Mitochondria as Signaling Organelles Control Physiology and Disease

Event Details

Type

Friday Lecture Series

Speaker(s)

Navdeep Chandel, Ph.D., David W. Cugell, M.D., Professor of Medicine, Biochemistry and Molecular Genetics, Northwestern University

Speaker bio(s)

The Chandel Lab is interested in understanding how mitochondria control physiology and pathology beyond ATP production. For decades, mitochondria have been primarily viewed as biosynthetic and bioenergetic organelles generating metabolites to produce macromolecules and ATP, respectively. The lab's work has revealed mitochondria have a third distinct role whereby mitochondria beyond ATP production can generate signals to control cell fate and function. Their work reveals that mitochondria can release reactive oxygen species (ROS) and the metabolites in controlling hypoxic responses, cellular differentiation, and immune responses in vivo. They also have established that mitochondrial metabolism is necessary for cancer cell, endothelial cell, and conventional T cell proliferation in vivo. Dr. Chandel will present his lab's current findings on how mitochondria as signaling organelles dictate cellular fate and function in physiology and diseases.

Navdeep S. Chandel (Nav) is the David W. Cugell Professor of Medicine, Biochemistry, and Molecular Genetics at Northwestern University. He received his B.A. in Mathematics (1991) and Ph.D. in Cell Physiology at the University of Chicago (1993-1997, Paul Schumacker) as well as a post-doctoral fellowship at the University of Chicago (1997-1999, jointly with Paul Schumacker and Craig Thompson). In 2000, he started his laboratory at Northwestern University on the concept of “Mitochondria as signaling organelles”. He has written a widely utilized introductory book entitled “Navigating Metabolism” (Cold Spring Harbor Press). He received the Clarence Ver Steeg Faculty Mentor Award in 2013, which recognizes faculty members from any department throughout Northwestern University for their outstanding mentorship of graduate students. In 2023, he was co-recipient of the FNIH Lurie Prize in Biomedical Science.

This Friday Lecture will take place in Caspary Auditorium and virtually via Zoom. We recommend virtual participants log out of VPN prior to logging in to Zoom. Please do not share the link or post on social media.

Open to

Tri-Institutional