The rockefeller university

Post-transcriptional regulation of RNA stability is a key step in gene

Background: Familial Hidradenitis Suppurativa and Familial Alzheimer's

Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN

In bacteria, a primary a-factor associates with the core RNA polymerase

Voltage-gated potassium channels (K(v)s) are gated by transmembrane

Stewart Cole and colleagues determined the complete genome sequence of

Cooperative binding of transcription factors (TFs) to chromatin

Fanconi anaemia (FA), ataxia telangiectasia (A-T), Nijmegen breakage

Neuronal cell types are the nodes of neural circuits that determine the flow of information within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides an essential descriptor of cell type and reveals how individual neurons route their output across the brain. Despite the importance of morphology, few projection neurons in the mouse brain have been reconstructed in their entirety. Here we present a robust and efficient platform for imaging and reconstructing complete neuronal morphologies, including axonal arbors that span substantial portions of the brain. We used this platform to reconstruct more than 1,000 projection neurons in the motor cortex, thalamus, subiculum, and hypothalamus. Together, the reconstructed neurons constitute more than 85 meters of axonal length and are available in a searchable online database. Axonal shapes revealed previously unknown subtypes of projection neurons and suggest organizational principles of long-range connectivity.

Despite extensive studies suggesting increased susceptibility to HIV