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Lab members in bold.


  1. Onishi, M., Pecani, K., Jones, T. 4th, Pringle, J.R., Cross, F.R. (2018) F-actin homeostasis through transcriptional regulation and proteasome-mediated proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 115(28):E6487-E6496.
  2. Breker, M., Lieberman, K., Cross, F.R. (2018) Comprehensive Discovery of Cell-Cycle-Essential Pathways in Chlamydomonas reinhardtii. Plant Cell. 30(6):1178-1198.
  3. Atkins, K.C., Cross, F.R. (2018) Interregulation of CDKA/CDK1 and the Plant-Specific Cyclin-Dependent Kinase CDKB in Control of the Chlamydomonas Cell Cycle. Plant Cell. 30(2):429-446.


  1. Rahi, S.J., Larsch, J., Pecani, K., Katsov, A.Y., Mansouri, N., Tsaneva-Atanasova, K., Sontag, E.D., Cross, F.R. (2017) Oscillatory stimuli differentiate adapting circuit topologies. Nature Methods. 14(10):1010-1016.
  2. Cross, F.R., Breker, M., Lieberman, K. (2017) Validated Bayesian Differentiation of Causative and Passenger Mutations. G3 (Bethesda). 7(7):2081-2094.


  1. Breker, M., Lieberman, K., Tulin, F., Cross, F.R. (2016) High-Throughput Robotically Assisted Isolation of Temperature-sensitive Lethal Mutants in Chlamydomonas reinhardtii. Journal of Visualized Experiments. (118)
  2. Pecani, K., Cross, F.R. (2016) Degradation of the Mitotic Cyclin Clb3 Is not Required for Mitotic Exit but Is Necessary for G1 Cyclin Control of the Succeeding Cell Cycle. Genetics. 204(4):1479-1494.
  3. Ondracka, A., Robbins, J.A., Cross, F.R. (2016) An APC/C-Cdh1 Biosensor Reveals the Dynamics of Cdh1 Inactivation at the G1/S Transition. PLoS One. 11(7):e0159166.
  4. Tulin, F., Cross, F.R. (2016) Patching Holes in the Chlamydomonas Genome. G3 (Bethesda). 6(7):1899-910.
  5. Rahi, S.J., Pecani, K., Ondracka, A., Oikonomou, C., Cross, F.R. (2016) The CDK-APC/C Oscillator Predominantly Entrains Periodic Cell-Cycle Transcription. Cell. 165(2):475-87.
  6. Onishi, M., Pringle, J.R., Cross, F.R. (2016) Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas. Genetics. 202(3):977-96.


  1. Cross, F.R. (2015) Tying Down Loose Ends in the Chlamydomonas Genome: Functional Significance of Abundant Upstream Open Reading Frames. G3 (Bethesda). 6(2):435-46.
  2. Tulin, F., Cross, F.R. (2015) Cyclin-Dependent Kinase Regulation of Diurnal Transcription in Chlamydomonas. Plant Cell. 27(10):2727-42.


  1. Tulin, F,. Cross, F.R. (2014) A microbial avenue to cell cycle control in the plant superkingdom. Plant Cell. 26(10):4019-38.
  2. Li, Y., Cross, F.R., Chait, B.T. (2014) Method for identifying phosphorylated substrates of specific cyclin/cyclin-dependent kinase complexes. Proceedings of the National Academy of Sciences of the United States of America. 111(31):11323-8.


  1. Zhang, Q., Yoon, Y., Yu, Y., Parnell, E.J., Garay, J.A., Mwangi, M.M., Cross, F.R., Stillman, D.J., Bai, L. (2013) Stochastic expression and epigenetic memory at the yeast HO promoter. Proceedings of the National Academy of Sciences of the United States of America. 110(34):14012-7.
  2. Kaiser, B.K., Carleton, M., Hickman, J.W., Miller, C., Lawson, D., Budde, M., Warrener, P., Paredes, A., Mullapudi, S., Navarro, P., Cross, F., Roberts, J.M. (2013) Fatty aldehydes in cyanobacteria are a metabolically flexible precursor for a diversity of biofuel products. PLoS One. 8(3):e58307.


  1. Oikonomou, C., Cross, F.R. (2011) Rising cyclin-CDK levels order cell cycle events. PLoS One. 6(6):e20788. Rosenberg, J.S., Cross, F.R., Funabiki, H. (2011) KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint. Current Biology. 21(11):942-7.
  2. Bai, L., Ondracka, A., Cross, F.R. (2011) Multiple sequence-specific factors generate the nucleosome-depleted region on CLN2 promoter. Molecular Cell. 42(4):465-76.
  3. Cross, F.R., Pecani, K. (2011) Efficient and rapid exact gene replacement without selection. Yeast. 28(2):167-79.
  4. Bloom, J., Cristea, I.M., Procko, A.L., Lubkov, V., Chait, B.T., Snyder, M., Cross, F.R. (2011) Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. The Journal of  Biological Chemistry. 286(7):5434-45.


  1. Robbins, J.A., Cross, F.R. (2010) Regulated degradation of the APC coactivator Cdc20. Cell Division. 5(1):23.
  2. Bai, L., Charvin, G., Siggia, E.D., Cross, F.R. (2010) Nucleosome-depleted regions in cell-cycle-regulated promoters ensure reliable gene expression in every cell cycle. Developmental Cell. 18(4):544-55.
  3. Lu, Y., Cross, F.R. (2010) Periodic Cyclin-Cdk Activity Entrains an Autonomous Cdc14 Release Oscillator. Cell. 141(2):268-79.
  4. Robbins, J.A., Cross, F.R. (2010) Requirements and Reasons for Effective Inhibition of the Anaphase Promoting Complex Activator Cdh1. Molecular Biology of the Cell. 21(6):914-25.
  5. Charvin, G., Oikonomou, C., Siggia, E.D., Cross, F.R. (2010) Origin of irreversibility of cell cycle start in budding yeast. PLoS Biology. 8(1):e1000284.


  1. Buchler, N.E., Cross, F.R. (2009) Protein sequestration generates a flexible ultrasensitive response in a genetic network. Molecular Systems Biology. 2009;5:272.
  2. Ikui, A.E., Cross, F.R. (2009) Specific genetic interactions between spindle assembly checkpoint proteins and B-Type cyclins in Saccharomyces cerevisiae. Genetics. 2009 Sep;183(1):51-61.
  3. Di Talia, S., Wang, H., Skotheim, J.M., Rosebrock, A.P., Futcher, B., Cross, F.R. (2009) Daughter-specific transcription factors regulate cell size control in budding yeast. PLoS Biology. 7(10):e1000221.
  4. Drapkin, B.J., Lu, Y., Procko, A.L., Timney, B.L., Cross, F.R. (2009) Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin. Molecular Systems Biology. 5:328.
  5. Charvin, G., Cross, F.R., Siggia, E.D. (2009) Forced periodic expression of G1 cyclins phase-locks the budding yeast cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 106(16):6632-7.


  1. Cross, F.R., Umen, J.G. (2015) The Chlamydomonas cell cycle. The Plant Journal. 82(3):370-92.
  2. Cross, F.R., Buchler, N.E., Skotheim, J.M. (2011) Evolution of networks and sequences in eukaryotic cell cycle control. Philosophical Transactions of the Royal Society London B: Biological Sciences. 2011 366(1584):3532-44.
  3. Oikonomou, C., Cross, F.R. (2010) Frequency control of cell cycle oscillators. Current Opinion in Genetics & Development. 20(6):605-12.
  4. Wäsch, R, Robbins, J.A., Cross, F.R. (2010) The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression. Oncogene. 29(1):1-10.


Contact Us

Laboratory of Cell Cycle Genetics
The Rockefeller University
1230 York Avenue
New York, NY 10065

Fred Cross