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Liu K

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PI31 Is an Adaptor Protein for Proteasome Transport in Axons and

DEVELOPMENTAL CELL 2019 AUG 19; 50(4):509-524.e10

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Protein degradation by the ubiquitin-proteasome system is critical for

Borges R

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Avian Binocularity and Adaptation to Nocturnal Environments: Genomic

GENOME BIOLOGY AND EVOLUTION 2019 AUG; 11(8):2244-2255

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Typical avian eyes are phenotypically engineered for photopic vision

Cohen YZ

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Safety, pharmacokinetics, and immunogenicity of the combination of the

PLOS ONE 2019 AUG 8; 14(8):? Article e0219142

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Background

Zhang SY, Jouanguy E, Zhang Q, Abel L, Puel A, Casanova JL

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Human inborn errors of immunity to infection affecting cells other than leukocytes: from the immune system to the whole organism

CURRENT OPINION IN IMMUNOLOGY 2019 AUG; 59(?):88-100

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Studies of vertebrate immunity have traditionally focused on professional cells, including circulating and tissue-resident leukocytes. Evidence that non-professional cells are also intrinsically essential (i.e. not via their effect on leukocytes) for protective immunity in natural conditions of infection has emerged from three lines of research in human genetics. First, studies of Mendelian resistance to infection have revealed an essential role of DARC-expressing erythrocytes in protection against Plasmodium vivax infection, and an essential role of FUT2-expressing intestinal epithelial cells for protection against norovirus and rotavirus infections. Second, studies of inborn errors of non-hematopoietic cell-extrinsic immunity have shown that APOL1 and complement cascade components secreted by hepatocytes are essential for protective immunity to trypanosome and pyogenic bacteria, respectively. Third, studies of inborn errors of non-hematopoietic cell-intrinsic immunity have suggested that keratinocytes, pulmonary epithelial cells, and cortical neurons are essential for tissue-specific protective immunity to human papillomaviruses, influenza virus, and herpes simplex virus, respectively. Various other types of genetic resistance or predisposition to infection in human populations are not readily explained by inborn variants of genes operating in leukocytes and may, therefore, involve defects in other cells. The probing of this unchartered territory by human genetics is reshaping immunology, by scaling immunity to infection up from the immune system to the whole organism.

Colosimo DA

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Mapping Interactions of Microbial Metabolites with Human

CELL HOST & MICROBE 2019 AUG 14; 26(2):273-282.e7

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Despite evidence linking the human microbiome to health and disease, how

Khan I

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The Vertebrate TLR Supergene Family Evolved Dynamically by Gene

DIVERSITY-BASEL 2019 AUG; 11(8):? Article 131

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The vertebrate toll-like receptor (TLRs) supergene family is a

Hawkes JE

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Impact of Online Prescription Management Systems on Biologic Treatment

ADVANCES IN THERAPY 2019 AUG; 36(8):2021-2033

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IntroductionPharmaceutical firms have begun offering online prescription

Munoz E

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Canal shaping with a reciprocating system is easy to learn

INTERNATIONAL ENDODONTIC JOURNAL 2019 AUG; 52(8):1244-1249

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Aim To assess progressive learning of root canal shaping in order to

Cederroth CR

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Medicine in the Fourth Dimension

CELL METABOLISM 2019 AUG 6; 30(2):238-250

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The importance of circadian biology has rarely been considered in

Frew JW

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Assessing the efficacy of new biologic therapies in hidradenitis

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 2019 AUG; 33(8):E298-E300

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Linked article: M. Kovacs et al. J Eur Acad Dermatol Venereol 2019; 33: