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Found 37769 matches. Displaying 2801-2810
Frank I
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A Tat/Rev Induced Limiting Dilution Assay to Measure Viral Reservoirs in

SCIENTIFIC REPORTS 2019 AUG 19; 9(?):? Article 12078
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The establishment of latent infection and poorly characterized viral
Yuan LW
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14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking

SCIENTIFIC REPORTS 2019 AUG 1; 9(?):? Article 11156
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Receptor trafficking is pivotal for the temporal and spatial control of
Libis V
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Uncovering the biosynthetic potential of rare metagenomic DNA using

NATURE COMMUNICATIONS 2019 AUG 26; 10(?):? Article 3848
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Sequencing of DNA extracted from environmental samples can provide key
Lopez-Hernandez I
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Skewed X-inactivation in a Female Carrier with X-linked Chronic

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY 2019 AUG; 18(4):447-451
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Chronic granulomatous disease (CGD) is a primary immunodeficiency caused
Hertz NT
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Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon

NEURON 2019 AUG 7; 103(3):412-422.e4
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Selective synaptic and axonal degeneration are critical aspects of both
Witt E
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Testis single-cell RNA-seq reveals the dynamics of de novo gene

ELIFE 2019 AUG 16; 8(?):? Article e47138
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The testis is a peculiar tissue in many respects. It shows patterns of
Pamula MC
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High-resolution imaging reveals how the spindle midzone impacts

JOURNAL OF CELL BIOLOGY 2019 AUG; 218(8):2529-2544
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In the spindle midzone, microtubules from opposite half-spindles form
Khourieh J
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A deep intronic splice mutation of STAT3 underlies hyper IgE syndrome by

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 2019 AUG 13; 116(33):16463-16472
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Heterozygous in-frame mutations in coding regions of human STAT3
Brunner PM, He H, Pavel AB, Czarnowicki T, Lefferdink R, Erickson T, Canter T, Puar N, Rangel SM, Malik K, Estrada Y, Krueger JG, Guttman-Yassky E, Paller AS
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The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 2019 AUG; 81(2):510-519
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Background: Despite increasing evidence that adults with long-standing atopic dermatitis (AD) have systemic inflammation, little is known about systemic inflammation in recent-onset early pediatric AD. Objective: To analyze blood inflammatory proteins of early pediatric AD. Methods: Using high-throughput proteomics (proximity extension assay), we assessed 257 inflammatory and cardiovascular risk proteins in the blood of 30 children with moderate to severe AD younger than 5 years of age (within 6 months of onset) compared with age-matched pediatric control individuals and adult patients with AD. Results: In pediatric AD blood, T helper (Th) type 2 (CCL13, CCL22) and Th17 (peptidase inhibitor-3/elafin) markers were increased, together with markers of tissue remodeling (matrix metalloproteinases 3/9/10, urokinase receptor), endothelial activation (E-selectin), T-cell activation (IL2RA), neutrophil activation (myeloperoxidase), lipid metabolism (FABP4), and growth factors (FGF21, transforming growth factor-alpha). Total numbers of dysregulated proteins were smaller in pediatric AD (n = 22) than in adult AD (n = 61). Clinical severity scores were positively correlated with receptors for interleukins 33 and 36 and inversely correlated with some Th1 markers (interferon gamma, CXCL11). Limitations: Different baseline expression levels in healthy pediatric vs adult samples. Conclusions: Within months of pediatric AD onset, systemic immune activation is present, with Th2/Th17 skewing but otherwise different proteomic patterns from adult AD. Future correlation of proteomic patterns with disease course, comorbidity development, and drug response may yield predictive biomarkers.
Dunn AD
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Signaling Properties of Structurally Diverse Kappa Opioid Receptor

ACS CHEMICAL NEUROSCIENCE 2019 AUG; 10(8):3590-3600
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Biased ligands preferentially activate certain signaling pathways