Event Detail (Archived)
Deep Linearity in Adaptation and Evolution: Macroscopic Theory, Microscopic Simulation, and Bacterial Experiments
- This event already took place in April 2017
- A Level Physics Seminar Room, Room A30, Smith Hall Annex (CRC)
Event Details
- Type
- Center for Studies in Physics and Biology Seminars
- Speaker(s)
-
Kunihiko Kaneko, Ph.D., professor, department of basic science, University of Tokyo
- Open to
- Public
- Contact
- Melanie Lee
- Phone
- (212) 327-8636
- Sponsor
-
Melanie Lee
(212) 327-8636
leem@rockefeller.edu - Notes
- Quantitative characterization of plasticity, robustness, and evolvability is one of the most important issues in biology. Based on statistical physics and dynamical-systems theory, we present a macroscopic theory of fluctuation and responses in cellular states. By assuming that cells undergo steady growth, protein expression of thousands of genes is shown to change along a one-dimensional manifold in the state space in response to the environmental stress. This leads to a macroscopic law that cellular-state changes satisfy, as is confirmed by adaptation experiments of bacteria under stress. Next, we present proportionality between phenotypic changes by genetic evolution and by environmental adaptation, uncovered both in bacterial experiments and simulations. This relationship is then formulated by the hypothesis that phenotypic changes in adaptation and evolution are dominantly constrained along one-dimensional path. Possible extension of the theory to non-growing cellular states and to multi-level evolution for multicellularity will be briefly discussed.