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sakmar gpcr ramp beads
Science News

This technique for studying cell receptors could have sweeping implications for drug development

...While this work is the culmination of a team effort over a long period of time, Kotliar made herculean efforts to drag it across the finish line—shuttling samples and scarce reagents back and forth from Sweden in rare travel windows during COVID. It paid off. The results provide a handf...
Chickens on a farm
Science News

What we need to worry about with avian flu—and what we don’t 

...You’d hope after the COVID pandemic that there’d be much more surveillance and screening. Instead, we have significant gaps in information. However, scientists are doing whatever they can. They’ve analyzed the sequence of the virus and calculated when this flu jumped from birds into cow...
llamas participating in research
Science News

Innovative approach opens the door to COVID nanobody therapies

COVID is not yet under control. Despite a bevy of vaccines, monoclonal antibodies, and antivirals, the virus continues to mutate and elude us. One solution that scientists have been exploring since the early days of the pandemic may come in the form of tiny antibodies derived from llamas, ...
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In Brief

Boosters are key to protecting pregnant individuals and newborns against the worst effects of COVID

...But how long does this protection last? A new study from The Rockefeller University and Weill Cornell Medicine (WCM), published in Nature Communications, found that patients with a specific cocktail of COVID exposure—vaccination, up-to-date boosters, and previous infection—had the highe...
llamas participating in research
Science News

How antibodies from llamas may lead to COVID-19 treatment

...Nanobodies could become one more weapon in our arsenal against COVID-19, and potentially a widely available one.” In order to get there, Rout, Chait and their colleagues are now extracting antibodies from llamas and examining their molecular properties to identify those most effective a...
drug screenings
Science News

As COVID-19 vaccines emerge, the search for antiviral drugs continues

Highly promising vaccines have recently emerged for COVID-19, but this doesn’t mean research into other treatments can slow down. There is still no cure for the disease, and people will likely continue to get sick even after vaccines become widely available—by not getting their COVID
Teal-colored scanning electron micrograph image of a dendritic cell
Science News

Homing in on the genetics of severe COVID in children

One of the most terrifying aspects of the COVID pandemic has been its unpredictably severe impact on some children. While most infected kids have few or no symptoms, one in 10,000 fall suddenly and dramatically ill about a month after a mild infection, landing in the hospital with inflamed...
covid helicase
Science News

Rogue enzymes cause numerous diseases. A new method could help design drugs to treat them.

...The paper, published in the Journal of the American Chemical Society, describes how researchers used this innovative new platform to design molecules that take aim at helicases involved in COVID and certain cancers. "High-resolution structural and biochemical data alone are not sufficie...
covid car shot
Science News

How antibody therapy impacts COVID vaccines

...The findings suggest that feedback inhibition increases the coverage provided by COVID vaccines in people who previously received monoclonal antibodies. "Depending on the virus, feedback inhibition can either enhance immunity or inhibit it," says Michel C. Nussenzweig, who co-led the st...
tavazoieostendorf
Science News

Common mutation linked to COVID mortality

It may be the most baffling quirk of COVID: What manifests as minor, flu-like symptoms in some individuals spirals into severe disease, disability, or even death in others. New research published in Nature may explain the genetic underpinnings of this dichotomy.  The researchers demonstrat...
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