Event Detail (Archived)
From Ancestry to Biochemistry in Steatotic Liver Disease
The Joshua Lederberg Distinguished Lecture in Molecular Genetics
- This event already took place in December 2025
- Caspary Auditorium
Event Details
- Type
- Friday Lecture Series
- Speaker(s)
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Helen Hobbs, M.D., professor of internal medicine and molecular genetics, University of Texas Southwestern Medical Center; investigator, Howard Hughes Medical Institute
- Speaker bio(s)
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Helen H. Hobbs is an HHMI Investigator and Professor at UT Southwestern. With Jonathan Cohen, she has used human genetics to identify variants of large effect sizes that alter plasma levels of Lp(a) [APOA], LDL-cholesterol (ABCG5/ABCG8, LDLRAP, PCSK9, NPC1L1, ANGPTL3), and triglyceride (ANGPTL3,-4,-8). She also discovered the two most impactful genetic differences conferring risk of steatotic liver disease (PNPLA3, TM6SF2). Gene discovery is the starting point for studies elucidating the pathways disrupted by the defective genes she identifies. She is a member of the National Academy of Sciences (2007) and received the Breakthrough Prize in Life Sciences (2016).
- Open to
- Tri-Institutional