To explore in detail how specific genetic errors can lead to disease, scientists need to perform experiments in cells that carry these exact mutations. Now, the ability to create these cellular replicas using new genome editing technology has been facilitated thanks to work by Rockefeller Univers...

Each time a cell divides, it replicates its DNA once, then separates the two copies from each other and splits into two daughter cells. The event is intricately coordinated and was long known to be under the influence of cyclins—an aptly named group of proteins whose levels go up and down as the ...

Accompanying commentary recommends revisiting current bioethical guidelines in light of advance       Despite significant biomedical advances in recent decades, the very earliest events of human development­—those that occur during a critical window just after fertilization—h...

Scientists Grow Embryos for Up to 13 Days Outside the Uterus   "In addition, to both teams’ surprise, the embryos outside the womb were able to 'self-organize' or begin to set in motion early development of key body organs without any biological cues from the mother. 'That is counterintuitive to ...

Nathaniel Heintz, James and Marilyn Simons Professor and head of the Laboratory of Molecular Biology, and Stanislas Leibler, Gladys T. Perkin Professor and head of the Laboratory of Living Matter, have been elected to the U.S. National Academy of Sciences. They are among 84 new national and 21 ne...

Charles M. Rice, Maurice R. and Corinne P. Greenberg Professor in Virology and head of the Laboratory of Virology and Infectious Disease, has been honored with the 2016 InBev-Baillet Latour Health Prize for his work on the hepatitis C virus. Queen Mathilde of Belgium presented Rice with the prize...

Aging takes its toll on the brain, and the cells of the hippocampus—a brain region with circuitry crucial to learning and memory—are particularly vulnerable to changes that can lead to Alzheimer’s disease or cognitive decline. With the hope of counteracting the changes that can lead to these t...

Scientists solve CRISPR's 'Energizer Bunny' problem   "'It works beautifully,' Tessier-Lavigne said. With standard CRISPR-Cas9, 6 percent to 35 percent of the edits were clean, without random insertions and deletions due to Cas9’s repeated cuts, but with their upgrade, the percentage of clean e...

Same but Different: How epigenetics can blur the line between nature and nurture "Allis walked me to his lab, a fluorescent-lit space overlooking the East River, divided by wide, polished-stone benches. A mechanical stirrer, whirring in a corner, clinked on the edge of a glass beaker. 'Two featur...

by Alexandra MacWade, assistant editor and Zach Veilleux, director of publications & editor-in-chief The last time Rockefeller’s website was rebuilt, mobile phones had hinges and Netflix sent movies only on disks. Broadband was still a novelty and Myspace was on the rise. That was in 2004, an...