News & HighlightsNews
Protein proves vital in immune response to bacteria
A team of researchers led by scientists at Rockefeller University have discovered that a protein once thought to be mainly involved in antiviral immunity is in fact more important in fighting bacterial infections and could provide new mechanisms for treating diseases like tuberculosis, which is i...
Collaboration finds kidney disease tied to DNA damage
A research collaboration involving Rockefeller University and more than two dozen other institutions has found a link between a gene mutation and chronic kidney failure. The study, published in Nature Genetics in July, found patients who had a specific kind of kidney disease — called karyomegalic...
Cell 150: 533-548 (August 3, 2012)
Cell 150: 533-548 (August 3, 2012) Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling Moumita Chaki, Rannar Airik, Amiya K. Ghosh, Rachel H. Giles, Rui Chen, Gisela G. Slaats, Hui Wang, Toby W. Hurd, Weibin Zhou, Andrew Cluckey, Heon Yun...
Starr collaboration illuminates mysterious pathway to immortality in cancer cells
Cancer cells are immortal because they circumvent failsafe mechanisms that stop out-of-control cell proliferation. One of these mechanisms – the progressive shortening of chromosomes – is prevented by replenishment of telomeres, the protective elements at the ends of chromosomes. Most cancer cel...
Sweat glands grown from newly identified stem cells
To date, few fundamentals have been known about the most common gland in the body, the sweat glands that are essential to controlling body temperature, allowing humans to live in the world’s diverse climates. Now, in a tour de force, researchers at The Rockefeller University and the Howard Hughes...
Rockefeller scientists pioneer new method to determine mechanisms of drug action
Knowing that a drug works is great. Knowing how it works is a luxury. And until now, determining a drug’s mechanism of action has been a tedious and difficult process for scientists. Researchers led by Tarun Kapoor at The Rockefeller University, in collaboration with Olivier Elemento at Weill Cor...
Influenza “histone mimic” suppresses antiviral response
For a virus like influenza, the key to success isn’t in overpowering the immune system, it’s in tricking it. A team of researchers led by scientists at The Rockefeller University has identified a novel mechanism by which influenza viruses hijack key regulators of the human body’s normal antivi...
Study in fruit flies reveals a gene affecting the ability to sleep
On the surface, it’s simple: when night falls, our bodies get sleepy. But behind the scenes, a series of complex molecular events, controlled by our genes, is hard at work to make us groggy. Now, research suggests that a newly identified gene known as insomniac may play a role in keeping us aslee...
In cancer, molecular signals that recruit blood vessels also trigger metastasis
Cancer cells are most deadly when they’re on the move — able not only to destroy whatever organ they are first formed in, but also to create colonies elsewhere in the body. New research has now shown how a small RNA prevents the recruitment and formation of blood vessels near cancer cell destine...
Resident protection
First "live" imaging of specialized immune system cells reveals new clues about body’s security system To keep the body safe, the immune system enlists more than one form of protection. A circulating task force of immune system cells monitors the body’s periphery, and sends information back to ...
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