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Found 37769 matches. Displaying 1571-1580
Al-Sadawi M, Hussain Y, Copeland-Halperin RS, Tobin JN, Moskowitz CS, Dang CT, Liu JE, Steingart RM, Johnson MN, Yu AF
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Racial and Socioeconomic Disparities in Cardiotoxicity Among Women With HER2-Positive Breast Cancer
AMERICAN JOURNAL OF CARDIOLOGY 2021 MAY 15; 147(?):116-121
Breast cancer and cardiovascular-specific mortality are higher among blacks compared with whites, but disparities in cancer therapy-related adverse cardiovascular outcomes have not been well studied. We assessed for the contribution of race and socioeconomic status on cardiotoxicity among women with HER2-positive breast cancer. This retrospective cohort analysis studied women diagnosed with stage I-III HER2-positive breast cancer from 2004-2013. All underwent left ventricular ejection fraction assessment at baseline and at least one follow-up after beginning trastuzumab. Multivariable logistic regression was used to assess the association between race and socioeconomic status (SES) on cardiotoxicity, defined by clinical heart failure (New York Heart Association class III or IV) or asymptomatic left ventricular ejection fraction decline (absolute decrease >= 10% to < 53%, or >= 16%). Blacks had the highest prevalence of hypertension, diabetes, and increased BMI. Neighborhood-level SES measures including household income and educational attainment were lower for blacks compared with whites and others. The unadjusted cardiotoxicity risk was significantly higher in black compared with white women (OR, 2.10; 95% CI, 1.42 to 3.10). In a multivariable analysis, this disparity persisted after controlling for relevant cardiovascular risk factors (adjusted OR, 1.88; 95% CI, 1.25 to 2.84). Additional models adjusting for SES factors of income, educational attainment, and insurance status did not significantly alter the association between race and cardiotoxicity. In conclusion, black women are at increased risk of cardiotoxicity during HER2-targeted breast cancer therapy. Future etiologic analyses, particularly studies exploring biologic or genetic mechanisms, are needed to further elucidate and reduce racial disparities in cardiotoxicity. (C) 2021 Elsevier Inc. All rights reserved.
Wanke F, Gutbier S, Rummelin A, Steinberg M, Hughes LD, Koenen M, Komuczki J, Regan-Komito D, Wagage S, Hesselmann J, Thoma R, Brugger D, Christopeit T, Wang HY, Point F, Hallet R, Ghosh S, Rothlin CV, Patsch C, Geering B
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Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages
CELL DEATH & DISEASE 2021 MAY 25; 12(6):? Article 538
Removal of apoptotic cells by phagocytes (also called efferocytosis) is a crucial process for tissue homeostasis. Professional phagocytes express a plethora of surface receptors enabling them to sense and engulf apoptotic cells, thus avoiding persistence of dead cells and cellular debris and their consequent effects. Dysregulation of efferocytosis is thought to lead to secondary necrosis and associated inflammation and immune activation. Efferocytosis in primarily murine macrophages and dendritic cells has been shown to require TAM RTKs, with MERTK and AXL being critical for clearance of apoptotic cells. The functional role of human orthologs, especially the exact contribution of each individual receptor is less well studied. Here we show that human macrophages differentiated in vitro from iPSC-derived precursor cells express both AXL and MERTK and engulf apoptotic cells. TAM RTK agonism by the natural ligand growth-arrest specific 6 (GAS6) significantly enhanced such efferocytosis. Using a newly-developed mouse model of kinase-dead MERTK, we demonstrate that MERTK kinase activity is essential for efferocytosis in peritoneal macrophages in vivo. Moreover, human iPSC-derived macrophages treated in vitro with blocking antibodies or small molecule inhibitors recapitulated this observation. Hence, our results highlight a conserved MERTK function between mice and humans, and the critical role of its kinase activity in homeostatic efferocytosis.
Moreews M, Le Gouge K, Khaldi-Plassart S, Pescarmona R, Mathieu AL, Malcus C, Djebali S, Bellomo A, Dauwalder O, Perret M, Villard M, Chopin E, Rouvet I, Vandenesh F, Dupieux C, Pouyau R, Teyssedre S, Guerder M, Louazon T, Moulin-Zinsch A, Duperril M, Patural H, Giovannini-Chami L, Portefaix A, Kassai B, Venet F, Monneret G, Lombard C, Flodrops H, De Guillebon JM, Bajolle F, Launay V, Bastard P, Zhang SY, Dubois V, Thaunat O, Richard JC, Mezidi M, Allatif O, Saker K, Dreux M, Abel L, Casanova JL, Marvel J, Trouillet-Assant S, Klatzmann D, Walzer T, Mariotti-Ferrandiz E, Javouhey E, Belot A
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Polyclonal expansion of TCR V beta 21.3(+) CD4(+) and CD8(+) T cells is a hallmark of multisystem inflammatory syndrome in children
SCIENCE IMMUNOLOGY 2021 MAY; 6(59):? Article eabh1516
Multisystem inflammatory syndrome in children (MIS-C) is a delayed and severe complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that strikes previously healthy children. As MIS-C combines clinical features of Kawasaki disease (KD) and toxic shock syndrome (TSS), we aimed to compare the immunological profile of pediatric patients with these different conditions. We analyzed blood cytokine expression and the T cell repertoire and phenotype in 36 MIS-C cases, which were compared with 16 KD, 58 TSS, and 42 coronavirus disease 2019 (COVID-19) cases. We observed an increase of serum inflammatory cytokines (IL-6, IL-10, IL-18, TNF-alpha, IFN-gamma, sCD25, MCP1, and IL-1RA) in MIS-C, TSS, and KD, contrasting with low expression of HLA-DR in monocytes. We detected a specific expansion of activated T cells expressing the V.21.3 T cell receptor beta chain variable region in both CD4 and CD8 subsets in 75% of patients with MIS-C and not in any patient with TSS, KD, or acute COVID-19; this correlated with the cytokine storm detected. The T cell repertoire returned to baseline within weeks after MIS-C resolution. V beta 21.3+ T cells from patients with MIS-C expressed high levels of HLA-DR, CD38, and CX3CR1 but had weak responses to SARS-CoV-2 peptides in vitro. Consistently, the T cell expansion was not associated with specific classical HLA alleles. Thus, our data suggested that MIS-C is characterized by a polyclonal V.21.3 T cell expansion not directed against SARS-CoV-2 antigenic peptides, which is not seen in KD, TSS, and acute COVID-19.
Al-Sadawi M, Hussain Y, Copeland-Halperin RS, Tobin JN, Moskowitz CS, Dang C, Liu JE, Steingart RM, Johnson MN, Yu AO
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Racial and Socioeconomic Disparities in Cardiotoxicity Among Women With HER2-Positive Breast Cancer
AMERICAN JOURNAL OF CARDIOLOGY 2021 MAY 15; 147(?):116-121
Breast cancer and cardiovascular-specific mortality are higher among blacks compared with whites, but disparities in cancer therapy-related adverse cardiovascular outcomes have not been well studied. We assessed for the contribution of race and socioeconomic status on cardiotoxicity among women with HER2-positive breast cancer. This retrospective cohort analysis studied women diagnosed with stage I-III HER2-positive breast cancer from 2004-2013. All underwent left ventricular ejection fraction assessment at baseline and at least one follow-up after beginning trastuzumab. Multivariable logistic regression was used to assess the association between race and socioeconomic status (SES) on cardiotoxicity, defined by clinical heart failure (New York Heart Association class III or IV) or asymptomatic left ventricular ejection fraction decline (absolute decrease >= 10% to < 53%, or >= 16%). Blacks had the highest prevalence of hypertension, diabetes, and increased BMI. Neighborhood-level SES measures including household income and educational attainment were lower for blacks compared with whites and others. The unadjusted cardiotoxicity risk was significantly higher in black compared with white women (OR, 2.10; 95% CI, 1.42 to 3.10). In a multivariable analysis, this disparity persisted after controlling for relevant cardiovascular risk factors (adjusted OR, 1.88; 95% CI, 1.25 to 2.84). Additional models adjusting for SES factors of income, educational attainment, and insurance status did not significantly alter the association between race and cardiotoxicity. In conclusion, black women are at increased risk of cardiotoxicity during HER2-targeted breast cancer therapy. Future etiologic analyses, particularly studies exploring biologic or genetic mechanisms, are needed to further elucidate and reduce racial disparities in cardiotoxicity. (C) 2021 Elsevier Inc. All rights reserved.
Sirunyan AM, Tumasyan A, Adam W, Ambrogi F, Asilar E, Bergauer T, Brandstetter J, Dragicevic M, Ero J, Del Valle AE, Flechl M, Fruhwirth R, Ghete VM, Hrubec J, Jeitler M, Krammer N, Kratschmer I, Liko D, Madlener T, Mikulec I, Rad N, Rohringer H, Schieck J, Schofbeck R, Spanring M, Spitzbart D, Waltenberger W, Wittmann J, Wulz CE, Zarucki M, Chekhovsky V, Mossolov V, Gonzalez JS, DeWolf EA, Di Croce D, Janssen X, Lauwers J, Lelek A, Pieters M, Van Haevermaet H, Van Mechelen P, Van Remortel N, Abu Zeid S, Blekman F, D'Hondt J, De Clercq J, Deroover K, Flouris G, Lontkovskyi D, Lowette S, Marchesini I, Moortgat S, Moreels L, Python Q, Skovpen K, Tavernier S, Van Doninck W, Van Mulders P, Van Parijs I, Beghin D, Bilin B, Brun H, Clerbaux B, De Lentdecker G, Delannoy H, Dorney B, Fasanella G, Favart L, Grebenyuk A, Kalsi AK, Lenzi T, Luetic J, Postiau N, Starling E, Thomas L, Velde CV, Vanlaer P, Vannerom D, Wang Q, Cornelis T, Dobur D, Fagot A, Gul M, Khvastunov I, Poyraz D, Roskas C, Trocino D, Tytgat M, Verbeke W, Vermassen B, Vit M, Zaganidis N, Bakhshiansohi H, Bondu O, Bruno G, Caputo C, David P, Delaere C, Delcourt M, Giammanco A, Krintiras G, Lemaitre V, Magitteri A, Piotrzkowski K, Saggio A, Marono MV, Vischia P, Zobec J, Alves FL, Alves GA, Silva GC, Hensel C, Moraes A, Pol ME, Teles PR, Das Chagas EBB, Carvalho W, Chinellato J, Coelho E, Da Costa EM, Da Silveira GG, Damiao DD, Martins CD, De Souza SF, Guativa LMH, Malbouisson H, Figueiredo DM, De Almeida MM, Herrera CM, Mundim L, Nogima H, Da Silva WLP, Rosas LJS, Santoro A, Sznajder A, Thiel M, Manganote EJT, De Araujo FTD, Pereira AV, Ahuja S, Bernardes CA, Calligaris L, Tomei TRFP, Gregores EM, Mercadante PG, Novaes SF, Padula SS, Aleksandrov A, Hadjiiska R, Iaydjiev P, Marinov A, Misheva M, Rodozov M, Shopova M, Sultanov G, Dimitrov A, Litov L, Pavlov B, Petkov P, Fang W, Gao X, Yuan L, Wang Y, Ahmad M, Bian JG, Chen GM, Chen HS, Chen M, Chen Y, Jiang CH, Leggat D, Liao H, Liu Z, Shaheen SM, Spiezia A, Tao J, Yazgan E, Zhang H, Zhang S, Zhao J, Ban Y, Chen G, Levin A, Li J, Li L, Li Q, Mao Y, Qian SJ, Wang D, Avila C, Cabrera A, Montoya CAC, Sierra LFC, Florez C, Hernandez CFG, Delgado MAS, Courbon B, Godinovic N, Lelas D, Puljak I, Sculac T, Antunovic Z, Kovac M, Brigljevic V, Ferencek D, Kadija K, Mesic B, Roguljic M, Starodumov A, Susa T, Ather MW, Attikis A, Kolosova M, Mavromanolakis G, Mousa J, Nicolaou C, Ptochos F, Razis PA, Rykaczewski H, Finger, Finger M, Ayala E, Jarrin EC, Kamel AE, Mahmoud MA, Salama E, Bhowmik S, De Oliveira ACA, Dewanjee RK, Ehataht K, Kadastik M, Raidal M, Veelken C, Eerola P, Kirschenmann H, Pekkanen J, Voutilainen M, Havukainen J, Heikkila JK, Jarvinen T, Karimaki V, Kinnunen R, Lampen T, Lassila-Perini K, Laurila S, Lehti S, Linden T, Luukka P, Maenpaa T, Siikonen H, Tuominen E, Tuominiemi J, Tuuva T, Besancon M, Couderc F, Dejardin M, Denegri D, Faure JL, Ferri F, Ganjour S, Givernaud A, Gras P, de Monchenault GH, Jarry P, Leloup C, Locci E, Malcles J, Negro G, Rander J, Rosowsky A, Sahin MO, Titov M, Abdulsalam A, Amendola C, Antropov I, Beaudette F, Busson P, Charlot C, de Cassagnac RG, Kucher I, Lobanov A, Blanco JM, Perez CM, Nguyen M, Ochando C, Ortona G, Paganini P, Rembser J, Salerno R, Sauvan JB, Sirois Y, Leiton AGS, Zabi A, Zghiche A, Agram JL, Andrea J, Bloch D, Bourgatte G, Brom JM, Chabert EC, Cherepanov V, Collard C, Conte E, Fontaine JC, Gele D, Goerlach U, Jansova M, Le Bihan AC, Tonon N, Van Hove P, Gadrat S, Beauceron S, Bernet C, Boudoul G, Chanon N, Chierici R, Contardo D, Depasse P, El Mamouni H, Fay J, Finco L, Gascon S, Gouzevitch M, Grenier G, Ille B, Lagarde F, Laktineh IB, Lattaud H, Lethuillier M, Mirabito L, Perries S, Popov A, Sordini V, Touquet G, Vander Donckt M, Viret S, Toriashvili T, Tsamalaidze Z, Autermann C, Feld L, Kiesel MK, Klein K, Lipinski M, Preuten M, Rauch MP, Schomakers C, Schulz J, Teroerde M, Wittmer B, Albert A, Erdmann M, Erdweg S, Esch T, Fischer R, Ghosh S, Guth A, Hebbeker T, Heidemann C, Hoepfner K, Keller H, Mastrolorenzo L, Merschmeyer M, Meyer A, Millet P, Mukherjee S, Pook T, Radziej M, Reithler H, Rieger M, Schmidt A, Teyssier D, Thuer S, Flugge G, Hlushchenko O, Kress T, Muller T, Nehrkorn A, Nowack A, Pistone C, Pooth O, Roy D, Sert H, Stahl A, Martin MA, Arndt T, Asawatangtrakuldee C, Babounikau I, Beernaert K, Behnke O, Behrens U, Martinez AB, Bertsche D, Bin Anuar AA, Borras K, Botta V, Campbell A, Connor P, Contreras-Campana C, Danilov V, De Wit A, Defranchis MM, Pardos CD, Damiani DD, Eckerlin G, Eichhorn T, Elwood A, Eren E, Gallo E, Geiser A, Luyando JMG, Grohsjean A, Guthoff M, Haranko M, Harb A, Jung H, Kasemann M, Keaveney J, Kleinwort C, Knolle J, Krucker D, Lange W, Lenz T, Leonard J, Lipka K, Lohmann W, Mankel R, Melzer-Pellmann IA, Meyer AB, Meyer M, Missiroli M, Mittag G, Mnich J, Myronenko V, Pflitsch SK, Pitzl D, Raspereza A, Saibel A, Savitskyi M, Saxena P, Schutze P, Schwanenberger C, Shevchenko R, Singh A, Tholen H, Turkot O, Vagnerini A, Van De Klundert M, Van Onsem GP, Walsh R, Wen Y, Wichmann K, Wissing C, Zenaiev O, Aggleton R, Bein S, Benato L, Benecke A, Dreyer T, Ebrahimi A, Garutti E, Gonzalez D, Gunnellini P, Haller J, Hinzmann A, Karavdina A, Kasieczka G, Klanner R, Kogler R, Kovalchuk N, Kurz S, Kutzner V, Lange J, Marconi D, Multhaup J, Niedziela M, Niemeyer CEN, Nowatschin D, Perieanu A, Reimers A, Rieger O, Scharf C, Schleper P, Schumann S, Schwandt J, Sonneveld J, Stadie H, Steinbruck G, Stober FM, Stover M, Vormwald B, Zoi I, Akbiyik M, Barth C, Baselga M, Baur S, Butz E, Caspart R, Chwalek T, Colombo F, De Boer W, Dierlamm A, El Morabit K, Faltermann N, Freund B, Giffels M, Harrendorf MA, Hartmann F, Heindl SM, Husemann U, Katkov I, Kudella S, Mitra S, Mozer MU, Muller T, Musich M, Plagge M, Quast G, Rabbertz K, Schroder M, Shvetsov I, Simonis HJ, Ulrich R, Wayand S, Weber M, Weiler T, Wohrmann C, Wolf R, Anagnostou G, Daskalakis G, Geralis T, Kyriakis A, Loukas D, Paspalaki G, Agapitos A, Karathanasis G, Kontaxakis P, Panagiotou A, Papavergou I, Saoulidou N, Vellidis K, Kousouris K, Papakrivopoulos I, Tsipolitis G, Evangelou I, Foudas C, Gianneios P, Katsoulis P, Kokkas P, Mallios S, Manthos N, Papadopoulos I, Paradas E, Strologas J, Triantis FA, Tsitsonis D, Bartok M, Csanad M, Filipovic N, Major P, Nagy MI, Pasztor G, Suranyi O, Veres GI, Bencze G, Hajdu C, Horvath D, Hunyadi A, Sikler F, Vami TA, Veszpremi V, Vesztergombi G, Beni N, Czellar S, Karancsi J, Makovec A, Molnar J, Szillasi Z, Raics P, Trocsanyi ZL, Ujvari B, Choudhury S, Komaragiri JR, Tiwari PC, Bahinipati S, Kar C, Mal P, Mandal K, Nayak A, Chowdhury SR, Sahoo DK, Swain SK, Bansal S, Beri SB, Bhatnagar V, Chauhan S, Chawla R, Dhingra N, Gupta R, Kaur A, Kaur M, Kaur S, Kumari P, Lohan M, Meena M, Mehta A, Sandeep K, Sharma S, Singh JB, Virdi AK, Walia G, Bhardwaj A, Choudhary BC, Garg RB, Gola M, Keshri S, Kumar A, Malhotra S, Naimuddin M, Priyanka P, Ranjan K, Shah A, Sharma R, Bhardwaj R, Bharti M, Bhattacharya R, Bhattacharya S, Bhawandeep U, Bhowmik D, Dey S, Dutt S, Dutta S, Ghosh S, Maity M, Mondal K, Nandan S, Purohit A, Rout PK, Roy A, Saha G, Sarkar S, Sarkar T, Sharan M, Singh B, Thakur S, Behera PK, Muhammad A, Chudasama R, Dutta D, Jha V, Kumar V, Mishra DK, Netrakanti PK, Pant LM, Shukla P, Suggisetti P, Aziz T, Bhat MA, Dugad S, Mohanty GB, Sur N, Verma RK, Banerjee S, Bhattacharya S, Chatterjee S, Das P, Guchait M, Jain S, Karmakar S, Kumar S, Majumder G, Mazumdar K, Sahoo N, Chauhan S, Dube S, Hegde V, Kapoor A, Kothekar K, Pandey S, Rane A, Rastogi A, Sharma S, Chenarani S, Tadavani EE, Etesami SM, Khakzad M, Najafabadi MM, Naseri M, Hosseinabadi FR, Safarzadeh B, Zeinali M, Felcini M, Grunewald M, Abbrescia M, Calabria C, Colaleo A, Creanza D, Cristella L, De Filippis N, De Palma M, Di Florio A, Errico F, Fiore L, Gelmi A, Iaselli G, Ince M, Lezki S, Maggi G, Maggi M, Miniello G, My S, Nuzzo S, Pompili A, Pugliese G, Radogna R, Ranieri A, Selvaggi G, Sharma A, Silvestris L, Venditti R, Verwilligen P, Abbiendi G, Battilana C, Bonacorsi D, Borgonovi L, Braibant-Giacomelli S, Campanini R, Capiluppi P, Castro A, Cavallo FR, Chhibra SS, Codispoti G, Cuffiani M, Dallavalle GM, Fabbri F, Fanfani A, Fontanesi E, Giacomelli P, Grandi C, Guiducci L, Iemmi F, Lo Meo S, Marcellini S, Masetti G, Montanari A, Navarria FL, Perrotta A, Primavera F, Rossi AM, Rovelli T, Siroli GP, Tosi N, Albergo S, Di Mattia A, Potenza R, Tricomi A, Tuve C, Barbagli G, Chatterjee K, Ciulli V, Civinini C, D'Alessandro R, Focardi E, Latino G, Lenzi P, Meschini M, Paoletti S, Russo L, Sguazzoni G, Strom D, Viliani L, Benussi L, Bianco S, Fabbri F, Piccolo D, Ferro F, Mulargia R, Robutti E, Tosi S, Benaglia A, Beschi A, Brivio F, Ciriolo V, Di Guida S, Dinardo ME, Fiorendi S, Gennai S, Ghezzi A, Govoni P, Malberti M, Malvezzi S, Menasce D, Monti F, Moroni L, Paganoni M, Pedrini D, Ragazzi AS, de Fatis TT, Zuolo D, Buontempo S, Cavallo N, De Iorio A, Di Crescenzo A, Fabozzi F, Fienga F, Galati G, Iorio AOM, Lista L, Meola S, Paolucci P, Sciacca C, Voevodina E, Azzi P, Bacchetta N, Bisello D, Boletti A, Bragagnolo A, Carlin R, Checchia P, Dall'Osso M, Manzano PD, Dorigo T, Dosselli U, Gasparini F, Gasparini U, Gozzelino A, Hoh SY, Lacaprara S, Lujan P, Margoni M, Meneguzzo AT, Pazzini J, Presilla M, Ronchese P, Rossin R, Simonetto F, Tiko A, Torassa E, Tosi M, Zanetti M, Zotto P, Zumerle G, Braghieri A, Magnani A, Montagna P, Ratti SP, Re V, Ressegotti M, Riccardi C, Salvini P, Vai I, Vitulo P, Biasini M, Bilei GM, Cecchi C, Ciangottini D, Fano L, Lariccia P, Leonardi R, Manoni E, Mantovani G, Mariani V, Menichelli M, Rossi A, Santocchia A, Spiga D, Androsov K, Azzurri P, Bagliesi G, Bianchini L, Boccali T, Borrello L, Castaldi R, Ciocci MA, Dell'Orso R, Fedi G, Fiori F, Giannini L, Giassi A, Grippo MT, Ligabue F, Manca E, Mandorli G, Messineo A, Palla F, Rizzi A, Rolandi G, Spagnolo P, Tenchini R, Tonelli G, Venturi A, Verdini PG, Barone L, Cavallari F, Cipriani M, Del Re D, Di Marco E, Diemoz M, Gelli S, Longo E, Marzocchi B, Meridiani P, Organtini G, Pandolfi F, Paramatti R, Preiato F, Rahatlou S, Rovelli C, Santanastasio F, Amapane N, Arcidiacono R, Argiro S, Arneodo M, Bartosik N, Bellan R, Biino C, Cappati A, Cartiglia N, Cenna F, Cometti S, Costa M, Covarelli R, Demaria N, Kiani B, Mariotti C, Maselli S, Migliore E, Monaco V, Monteil E, Monteno M, Obertino MM, Pacher L, Pastrone N, Pelliccioni M, Angioni GLP, Romero A, Ruspa M, Sacchi R, Salvatico R, Shchelina K, Sola V, Solano A, Soldi D, Staiano A, Belforte S, Candelise V, Casarsa M, Cossutti F, Da Rold A, Della Ricca G, Vazzoler F, Zanetti A, Kim DH, Kim GN, Kim MS, Lee J, Lee S, Lee SW, Moon CS, Oh YD, Pak SI, Sekmen S, Son DC, Yang YC, Kim H, Moon DH, Oh G, Francois B, Goh J, Kim TJ, Cho S, Choi S, Go Y, Gyun D, Ha S, Hong B, Jo Y, Lee K, Lee KS, Lee S, Lim J, Park SK, Roh Y, Kim HS, Almond J, Kim J, Kim JS, Lee H, Lee K, Nam K, Oh SB, Radburn-Smith BC, Seo SH, Yang UK, Yoo HD, Yu GB, Jeon D, Kim H, Kim JH, Lee JSH, Park IC, Choi Y, Hwang C, Lee J, Yu I, Veckalns V, Dudenas V, Juodagalvis A, Vaitkus J, Ibrahim ZA, Ali MABM, Idris FM, Abdullah WATW, Yusli MN, Zolkapli Z, Benitez JF, Hernandez AC, Quijada JAM, Castilla-Valdez H, De la Cruz-Burelo E, Duran-Osuna MC, Heredia-De La Cruz I, Lopez-Fernandez R, Guisao JM, Rabadan-Trejo RI, Ramirez-Garcia M, Ramirez-Sanchez G, Reyes-Almanza R, Sanchez-Hernandez A, Moreno SC, Barrera CO, Valencia FV, Eysermans J, Pedraza I, Ibarguen HAS, Estrada CU, Pineda AM, Krofcheck D, Bheesette S, Butler PH, Ahmad A, Ahmad M, Asghar MI, Hassan Q, Hoorani HR, Khan WA, Shah MA, Shoaib M, Waqas M, Bialkowska H, Bluj M, Boimska B, Frueboes T, Gorski M, Kazana M, Szleper M, Traczyk P, Zalewski P, Bunkowski K, Byszuk A, Doroba K, Kalinowski A, Konecki M, Krolikowski J, Misiura M, Olszewski M, Pyskir A, Walczak M, Araujo M, Bargassa P, Silva CBDE, Di Francesco A, Faccioli P, Galinhas B, Gallinaro M, Hollar J, Leonardo N, Seixas J, Strong G, Toldaiev O, Varela J, Afanasiev S, Bunin P, Gavrilenko M, Golutvin I, Gorbunov I, Kamenev A, Karjavine V, Lanev A, Malakhov A, Matveev V, Moisenz P, Palichik V, Perelygin V, Shmatov S, Shulha S, Skatchkov N, Smirnov V, Voytishin N, Zarubin A, Golovtsov V, Ivanov Y, Kim V, Kuznetsova E, Levchenko P, Murzin V, Oreshkin V, Smirnov I, Sosnov D, Sulimov V, Uvarov L, Vavilov S, Vorobyev A, Andreev Y, Dermenev A, Gninenko S, Golubev N, Karneyeu A, Kirsanov M, Krasnikov N, Pashenkov A, Shabanov A, Tlisov D, Toropin A, Epshteyn V, Gavrilov V, Lychkovskaya N, Popov V, Pozdnyakov I, Safronov G, Spiridonov A, Stepennov A, Stolin V, Toms M, Vlasov E, Zhokin A, Aushev T, Andreev V, Azarkin M, Dremin I, Kirakosyan M, Terkulov A, Belyaev A, Boos E, Ershov A, Gribushin A, Khein L, Klyukhin V, Kodolova O, Lokhtin I, Lukina O, Obraztsov S, Petrushanko S, Savrin V, Snigirev A, Barnyakov A, Blinov V, Dimova T, Kardapoltsev L, Skovpen Y, Azhgirey I, Bayshev I, Bitioukov S, Kachanov V, Kalinin A, Konstantinov D, Mandrik P, Petrov V, Ryutin R, Slabospitskii S, Sobol A, Troshin S, Tyurin N, Uzunian A, Volkov A, Babaev A, Baidali S, Okhotnikov V, Adzic P, Cirkovic P, Devetak D, Dordevic M, Milenovic P, Milosevic J, Maestre JA, Fernandez AA, Bachiller I, Luna MB, Cifuentes JAB, Cerrada M, Colino N, De La Cruz B, Peris AD, Bedoya CF, Ramos JPF, Flix J, Fouz MC, Lopez OG, Lopez SG, Hernandez JM, Josa MI, Moran D, Yzquierdo APC, Pelayo JP, Redondo I, Romero L, Navas SS, Soares MS, Triossi A, Albajar C, de Troconiz JF, Cuevas J, Erice C, Menendez JF, Folgueras S, Caballero IG, Fernandez JRG, Cortezon EP, Bouza VR, Cruz SS, Garcia JMV, Cabrillo IJ, Calderon A, Quero BC, Campderros JD, Fernandez M, Manteca PJF, Alonso AG, Garcia-Ferrero J, Gomez G, Virto AL, Marco J, Rivero CM, del Arbol PMR, Matorras F, Gomez JP, Prieels C, Rodrigo T, Ruiz-Jimeno A, Scodellaro L, Trevisani N, Vila I, Cortabitarte RV, Wickramage N, Abbaneo D, Akgun B, Auffray E, Auzinger G, Baillon P, Ball AH, 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Taylor D, Tos K, Tripathi M, Wang Z, Zhang F, Bachtis M, Bravo C, Cousins R, Dasgupta A, Erhan S, Florent A, Hauser J, Ignatenko M, Mccoll N, Regnard S, Saltzberg D, Schnaible C, Valuev V, Bouvier E, Burt K, Clare R, Gary JW, Shirazi SMAG, Hanson G, Karapostoli G, Kennedy E, Lacroix F, Long OR, Negrete MO, Paneva MI, Wang WSL, Wei H, Wimpenny S, Yates BR, Branson JG, Chang P, Cittolin S, Derdzinski M, Gerosa R, Gilbert D, Hashemi B, Holzner A, Klein D, Kole G, Krutelyov V, Letts J, Masciovecchio M, May S, Olivito D, Padhi S, Pieri M, Sharma V, Tadel M, Wood J, Wurthwein F, Yagil A, Della Porta GZ, Amin N, Bhandari R, Campagnari C, Citron M, Dutta V, Sevilla MF, Gouskos L, Heller R, Incandela J, Mei H, Ovcharova A, Qu H, Richman J, Stuart D, Suarez I, Wang S, Yoo J, Anderson D, Bornheim A, Lawhorn JM, Lu N, Newman HB, Nguyen TQ, Pata J, Spiropulu M, Vlimant JR, Wilkinson R, Xie S, Zhang Z, Zhu RY, Andrews MB, Ferguson T, Mudholkar T, Paulini M, Sun M, Vorobiev I, Weinberg M, Cumalat JP, Ford WT, Jensen F, Johnson A, MacDonald E, Mulholland T, Patel R, Perloff A, Stenson K, Ulmer KA, Wagner SR, Alexander J, Chaves J, Cheng Y, Chu J, Datta A, Mcdermott K, Mirman N, Patterson JR, Quach D, Rinkevicius A, Ryd A, Skinnari L, Soffi L, Tan SM, Tao Z, Thom J, Tucker J, Wittich P, Zientek M, Abdullin S, Albrow M, Alyari M, Apollinari G, Apresyan A, Apyan A, Banerjee S, Bauerdick LAT, Beretvas A, Berryhill J, Bhat PC, Burkett K, Butler JN, Canepa A, Cerati GB, Cheung HWK, Chlebana F, Cremonesi M, Duarte J, Elvira VD, Freeman J, Gecse Z, Gottschalk E, Gray L, Green D, Grunendahl S, Gutsche O, Hanlon J, Harris RM, Hasegawa S, Hirschauer J, Hu Z, Jayatilaka B, Jindariani S, Johnson M, Joshi U, Klima B, Kortelainen MJ, Kreis B, Lammel S, Lincoln D, Lipton R, Liu M, Liu T, Lykken J, Maeshima K, Marraffino JM, Mason D, McBride P, Merkel P, Mrenna S, Nahn S, O'Dell V, Pedro K, Pena C, Prokofyev O, Rakness G, Ravera F, Reinsvold A, Ristori L, Savoy-Navarro A, Schneider B, Sexton-Kennedy E, Soha A, Spalding WJ, Spiegel L, Stoynev S, Strait J, Strobbe N, Taylor L, Tkaczyk S, Tran NV, Uplegger L, Vaandering EW, Vernieri C, Verzocchi M, Vidal R, Wang M, Weber HA, Acosta D, Avery P, Bortignon P, Bourilkov D, Brinkerhoff A, Cadamuro L, Carnes A, Curry D, Field RD, Gleyzer SV, Joshi BM, Konigsberg J, Korytov A, Lo KH, Ma P, Matchev K, Menendez N, Mitselmakher G, Rosenzweig D, Shi K, Sperka D, Wang J, Wang S, Zuo X, Joshi YR, Linn S, Ackert A, Adams T, Askew A, Hagopian S, Hagopian V, Johnson KF, Kolberg T, Martinez G, Perry T, Prosper H, Saha A, Schiber C, Yohay R, Baarmand MM, Bhopatkar V, Colafranceschi S, Hohlmann M, Noonan D, Rahmani M, Roy T, Saunders M, Yumiceva F, Adams MR, Apanasevich L, Berry D, Betts RR, Cavanaugh R, Chen X, Dittmer S, Evdokimov O, Gerber CE, Hangal DA, Hofman DJ, Jung K, Kamin J, Mills C, Tonjes MB, Varelas N, Wang H, Wang X, Wu Z, Zhang J, Alhusseini M, Bilki B, Clarida W, Dilsiz K, Durgut S, Gandrajula RP, Haytmyradov M, Khristenko V, Merlo JP, Mestvirishvili A, Moeller A, Nachtman J, Ogul H, Onel Y, Ozok F, Penzo A, Snyder C, Tiras E, Wetzel J, Blumenfeld B, Cocoros A, Eminizer N, Fehling D, Feng L, Gritsan AV, Hung WT, Maksimovic P, Roskes J, Sarica U, Swartz M, Xiao M, Al-Bataineh A, Baringer P, Bean A, Boren S, Bowen J, Bylinkin A, Castle J, Khalil S, Kropivnitskaya A, Majumder D, Mcbrayer W, Murray M, Rogan C, Sanders S, Schmitz E, Takaki JDT, Wang Q, Duric S, Ivanov A, Kaadze K, Kim D, Maravin Y, Mendis DR, Mitchell T, Modak A, Mohammadi A, Rebassoo F, Wright D, Baden A, Baron O, Belloni A, Eno SC, Feng Y, Ferraioli C, Hadley NJ, Jabeen S, Jeng GY, Kellogg RG, Kunkle J, Mignerey AC, Nabili S, Ricci-Tam F, Seidel M, Shin YH, Skuja A, Tonwar SC, Wong K, Abercrombie D, Allen B, Azzolini V, Baty A, Bi R, Brandt S, Busza W, Cali IA, D'Alfonso M, Demiragli Z, Ceballos GG, Goncharov M, Harris P, Hsu D, Hu M, Iiyama Y, Klute M, Kovalskyi D, Lee YJ, Luckey PD, Maier B, Marini AC, Mcginn C, Mironov C, Narayanan S, Niu X, Paus C, Rankin D, Roland C, Roland G, Shi Z, Stephans GSF, Sumorok K, Tatar K, Velicanu D, Wang J, Wang TW, Wyslouch B, Benvenuti AC, Chatterjee RM, Evans A, Hansen P, Hiltbrand J, Jain S, Kalafut S, Krohn M, Kubota Y, Lesko Z, Mans J, Rusack R, Wadud MA, Acosta JG, Oliveros S, Avdeeva E, Bloom K, Claes DR, Fangmeier C, Golf F, Suarez RG, Kamalieddin R, Kravchenko I, Monroy J, Siado JE, Snow GR, Stieger B, Godshalk A, Harrington C, Iashvili I, Kharchilava A, Mclean C, Nguyen D, Parker A, Rappoccio S, Roozbahani B, Alverson G, Barberis E, Freer C, Haddad Y, Hortiangtham A, Madigan G, Morse DM, Orimoto T, Tishelman-charny A, Wamorkar T, Wang B, Wisecarver A, Wood D, Bhattacharya S, Bueghly J, Charaf O, Gunter T, Hahn KA, Odell N, Schmitt MH, Sung K, Trovato M, Velasco M, Bucci R, Dev N, Goldouzian R, Hildreth M, Anampa KH, Jessop C, Karmgard DJ, Lannon K, Li W, Loukas N, Marinelli N, Meng F, Mueller C, Musienko Y, Planer M, Ruchti R, Siddireddy P, Smith G, Taroni S, Wayne M, Wightman A, Wolf M, Woodard A, Alimena J, Antonelli L, Bylsma B, Durkin LS, Flowers S, Francis B, Hill C, Ji W, Ling TY, Luo W, Winer BL, Cooperstein S, Elmer P, Hardenbrook J, Haubrich N, Higginbotham S, Kalogeropoulos A, Kwan S, Lange D, Lucchini MT, Luo J, Marlow D, Mei K, Ojalvo I, Olsen J, Palmer C, Piroue P, Salfeld-Nebgen J, Stickland D, Tully C, Malik S, Norberg S, Barker A, Barnes VE, Das S, Gutay L, Jones M, Jung AW, Khatiwada A, Mahakud B, Miller DH, Neumeister N, Peng CC, Piperov S, Qiu H, Schulte JF, Sun J, Wang F, Xiao R, Xie W, Cheng T, Dolen J, Parashar N, Chen Z, Ecklund KM, Freed S, Geurts FJM, Kilpatrick M, Kumar A, Li W, Padley BP, Redjimi R, Roberts J, Rorie J, Shi W, Tu Z, Zhang A, Bodek A, De Barbaro P, Demina R, Duh YT, Dulemba JL, Fallon C, Ferbel T, Galanti M, Garcia-Bellido A, Han J, Hindrichs O, Khukhunaishvili A, Ranken E, Tan P, Taus R, Ciesielski R, Goulianos K, Chiarito B, Chou JP, Gershtein Y, Halkiadakis E, Hart A, Heindl M, Hughes E, Kaplan S, Elayavalli RK, Kyriacou S, Laflotte I, Lath A, Montalvo R, Nash K, Osherson M, Saka H, Salur S, Schnetzer S, Sheffield D, Somalwar S, Stone R, Thomas S, Thomassen P, Acharya H, Delannoy AG, Heideman J, Riley G, Spanier S, Bouhalia O, Celik A, Dalchenko M, De Mattia M, Delgado A, Dildick S, Eusebi R, Gilmore J, Huang T, Kamon T, Luo S, Marley D, Mueller R, Overton D, Pernie L, Rathjens D, Safonov A, Akchurin N, Damgov J, De Guio F, Dudero PR, Kunori S, Lamichhane K, Lee SW, Mengke T, Muthumuni S, Peltola T, Undleeb S, Volobouev I, Wang Z, Whitbeck A, Greene S, Gurrola A, Janjam R, Johns W, Maguire C, Melo A, Ni H, Padeken K, Romeo F, Sheldon P, Tuo S, Velkovska J, Verweij M, Xu Q, Arenton MW, Barria P, Cox B, Hirosky R, Joyce M, Ledovskoy A, Li H, Neu C, Sinthuprasith T, Wang Y, Wolfe E, Xia F, Harr R, Karchin PE, Poudyal N, Sturdy J, Thapa P, Zaleski S, Buchanan J, Caillol C, Carlsmith D, Dasu S, De Bruyn I, Dodd L, Gomber B, Grothe M, Herndon M, Herve A, Hussain U, Klabbers P, Lanaro A, Long K, Loveless R, Ruggles T, Savin A, Sharma V, Smith N, Smith WH, Woods N, Antchev G, Aspell P, Atanassov I, Avati V, Baechler J, Barrera CB, Berardi V, Berretti M, Borchsh V, Bossini E, Bottigli U, Bozzo M, Burkhardt H, Cafagna FS, Catanesi MG, Csanad M, Csorgo T, Deile M, De Leonardis F, Doubek M, Druzhkin D, Eggert K, Eremin V, Fiergolski A, Forthomme L, Garcia F, Georgiev V, Giani S, Grzanka L, Hammerbauer J, Isidori T, Ivanchenko V, Janda M, Karev A, Kaspar J, Kaynak B, Kopal J, Kundrat V, Lami S, Linhart R, Lindsey C, Lokajicek MV, Losurdo L, Rodriguez FL, Macria M, Malawski M, Minafra N, Minutoli S, Naaranoja T, Nemes F, Niewiadomski H, Novak T, Oliveri E, Oljemark F, Oriunno M, Osterberg K, Palazzi P, Passaro V, Peroutka Z, Prochazka J, Quinto M, Radermacher E, Radicioni E, Ravotti F, Royon C, Ruggiero G, Saarikko H, Samoylenko VD, Scribano A, Siroky J, Smajek J, Snoeys W, Stefanovitch R, Sziklai J, Taylor C, Tcherniaev E, Turini N, Urban O, Vacek V, Vavroch O, Welti J, Williams J, Zich J, Zielinski K
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Measurement of single-diffractive dijet production in proton-proton collisions at root s = 8 TeV with the CMS and TOTEM experiments (vol 80, 1164, 2020)
EUROPEAN PHYSICAL JOURNAL C 2021 MAY; 81(5):? Article 383
Boisson B, Casanova JL
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TLR8 gain of function: a tall surprise
BLOOD 2021 MAY 6; 137(18):2420-2422
In this issue of Blood, Aluri et al report 6 unrelated male patients who carried gain-of-function (GOF) variants of the X-linked gene TLR8.(1) The patients had invasive bacterial and fungal infections associated with splenomegaly and lymphadenopathy. They had an excess of double-negative T cells, abnormal B-cell maturation, and neutropenia, and some patients had bone marrow failure.
Witt E, Svetec N, Benjamin S, Zhao L
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Transcription Factors Drive Opposite Relationships between Gene Age and Tissue Specificity in Male and Female Drosophila Gonads
MOLECULAR BIOLOGY AND EVOLUTION 2021 MAY; 38(5):2104-2115
Evolutionarily young genes are usually preferentially expressed in the testis across species. Although it is known that older genes are generally more broadly expressed than younger genes, the properties that shaped this pattern are unknown. Older genes may gain expression across other tissues uniformly, or faster in certain tissues than others. Using Drosophila gene expression data, we confirmed previous findings that younger genes are disproportionately testis biased and older genes are disproportionately ovary biased. We found that the relationship between gene age and expression is stronger in the ovary than any other tissue and weakest in testis. We performed ATAC-seq on Drosophila testis and found that although genes of all ages are more likely to have open promoter chromatin in testis than in ovary, promoter chromatin alone does not explain the ovary bias of older genes. Instead, we found that upstream transcription factor (TF) expression is highly predictive of gene expression in ovary but not in testis. In the ovary, TF expression is more predictive of gene expression than open promoter chromatin, whereas testis gene expression is similarly influenced by both TF expression and open promoter chromatin. We propose that the testis is uniquely able to express younger genes controlled by relatively few TFs, whereas older genes with more TF partners are broadly expressed with peak expression most likely in the ovary. The testis allows widespread baseline expression that is relatively unresponsive to regulatory changes, whereas the ovary transcriptome is more responsive to trans-regulation and has a higher ceiling for gene expression.
Almeida ST, Paulo AC, Froes F, de Lencastre H, Sa-Leao R
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Dynamics of Pneumococcal Carriage in Adults: A New Look at an Old Paradigm
JOURNAL OF INFECTIOUS DISEASES 2021 MAY 1; 223(9):1590-1600
Background. Limited information is available on pneumococcal colonization among adults. We studied pneumococcal carriage dynamics in healthy adults using high-sensitivity approaches. Methods. Eighty-seven adults (25-50 years old) were followed for 6 months in Portugal. Nasopharyngeal, oropharyngeal, and saliva samples were obtained monthly; pneumococcal carriers were also sampled weekly. Carriage was investigated by quantitative polymerase chain reaction (targeting lytA and piaB) and culture. Positive samples were serotyped. Results. Approximately 20% of the adults were intermittent carriers; 10% were persistent carriers (>4 months). Pneumococcal acquisition and clearance rates were 16.5 (95% confidence interval [Cl], 11.2-24.2) and 95.9 (95% CI, 62.3-145.0) cases/1000 person-weeks, respectively. Living with children increased pneumococcal acquisition (hazard ratio, 9.7 [95% Cl, 2.6-20.5]; P < .001). Median duration of carriage was 7 weeks and did not depend on regular contact with children. Conclusions. The pneumococcal carrier state in healthy adults is more dynamic than generally assumed: Acquisition is frequent and duration of carriage is often long. 'Ibis suggests that some adults may act as reservoirs of pneumococci and hence, depending on the social structure of a community, the magnitude of herd effects potentially attainable through children vaccination may vary. These findings are important when designing strategies to prevent pneumococcal disease in adults.
Sanders M, Tobin JN, Cassells A, Carroll J, Holder T, Thomas M, Luque A, Fiscella K
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Can a brief peer-led group training intervention improve health literacy in persons living with HIV? Results from a randomized controlled trial
PATIENT EDUCATION AND COUNSELING 2021 MAY; 104(5):1176-1182
Objective: The goal of this study was to determine if a 6-week, peer-led intervention improves health literacy and numeracy among people living with HIV (PLWH). Methods: We used a randomized controlled trial with repeated measurements, which included six, 90 minute, group-based training sessions. We recruited PLWH participants (n = 359) from safety-net practices in the New York City Metropolitan area and Rochester, NY. Participants were randomly assigned (1:1) to an intervention group (n = 180) or a control group (n = 179). Outcome measures were collected at baseline, eight weeks post-baseline, and at six months using the Brief Estimate of Health Knowledge and Action-HIV (BEHKA-HIV), the Electronic Health Literacy Scale (eHEALS), the Rapid Estimate of Adult Literacy (REALM), and the Newest Vital Sign (NVS). Results: The intervention group had statistically significant improvements in eHealth literacy and BEHKAHIV compared to the control group. There were no statistically significant changes in general health literacy or numeracy in either group. The intervention had the greatest impact on participants with the lowest levels of eHealth literacy at baseline. Conclusion: The intervention had a positive impact on participants & rsquo; HIV health literacy and eHealth literacy. Practice implications: Our findings have implications for broadening the function of peer-workers in the health care continuum. (c) 2020 Elsevier B.V. All rights reserved.
Malone B, Chen J, Wang Q, Llewellyn E, Choi YJ, Olinares PDB, Cao XY, Hernandez C, Eng ET, Chait BT, Shaw DE, Landick R, Darst SA, Campbell EA
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Structural basis for backtracking by the SARS-CoV-2 replication & ndash;transcription complex
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2021 MAY 11; 118(19):? Article e2102516118
Backtracking, the reverse motion of the transcriptase enzyme on the nucleic acid template, is a universal regulatory feature of transcription in cellular organisms but its role in viruses is not established. Here we present evidence that backtracking extends into the viral realm, where backtracking by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) may aid viral transcription and replication. Structures of SARS-CoV-2 RdRp bound to the essential nsp13 helicase and RNA suggested the helicase facilitates backtracking. We use cryo-electron microscopy, RNA-protein cross-linking, and unbiased molecular dynamics simulations to characterize SARS-CoV-2 RdRp backtracking. The results establish that the single-stranded 3 ' segment of the product RNA generated by backtracking extrudes through the RdRp nucleoside triphosphate (NTP) entry tunnel, that a mismatched nucleotide at the product RNA 3 ' end frays and enters the NTP entry tunnel to initiate backtracking, and that nsp13 stimulates RdRp backtracking. Backtracking may aid proofreading, a crucial process for SARS-CoV-2 resistance against antivirals.