of community-associated Staphylococcus aureus (CA-SA) in Europe; nonetheless, a comprehensive perspective remains unclear. In this study, we aimed to describe the population structure of CA-SA and to shed light on the origin of methicillin-resistant S. aureus (MRSA) in this continent. Methods and Findings: A total of 568 colonization and infection isolates, comprising both MRSA and methicillin-susceptible S. aureus (MSSA), were recovered in 16 European countries, from community and community-onset infections. The genetic background of isolates was characterized by molecular typing techniques (spa typing, pulsed-field gel electrophoresis and multilocus sequence typing) and the presence of PVL and ACME was tested by PCR. MRSA were further characterized by SCCmec typing. We found that 59% of all isolates were associated with community-associated clones. Most MRSA were related with USA300 (ST8-IVa and variants) (40%), followed by the European clone (ST80-IVc and derivatives) (28%) and the Taiwan clone (ST59-IVa and related clonal types) (15%). A total of 83% of MRSA carried Panton-Valentine leukocidin (PVL) and 14% carried the arginine catabolic mobile element (ACME). Surprisingly, we found a high genetic diversity among MRSA clonal types (ST-SCCmec), Simpson's index of diversity = 0.852 (0.788-0.916). Specifically, about half of the isolates carried novel associations between genetic background and SCCmec. Analysis by BURP showed that some CA-MSSA and CA-MRSA isolates were highly related, suggesting a probable local acquisition/loss of SCCmec. Conclusions: Our results imply that CA-MRSA origin, epidemiology and population structure in Europe is very dissimilar from that of USA.
Aaltonen T, Gonzalez BA, Amerio S, Amidei D, Anastassov A, Annovi A, Antos J, Apollinari G, Appel JA, Arisawa T, Artikov A, Asaadi J, Ashmanskas W, Auerbach B, Aurisano A, Azfar F, Badgett W, Bae T, Barbaro-Galtieri A, Barnes VE, Barnett BA, Barria P, Bartos P, Bauce M, Bedeschi F, Beecher D, Behari S, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Bhatti A, Binkley M, Bisello D, Bizjak I, Bland KR, Blumenfeld B, Bocci A, Bodek A, Bortoletto D, Boudreau J, Boveia A, Brigliadori L, Bromberg C, Brucken E, Budagov J, Budd HS, Burkett K, Busetto G, Bussey P, Buzatu A, Calamba A, Calancha C, Camarda S, Campanelli M, Campbell M, Canelli F, Carls B, Carlsmith D, Carosi R, Carrillo S, Carron S, Casal B, Casarsa M, Castro A, Catastini P, Cauz D, Cavaliere V, Cavalli-Sforza M, Cerri A, Cerrito L, Chen YC, Chertok M, Chiarelli G, Chlachidze G, Chlebana F, Cho K, Chokheli D, Chung WH, Chung YS, Ciocci MA, Clark A, Clarke C, Compostella G, Convery ME, Conway J, Corbo M, Cordelli M, Cox CA, Cox DJ, Crescioli F, Cuevas J, Culbertson R, Dagenhart D, d'Ascenzo N, Datta M, de Barbaro P, Dell'Orso M, Demortier L, Deninno M, Devoto F, d'Errico M, Canto A, Di Ruzza B, Dittmann JR, D'Onofrio M, Donati S, Dong P, Dorigo M, Dorigo T, Ebina K, Elagin A, Eppig A, Erbacher R, Errede S, Ershaidat N, Eusebi R, Farrington S, Feindt M, Fernandez JP, Field R, Flanagan G, Forrest R, Frank MJ, Franklin M, Freeman JC, Funakoshi Y, Furic I, Gallinaro M, Garcia JE, Garfinkel AF, Garosi P, Gerberich H, Gerchtein E, Giagu S, Giakoumopoulou V, Giannetti P, Gibson K, Ginsburg CM, Giokaris N, Giromini P, Giurgiu G, Glagolev V, Glenzinski D, Gold M, Goldin D, Goldschmidt N, Golossanov A, Gomez G, Gomez-Ceballos G, Goncharov M, Gonzalez O, Gorelov I, Goshaw AT, Goulianos K, Grinstein S, Grosso-Pilcher C, Group RC, da Costa JG, Hahn SR, Halkiadakis E, Hamaguchi A, Han JY, Happacher F, Hara K, Hare D, Hare M, Harr RF, Hatakeyama K, Hays C, Heck M, Heinrich J, Herndon M, Hewamanage S, Hocker A, Hopkins W, Horn D, Hou S, Hughes RE, Hurwitz M, Husemann U, Hussain N, Hussein M, Huston J, Introzzi G, Iori M, Ivanov A, James E, Jang D, Jayatilaka B, Jeon EJ, Jindariani S, Jones M, Joo KK, Jun SY, Junk TR, Kamon T, Karchin PE, Kasmi A, Kato Y, Ketchum W, Keung J, Khotilovich V, Kilminster B, Kim DH, Kim HS, Kim JE, Kim MJ, Kim SB, Kim SH, Kim YK, Kim YJ, Kimura N, Kirby M, Klimenko S, Knoepfel K, Kondo K, Kong DJ, Konigsberg J, Kotwal AV, Kreps M, Kroll J, Krop D, Kruse M, Krutelyov V, Kuhr T, Kurata M, Kwang S, Laasanen AT, Lami S, Lammel S, Lancaster M, Lander RL, Lannon K, Lath A, Latino G, LeCompte T, Lee E, Lee HS, Lee JS, Lee SW, Leo S, Leone S, Lewis JD, Limosani A, Lin CJ, Lindgren M, Lipeles E, Lister A, Litvintsev DO, Liu C, Liu H, Liu Q, Liu T, Lockwitz S, Loginov A, Lucchesi D, Lueck J, Lujan P, Lukens P, Lungu G, Lys J, Lysak R, Madrak R, Maeshima K, Maestro P, Malik S, Manca G, Manousakis-Katsikakis A, Margaroli F, Marino C, Martinez M, Mastrandrea P, Matera K, Mattson ME, Mazzacane A, Mazzanti P, McFarland KS, McIntyre P, McNulty R, Mehta A, Mehtala P, Mesropian C, Miao T, Mietlicki D, Mitra A, Miyake H, Moed S, Moggi N, Mondragon MN, Moon CS, Moore R, Morello MJ, Morlock J, Fernandez PM, Mukherjee A, Muller T, Murat P, Mussini M, Nachtman J, Nagai Y, Naganoma J, Nakano I, Napier A, Nett J, Neu C, Neubauer MS, Nielsen J, Nodulman L, Noh SY, Norniella O, Nurse E, Oakes L, Oh SH, Oh YD, Oksuzian I, Okusawa T, Orava R, Ortolan L, Griso SP, Pagliarone C, Palencia E, Papadimitriou V, Paramonov AA, Patrick J, Pauletta G, Paulini M, Paus C, Pellett DE, Penzo A, Phillips TJ, Piacentino G, Pianori E, Pilot J, Pitts K, Plager C, Pondrom L, Poprocki S, Potamianos K, Prokoshin F, Pranko A, Ptohos F, Punzi G, Rahaman A, Ramakrishnan V, Ranjan N, Redondo I, Renton P, Rescigno M, Riddick T, Rimondi F, Ristori L, Robson A, Rodrigo T, Rodriguez T, Rogers E, Rolli S, Roser R, Ruffini F, Ruiz A, Russ J, Rusu V, Safonov A, Sakumoto WK, Sakurai Y, Santi L, Sato K, Saveliev V, Savoy-Navarro A, Schlabach P, Schmidt A, Schmidt EE, Schwarz T, Scodellaro L, Scribano A, Scuri F, Seidel S, Seiya Y, Semenov A, Sforza F, Shalhout SZ, Shears T, Shekhar R, Shepard PF, Shimojima M, Shochet M, Shreyber-Tecker I, Simonenko A, Sinervo P, Sliwa K, Smith JR, Snider FD, Soha A, Sorin V, Song H, Squillacioti P, Stancari M, St Denis R, Stelzer B, Stelzer-Chilton O, Stentz D, Strologas J, Strycker GL, Sudo Y, Sukhanov A, Sun S, Suslov I, Takemasa K, Takeuchi Y, Tang J, Tecchio M, Teng PK, Thom J, Thome J, Thompson DS, Thompson GA, Thomson E, Toback D, Tokar S, Tollefson K, Tomura T, Tonelli D, Torre S, Torretta D, Totaro P, Trovato M, Ukegawa F, Uozumi S, Varganov A, Vazquez F, Velev G, Vellidis C, Vidal M, Vila I, Vilar R, Vizan J, Vogel M, Volpi G, Wagner P, Wagner RL, Wakisaka T, Wallny R, Wang SM, Warburton A, Waters D, Wester WC, Whiteson D, Wicklund AB, Wicklund E, Wilbur S, Wick F, Williams HH, Wilson JS, Wilson P, Winer BL, Wittich P, Wolbers S, Wolfe H, Wright T, Wu X, Wu Z, Yamamoto K, Yamato D, Yang T, Yang UK, Yang YC, Yao WM, Yeh GP, Yi K, Yoh J, Yorita K, Yoshida T, Yu GB, Yu I, Yu SS, Yun JC, Zanetti A, Zeng Y, Zhou C, Zucchelli S
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Precise Measurement of the W-Boson Mass with the CDF II Detector
PHYSICAL REVIEW LETTERS 2012 APR 12; 108(15):? Article 151803
We have measured the W-boson mass MW using data corresponding to 2.2 fb(-1) of integrated luminosity collected in p (p) over bar collisions at root s = 1.96 TeV with the CDF II detector at the Fermilab Tevatron collider. Samples consisting of 470 126 W -> e nu candidates and 624 708 W -> mu nu candidates yield the measurement M-W = 80 387 +/- 12(stat.) +/- 15(syst.) = 80 387 +/- 19 MeV/c(2). This is the most precise measurement of the W-boson mass to date and significantly exceeds the precision of all previous measurements combined.
Kiang L, Sippel KC, Starr CE, Ciralsky J, Rosenblatt MI, Radcliffe NM, D'Amico DJ, Kiss S
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Vitreoretinal Surgery in the Setting of Permanent Keratoprosthesis
ARCHIVES OF OPHTHALMOLOGY 2012 APR; 130(4):487-492
Objectives: To evaluate the surgical management of vitreoretinal pathology in patients with a permanent Boston Type 1 keratoprosthesis (hereafter referred to as a KPro) in the era of small-gauge vitrectomy techniques. Methods: Retrospective review of 23 small-gauge vitreoretinal surgical procedures during or after Dohlman-Doane KPro placement in 14 eyes. Results: Established and innovative techniques were used, including sutureless small-gauge vitrectomy, temporal positioning of surgeon, long-term tamponades, and exploratory endoscopy. Retro-KPro membranes formed less frequently when vitrectomy was performed during KPro placement. Anatomical goals were achieved, and no serious complications directly resulted from these techniques. Visual acuity, frequently limited by preexisting pathology, improved in most cases. Conclusions: Modern posterior segment surgical techniques, including small-gauge sutureless vitrectomy, can be effectively used for patients with a permanent KPro. Vitrectomy and glaucoma tube revision by a team of subspecialists at the time of KPro placement may reduce subsequent complications.
Spiteri T, Ogawa S, Musatov S, Pfaff DW, Agmo A
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The role of the estrogen receptor a in the medial preoptic area in sexual incentive motivation, proceptivity and receptivity, anxiety, and wheel running in female rats
BEHAVIOURAL BRAIN RESEARCH 2012 APR 21; 230(1):11-20
Ovariectomized females were given an infusion in the medial preoptic area (MPOA) of a viral vector carrying either a shRNA directed against the estrogen receptor a (ERet) or luciferase. The females were subjected to a test for sexual incentive motivation immediately followed by a test for receptivity and proceptive behaviors. Two weeks later they were tested in the light/dark choice procedure, and after another 2 weeks they were subjected to a test in a brightly lit open field. Finally, the females were given free access to a running wheel for 88 h. The females were treated with estradiol benzoate (EB), 18 or 1.5 mu g/kg, in randomized order 52 h before each test except the running wheel. In that experiment, they were given EB 48 h after introduction into the wheel cage. They were given progesterone, 1 mg/rat, about 4 h before all tests, except the running wheel. The shRNA reduced the number of ER alpha with 83%. Females with few ER alpha in the MPOA showed increased lordosis quotient after the 1.5 mu g/kg dose of EB. There was no effect on proceptive behaviors or on rejections. When given the 18 mu g/kg EB dose, there was no difference between females with few preoptic ER alpha and controls. In the test for sexual incentive motivation, females with few preoptic ER alpha approached the castrated male incentive more than controls, regardless of EB dose. They also moved a shorter distance. In the light/dark choice test as well as in the open field, females with few ER alpha in the MPOA showed signs of reduced fear/anxiety, since they spent more time in the light part of the dark/light box and in the center of the open field. Finally, the data from the running wheel showed that females with few preoptic ER alpha failed to show enhanced activity after treatment with EB. These data show that the preoptic ER alpha inhibits lordosis in females with an intermediate level of receptivity while it fails to do so in fully receptive females. The ER alpha in the MPOA seems to be necessary for selective approach to a sexual incentive. Finally, activation of this receptor appears to have anxiogenic effects in the procedures employed here. A hypothesis for how all these actions of the preoptic ER alpha contributes to efficient reproductive behavior is outlined. (C) 2012 Elsevier B.V. All rights reserved.
Kaunzner UW, Miller MM, Gottfried-Blackmore A, Gal-Toth J, Felger JC, McEwen BS, Bulloch K
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Accumulation of resident and peripheral dendritic cells in the aging CNS
NEUROBIOLOGY OF AGING 2012 APR; 33(4):681-+
Dendritic cells (DC) are specialized antigen-presenting cells, responsible for peripheral immune responses. Recently, resident brain dendritic cells (bDC) were identified and functionally characterized in the young adult Itgax (CD11c) EYFP+ transgenic mouse brain. In the present study, we describe changes in number, phenotype, and source of bDC in the aging mouse brain. Immunohistochemistry and fluorescent activated cell sorting (FACS) analysis revealed an age-related increase in bDC with a concomitant rise in the expression of immune activation markers MHCII, CD80, and CD86. Quantification of immunolabeled bDC in the cortex, corpus callosum, and cerebellum of the aged brain revealed a 2- to 5-fold increase. In contrast, either no change or a decrease in bDC was noted in regions of adult neurogenesis. Chimeras (wild type host/EYFP+ bone marrow) suggest that the increase of EYFP+ cells in the aging brain is in part due to an accumulation of peripherally derived cells. Collectively, the numerical and phenotypic changes in bDC indicate these cells may serve as an important immune component in the functional and anatomic alterations associated with aging. (C) 2012 Elsevier Inc. All rights reserved.
Chakravarty AK, Subbotin R, Chait BT, Shuman S
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RNA ligase RtcB splices 3 '-phosphate and 5 '-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3 ')pp(5 ')G intermediates
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2012 APR 17; 109(16):6072-6077
A cherished tenet of nucleic acid enzymology holds that synthesis of polynucleotide 3'-5' phosphodiesters proceeds via the attack of a 3'-OH on a high-energy 5' phosphoanhydride: either a nucleoside 5'-triphosphate in the case of RNA/DNA polymerases or an adenylylated intermediate A(5')pp(5')N- in the case of polynucleotide ligases. RtcB exemplifies a family of RNA ligases implicated in tRNA splicing and repair. Unlike classic ligases, RtcB seals broken RNAs with 3'-phosphate and 5'-OH ends. Here we show that RtcB executes a three-step ligation pathway entailing (i) reaction of His337 of the enzyme with GTP to form a covalent RtcB-(histidinyl-N)-GMP intermediate; (ii) transfer of guanylate to a polynucleotide 3'-phosphate to form a polynucleotide-(3')pp(5')G intermediate; and (iii) attack of a 5'-OH on the -N(3')pp(5')G end to form the splice junction. RtcB is structurally sui generis, and its chemical mechanism is unique. The wide distribution of RtcB proteins in bacteria, archaea, and metazoa raises the prospect of an alternative enzymology based on covalently activated 3' ends.
Chatrchyan S, Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Bergauer T, Dragicevic M, Ero J, Fabjan C, Friedl M, Fruhwirth R, Ghete VM, Hammer J, Hormann N, Hrubec J, Jeitler M, Kiesenhofer W, Krammer M, Liko D, Mikulec I, Pernicka M, Rahbaran B, Rohringer C, Rohringer H, Schofbeck R, Strauss J, Taurok A, Wagner P, Waltenberger W, Walzel G, Widl E, Wulz CE, Mossolov V, Shumeiko N, Gonzalez JS, Bansal S, Cerny K, Cornelis T, De Wolf EA, Janssen X, Luyckx S, Maes T, Mucibello L, Ochesanu S, Roland B, Rougny R, Selvaggi M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Van Spilbeeck A, Blekman F, Blyweert S, D'Hondt J, Suarez RG, Kalogeropoulos A, Maes M, Olbrechts A, Van Doninck W, Van Mulders P, Van Onsem GP, Villella I, Charaf O, Clerbaux B, De Lentdecker G, Dero V, Gay APR, Hreus T, Leonard A, Marage PE, Reis T, Thomas L, Vander Velde C, Vanlaer P, Adler V, Beernaert K, Cimmino A, Costantini S, Garcia G, Grunewald M, Klein B, Lellouch J, Marinov A, Mccartin J, Rios AAO, Ryckbosch D, Strobbe N, Thyssen F, Tytgat M, Vanelderen L, Verwilligen P, Walsh S, Yazgan E, Zaganidis N, Basegmez S, Bruno G, Ceard L, Delaere C, du Pree T, Favart D, Forthomme L, Giammanco A, Hollar J, Lemaitre V, Liao J, Militaru O, Nuttens C, Pagano D, Pin A, Piotrzkowski K, Schul N, Beliy N, Caebergs T, Daubie E, Hammad GH, Alves GA, Martins MC, Damiao DD, Martins T, Pol ME, Souza MHG, Alda WL, Carvalho W, Custodio A, Da Costa EM, Martins CD, De Souza SF, Figueiredo DM, Mundim L, Nogima H, Oguri V, Da Silva WLP, Santoro A, Do Amaral SMS, Jorge LS, Sznajder A, Bernardes CA, Dias FA, Tomei TRFP, Gregores EM, Lagana C, Marinho F, Mercadante PG, Novaes SF, Padula SS, Genchev V, Iaydjiev P, Piperov S, Rodozov M, Stoykova S, Sultanov G, Tcholakov V, Trayanov R, Vutova M, Dimitrov A, Hadjiiska R, Kozhuharov V, Litov L, Pavlov B, Petkov P, Bian JG, Chen GM, Chen HS, Jiang CH, Liang D, Liang S, Meng X, Tao J, Wang J, Wang J, Wang X, Wang Z, Xiao H, Xu M, Zang J, Zhang Z, Asawatangtrakuldee C, Ban Y, Guo S, Guo Y, Li W, Liu S, Mao Y, Qian SJ, Teng H, Wang S, Zhu B, Zou W, Avila C, Moreno BG, Oliveros AFO, Sanabria JC, Godinovic N, Lelas D, Plestina R, Polic D, Puljak I, Antunovic Z, Kovac M, Brigljevic V, Duric S, Kadija K, Luetic J, Morovic S, Attikis A, Galanti M, Mavromanolakis G, Mousa J, Nicolaou C, Ptochos F, Razis PA, Finger M, Finger M, Assran Y, Elgammal S, Kamel AE, Khalil S, Mahmoud MA, Radi A, Kadastik M, Muntel M, Raidal M, Rebane L, Tiko A, Azzolini V, Eerola P, Fedi G, Voutilainen M, Harkonen J, Heikkinen A, Karimaki V, Kinnunen R, Kortelainen MJ, Lampen T, Lassila-Perini K, Lehti S, Linden T, Luukka P, Maenpaa T, Peltola T, Tuominen E, Tuominiemi J, Tuovinen E, Ungaro D, Wendland L, Banzuzi K, Korpela A, Tuuva T, Besancon M, Choudhury S, Dejardin M, Denegri D, Fabbro B, Faure JL, Ferri F, Ganjour S, Givernaud A, Gras P, de Monchenault GH, Jarry P, Locci E, Malcles J, Millischer L, Nayak A, Rander J, Rosowsky A, Shreyber I, Titov M, Baffioni S, Beaudette F, Benhabib L, Bianchini L, Bluj M, Broutin C, Busson P, Charlot C, Daci N, Dahms T, Dobrzynski L, de Cassagnac RG, Haguenauer M, Mine P, Mironov C, Ochando C, Paganini P, Sabes D, Salerno R, Sirois Y, Veelken C, Zabi A, Agram JL, Andrea J, Bloch D, Bodin D, Brom JM, Cardaci M, Chabert EC, Collard C, Conte E, Drouhin F, Ferro C, Fontaine JC, Gele D, Goerlach U, Juillot P, Karim M, Le Bihan AC, Van Hove P, Fassi F, Mercier D, Beauceron S, Beaupere N, Bondu O, Boudoul G, Brun H, Chasserat J, Chierici R, Contardo D, Depasse P, El Mamouni H, Fay J, Gascon S, Gouzevitch M, Ille B, Kurca T, Lethuillier M, Mirabito L, Perries S, Sordini V, Tosi S, Tschudi Y, Verdier P, Viret S, Tsamalaidze Z, Anagnostou G, Beranek S, Edelhoff M, Feld L, Heracleous N, Hindrichs O, Jussen R, Klein K, Merz J, Ostapchuk A, Perieanu A, Raupach F, Sammet J, Schael S, Sprenger D, Weber H, Wittmer B, Zhukov V, Ata M, Caudron J, Dietz-Laursonn E, Duchardt D, Erdmann M, Fischer R, Guth A, Hebbeker T, Heidemann C, Hoepfner K, Klimkovich T, Klingebiel D, Kreuzer P, Lanske D, Lingemann J, Magass C, Merschmeyer M, Meyer A, Olschewski M, Papacz P, Pieta H, Reithler H, Schmitz SA, Sonnenschein L, Steggemann J, Teyssier D, Weber M, Bontenackels M, Cherepanov V, Davids M, Fluegge G, Geenen H, Geisler M, Ahmad WH, Hoehle F, Kargoll B, Kress T, Kuessel Y, Linn A, Nowack A, Perchalla L, Pooth O, Rennefeld J, Sauerland P, Stahl A, Martin MA, Behr J, Behrenhoff W, Behrens U, Bergholz M, Bethani A, Borras K, Burgmeier A, Cakir A, Calligaris L, Campbell A, Castro E, Costanza F, Dammann D, Eckerlin G, Eckstein D, Fischer D, Flucke G, Geiser A, Glushkov I, Habib S, Hauk J, Jung H, Kasemann M, Katsas P, Kleinwort C, Kluge H, Knutsson A, Kramer M, Krucker D, Kuznetsova E, Lange W, Lohmann W, Lutz B, Mankel R, Marfin I, Marienfeld M, Melzer-Pellmann IA, Meyer AB, Mnich J, Mussgiller A, Naumann-Emme S, Olzem J, Perrey H, Petrukhin A, Pitzl D, Raspereza A, Cipriano PMR, Riedl C, Rosin M, Salfeld-Nebgen J, Schmidt R, Schoerner-Sadenius T, Sen N, Spiridonov A, Stein M, Walsh R, Wissing C, Autermann C, Blobel V, Bobrovskyi S, Draeger J, Enderle H, Erfle J, Gebbert U, Gorner M, Hermanns T, Hoing RS, Kaschube K, Kaussen G, Kirschenmann H, Klanner R, Lange J, Mura B, Nowak F, Pietsch N, Rathjens D, Sander C, Schettler H, Schleper P, Schlieckau E, Schmidt A, Schroeder M, Schum T, Seidel M, Stadie H, Steinbrueck G, Thomsen J, Barth C, Berger J, Chwalek T, De Boer W, Dierlamm A, Feindt M, Guthoff M, Hackstein C, Hartmann F, Heinrich M, Held H, Hoffmann KH, Honc S, Husemann U, Katkov I, Komaragiri JR, Martschei D, Mueller S, Mueller T, Niegel M, Nurnberg A, Oberst O, Oehler A, Ott J, Peiffer T, Quast G, Rabbertz K, Ratnikov F, Ratnikova N, Rocker S, Saout C, Scheurer A, Schilling FP, Schmanau M, Schott G, Simonis HJ, Stober FM, Troendle D, Ulrich R, Wagner-Kuhr J, Weiler T, Zeise M, Ziebarth EB, Daskalakis G, Geralis T, Kesisoglou S, Kyriakis A, Loukas D, Manolakos I, Markou A, Markou C, Mavrommatis C, Ntomari E, Gouskos L, Mertzimekis TJ, Panagiotou A, Saoulidou N, Evangelou I, Foudasz C, Kokkas P, Manthos N, Papadopoulos I, Patras V, Bencze G, Hajdu C, Hidas P, Horvath D, Krajczar K, Radics B, Sikler F, Veszpremi V, Vesztergombi G, Beni N, Czellar S, Molnar J, Palinkas J, Szillasi Z, Karancsi J, Raics P, Trocsanyi ZL, Ujvari B, Beri SB, Bhatnagar V, Dhingra N, Gupta R, Jindal M, Kaur M, Kohli JM, Mehta MZ, Nishu N, Saini LK, Sharma A, Singh J, Singh SP, Ahuja S, Bhardwaj A, Choudhary BC, Kumar A, Kumar A, Malhotra S, Naimuddin M, Ranjan K, Sharma V, Shivpuri RK, Banerjee S, Bhattacharya S, Dutta S, Gomber B, Jain S, Jain S, Khurana R, Sarkar S, Abdulsalam A, Choudhury RK, Dutta D, Kailas S, Kumar V, Mohanty AK, Pant LM, Shukla P, Aziz T, Ganguly S, Guchait M, Maity M, Majumder G, Mazumdar K, Mohanty GB, Parida B, Sudhakar K, Wickramage N, Banerjee S, Dugad S, Arfaei H, Bakhshiansohi H, Etesami SM, Fahim A, Hashemi M, Hesari H, Jafari A, Khakzad M, Mohammadi A, Najafabadi MM, 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Search for B-S(0) -> mu(+)mu(-) and B-0 -> mu(+)mu(-) decays
JOURNAL OF HIGH ENERGY PHYSICS 2012 APR; ?(4):? Article 033
A search for the rare decays B-S(0) -> mu(+)mu(-) and B-0 -> mu(+)mu(-) performed in pp collisions at root s = 7 TeV, with a data sample corresponding to an integrated luminosity of 5 fb(-1) collected by the CMS experiment at the LHC. In both decays, the number of events observed after all selection requirements is consistent with the expectation from background plus standard model signal predictions. The resulting upper limits on the branching fractions are B(B-S(0) -> mu(+)mu(-)) < 7.7 x 10(-9) and B(B-0 -> mu(+)mu(-) ) < 1.8 x 10(-9) at 95% confidence level.
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Smith WH, Swanson J
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Inclusive b-jet production in pp collisions at root s=7 TeV
JOURNAL OF HIGH ENERGY PHYSICS 2012 APR; ?(4):? Article 084
The inclusive b-jet production cross section in pp collisions at a center-of-mass energy of 7TeV is measured using data collected by the CMS experiment at the LHC. The cross section is presented as a function of the jet transverse momentum in the range 18 < p(T) < 200 GeV for several rapidity intervals. The results are also given as the ratio of the b-jet production cross section to the inclusive jet production cross section. The measurement is performed with two different analyses, which differ in their trigger selection and b-jet identification: a jet analysis that selects events with a b jet using a sample corresponding to an integrated luminosity of 34 pb(-1), and a muon analysis requiring a b jet with a muon based on an integrated luminosity of 3 pb(-1). In both approaches the b jets are identified by requiring a secondary vertex. The results from the two methods are in agreement with each other and with next-to-leading order calculations, as well as with predictions based on the PYTHIA event generator.