News & HighlightsNews
Statin-intolerant patients need a different type of clinical trial, Rockefeller researchers say
Millions of people take statins, the blockbuster drug that lowers low-density lipoprotein (LDL), the so-called bad cholesterol. But as many as 20 percent of them develop adverse effects such as muscle fatigue and weakness and impaired cognition. Rockefeller University scientists Patricia Maningat...
DNA testing by high school students shows many teas contain unlisted ingredients
Your tea may not be what you think. Three New York City high school students, working with Rockefeller scientists, have found several herbal brews and a few brands of tea contain ingredients unlisted on the manufacturers’ package. The teen sleuths also demonstrated new-to-science genetic variatio...
Scientists identify broad and potent HIV antibodies that mimic CD4 binding
In a finding that may be good news for scientists developing HIV vaccines and therapies, a team of researchers at The Rockefeller University and the Howard Hughes Medical Institute have found a way to investigate the broadly neutralizing antibody response against the CD4 binding site of HIV on a ...
Cancer stem cells identified, offering new drug targets
Like carpet bombing, traditional chemotherapy is not very discriminating. Both can cause disastrous collateral damage and still fail to take out the real enemy. New research offers the potential for a surgical strike against cancer that would target only its root cause — cancer stem cells. Elaine...
Scientists create humanized mouse model for hepatitis C
For researchers searching for new treatments for hepatitis C, the only animal model available to study the virus's life cycle has been the chimpanzee, which is naturally susceptible to infection by the virus. But ethical, logistical and financial hurdles have limited the use of this large ape. No...
The Great Reversal, an increase in forest density worldwide, is under way
Forests in many regions are becoming larger carbon sinks thanks to higher density, U.S. and European researchers say in a new report. In Europe and North America, increased density significantly raised carbon storage despite little or no expansion of forest area, according to the study, conducted...
Genes help worms decide where to dine
In the famous song by The Clash, “Should I Stay or Should I Go,” the lyrics wrestle with one of the more complicated decisions people make — whether to end a difficult love affair or try to make it work. We aren’t likely to understand exactly how specific genes affect such momentous choices ...
Analysis of sperm differentiation reveals new mode of proteasome regulation
Early in development, cells undergo a controlled demolition that helps to shape their raw, pliable material into the specialized forms they must have to do their jobs as adults. The process by which this occurs is also crucial later in the cell’s life, to take out potentially dangerous trash that...
Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants
Scientists at Rockefeller University have shown that anti-inflammatory drugs, which include ibuprofen, aspirin and naproxen, reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors, or SSRIs, often prescribed for depression...
Polarized microscopy technique shows new details of how proteins are arranged
Whether you’re talking about genes, or neurons, or the workings of a virus, at the most fundamental level, biology is a matter of proteins. So understanding what protein complexes look like and how they operate is the key to figuring out what makes cells tick. By harnessing the unique properties ...
View
View