News & HighlightsNews
Breakthrough in cell-type analysis offers new way to study development and disease
Like skilled assassins, many diseases seem to know exactly what types of cells to attack. While decimating one cadre of cells, diseases will inexplicably spare a seemingly identical group of neighbors. What makes cells vulnerable or not depends largely on the kinds and amounts of proteins they pr...
Fatty diet during pregnancy produces new neurons to fetal brain
A study in rats shows that exposure to a high-fat diet during pregnancy produces permanent changes in the offspring’s brain that lead to overeating and obesity early in life, according to new research by Rockefeller University scientists. This surprising finding, reported in the November 12 issue...
Scientists confirm a molecular clipping mechanism behind stem cell development
Stem cells don’t just become a part of the liver or the brain in a flash; it takes a complex molecular choreography and requires that specific genes be switched on and off at specific times. Some of these genes are regulated through a process by which proteins in the cell nucleus, called histones...
Researchers find new path to antibiotics in dirt
A teaspoon of dirt contains an estimated 10,000 species of bacteria, but it’s only one percent of these microbial bugs — the ones that can be grown easily in a lab — that have brought us antibiotics, anticancer agents and other useful drugs. The odds favor the other 99 percent for clinical pro...
Without glial cells, animals lose their senses
Sensory neurons have always put on a good show. But now it turns out they’ll be sharing the credit. In groundbreaking research to appear in the October 31 issue of Science, Rockefeller University scientists show that while neurons play the lead role in detecting sensory information, a second type...
New method provides panoramic view of protein-RNA interactions in living cells
DNA, it has turned out, isn’t all it was cracked up to be. In recent years we learned that the molecule of life, the discovery of the 20th century, did not — could not — by itself explain the huge differences in complexity between a human and a worm. Forced to look elsewhere, scientists turned...
By imaging living cells, researchers show how hepatitis C replicates
The hepatitis C virus is a prolific replicator, able to produce up to a trillion particles per day in an infected person by hijacking liver cells in which to build up its viral replication machinery. Now new research — in which scientists have for the first time used fluorescent proteins to image...
Simulator allows scientists to predict evolution's next best move
Biologists today are doing what Darwin thought impossible. They are studying the process of evolution not through fossils but directly, as it is happening. Now, by modeling the steps evolution takes to build, from scratch, an adaptive biochemical network, biophysicists Eric D. Siggia and Paul Fra...
Plant virus spreads by making life easy for crop pests
In 752, Japanese Empress Koken wrote a short poem about the summertime yellowing of a field in what is thought to be the first account of a viral plant disease. More than 1,250 years later, scientists concluded that the virus Koken described was part of the particularly insidious geminivirus fami...
In mice, anxiety is linked to immune system
In the first study ever to genetically link the immune system to normal behavior, scientists at Rockefeller and Columbia Universities show that mast cells, known as the pharmacologic bombshells of the immune system, directly influence how mice respond to stressful situations. The work, to appear ...
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