Greengard Cascade

TUESDAY, SEPTEMBER 20, 2022
9:00 AM – 5:30 PM | Scientific Symposium
Caspary Auditorium
The Rockefeller University
1230 York Avenue at East 66th Street
New York, NY 10065

Schedule of Events

8:30 – 9:00 AMBreakfast

9:00 – 9:10 AMWelcome Remarks

Richard P. Lifton, M.D., Ph.D.
President and Carson Family Professor
The Rockefeller University

9:10 – 9:20 AMIntroduction

Marc Flajolet, Ph.D.
Research Associate Professor
Laboratory of Molecular and Cellular Neuroscience
The Rockefeller University

SESSION I

9:20 – 9:25 AMChair

Angus Nairn, Ph.D.
Charles B. G. Murphy Professor of Psychiatry
Professor of Pharmacology
Yale School of Medicine

9:25 – 9:50 AMCholinergic Regulation of Reward and Stress
Learning in the Amygdala

Marina Picciotto, Ph.D.
Charles B. G. Murphy Professor of Psychiatry
Deputy Director, Kavli Institute for Neuroscience
Yale School of Medicine

9:50 – 10:15 AMCell Type-Specific Contributions to
Huntington’s Disease Mechanisms

Myriam Heiman, Ph.D.
Assistant Professor of Neuroscience
Department of Brain and Cognitive Sciences
The Picower Institute for Learning and Memory
Massachusetts Institute of Technology

10:15 – 10:40 AM The Operational Principles of Neuron-microglia Circuits

Anne Schaefer, M.D., Ph.D.
Professor of Neuroscience
Icahn School of Medicine at Mount Sinai
Director, Max Planck Institute for Biology of Ageing, Cologne

10:40 – 10:55 AMBreak

SESSION II

10:55 – 11:00 AMChair

Fred Gorelick, M.D.
Henry J. and Joan W. Binder Professor of Medicine
and of Cell Biology
Director, Investigative Gastroenterology NIH T32,
Internal Medicine
Deputy Director, Yale University M.D., Ph.D. Program

11:00 – 11:25 AMGlia-Neuron Crosstalk Regulates the Onset of the
Antidepressant Response

Revathy Chottekalapanda, Ph.D.
Senior Research Associate
Laboratory of Molecular and Cellular Neuroscience
The Rockefeller University

11:25 – 11:50 AMDecoding Transcriptional and Post-transcriptional
Effects of Genomic Variants

Olga Troyanskaya, Ph.D.
Professor,
Department of Computer Science and
the Lewis-Sigler Institute for Integrative Genomics
Princeton University
Deputy Director for Genomics
Center for Computational Biology
Flatiron Institute, Simons Foundation

11:50 – 12:15 PMCell Types, Circuits, and CNS Therapies

Nathaniel Heintz, Ph.D.
James and Marilyn Simons Professor
Laboratory of Molecular Biology
The Rockefeller University
Investigator, Howard Hughes Medical Institute

12:15 – 1:45 PMLunch Break
Abby Aldrich Rockefeller Lounge and Dining Room
Faculty and Student Club

SESSION III

1:45 – 1:50 PMChair

Leslie Greengard, M.D., Ph.D.
Silver Professor of Mathematics and Computer Science
New York University
Director, Center for Computational Mathematics
Flatiron Institute, Simons Foundation

1:50 – 2:15 PMNeurodegeneration Genes Provide Insight into
Novel Mechanisms of Intracellular Lipid Transport

Pietro De Camilli, M.D.
John Klingenstein Professor of Neuroscience and Professor
of Cell Biology
Director, Program in Cellular Neuroscience,
Neurodegeneration and Repair
Yale School of Medicine
Investigator, Howard Hughes Medical Institute

2:15 – 2:40 PMRegulation of Neurotransmitter Receptors
in the Brain in Health and Disease

Richard Huganir, Ph.D.
Bloomberg Distinguished Professor
Professor and Director, Solomon H. Snyder
Department of Neuroscience
Kavli Neuroscience Discovery Institute
Johns Hopkins University

2:40 – 3:05 PMGene Therapy to Manipulate Neuronal Signaling Pathways

Michael Kaplitt, M.D., Ph.D.
Professor of Neurological Surgery
Vice-Chairman for Research
Residency Program Director
Department of Neurological Surgery
Weill Cornell Medicine

3:05 – 3:20 PMBreak

SESSION IV

3:20 – 3:25 PMChair

Cori Bargmann, Ph.D.
Torsten N. Wiesel Professor
Lulu and Anthony Wang Laboratory of Neural Circuits
and Behavior
The Rockefeller University

3:25 – 3:50 PMAlzheimer’s Disease: From In Vitro Single Phosphorylation to
In Vivo Fully Integrated Views

Dr. Flajolet

3:50 – 4:15 PMTranscriptional and Epigenetic Mechanisms of Addiction

Eric J. Nestler, M.D., Ph.D.
Nash Family Professor of Neuroscience
Director, Friedman Brain Institute
Dean for Academic Affairs and Chief Scientific Officer
Icahn School of Medicine at Mount Sinai

4:15 – 4:25 PMBreak

SESSION V

4:25 – 4:30 PMChair

Leslie Vosshall, Ph.D.
Robin Chemers Neustein Professor
Laboratory of Neurogenetics and Behavior
The Rockefeller University
Vice President and Chief Scientific Officer
Howard Hughes Medical Institute

4:30– 5:15 PMRegional Vulnerability in Adult Neurodegenerative Disorders:
Lessons from Spinocerebellar Ataxia Type

Huda Zoghbi, M.D.
Professor, Department of Pediatrics,
Department of Molecular and Human Genetics,
Department of Neuroscience
Baylor College of Medicine
Investigator, Howard Hughes Medical Institute
Director, Jan and Dan Duncan Neurological Research Institute
Texas Children’s Hospital

Closing Remarks

5:15 – 5:25 PMUrsula von Rydingsvard

5:25 – 5:30 PMPresident Lifton

5:30 – 7:00 PMReception
Abby Aldrich Rockefeller Lounge and Dining Room