Journal of Experimental Medicine 211(6):1049-62 A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice Hyung Jin Ahn, J. Fraser Glickman, Ka Lai Poon, Daria Zamolodchikov, Odella C. Jno-Charles, Erin H. Norris and Sidney Strickland

Cell 157: 935-949 Transit-amplifying cells orchestrate stem cell activity and tissue regeneration Ya-Chieh Hsu, Lishi Li and Elaine Fuchs  

Stem cells switch off and on, sometimes dividing to produce progeny cells and sometimes resting. But scientists don’t fully understand what causes the cells to toggle between active and quiet states. New research in Elaine Fuchs’ Laboratory of Mammalian Cell Biology and Development focused on s...

Neuron 82: 682-694 Incremental integration of global contours through interplay between visual cortical areas Minggui Chen, Yin Yan, Xiajing Gong, Charles D. Gilbert, Hualou Liang and Wu Li

Over the weeks following an invasion by a disease-causing microbe, the human immune system fine tunes its defenses, producing proteins called antibodies that are ever more precisely targeted at the invader. New research in Michel Nussenzweig’s Laboratory of Molecular Immunology helps explain how ...

Robert B. Darnell, Robert and Harriet Heilbrunn Professor and head of the Laboratory of Molecular Neuro-oncology, has been named a member of the National Academy of Sciences. Darnell is one of 84 newly elected members announced today by the Academy; an additional 21 foreign associates from 15 cou...

This land is your land   "Food, [Jesse Ausubel] told me, is a little like clothing. 'There are large companies that turn out the blue jeans and T-shirts we all wear. We don't mind large scale for that. But sometimes we all want a little something nicer, a little more fashionable. Even people with...

Proceedings of the National Academy of Sciences USA online: April 28, 2014 Structure of the branched intermediate in protein splicing Zhihua Liu, Silvia Frutos, Matthew J. Bick, Miquel Vila-Perelló, Galia T. Debelouchina, Seth A. Darst and Tom W. Muir

Cell 157: 636-650 Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function Ender Karaca, Stefan Weitzer, Davut Pehlivan, Hiroshi  Shiraishi, Tasos Gogakos, Toshikatsu Hanada, Shalini N. Jhangiani, Wojciech Wiszniewski, Marjorie Withers, Ian M. Camp...

Proceedings of the National Academy of Sciences USA online: April 24, 2014 A model for the generation and transmission of variations in evolution Olivier Rivoire and Stanislas Leibler