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Found 37769 matches. Displaying 8041-8050
Gotuzzo E, Markowitz M, Ratanasuwan W, Smith G, Prada G, Morales-Ramirez JO, Strohmaier KM, Lu CX, Bhanja S, Nguyen BY, Teppler H
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Sustained Efficacy and Safety of Raltegravir After 5 Years of Combination Antiretroviral Therapy as Initial Treatment of HIV-1 Infection: Final Results of a Randomized, Controlled, Phase II Study (Protocol 004)
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 2012 SEP 1; 61(1):73-77
Raltegravir as initial HIV therapy was examined in a double-blind study; 160 patients were randomized to raltegravir (400 mg bid after dose-ranging), 38 to efavirenz, both with tenofovir/lamivudine. At week 240, HIV-RNA remained <50 copies per milliliter in 68.8% (raltegravir) versus 63.2% (efavirenz), and CD4 increases were 302 versus 276 cells per microliter, respectively. Early HIV-RNA decline predicted later CD4 increases in both groups. Raltegravir resistance was observed in 3 of 10 raltegravir recipients with virologic failure. Few drug-related adverse events were reported after week 48. Raltegravir had minimal effect on laboratory values, including lipids. Raltegravir with tenofovir/lamivudine showed durable efficacy and good tolerability over 5 years.
Mancuso F, Bunkenborg J, Wierer M, Molina H
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Data extraction from proteomics raw data: An evaluation of nine tandem MS tools using a large Orbitrap data set
JOURNAL OF PROTEOMICS 2012 SEP 18; 75(17):5293-5303
In shot-gun proteomics raw tandem MS data are processed with extraction tools to produce condensed peak lists that can be uploaded to database search engines. Many extraction tools are available but to our knowledge, a systematic comparison of such tools has not yet been carried out. using raw data containing more than 400,000 tandem MS spectra acquired using an Orbitrap Velos we compared 9 tandem MS extraction tools, freely available as well as commercial. We compared the tools with respect to number of extracted MS/mS events, fragment ion information, number of matches, precursor mass accuracies and agreement in-between tools. Processing a primary data set with 9 different tandem MS extraction tools resulted in a low overlap of identified peptides. The tools differ by assigned charge states of precursors, precursor and fragment ion masses, and we show that peptides identified very confidently using one extraction tool might not be matched when using another tool. We also found a bias towards peptides of lower charge state when extracting fragment ion data from higher resolution raw data without deconvolution. Collecting and comparing the extracted data from the same raw data allow adjusting parameters and expectations and selecting the right tool for extraction of tandem MS data. (C) 2012 Elsevier B.V. All rights reserved.
Kopycinski J, Cheeseman H, Ashraf A, Gill D, Hayes P, Hannaman D, Gilmour J, Cox JH, Vasan S
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A DNA-Based Candidate HIV Vaccine Delivered via In Vivo Electroporation Induces CD4 Responses toward the alpha 4 beta 7-Binding V2 Loop of HIV gp120 in Healthy Volunteers
CLINICAL AND VACCINE IMMUNOLOGY 2012 SEP; 19(9):1557-1559
Administration of a clade C/B' candidate HIV-1 DNA vaccine, ADVAX, by in vivo electroporation (EP) was safe and more immunogenic than intramuscular administration without EP. The breadth and specificity of T-cell responses to full-length Env were mapped. Responses to multiple Env regions were induced, with most focusing on V3/C4 and V2 regions, including the alpha 4 beta 7 integrin-binding domain. The breadth of responses induced by this DNA vaccine regimen was comparable to that of viral-vectored vaccine regimens.
Aaltonen T, Gonzalez BA, Amerio S, Amidei D, Anastassov A, Annovi A, Antos J, Apollinari G, Appel JA, Arisawa T, Artikov A, Asaadi J, Ashmanskas W, Auerbach B, Aurisano A, Azfar F, Badgett W, Bae T, Barbaro-Galtieri A, Barnes VE, Barnett BA, Barria P, Bartos P, Bauce M, Bedeschi F, Behari S, Bellettini G, Bellinger J, Benjamin D, Beretvas A, Bhatti A, Binkley ME, Bisello D, Bizjak I, Bland KR, Blumenfeld B, Bocci A, Bodek A, Bortoletto D, Boudreau J, Boveia A, Brigliadori L, Bromberg C, Brucken E, Budagov J, Budd HS, Burkett K, Busetto G, Bussey P, Buzatu A, Calamba A, Calancha C, Camarda S, Campanelli M, Campbell M, Canelli F, Carls B, Carlsmith D, Carosi R, Carrillo S, Carron S, Casal B, Casarsa M, Castro A, Catastini P, Cauz D, Cavaliere V, Cavalli-Sforza M, Cerri A, Cerrito L, Chen YC, Chertok M, Chiarelli G, Chlachidze G, Chlebana F, Cho K, Chokheli D, Chung WH, Chung YS, Ciocci MA, Clark A, Clarke C, Compostella G, Convery ME, Conway J, Corbo M, Cordelli M, Cox CA, Cox DJ, Crescioli F, Cuevas J, Culbertson R, Dagenhart D, d'Ascenzo N, Datta M, de Barbaro P, Dell'Orso M, Demortier L, Deninno M, Devoto F, d'Errico M, Di Canto A, Di Ruzza B, Dittmann JR, D'Onofrio M, Donati S, Dong P, Dorigo M, Dorigo T, Ebina K, Elagin A, Eppig A, Erbacher R, Errede S, Ershaidat N, Eusebi R, Farrington S, Feindt M, Fernandez JP, Ferrazza C, Field R, Flanagan G, Forrest R, Frank MJ, Franklin M, Freeman JC, Funakoshi Y, Furic I, Gallinaro M, Garcia JE, Garfinkel AF, Garosi P, Gerberich H, Gerchtein E, Giagu S, Giakoumopoulou V, Giannetti P, Gibson K, Ginsburg CM, Giokaris N, Giromini P, Giurgiu G, Glagolev V, Glenzinski D, Gold M, Goldin D, Goldschmidt N, Golossanov A, Gomez G, Gomez-Ceballos G, Goncharov M, Gonzalez O, Gorelov I, Goshaw AT, Goulianos K, Grinstein S, Grosso-Pilcher C, Group RC, da Costa JG, Hahn SR, Halkiadakis E, Hamaguchi A, Han JY, Happacher F, Hara K, Hare D, Hare M, Harr RF, Hatakeyama K, Hays C, Heck M, Heinrich J, Herndon M, Hewamanage S, Hocker A, Hopkins W, Horn D, Hou S, Hughes RE, Hurwitz M, Husemann U, Hussain N, Hussein M, Huston J, Introzzi G, Iori M, Ivanov A, James E, Jang D, Jayatilaka B, Jeans DT, Jeon EJ, Jindariani S, Jones M, Joo KK, Jun SY, Junk TR, Kamon T, Karchin PE, Kasmi A, Kato Y, Ketchum W, Keung J, Khotilovich V, Kilminster B, Kim DH, Kim HS, Kim JE, Kim MJ, Kim SB, Kim SH, Kim YK, Kim YJ, Kimura N, Kirby M, Klimenko S, Knoepfel K, Kondo K, Kong DJ, Konigsberg J, Kotwal AV, Kreps M, Kroll J, Krop D, Kruse M, Krutelyov V, Kuhr T, Kurata M, Kwang S, Laasanen AT, Lami S, Lammel S, Lancaster M, Lander RL, Lannon K, Lath A, Latino G, LeCompte T, Lee E, Lee HS, Lee JS, Lee SW, Leo S, Leone S, Lewis JD, Limosani A, Lin CJ, Lindgren M, Lipeles E, Lister A, Litvintsev DO, Liu C, Liu H, Liu Q, Liu T, Lockwitz S, Loginov A, Lucchesi D, Lueck J, Lujan P, Lukens P, Lungu G, Lys J, Lysak R, Madrak R, Maeshima K, Maestro P, Malik S, Manca G, Manousakis-Katsikakis A, Margaroli F, Marino C, Martinez M, Mastrandrea P, Matera K, Mattson ME, Mazzacane A, Mazzanti P, McFarland KS, McIntyre P, McNulty R, Mehta A, Mehtala P, Mesropian C, Miao T, Mietlicki D, Mitra A, Miyake H, Moed S, Moggi N, Mondragon MN, Moon CS, Moore R, Morello MJ, Morlock J, Fernandez PM, Mukherjee A, Muller T, Murat P, Mussini M, Nachtman J, Nagai Y, Naganoma J, Nakano I, Napier A, Nett J, Neu C, Neubauer MS, Nielsen J, Nodulman L, Noh SY, Norniella O, Oakes L, Oh SH, Oh YD, Oksuzian I, Okusawa T, Orava R, Ortolan L, Griso SP, Pagliarone C, Palencia E, Papadimitriou V, Paramonov AA, Patrick J, Pauletta G, Paulini M, Paus C, Pellett DE, Penzo A, Phillips TJ, Piacentino G, Pianori E, Pilot J, Pitts K, Plager C, Pondrom L, Poprocki S, Potamianos K, Prokoshin F, Pranko A, Ptohos F, Punzi G, Rahaman A, Ramakrishnan V, Ranjan N, Redondo I, Renton P, Rescigno M, Riddick T, Rimondi F, Ristori L, Robson A, Rodrigo T, Rodriguez T, Rogers E, Rolli S, Roser R, Ruffini F, Ruiz A, Russ J, Rusu V, Safonov A, Sakumoto WK, Sakurai Y, Santi L, Sato K, Saveliev V, Savoy-Navarro A, Schlabach P, Schmidt A, Schmidt EE, Schwarz T, Scodellaro L, Scribano A, Scuri F, Seidel S, Seiya Y, Semenov A, Sforza F, Shalhout SZ, Shears T, Shepard PF, Shimojima M, Shochet M, Shreyber-Tecker I, Simonenko A, Sinervo P, Sliwa K, Smith JR, Snider FD, Soha A, Sorin V, Song H, Squillacioti P, Stancari M, Denis RS, Stelzer B, Stelzer-Chilton O, Stentz D, Strologas J, Strycker GL, Sudo Y, Sukhanov A, Suslov I, Takemasa K, Takeuchi Y, Tang J, Tecchio M, Teng PK, Thom J, Thome J, Thompson GA, Thomson E, Tipton P, Toback D, Tokar S, Tollefson K, Tomura T, Tonelli D, Torre S, Torretta D, Totaro P, Trovato M, Ukegawa F, Uozumi S, Varganov A, Vazquez F, Velev G, Vellidis C, Vidal M, Vila I, Vilar R, Vizan J, Vogel M, Volpi G, Wagner P, Wagner RL, Wakisaka T, Wallny R, Wang SM, Warburton A, Waters D, Wester WC, Whiteson D, Wicklund AB, Wicklund E, Wilbur S, Wick F, Williams HH, Wilson JS, Wilson P, Winer BL, Wittich P, Wolbers S, Wolfe H, Wright T, Wu X, Wu Z, Yamamoto K, Yamato D, Yang T, Yang UK, Yang YC, Yao WM, Yeh GP, Yi K, Yoh J, Yorita K, Yoshida T, Yu GB, Yu I, Yu SS, Yun JC, Zanetti A, Zeng Y, Zhou C, Zucchelli S
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Search for the Standard Model Higgs Boson Decaying to a b(b)over-bar Pair in Events with Two Oppositely Charged Leptons Using the Full CDF Data Set
PHYSICAL REVIEW LETTERS 2012 SEP 10; 109(11):? Article 111803
We present a search for the standard model Higgs boson produced in association with a Z boson in data collected with the CDF II detector at the Tevatron, corresponding to an integrated luminosity of 9.45 fb(-1). In events consistent with the decay of the Higgs boson to a bottom-quark pair and the Z boson to electron or muon pairs, we set 95% credibility level upper limits on the ZH production cross section times the H -> b (b) over bar branching ratio as a function of Higgs boson mass. At a Higgs boson mass of 125 GeV/c(2), we observe (expect) a limit of 7.1 (3.9) times the standard model value.
Chatrchyan S, Khachatryan V, Sirunyan AM, Tumasyan A, Adam W, Bergauer T, Dragicevic M, Ero J, Fabjan C, Friedl M, Fruhwirth R, Ghete VM, Hammer J, Hoch M, Hormann N, Hrubec J, Jeitler M, Kiesenhofer W, Krammer M, Liko D, Mikulec I, Pernicka M, Rahbaran B, Rohringer C, Rohringer H, Schofbeck R, Strauss J, Taurok A, Teischinger F, Wagner P, Waltenberger W, Walzel G, Widl E, Wulz CE, Mossolov V, Shumeiko N, Gonzalez JS, Bansal S, Benucci L, Cornelis T, De Wolf EA, Janssen X, Luyckx S, Maes T, Mucibello L, Ochesanu S, Roland B, Rougny R, Selvaggi M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Van Spilbeeck A, Blekman F, Blyweert S, D'Hondt J, Suarez RG, Kalogeropoulos A, Maes M, Olbrechts A, Van Doninck W, Van Mulders P, Van Onsem GP, Villella I, Charaf O, Clerbaux B, De Lentdecker G, Dero V, Gay APR, Hammad GH, Hreus T, Leonard A, Marage PE, Thomas L, Vander Velde C, Vanlaer P, Wickens J, Adler V, Beernaert K, Cimmino A, Costantini S, Garcia G, Grunewald M, Klein B, Lellouch J, Marinov A, Mccartin J, Rios AAO, Ryckbosch D, Strobbe N, Thyssen F, Tytgat M, Vanelderen L, Verwilligen P, Walsh S, Yazgan E, Zaganidis N, Basegmez S, Bruno G, Ceard L, De Jeneret JD, Delaere C, du Pree T, Favart D, Forthomme L, Giammanco A, Gregoire G, Hollar J, Lemaitre V, Liao J, Militaru O, Nuttens C, Pagano D, Pin A, Piotrzkowski K, Schul N, Beliy N, Caebergs T, Daubie E, Alves GA, Damiao DD, Martins T, Pol ME, Souza MHG, Alda WL, Carvalho W, Custodio A, Da Costa EM, Martins CD, De Souza SF, Figueiredo DM, Mundim L, Nogima H, Oguri V, Da Silva WLP, Santoro A, Do Amaral SMS, Jorge LS, Sznajder A, Anjos TS, Bernardes CA, Dias FA, Tomei TRFP, Gregores EM, Lagana C, Marinho F, Mercadante PG, Novaes SF, Padula SS, Genchev V, Iaydjiev P, Piperov S, Rodozov M, Stoykova S, Sultanov G, Tcholakov V, Trayanov R, Vutova M, Dimitrov A, Hadjiiska R, Karadzhinova A, Kozhuharov V, Litov L, Pavlov B, Petkov P, Bian JG, Chen GM, Chen HS, Jiang CH, Liang D, Liang S, Meng X, Tao J, Wang J, Wang J, Wang X, Wang Z, Xiao H, Xu M, Zang J, Zhang Z, Asawatangtrakuldee C, Ban Y, Guo S, Guo Y, Li W, Liu S, Mao Y, Qian SJ, Teng H, Wang S, Zhu B, Zou W, Cabrera A, Moreno BG, Oliveros AFO, Sanabria JC, Godinovic N, Lelas D, Plestina R, Polic D, Puljak I, Antunovic Z, Dzelalija M, Kovac M, Brigljevic V, Duric S, Kadija K, Luetic J, Morovic S, Attikis A, Galanti M, Mousa J, Nicolaou C, Ptochos F, Razis PA, Finger M, Finger M, Assran Y, Kamel AE, Khalil S, Mahmoud MA, Radi A, Hektor A, Kadastik M, Muntel M, Raidal M, Rebane L, Tiko A, Azzolini V, Eerola P, Fedi G, Voutilainen M, Czellar S, Harkonen J, Heikkinen A, Karimaki V, Kinnunen R, Kortelainen MJ, Lampen T, Lassila-Perini K, Lehti S, Linden T, Luukka P, Maenpaa T, Peltola T, Tuominen E, Tuominiemi J, Tuovinen E, Ungaro D, Wendland L, Banzuzi K, Korpela A, Tuuva T, Sillou D, Besancon M, Choudhury S, Dejardin M, Denegri D, Fabbro B, Faure JL, Ferri F, Ganjour S, Givernaud A, Gras P, de Monchenault GH, Jarry P, Locci E, Malcles J, Marionneau M, Millischer L, Rander J, Rosowsky A, Shreyber I, Titov M, Baffioni S, Beaudette F, Benhabib L, Bianchini L, Bluj M, Broutin C, Busson P, Charlot C, Daci N, Dahms T, Dobrzynski L, Elgammal S, de Cassagnac RG, Haguenauer M, Mine P, Mironov C, Ochando C, Paganini P, Sabes D, Salerno R, Sirois Y, Thiebaux C, Veelken C, Zabi A, Agram JL, Andrea J, Bloch D, Bodin D, Brom JM, Cardaci M, Chabert EC, Collard C, Conte E, Drouhin F, Ferro C, Fontaine JC, Gele D, Goerlach U, Greder S, Juillot P, Karim M, Le Bihan AC, Van Hove P, Fassi F, Mercier D, Baty C, Beauceron S, Beaupere N, Bedjidian M, Bondu O, Boudoul G, Boumediene D, Brun H, Chasserat J, Chierici R, Contardo D, Depasse P, El Mamouni H, Falkiewicz A, Fay J, Gascon S, Gouzevitch M, Ille B, Kurca T, Le Grand T, Lethuillier M, Mirabito L, Perries S, Sordini V, Tosi S, Tschudi Y, Verdier P, Viret S, Lomidze D, Anagnostou G, Beranek S, Edelhoff M, Feld L, Heracleous N, Hindrichs O, Jussen R, Klein K, Merz J, Ostapchuk A, Perieanu A, Raupach F, Sammet J, Schael S, Sprenger D, Weber H, Wittmer B, Zhukov V, Ata M, Caudron J, Dietz-Laursonn E, Erdmann M, Guth A, Hebbeker T, Heidemann C, Hoepfner K, Klimkovich T, Klingebiel D, Kreuzer P, Lanske D, Lingemann J, Magass C, Merschmeyer M, Meyer A, Olschewski M, Papacz P, Pieta H, Reithler H, Schmitz SA, Sonnenschein L, Steggemann J, Teyssier D, Weber M, Bontenackels M, Cherepanov V, Davids M, Flugge G, Geenen H, Geisler M, Ahmad WH, Hoehle F, Kargoll B, Kress T, Kuessel Y, Linn A, Nowack A, Perchalla L, Pooth O, Rennefeld J, Sauerland P, Stahl A, Zoeller MH, Martin MA, Behrenhoff W, Behrens U, Bergholz M, Bethani A, Borras K, Cakir A, Campbell A, Castro E, Dammann D, Eckerlin G, Eckstein D, Flossdorf A, Flucke G, Geiser A, Hauk J, Jung H, Kasemann M, Katsas P, Kleinwort C, Kluge H, Knutsson A, Kramer M, Krucker D, Kuznetsova E, Lange W, Lohmann W, Lutz B, Mankel R, Marfin I, Marienfeld M, Melzer-Pellmann IA, Meyer AB, Mnich J, Mussgiller A, Naumann-Emme S, Olzem J, Petrukhin A, Pitzl D, Raspereza A, Cipriano PMR, Rosin M, Salfeld-Nebgen J, Schmidt R, Schoerner-Sadenius T, Sen N, Spiridonov A, Stein M, Tomaszewska J, Walsh R, Wissing C, Autermann C, Blobel V, Bobrovskyi S, Draeger J, Enderle H, Erfle J, Gebbert U, Gorner M, Hermanns T, Kaschube K, Kaussen G, Kirschenmann H, Klanner R, Lange J, Mura B, Nowak F, Pietsch N, Sander C, Schettler H, Schleper P, Schlieckau E, Schroder M, Schum T, Stadie H, Steinbruck G, Thomsen J, Barth C, Berger J, Chwalek T, De Boer W, Dierlamm A, Dirkes G, Feindt M, Gruschke J, Guthoff M, Hackstein C, Hartmann F, Heinrich M, Held H, Hoffmann KH, Honc S, Katkov I, Komaragiri JR, Kuhr T, Martschei D, Mueller S, Muller T, Niegel M, Oberst O, Oehler A, Ott J, Peiffer T, Quast G, Rabbertz K, Ratnikov F, Ratnikova N, Renz M, Rocker S, Saout C, Scheurer A, Schieferdecker P, Schilling FP, Schmanau M, Schott G, Simonis HJ, Stober FM, Troendle D, Wagner-Kuhr J, Weiler T, Zeise M, Ziebarth EB, Daskalakis G, Geralis T, Kesisoglou S, Kyriakis A, Loukas D, Manolakos I, Markou A, Markou C, Mavrommatis C, Ntomari E, Gouskos L, Mertzimekis TJ, Panagiotou A, Saoulidou N, Stiliaris E, Evangelou I, Foudas C, Kokkas P, Manthos N, Papadopoulos I, Patras V, Triantis FA, Aranyi A, Bencze G, Boldizsar L, Hajdu C, Hidas P, Horvath D, Kapusi A, Krajczar K, Sikler F, Vesztergombi G, Beni N, Molnar J, Palinkas J, Szillasi Z, Veszpremi V, Karancsi J, Raics P, Trocsanyi ZL, Ujvari B, Beri SB, Bhatnagar V, Dhingra N, Gupta R, Jindal M, Kaur M, Kohli JM, Mehta MZ, Nishu N, Saini LK, Sharma A, Singh AP, Singh J, Singh SP, Ahuja S, Choudhary BC, Kumar A, Kumar A, Malhotra S, Naimuddin M, Ranjan K, Sharma V, Shivpuri RK, Banerjee S, Bhattacharya S, Dutta S, Gomber B, Jain S, Jain S, Khurana R, Sarkar S, Choudhury RK, Dutta D, Kailas S, Kumar V, Mohanty AK, Pant LM, Shukla P, Aziz T, Ganguly S, Guchait M, Gurtu A, Maity M, Majumder G, Mazumdar K, Mohanty GB, Parida B, Saha A, Sudhakar K, Wickramage N, Banerjee S, Dugad S, Mondal NK, Arfaei H, Bakhshiansohi H, Etesami SM, Fahim A, Hashemi M, Hesari H, Jafari A, Khakzad M, Mohammadi A, Najafabadi MM, Mehdiabadi SP, Safarzadeh B, Zeinali M, Abbrescia M, Barbone L, Calabria C, Chhibra SS, Colaleo A, Creanza D, De Filippis N, De Palma M, Fiore L, Iaselli G, Lusito L, Maggi G, Maggi M, Manna N, Marangelli B, My S, Nuzzo S, Pacifico N, Pompili A, Pugliese G, Romano F, Selvaggi G, Silvestris L, Singh G, Tupputi S, Zito G, Abbiendi G, Benvenuti AC, Bonacorsi D, Braibant-Giacomelli S, Brigliadori L, Capiluppi P, Castro A, Cavallo FR, Cuffiani M, Dallavalle GM, Fabbri F, Fanfani A, Fasanella D, Giacomelli P, Grandi C, Marcellini S, Masetti G, Meneghelli M, Montanari A, Navarria FL, Odorici F, Perrotta A, Primavera F, Rossi AM, Rovelli T, Siroli G, Travaglini R, Albergo S, Cappello G, Chiorboli M, Costa S, Potenza R, Tricomi A, Tuve C, Barbagli G, Ciulli V, Civinini C, D'Alessandro R, Focardi E, Frosali S, Gallo E, Gonzi S, Meschini M, Paoletti S, Sguazzoni G, Tropiano A, Benussi L, Bianco S, Colafranceschi S, Fabbri F, Piccolo D, Fabbricatore P, Musenich R, Benaglia A, De Guio F, Di Matteo L, Fiorendi S, Gennai S, Ghezzi A, Malvezzi S, Manzoni RA, Martelli A, Massironi A, Menasce D, Moroni L, Paganoni M, Pedrini D, Ragazzi S, Redaelli N, Sala S, de Fatis TT, Buontempo S, Montoya CAC, Cavallo N, De Cosa A, Dogangun O, Fabozzi F, Iorio AOM, Lista L, Merola M, Paolucci P, Azzi P, Bacchetta N, Bellan P, Bisello D, Branca A, Carlin R, Checchia P, Dorigo T, Dosselli U, Gasparini F, Gasparini U, Gozzelino A, Kanishchev K, Lacaprara S, Lazzizzera I, Margoni M, Mazzucato M, Meneguzzo AT, Nespolo M, Perrozzi L, Pozzobon N, Ronchese P, Simonetto F, Torassa E, Tosi M, Triossi A, Vanini S, Zotto P, Zumerle G, Baesso P, Berzano U, Ratti SP, Riccardi C, Torre P, Vitulo P, Viviani C, Biasini M, Bilei GM, Caponeri B, Fano L, Lariccia P, Lucaroni A, Mantovani G, Menichelli M, Nappi A, Romeo F, Santocchia A, Taroni S, Valdata M, Azzurri P, Bagliesi G, Boccali T, Broccolo G, Castaldi R, D'Agnolo RT, Dell'Orso R, Fiori F, Foa L, Giassi A, Kraan A, Ligabue F, Lomtadze T, Martini L, Messineo A, Palla F, Palmonari F, Rizzi A, Serban AT, Spagnolo P, Tenchini R, Tonelli G, Venturi A, Verdini PG, Barone L, Cavallari F, Del Re D, Diemoz M, Fanelli C, Franci D, Grassi M, Longo E, Meridiani P, Micheli F, Nourbakhsh S, Organtini G, Pandolfi F, Paramatti R, Rahatlou S, Sigamani M, Soffi L, Amapane N, Arcidiacono R, Argiro S, Arneodo M, Biino C, Botta C, Cartiglia N, Castello R, Costa M, Demaria N, Graziano A, Mariotti C, Maselli S, Migliore E, Monaco V, Musich M, Obertino MM, Pastrone N, Pelliccioni M, Potenza A, Romero A, Ruspa M, Sacchi R, Solano A, Staiano A, Trapani PP, Pereira AV, Belforte S, Cossutti F, Della Ricca G, Gobbo B, Marone M, Montanino D, Penzo A, Heo SG, Nam SK, Chang S, Chung J, Kim DH, Kim GN, Kim JE, Kong DJ, Park H, Ro SR, Son DC, Kim JY, Kim ZJ, Song S, Jo HY, Choi S, Gyun D, Hong B, Jo M, Kim H, Kim TJ, Lee KS, Moon DH, Park SK, Seo E, Sim 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Pierro GA, Ross I, Savin A, Smith WH, Swanson J
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Measurement of the underlying event in the Drell-Yan process in proton-proton collisions at root s=7 TeV
EUROPEAN PHYSICAL JOURNAL C 2012 SEP; 72(9):? Article 2080
A measurement of the underlying event (UE) activity in proton-proton collisions at a center-of-mass energy of 7 TeV is performed using Drell-Yan events in a data sample corresponding to an integrated luminosity of 2.2 fb(-1), collected by the CMS experiment at the LHC. The activity measured in the muonic final state (q (q) over bar -> mu(+) mu(-)) is corrected to the particle level and compared with the predictions of various Monte Carlo generators and hadronization models. The dependence of the UE activity on the dimuon invariant mass is well described by PYTHIA and HERWIG++ tunes derived from the leading jet/track approach, illustrating the universality of the UE activity. The UE activity is observed to be independent of the dimuon invariant mass in the region above 40 GeV/c(2), while a slow increase is observed with increasing transverse momentum of the dimuon system. The dependence of the UE activity on the transverse momentum of the dimuon system is accurately described by MADGRAPH, which simulates multiple hard emissions.
Papachristou PK, Katifori E, Diakonos FK, Constantoudis V, Mavrommatis E
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Quantum versus classical dynamics in a driven barrier: The role of kinematic effects
PHYSICAL REVIEW E 2012 SEP 24; 86(3):? Article 036213
We study the dynamics of the classical and quantum mechanical scattering of a wave packet from an oscillating barrier. Our main focus is on the dependence of the transmission coefficient on the initial energy of the wave packet for a wide range of oscillation frequencies. The behavior of the quantum transmission coefficient is affected by tunneling phenomena, resonances, and kinematic effects emanating from the time dependence of the potential. We show that when kinematic effects dominate (mainly in intermediate frequencies), classical mechanics provides very good approximation of quantum results. In that frequency region, the classical and quantum transmission coefficients are in optimal agreement. Moreover, the transmission threshold (i.e., the energy above which the transmission coefficient becomes larger than a specific small threshold value) is found to exhibit a minimum. We also consider the form of the transmitted wave packet and we find that for low values of the frequency the incoming classical and quantum wave packet can be split into a train of well-separated coherent pulses, a phenomenon that admits purely classical kinematic interpretation.
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Weber HA, Wehrli L, Weng J, Zelepoukine S, Amsler C, Chiochia V, De Visscher S, Favaro C, Rikova MI, Mejias BM, Otiougova P, Robmann P, Snoek H, Tupputi S, Verzetti M, Chang YH, Chen KH, Chen WT, Go A, Kuo CM, Li SW, Lin W, Liu MH, Liu ZK, Lu YJ, Mekterovic D, Singh AP, Volpe R, Wu JH, Yu SS, Bartalini P, Chang P, Chang YH, Chang YW, Chao Y, Chen KF, Dietz C, Gao Z, Grundler U, Hou WS, Hsiung Y, Kao KY, Lei YJ, Liau JJ, Lin SW, Lu RS, Majumder D, Petrakou E, Shi X, Shiu JG, Tzeng YM, Ueno K, Velikzhanin Y, Wan X, Wang CC, Wang M, Wei JT, Yeh P, Asavapibhop B, Srimanobhas N, Adiguzel A, Bakirci MN, Cerci S, Dozen C, Dumanoglu I, Eskut E, Girgis S, Gokbulut G, Gurpinar E, Hos I, Kangal EE, Karaman T, Karapinar G, Topaksu AK, Onengut G, Ozdemir K, Ozturk S, Polatoz A, Sogut K, Cerci DS, Tali B, Topakli H, Vergili LN, Vergili M, Akin IV, Aliev T, Bilin B, Deniz M, Gamsizkan H, Guler AM, Ocalan K, Ozpineci A, Serin M, Sever R, Surat UE, Zeyrek M, Deliomeroglu M, Gulmez E, Isildak B, Kaya M, 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Wagner SR, Zang SL, Agostino L, Alexander J, Chatterjee A, Eggert N, Gibbons LK, Heltsley B, Khukhunaishvili A, Kreis B, Kuznetsov V, Mirman N, Kaufman GN, Patterson JR, Riley D, Ryd A, Salvati E, Stroiney S, Sun W, Teo WD, Thom J, Thompson J, Tucker J, Vaughan J, Weng Y, Winstrom L, Wittich P, Winn D, Abdullin S, Albert M, Albrow M, Anderson J, Apollinari G, Atac M, Badgett W, Bakken JA, Baldin B, Banicz K, Bauerdick LAT, Beretvas A, Berryhill J, Bhat PC, Binkley M, Borcherding F, Burkett K, Butler JN, Chetluru V, Cheung HWK, Chlebana F, Cihangir S, Dagenhart W, Derylo G, Dumitrescu C, Dykstra D, Eartly DP, Elias JE, Elvira VD, Eulisse G, Evans D, Fagan D, Fisk I, Foulkes S, Freeman J, Gaines I, Gao Y, Gartung P, Giacchetti L, Gottschalk E, Green D, Guo Y, Gutsche O, Hahn A, Hanlon J, Harris RM, Hirschauer J, Holzman B, Hooberman B, Howell J, Huang CH, Hufnagel D, Jindariani S, Johnson M, Jones CD, Joshi U, Juska E, Kilminster B, Klima B, Kunori S, Kwan S, Larson K, Leonidopoulos C, Linacre J, Lincoln D, Lipton R, Perez JAL, Los S, Lykken J, Maeshima K, Marraffino JM, Maruyama S, Mason D, McBride P, McCauley T, Mishra K, Moccia S, Mommsen RK, Mrenna S, Musienko Y, Muzaffar S, Newman-Holmes C, O'Dell V, Osborne I, Pivarski J, Popescu S, Pordes R, Prokofyev O, Rapsevicius V, Ronzhin A, Rossman P, Ryu S, Sexton-Kennedy E, Sharma S, Shaw TM, Smith RP, Soha A, Spalding WJ, Spiegel L, Tanenbaum W, Taylor L, Thompson R, Tiradani A, Tkaczyk S, Tran NV, Tuura L, Uplegger L, Vaandering EW, Vidal R, Whitmore J, Wu W, Yang F, Yarba J, Yun JC, Zimmerman T, Acosta D, Avery P, Barashko V, Bourilkov D, Chen M, Cheng T, Das S, De Gruttola M, Di Giovanni GP, Dobur D, Dolinsky S, Drozdetskiy A, Field RD, Fisher M, Fu Y, Furic IK, Gartner J, Gorn L, Holmes D, Hugon J, Kim B, Konigsberg J, Korytov A, Kropivnitskaya A, Kypreos T, Low JF, Madorsky A, Matchev K, Milenovic P, Mitselmakher G, Muniz L, Park M, Remington R, Rinkevicius A, Scurlock B, Skhirtladze N, Snowball M, Stasko J, Yelton J, Zakaria M, Gaultney V, Hewamanage S, Lebolo LM, Linn S, Markowitz P, Martinez G, Rodriguez JL, Adams T, Askew A, Bertoldi M, Bochenek J, Chen J, Dharmaratna WGD, Diamond B, Gleyzer SV, Haas J, Hagopian S, Hagopian V, Jenkins M, Johnson KF, Prosper H, Tentindo S, Veeraraghavan V, Weinberg M, Baarmand MM, Dorney B, Hohlmann M, Kalakhety H, Ralich R, Vodopiyanov I, Yumiceva F, Adams MR, Anghel IM, Apanasevich L, Bai Y, Bazterra VE, Betts RR, Bucinskaite I, Callner J, Cavanaugh R, Chung MH, Evdokimov O, Garcia-Solis EJ, Gauthier L, Gerber CE, Hofman DJ, Hollis R, Iordanova A, Khalatyan S, Kunde GJ, Lacroix F, Malek M, O'Brien C, Silkworth C, Silvestre C, Smoron A, Strom D, Turner P, Varelas N, Akgun U, Albayrak EA, Ayan AS, Bilki B, Clarida W, Debbins P, Duru F, Ingram FD, McCliment E, Merlo JP, Mermerkaya H, Mestvirishvili A, Miller MJ, Moeller A, Nachtman J, Newsom CR, Norbeck E, Olson J, Onel Y, Ozok F, Schmidt I, Sen S, Tan P, Tiras E, Wetzel J, Yetkin T, Yi K, Barnett BA, 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Cooper SI, Cushman P, Dahmes B, De Benedetti A, Egeland R, Franzoni G, Gude A, Haupt J, Inyakin A, Kao SC, Klapoetke K, Kubota Y, Mans J, Pastika N, Rusack R, Singovsky A, Tambe N, Turkewitz J, Cremaldi LM, Kroeger R, Perera L, Rahmat R, Reidy J, Sanders DA, Summers D, Attebury G, Avdeeva E, Bloom K, Bockelman B, Bose S, Claes DR, Dominguez A, Eads M, Keller J, Kravchenko I, Lazo-Flores J, Lundstedt C, Malbouisson H, Malik S, Snihur R, Snow GR, Swanson D, Baur U, Godshalk A, Iashvili I, Jain S, Kharchilava A, Kumar A, Shipkowski SP, Smith K, Alverson G, Barberis E, Baumgartel D, Chasco M, Haley J, Moromisato J, Nash D, Swain J, Trocino D, Von Goeler E, Wood D, Zhang J, Anastassov A, Gobbi B, Kubik A, Lusito L, Odell N, Ofierzynski RA, Pollack B, Pozdnyakov A, Schmitt M, Stoynev S, Velasco M, Won S, Antonelli L, Baumbaugh B, Berry D, Brinkerhoff A, Chan KM, Heering AH, Hildreth M, Jessop C, Karmgard DJ, Kellams N, Kolb J, Lannon K, Luo W, Lynch S, Marinelli N, Morse DM, Pearson T, 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JH, Matveev M, Padley BP, Redjimi R, Roberts J, Tumanov A, Yepes P, Zabel J, Betchart B, Bodek A, Budd H, Chung YS, Covarelli R, de Barbaro P, Demina R, Eshaq Y, Ferbel T, Garcia-Bellido A, Ginther G, Goldenzweig P, Gotra Y, Han J, Harel A, Korjenevski S, Miner DC, Orbaker D, Sakumoto W, Slattery P, Vishnevskiy D, Zielinski M, Bhatti A, Ciesielski R, Demortier L, Goulianos K, Lungu G, Malik S, Mesropian C, Arora S, Barker A, Chou JP, Contreras-Campana C, Contreras-Campana E, Duggan D, Ferencek D, Gershtein Y, Gray R, Halkiadakis E, Hidas D, Lath A, Panwalkar S, Park M, Patel R, Rekovic V, Robles J, Rose K, Salur S, Schnetzer S, Seitz C, Somalwar S, Stone R, Thomas S, Cerizza G, Hollingsworth M, Ragghianti G, Spanier S, Yang ZC, York A, Bouhali O, Eusebi R, Flanagan W, Gilmore J, Kamon T, Khotilovich V, Montalvo R, Nguyen CN, Osipenkov I, Pakhotin Y, Perloff A, Roe J, Safonov A, Sakuma T, Sengupta S, Suarez I, Tatarinov A, Toback D, Akchurin N, Damgov J, Dragoiu C, Dudero PR, Jeong C, Kovitanggoon K, Lee SW, Libeiro T, Roh Y, Sill A, Volobouev I, Wigmans R, Appelt E, Delannoy AG, Engh D, Florez C, Gabella W, Greene S, Gurrola A, Johns W, Kurt P, Maguire C, Melo A, Sharma M, Sheldon P, Snook B, Tuo S, Velkovska J, Andelin D, Arenton MW, Balazs M, Boutle S, Conetti S, Cox B, Francis B, Goodell J, Hirosky R, Ledovskoy A, Lin C, Neu C, Phillips D, Wood J, Gollapinni S, Harr R, Karchin PE, Don CKK, Lamichhane P, Mattson M, Milstene C, Sakharov A, Anderson M, Belknap D, Bellinger JN, Borrello L, Bradley D, Carlsmith D, Cepeda M, Crotty I, Dasu S, Feyzi F, Friis E, Gorski T, Gray L, Grogg KS, Grothe M, Hall-Wilton R, Herndon M, Herve A, Klabbers P, Klukas J, Lackey J, Lanaro A, Lazaridis C, Leonard J, Loveless R, Lusin S, de Abril MM, Maier W, Mohapatra A, Ojalvo I, Palmonari F, Pierro GA, Reeder D, Ross I, Savin A, Smith WH, Swanson J, Wenman D
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Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC
PHYSICS LETTERS B 2012 SEP 17; 716(1):30-61
Results are presented from searches for the standard model Higgs boson in proton-proton collisions at root s = 7 and 8 TeV in the Compact Muon Solenoid experiment at the LHC, using data samples corresponding to integrated luminosities of up to 5.1 fb(-1) at 7 TeV and 5.3 fb(-1) at 8 TeV. The search is performed in five decay modes: gamma gamma, ZZ, W+W-, tau(+)tau(-), and b (b) over bar. An excess of events is observed above the expected background, with a local significance of 5.0 standard deviations, at a mass near 125 GeV, signalling the production of a new particle. The expected significance for a standard model Higgs boson of that mass is 5.8 standard deviations. The excess is most significant in the two decay modes with the best mass resolution, gamma gamma and ZZ; a fit to these signals gives a mass of 125.3 +/- 0.4(stat.) +/- 0.5(syst.) GeV. The decay to two photons indicates that the new particle is a boson with spin different from one. (C) 2012 CERN. Published by Elsevier B.V. All rights reserved.
Morganstern I, Liang S, Ye ZY, Karatayev O, Leibowitz SF
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Disturbances in behavior and cortical enkephalin gene expression during the anticipation of ethanol in rats characterized as high drinkers
ALCOHOL 2012 SEP; 46(6):559-568
The process of ethanol anticipation is a particularly important phenomenon that can determine subsequent drug-taking behavior. Recent studies suggest that systems within the medial prefrontal cortex (mPFC), during anticipation, may contribute to the goal-directed seeking of ethanol. The current investigation examined the possibility that the opioid peptide enkephalin (ENK), known to mediate some of the reinforcing properties of ethanol, may function in the mPFC during the anticipation of ethanol access. Using a limited access (3 h/d) paradigm for 10 days with 20% ethanol, Sprague-Dawley rats were first identified either as low drinkers (LD, <1.0 g/kg/3 h) or as high drinkers (HD, >2.0 g/kg/3 h) that exhibited a long-term phenotype of high ethanol consumption and a significant ethanol deprivation effect. During the anticipation period immediately preceding daily ethanol access, the HD rats compared to LD or Control animals with ad libitum ethanol access exhibited increased anticipatory behaviors, including greater exploratory behavior in a novel open field as revealed by significantly more time spent in the rearing position (+53-65%, p < 0.05) and increased number of rears made (+33-44%, p < 0.05) and greater novelty-seeking behavior in a hole-board apparatus revealed by an increase in total (+50-52%, p < 0.05) and novel nose pokes (+45-48%, p < 0.05). In the HD rats, analysis of the mPFC using real-time quantitative PCR showed significantly greater mRNA levels of ENK (p < 0.05) and the mu-opioid receptor (MOR) (p < 0.05), but not delta-opioid receptor (DOR), and this increase in ENK expression was found, using in situ hybridization, to occur specifically in the prelimbic (PrL) subregion of the mPFC. When injected into the PrL during the anticipation period, a MOR agonist but not DOR agonist significantly increased consumption of 20% ethanol (p < 0.05). These findings support the role of ENK, acting through MOR within the PrL to promote the anticipation and excessive consumption of ethanol. (c) 2012 Elsevier Inc. All rights reserved.
Allan S, Friedman J
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Leading the charge in leptin research: an interview with Jeffrey Friedman
DISEASE MODELS & MECHANISMS 2012 SEP; 5(5):576-579
Ivens ABF, Kronauer DJC, Pen I, Weissing FJ, Boomsma JJ
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Reproduction and dispersal in an ant-associated root aphid community
MOLECULAR ECOLOGY 2012 SEP; 21(17):4257-4269
Clonal organisms with occasional sex are important for our general understanding of the costs and benefits that maintain sexual reproduction. Cyclically parthenogenetic aphids are highly variable in their frequency of sexual reproduction. However, studies have mostly focused on free-living aphids above ground, whereas dispersal constraints and dependence on ant-tending may differentially affect the costs and benefits of sex in subterranean aphids. Here, we studied reproductive mode and dispersal in a community of root aphids that are obligately associated with the ant Lasius flavus. We assessed the genetic population structure of four species (Geoica utricularia, Tetraneura ulmi, Forda marginata and Forda formicaria) in a Dutch population and found that all species reproduce predominantly if not exclusively asexually, so that populations consist of multiple clonal lineages. We show that population viscosity is high and winged aphids rare, consistent with infrequent horizontal transmission between ant host colonies. The absence of the primary host shrub (Pistacia) may explain the absence of sex in three of the studied species, but elm trees (Ulmus) that are primary hosts of the fourth species (T. ulmi) occurred within a few km of the study population. We discuss the extent to which obligate ant-tending and absence of primary hosts may have affected selection for permanent parthenogenesis, and we highlight the need for further study of these aphids in Southern Europe where primary hosts may occur close to L. flavus populations, so that all four root aphid species would have realistic opportunities for completing their sexual life cycle.