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Luciano Marraffini receives the Hans Sigrist Prize for work on antibiotic resistance
Luciano Marraffini, assistant professor and head of the Laboratory of Bacteriology, has been recognized with the Hans Sigrist Prize for his work developing a new approach to combat antibiotic resistance. This Swiss award, bestowed by the University of Bern, specifically honors Marraffini for mani...
Researchers discover new aspect of gene regulation and a possible target for cancer drugs
There are about 20,000 genes in the human genome, but not all are used in all cells at all times. At any given moment, a cell is converting only roughly half its genes into proteins. And of those active genes, about 75 percent are regulated by a process known as “RNA polymerase pausing.” This...
Study suggests new way to help the immune system fight off sleeping sickness parasite
Some infectious diseases are particularly difficult to treat because of their ability to evade the immune system. One such illness, African sleeping sickness, is caused by the parasite Trypanosoma brucei, transmitted by the tsetse fly, and is fatal if left untreated. The trypanosome parasite is t...
New research helps to explain how temperature shifts the circadian clock
For many living things, a roughly 24-hour internal clock governs the rhythms of life—everything from sleep in animals, to leaf opening in plants and reproduction in bread mold. Scientists have come to understand much about this internal time-keeping system, but one important aspect, its complex r...
Study reveals new mechanism in nicotine addiction
Part of the reason people find smoking difficult to quit is that each time they have a cigarette, feelings of craving, irritability and anxiety melt away. This component of addiction is known as negative reward and is controlled in part by a region of the brain called the habenula. The neurotrans...
DNA strands often “wiggle” as part of genetic repair
Sometimes, the molecules that make up life exhibit strange behavior. For instance, in simple organisms such as yeast, when genetic material becomes damaged, the affected DNA strands increase their motion, waving about inside the cell like a sail unfurled. Over the years, scientists have seen more...
In the News - Newsday - O'Donnell
  Researchers at Brookhaven lab, Stony Brook and Rockefeller universities make new discoveries about double helix copying   "In Manhattan, Michael O'Donnell, who heads Rockefeller's Laboratory of DNA Replication, said the finding will change how students understand DNA replication. 'It's a pa...
Study reveals the architecture of the molecular machine that copies DNA
DNA replication is essential to all life, yet many basic mechanisms in that process remain unknown to scientists. The structure of the replisome—a block of proteins responsible for unwinding the DNA helix and then creating duplicate helices for cell division—is one such mystery. Now, for the ...
Researchers identify potential new leukemia drug target
New treatment options are badly needed for acute myeloid leukemia, a relatively rare form of cancer. The malignancy begins in the bone marrow, and from there can spread rapidly to the bloodstream, depriving the body of the essential blood cells that carry oxygen and fight infections. Now, new wor...
Helmsley Trust renews $15 million grant for novel digestive disorders research
by Wynne Parry, Science Writer The Leona M. and Harry B. Helmsley Charitable Trust has awarded a new three-year, $15-million grant to The Rockefeller University to help support the interdisciplinary Center for Basic and Translational Research on Disorders of the Digestive System. Established in 2...
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