Nature online: September 9, 2012 Initiation of transcription-coupled repair characterized at single-molecule resolution Kévin Howan, Abigail J. Smith, Lars F. Westblade, Nicolas Joly, Wilfried Grange, Sylvain  Zorman, Seth A. Darst, Nigel J. Savery and Terence R. Strick

Vitamin D has been touted for its beneficial effects on a range of human systems, from enhancing bone health to reducing the risk of developing certain cancers. But it does not improve cholesterol levels, according to a new study conducted at The Rockefeller University Hospital. A team of scienti...

A Redoubt of Learning Holds Firm   "More broadly, [Paul Nurse] doesn’t fret about American dominance. That is just the way it is. Perhaps some cultural differences even accrue to the British side of the ledger. 'The U.S.A. has a very strong work ethic, and you keep a very close eye to the cutti...

Bacteria may be simple creatures, but unlike “higher” organisms they have a neat evolutionary trick. When the going gets tough, they can simply pick up and incorporate a loose bit of genetic material from their environment. It’s instant evolution, no time-consuming mutations required. This pro...

Michael W. Young, Richard and Jeanne Fisher Professor and head of the Laboratory of Genetics, is being honored with the 2012 Massry Prize for his groundbreaking work on the molecular biology of circadian rhythms. Established by the Meira and Shaul G. Massry Foundation, the prize recognizes outsta...

Neuron 75: 585-592 Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans Heeun Jang, Kyuhyung Kim, Scott J. Neal, Evan Macosko, Dongshin Kim, Rebecca A. Butcher, Danna M. Zeiger, Cornelia I. Bargmann and Piali Sengupta

Proceedings of the National Academy of Sciences USA online: August 20, 2012 Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro John W. Schoggins, Marcus Dorner, Michael Feulner, Naoko Imanaka, Mary  Y. Murphy, Alexa...

Cell 150: 764-779 The BMP inhibitor coco reactivates breast cancer cells at lung metastatic sites Hua Gao, Goutam Chakraborty, Ai Ping Lee-Lim, Qianxing Mo, Markus  Decker, Alin Vonica, Ronglai Shen, Edi Brogi, Ali H. Brivanlou and Filippo G. Giancotti

Cell Host & Microbe 12: 177-186 CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection David Bikard, Asma Hatoum-Aslan, Daniel Mucida and Luciano A. Marraffini

Proceedings of the National Academy of Sciences USA online: August 13, 2012 Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry Anastasia A. Aksyuk, Valorie D. Bowman, Bärbel Kaufmann, Christopher  Fields, Thomas Klose, Heather A. Holda...