Molecular Recording of Mammalian Development
The Richard M. Furlaud Distinguished Lecture
Event Details
- Type
- Friday Lecture Series
- Speaker(s)
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Jay Shendure, M.D., Ph.D., scientific director, Brotman Baty Institute for Precision Medicine; scientific director, Seattle Hub for Synthetic Biology (Allen-CZI-UW); professor of genome sciences, University of Washington; investigator, Howard Hughes Medical Institute
- Speaker bio(s)
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Biology unfolds over time, within cells and tissues that are opaque to our eyes and instruments. Current molecular measurement paradigms are inherently limited: genomics is destructive and static, and imaging confined to a few channels in visually accessible systems. Dr. Shendure will describe our efforts to develop an alternative—molecular recording—in which cells are programmed to write their own histories from within. He will focus on DNA Typewriter and ENGRAM, which record lineage and cellular state information into genomic DNA. The Shendure Lab's long-term goal is to reframe phenotyping as an organism-wide, time-resolved measurement, capturing developmental statistics rather than static or tissue-restricted endpoints.
Jay Shendure, M.D., Ph.D. is an Investigator of the Howard Hughes Medical Institute, a Professor of Genome Sciences at the University of Washington, and Scientific Director of the Seattle Hub for Synthetic Biology (Allen-CZI-UW), the Allen Discovery Center for Cell Lineage Tracing, and the Brotman Baty Institute for Precision Medicine. His 2005 doctoral thesis with George Church included one of the first successful reductions to practice of next-generation DNA sequencing. Dr. Shendure's research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays, saturation genome editing; combinatorial single cell molecular technologies; and genome editing-based molecular recording technologies. Dr. Shendure is the recipient of the Curt Stern Award from the American Society of Human Genetics (2012), the Richard Lounsbery Award from the National Academy of Sciences (2019) and the Mendel Award from the European Society of Human Genetics (2022). He is an elected member of the American Association for the Advancement of Science and the National Academy of Sciences. He serves or previously served as an advisor to the NIH Director, the US Precision Medicine Initiative, National Human Genome Research Institute, Chan Zuckerberg Initiative, Gladstone Institute, New York Genome Center and Allen Institute. He received his M.D. and Ph.D. degrees from Harvard Medical School in 2007.
- Open to
- Tri-Institutional